format-version: 1.2 data-version: 2013-04-20/cl-merged.owl subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" subsetdef: cell_quality "cell_quality" subsetdef: Cross_product_review "Involved_in" subsetdef: cyclostome_subset "cyclostome structures" subsetdef: defined_by_ordinal_series "classes that are defined by relative position counting from first in a series of elements along an axis in an individual organism rather than by strict homology" subsetdef: developmental_classification "developmental_classification" subsetdef: disjointness_axiom_removed "A class which has a weakened disjointness axiom, to avoid inconsistency. These are kept separately in the uberon_disjoint_from_strict ontology." subsetdef: disposition_slim "Disposition slim" subsetdef: dubious_grouping "Indicates that subclasses in AOs may be inappropriately linked" subsetdef: early_development "A class that represents an early developmental structure, like a blastocyst. This part of the ontology is undergoing review to remove inappropriate grouping classes." subsetdef: emapa_ehdaa2 "derived from the union of EHDAA2 and EMAPA - still to be checked" subsetdef: functional_classification "functional_classification" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: grouping_class "Subset consisting of classes creating for grouping purposes" subsetdef: high_level_annotation_qc "High-level terms not to be used for direct annotation" subsetdef: inconsistent_with_fma "classes that have some inconsistency with FMA" subsetdef: inherited_grouping_class "A grouping class that originates in two or more separate anatomical ontologies. Includes 'region of X' type terms" subsetdef: loose_concept "loose concept" subsetdef: major_organ "somewhat fuzzy grouping for analysis purposes, currently composed of something like: liver, heart, skeletal, kidney, bladder, brain, skin, mouth, esophagus, stomach, small intestine, large intestines, trachea nose, lungs, brain, spinal cord, peripheral nerves, kidneys, ureters, bladder, urethra, gonads" subsetdef: metazoa_core "core classes typically found across metazoa. one purpose is to create a rough set of terms that could be used to start a new metazoan AO. Note this subset is not yet fully fleshed out" subsetdef: mf_needs_review "Catalytic activity terms in need of attention" subsetdef: mpath_slim "Pathology slim" subsetdef: non_informative "abstract class brought in to group ontology classes but not informative" subsetdef: organ_slim "organs, excluding individual muscles and skeletal elements" subsetdef: phenotype_rcn "A subset specifically created for the 2012 Phenotype RCN meeting. Includes some human-specific terms that may eventually be removed when they are adequately represented with part of relationships in FMA" subsetdef: relational_slim "Relational slim: types of quality that require an additional entity in order to exist" subsetdef: scalar_slim "Scalar slim" subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors" subsetdef: uberon_slim "Uberon slim - somewhat arbitrary subset that excludes obscure terms and deep compositional terms" subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: unverified_taxonomic_grouping "Indicates that the class encompasses classes from other AOs that have not been verified" subsetdef: unvetted "" subsetdef: upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: upper_ontology_conflict "Terms in this subset group together terms from different anatomy ontologies that have conflicting upper ontology/CARO assignments. For example, in FMA the naris is immaterial and in ZFA it is an organism subdivision." subsetdef: value_slim "Value slim" subsetdef: vertebrate_core "core classes typically found across vertebrates. one purpose is to create a rough set of terms that could be used to start a new vertebrate AO" subsetdef: vessel_or_tree "A term classified differently in FMA due to its treatment of branching structures - to be reviewed and revised by editors" subsetdef: virus_checked "Viral overhaul terms" synonymtypedef: ABBREVIATION "abbreviation" synonymtypedef: ATTRIBUTION_REQUIRED "expert consultation and attribution required" synonymtypedef: BRAND_NAME "BRAND NAME" synonymtypedef: DEPRECATED "A historic synonym, no longer encouraged" synonymtypedef: DEVELOPMENTAL "developmental term" synonymtypedef: DUBIOUS "dubious or contested synonym" synonymtypedef: FORMULA "FORMULA" synonymtypedef: HOMOLOGY "a synonym made on the basis of a possibly homologous structure in another species" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: InChI "InChI" synonymtypedef: InChIKey "InChIKey" synonymtypedef: INCONSISTENT "indicates that a synonym is used in an inconsistent or confusing way, typically between species" synonymtypedef: INN "INN" synonymtypedef: IUPAC_NAME "IUPAC NAME" synonymtypedef: LATIN "latin term" synonymtypedef: PLURAL "plural term" synonymtypedef: PRO-short-label "Unique short label for PRO terms for display purposes" EXACT synonymtypedef: PSI-MOD-label "Unique short label curated by PSI-MOD" EXACT synonymtypedef: SENSU "taxonomic disambiguation" synonymtypedef: SMILES "SMILES" synonymtypedef: systematic_synonym "Systematic synonym" EXACT remark: See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo. ontology: cl owl-axioms: Prefix(owl:=)\nPrefix(rdf:=)\nPrefix(xml:=)\nPrefix(xsd:=)\nPrefix(rdfs:=)\n\n\nOntology(\nEquivalentClasses( ObjectSomeValuesFrom( ))\n) [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] synonym: "entidad molecular" RELATED [IUPAC:] synonym: "entidades moleculares" RELATED [IUPAC:] synonym: "entite moleculaire" RELATED [IUPAC:] synonym: "molecular entities" RELATED [IUPAC:] synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC:] synonym: "molekulare Entitaet" RELATED [ChEBI:] is_a: CHEBI:24431 ! chemical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25179 name: melanin namespace: chebi_ontology alt_id: CHEBI:6727 is_a: CHEBI:26195 ! polyphenol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology synonym: "oxygen molecular entities" RELATED [ChEBI:] synonym: "oxygen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33304 ! chalcogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26195 name: polyphenol namespace: chebi_ontology def: "Any of the group of vegetable chemical substances, characterized by the presence of more than one phenolic group." [] synonym: "polyphenols" RELATED [ChEBI:] is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33243 name: natural product namespace: chebi_ontology synonym: "natural products" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] synonym: "chalcogen compounds" RELATED [ChEBI:] synonym: "chalcogen molecular entities" RELATED [ChEBI:] synonym: "chalcogen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] synonym: "main group compounds" RELATED [ChEBI:] synonym: "main group molecular entities" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology synonym: "carbon group molecular entities" RELATED [ChEBI:] synonym: "carbon group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology synonym: "hydrogen compounds" RELATED [ChEBI:] synonym: "hydrogen molecular entities" RELATED [ChEBI:] is_a: CHEBI:33674 ! s-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] synonym: "s-block compounds" RELATED [ChEBI:] synonym: "s-block molecular entities" RELATED [ChEBI:] synonym: "s-block molecular entity" EXACT [ChEBI:] is_a: CHEBI:33579 ! main group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element." [] synonym: "p-block compounds" RELATED [ChEBI:] synonym: "p-block molecular entities" RELATED [ChEBI:] synonym: "p-block molecular entitiy" RELATED [ChEBI:] is_a: CHEBI:33579 ! main group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "organic hydroxy compounds" RELATED [ChEBI:] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] synonym: "polyatomic entities" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] synonym: "chemical compound" RELATED [ChEBI:] synonym: "heteroatomic molecular entities" RELATED [ChEBI:] is_a: CHEBI:36357 ! polyatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] synonym: "organic compounds" RELATED [ChEBI:] synonym: "organic entity" RELATED [ChEBI:] synonym: "organic molecular entities" RELATED [ChEBI:] is_a: CHEBI:33582 ! carbon group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CL:0000000 name: cell namespace: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 [Term] id: CL:0000001 name: primary cultured cell namespace: cell def: "A cultured cell that is freshly isolated from some source organism and not yet passaged." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. synonym: "primary cell culture cell" EXACT [] synonym: "primary cell line cell" RELATED [] synonym: "unpassaged cultured cell" EXACT [] xref: BTO:0002290 is_a: CL:0000010 ! cultured cell [Term] id: CL:0000002 name: immortal cell line cell namespace: cell def: "A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. synonym: "continuous cell line cell" EXACT [] synonym: "permanent cell line cell" EXACT [] is_a: CL:0007014 ! cell line cell [Term] id: CL:0000003 name: native cell namespace: cell def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah] comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 is_a: CL:0000000 ! cell [Term] id: CL:0000004 name: cell by organism namespace: cell def: "A classification of cells by the organisms within which they are contained." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its species. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000005 name: fibroblast neural crest derived namespace: cell is_a: CL:0000057 ! fibroblast relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000006 name: neuronal receptor cell namespace: cell synonym: "neuronal receptor cell (sensu Animalia)" EXACT [] is_a: CL:0000197 ! receptor cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050906 ! capable_of detection of stimulus involved in sensory perception relationship: RO:0002215 GO:0050906 ! capable_of detection of stimulus involved in sensory perception [Term] id: CL:0000007 name: early embryonic cell namespace: cell def: "A cell found in the embryo before the formation of all the gem layers is complete." [GOC:tfm] is_a: CL:0002321 ! embryonic cell [Term] id: CL:0000008 name: migratory cranial neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000009 name: fusiform initial namespace: cell alt_id: CL:0000274 def: "Obsolete. Use PO:0000079 from Plant Ontology instead. An elongated cell with approximately wedge-shaped ends, found in the vascular cambium, which gives rise to the elements of the axial system in the secondary vascular tissues." [ISBN:0471245208] comment: replaced_by: PO:0000079 synonym: "xylem initial" RELATED [] synonym: "xylem mother cell" RELATED [] is_obsolete: true [Term] id: CL:0000010 name: cultured cell namespace: cell def: "A cell in vitro that is or has been maintained or propagated as part of a cell culture." [ReO:mhb] comment: Covers cells actively being cultured or stored in a quiescent state for future use. The class has been re-labeled to 'cultured cell' instead of 'cell line cell', as this class intends to cover cultured cells of multicellular and unicellular organisms, and both immortal and mortal cultured cells. 'Cell line' has different meanings to different people, in some cases referring to a culture that has been passaged, and in others referring to cultures that are immortal. 'Cell line cell' is included, however, as a narrow synonym. synonym: "cell line cell" NARROW [] is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000011 name: migratory trunk neural crest cell namespace: cell is_a: CL:0000333 ! migratory neural crest cell [Term] id: CL:0000012 name: cell by class namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000013 name: dentine secreting cell namespace: cell is_obsolete: true consider: CL:0000140 [Term] id: CL:0000014 name: germ line stem cell namespace: cell synonym: "germline stem cell" EXACT [] is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0000039 {is_inferred="true"} ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000015 name: male germ cell namespace: cell xref: FMA:72290 xref: MA:0002765 xref: ncithesaurus:Spermatogenic_Cell xref: VHOG:0001531 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0007283 ! capable_of spermatogenesis relationship: RO:0002215 GO:0007283 ! capable_of spermatogenesis [Term] id: CL:0000016 name: male germ line stem cell namespace: cell is_a: CL:0000014 ! germ line stem cell is_a: CL:0000015 ! male germ cell [Term] id: CL:0000017 name: spermatocyte namespace: cell def: "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids." [GOC:tfm, MESH:A05.360.490.890.880] xref: BTO:0001275 xref: CALOHA:TS-0951 xref: EMAPA:31484 xref: FBbt:00004936 xref: FMA:84049 xref: WBbt:0006799 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000015 ! male germ cell intersection_of: RO:0002215 GO:0048137 ! capable_of spermatocyte division relationship: develops_from CL:0000020 ! spermatogonium relationship: RO:0002215 GO:0048137 ! capable_of spermatocyte division [Term] id: CL:0000018 name: spermatid namespace: cell def: "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa." [MESH:A05.360.490.890.860] synonym: "nematoblast" EXACT [] xref: BTO:0001274 xref: CALOHA:TS-0950 xref: EMAPA:31486 xref: FBbt:00004942 xref: FMA:72294 xref: WBbt:0006800 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000413 ! haploid cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0001675 ! capable_of acrosome assembly intersection_of: RO:0002215 GO:0007288 ! capable_of sperm axoneme assembly intersection_of: RO:0002215 GO:0007289 ! capable_of spermatid nucleus differentiation relationship: bearer_of PATO:0001375 ! haploid relationship: develops_from CL:0000657 ! secondary spermatocyte relationship: RO:0002215 GO:0001675 ! capable_of acrosome assembly relationship: RO:0002215 GO:0007288 ! capable_of sperm axoneme assembly relationship: RO:0002215 GO:0007289 ! capable_of spermatid nucleus differentiation [Term] id: CL:0000019 name: sperm namespace: cell def: "A mature male germ cell that develops from a spermatid." [GOC:tfm, MESH:A05.360.490.890] synonym: "sperm cell" EXACT [] synonym: "spermatozoid" EXACT [] synonym: "spermatozoon" EXACT [] xref: BTO:0001277 xref: BTO:0002046 xref: CALOHA:TS-0949 xref: FBbt:00004954 xref: FMA:67338 xref: WBbt:0006798 is_a: CL:0000219 ! motile cell is_a: CL:0000408 {is_inferred="true"} ! male gamete intersection_of: CL:0000408 ! male gamete intersection_of: RO:0002215 GO:0030317 ! capable_of sperm motility intersection_of: RO:0002215 GO:0048240 ! capable_of sperm capacitation relationship: develops_from CL:0000018 ! spermatid relationship: RO:0002215 GO:0030317 ! capable_of sperm motility relationship: RO:0002215 GO:0048240 ! capable_of sperm capacitation [Term] id: CL:0000020 name: spermatogonium namespace: cell def: "An euploid male germ cell of an early stage of spermatogenesis." [MESH:A05.360.490.890.900] xref: BTO:0000958 xref: CALOHA:TS-2193 xref: EMAPA:31482 xref: FBbt:00004935 xref: FMA:72291 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: bearer_of PATO:0001501 ! immature relationship: bearer_of PATO:0001394 ! diploid relationship: bearer_of PATO:0001501 ! immature [Term] id: CL:0000021 name: female germ cell namespace: cell def: "Female germ cell is a germ cell that supports female gamete production." [GOC:tfm, PMID:11023867, PMID:20454446] xref: MA:0000388 xref: ncithesaurus:Egg xref: VHOG:0001530 is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: RO:0002215 GO:0048477 ! capable_of oogenesis relationship: RO:0002215 GO:0048477 ! capable_of oogenesis [Term] id: CL:0000022 name: female germ line stem cell namespace: cell is_a: CL:0000014 {is_inferred="true"} ! germ line stem cell is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000023 name: oocyte namespace: cell def: "A female germ cell that has entered meiosis." [GOC:tfm, ISBN:0721662544] synonym: "oogonium" RELATED [] xref: BTO:0000964 xref: CALOHA:TS-0711 xref: FBbt:00004886 xref: FMA:18644 xref: WBbt:0006797 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: participates_in GO:0007143 ! female meiosis relationship: participates_in GO:0007143 ! female meiosis [Term] id: CL:0000024 name: oogonial cell namespace: cell def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544] xref: FMA:83673 is_a: CL:0000021 {is_inferred="true"} ! female germ cell intersection_of: CL:0000021 ! female germ cell intersection_of: RO:0002215 GO:0007067 ! capable_of mitosis relationship: develops_from CL:0000670 ! primordial germ cell relationship: RO:0002215 GO:0007067 ! capable_of mitosis [Term] id: CL:0000025 name: egg namespace: cell def: "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization." [GOC:tfm, ISBN:0721662544] synonym: "mature oocyte" EXACT [] synonym: "ovum" EXACT [] xref: BTO:0000369 xref: BTO:0003801 xref: CALOHA:TS-2191 xref: FBbt:00000034 xref: FMA:67343 xref: MA:0000388 is_a: CL:0000023 ! oocyte is_a: CL:0000675 {is_inferred="true"} ! female gamete intersection_of: CL:0000675 ! female gamete intersection_of: participates_in GO:0007143 ! female meiosis intersection_of: RO:0002215 GO:0009566 ! capable_of fertilization relationship: develops_from CL:0000655 ! secondary oocyte relationship: participates_in GO:0007143 ! female meiosis relationship: RO:0002215 GO:0009566 ! capable_of fertilization [Term] id: CL:0000026 name: invertebrate nurse cell namespace: cell def: "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." [GOC:tfm, PMID:15848391] synonym: "nurse cell" RELATED [] xref: BTO:0000953 xref: FBbt:00004878 is_a: CL:0000039 ! germ line cell is_a: CL:0000412 ! polyploid cell relationship: develops_from CL:0000722 ! cystoblast [Term] id: CL:0000027 name: smooth muscle cell neural crest derived namespace: cell is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000028 name: CNS neuron (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000540 ! neuron relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000029 name: neuron neural crest derived namespace: cell is_a: CL:0000540 {is_inferred="true"} ! neuron intersection_of: CL:0000540 ! neuron intersection_of: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: develops_from CL:0002676 ! neural crest derived neuroblast [Term] id: CL:0000030 name: glioblast namespace: cell xref: FBbt:00005145 is_a: CL:0000055 ! non-terminally differentiated cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000031 name: neuroblast namespace: cell xref: BTO:0000930 xref: FBbt:00005146 xref: FMA:70563 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000032 name: neuroplacodal cell namespace: cell def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256] synonym: "neural placode cell" EXACT [] is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000033 name: apocrine cell namespace: cell def: "An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000034 name: stem cell namespace: cell def: "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:tfm, MESH:A11.872] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0017145 ! capable_of stem cell division relationship: RO:0002215 GO:0017145 ! capable_of stem cell division [Term] id: CL:0000035 name: single fate stem cell namespace: cell def: "A stem cell that self-renews as well as give rise to a single mature cell type." [GOC:tfm] synonym: "unipotent stem cell" EXACT [] synonym: "unipotential stem cell" EXACT [] xref: FMA:70569 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000036 name: epithelial fate stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000037 name: hematopoietic stem cell namespace: cell def: "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Hematopoietic_stem_cell, PMID:19022770] comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] synonym: "HSC" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 xref: FMA:86475 xref: VHOG:0001485 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0002244 ! capable_of hematopoietic progenitor cell differentiation intersection_of: RO:0002215 GO:0048103 ! capable_of somatic stem cell division relationship: develops_from CL:0000566 ! angioblastic mesenchymal cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0002244 ! capable_of hematopoietic progenitor cell differentiation relationship: RO:0002215 GO:0048103 ! capable_of somatic stem cell division [Term] id: CL:0000038 name: erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] synonym: "BFU-E" RELATED [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] synonym: "CFU-E" RELATED [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 is_a: CL:0000764 ! erythroid lineage cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation [Term] id: CL:0000039 name: germ line cell namespace: cell def: "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." [GOC:tfm, ISBN:0721662544] comment: Originally this term had some plant germ line cell children. subset: ubprop:upper_level is_a: CL:0000548 ! animal cell disjoint_from: CL:0002371 ! somatic cell relationship: RO:0002215 GO:0022414 ! capable_of reproductive process [Term] id: CL:0000040 name: monoblast namespace: cell def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. synonym: "CFU-M" RELATED [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] xref: CALOHA:TS-1195 xref: FMA:83553 is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000791 ! euchromatin intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000791 ! euchromatin relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation [Term] id: CL:0000041 name: mature eosinophil namespace: cell def: "A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464] comment: Eosinophils are CD125-positive (IL-5R), GM-CSFR-positive, IL-3R-positive, VLA4-positive. They can also express MHC Class I & II, CD4, CD9, CD11a, CD11b, CD11c, CD13, CD15, CD16, CD17, CD18, CD24, CD25,CD28, CD29, CD32, CD33, CD35, CD37, CD39, CD43, CD44, CD45, CD45RB, CD45RO, CD46, CD47, CD48, CD49d, CD49f, CD50, CD52, CD53, CD54, CD55, CD58, CD59, CD62L, CD63, CD65, CD66, CD69, CD71, CD76, CD80, CD81, CD82, CD86, CD87, CD88, CD89, CD92, CD95, CD97, CD98, CD99, CD100, CD101, CD116, CD117, CD119, CD120, CD123, CD124, CD125, CD131, CD137, CD139, CD148, CD149, CD151, CD153, CD156, CD162, CD161, CD162, CD165, CD174, CD182, CD183, CD191, CD192, CD193, CD196, CD213, IL9R, ad integrin, beta-7 integrin, FceRI, IL13Ra1, TGFbR, PAFR, LTB4R, C3aR, CystLT1R, CystLT2R, fMLPR, CRTH2 (PGD2 receptor), histamine 4R, IDO, KYN, PAR-2, Siglec-8, Siglec-10, LIR1, LIR2, LIR3, LIR7, TLR7, TLR8, and VLA-4. Eosinophils can also secrete CXCL1, eotaxin-1, GM-CSF, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-16, IL-18, IFN-gamma, LTC4, MIP-1alpha, NGF, PAF, RANTES, substance P, TGF-alpha, TGF-beta, TNF-alpha, and VIP. synonym: "mature eosinocyte" EXACT [] synonym: "mature eosinophil leucocyte" EXACT [] synonym: "mature eosinophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000771 ! eosinophil intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part PR:000007152 ! eosinophil peroxidase intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_part PR:000014046 ! non-secretory ribonuclease intersection_of: has_part PR:000014047 ! eosinophil cationic protein intersection_of: has_part PR:000022006 ! eosinophil granule major basic protein intersection_of: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 intersection_of: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II intersection_of: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response intersection_of: RO:0002215 GO:0045730 ! capable_of respiratory burst relationship: develops_from CL:0000774 ! band form eosinophil relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part PR:000007152 ! eosinophil peroxidase relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_part PR:000014046 ! non-secretory ribonuclease relationship: has_part PR:000014047 ! eosinophil cationic protein relationship: has_part PR:000022006 ! eosinophil granule major basic protein relationship: has_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response relationship: RO:0002215 GO:0045730 ! capable_of respiratory burst [Term] id: CL:0000042 name: neutrophilic myeloblast namespace: cell def: "A myeloblast committed to the neutrophil lineage. This cell type is GATA-1 positive, C/EBPa-positive, AML-1-positive, c-myb-positive and has low expression of PU.1 transcription factor." [GOC:add, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-negative, CD16-negative, CD35-negative, CD49d-positive, CD68-positive, lactotransferrin-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic granuloblast" RELATED [] is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010799 ! myb proto-oncogene protein intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000834 ! neutrophil progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010799 ! myb proto-oncogene protein relationship: has_part PR:000014362 ! runt-related transcription factor 1 relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000043 name: mature basophil namespace: cell alt_id: CL:0000739 def: "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030, PMID:19231594, PMID:20837449] comment: Mature basophils are also capable of producing IL-3, IL-5, IL-6, IL-8, IL-13, IL-25, CCL22, tslp, vegf, and LTC4. synonym: "mature basophil leucocyte" EXACT [] synonym: "mature basophil leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002242 ! nucleate cell is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000767 ! basophil intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response intersection_of: RO:0002215 GO:0002351 ! capable_of serotonin production involved in inflammatory response intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production intersection_of: RO:0002215 GO:0048295 ! capable_of positive regulation of isotype switching to IgE isotypes relationship: develops_from CL:0000770 ! band form basophil relationship: has_part CP:0000025 ! lobed nucleus relationship: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002351 ! capable_of serotonin production involved in inflammatory response relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: RO:0002215 GO:0048295 ! capable_of positive regulation of isotype switching to IgE isotypes [Term] id: CL:0000045 name: thymus processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-T cell ; CL:0000827' or the term 'thymocyte ; CL:0000893' or one of its children instead. is_obsolete: true [Term] id: CL:0000046 name: bursa processed stem cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using term 'pro-B cell ; CL:0000826' or the term 'immature B cell ; CL:0000816 or one of its children instead. is_obsolete: true [Term] id: CL:0000047 name: neuronal stem cell namespace: cell def: "Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors." [GOC:tfm, http://en.wikipedia.org/wiki/Neural_stem_cell, MESH:D058953, PMID:15247488] synonym: "neural stem cell" EXACT [] synonym: "NSC" EXACT [] xref: BTO:0002881 xref: CALOHA:TS-2360 xref: FMA:86684 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000048 name: multi fate stem cell namespace: cell def: "A stem cell that can give rise to multiple lineages of cells." [GOC:add] synonym: "multi-fate stem cell" EXACT [] synonym: "multifate stem cell" EXACT [] synonym: "multipotent cell" EXACT [] synonym: "multipotent stem cell" EXACT [] xref: FMA:84789 is_a: CL:0000723 {is_inferred="true"} ! somatic stem cell intersection_of: CL:0000723 ! somatic stem cell intersection_of: RO:0002215 GO:0030154 ! capable_of cell differentiation relationship: RO:0002215 GO:0030154 ! capable_of cell differentiation [Term] id: CL:0000049 name: common myeloid progenitor namespace: cell def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Common_myeloid_progenitor, ISBN:0878932437, MESH:D023461, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-GEMM" RELATED [ISBN:0878932437] synonym: "CFU-S" RELATED [ISBN:0878932437] synonym: "CMP" EXACT [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] synonym: "myeloid stem cell" RELATED [ISBN:0878932437] synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437] xref: BTO:0004730 is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: RO:0002215 GO:0002573 ! capable_of myeloid leukocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation disjoint_from: CL:0000050 ! megakaryocyte-erythroid progenitor cell disjoint_from: CL:0000051 ! common lymphoid progenitor disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: RO:0002215 GO:0002573 ! capable_of myeloid leukocyte differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation [Term] id: CL:0000050 name: megakaryocyte-erythroid progenitor cell namespace: cell def: "A progenitor cell committed to the megakaryocyte and erythroid lineages." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell, MESH:D055015, PMID:16647566] comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. synonym: "CFU-EM" EXACT [] synonym: "CFU-MegE" EXACT [] synonym: "colony forming unit erythroid megakaryocyte" EXACT [] synonym: "Meg/E progenitor" EXACT [] synonym: "megakaryocyte/erythrocyte progenitor" EXACT [] synonym: "megakaryocyte/erythroid progenitor cell" EXACT [] synonym: "MEP" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation intersection_of: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation disjoint_from: CL:0000557 ! granulocyte monocyte progenitor cell disjoint_from: CL:0002009 ! macrophage dendritic cell progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation [Term] id: CL:0000051 name: common lymphoid progenitor namespace: cell alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. synonym: "CLP" EXACT [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] synonym: "ELP" RELATED [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000052 name: totipotent stem cell namespace: cell def: "A stem cell from which all cells of the body can form." [GOC:add, GOC:tfm] synonym: "totipotential stem cell" EXACT [] xref: FMA:84790 is_a: CL:0000723 ! somatic stem cell [Term] id: CL:0000054 name: bone matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000055 name: non-terminally differentiated cell namespace: cell def: "A precursor cell with a limited number of potential fates." [SANBI:mhl] comment: define using PATO mulit-potent or oligopotent? synonym: "blast cell" EXACT [] xref: BTO:0000125 xref: FMA:84782 is_a: CL:0000003 ! native cell [Term] id: CL:0000056 name: myoblast namespace: cell def: "A precursor cell of the myogenic lineage that develops from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes." [GOC:tfm, MESH:A11.635] xref: BTO:0000222 xref: CALOHA:TS-0650 xref: FBbt:00005083 xref: FMA:70335 xref: VHOG:0001529 is_a: CL:0000680 ! muscle precursor cell relationship: develops_from CL:0000355 ! muscle stem cell [Term] id: CL:0000057 name: fibroblast namespace: cell def: "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." [http://en.wikipedia.org/wiki/Fibroblast, ISBN:0517223651, MESH:A11.329.228, MESH:D005347] comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative. xref: BTO:0000452 xref: CALOHA:TS-0362 xref: FMA:63877 xref: VHOG:0001482 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000058 name: chondroblast namespace: cell def: "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell." [GO_REF:0000034, GOC:tfm, ISBN:0618947256] synonym: "chrondoplast" EXACT [] xref: BTO:0003607 xref: FMA:66783 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007009 ! prechondroblast relationship: produces UBERON:0002418 ! cartilage tissue [Term] id: CL:0000059 name: ameloblast namespace: cell alt_id: CL:0000053 alt_id: CL:0000139 def: "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell." [GO_REF:0000034, GOC:tfm, MESH:A11.436.107] comment: non-encoded relationship from VSAO produces VSAO:0000066 synonym: "amelocyte" EXACT [] synonym: "enamel secreting cell" EXACT [] xref: BTO:0001663 xref: FMA:70576 is_a: CL:0000146 ! simple columnar epithelial cell is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0007000 ! preameloblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001752 ! enamel relationship: RO:0002215 GO:0097186 ! capable_of amelogenesis relationship: RO:0002220 UBERON:0001763 ! adjacent_to odontogenic papilla [Term] id: CL:0000060 name: odontoblast namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell." [GO_REF:0000034, ISBN:0618947256] comment: legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin. xref: BTO:0001769 xref: CALOHA:TS-0696 xref: FMA:62999 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002159 ! general ecto-epithelial cell relationship: develops_from CL:0007003 ! preodontoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000061 name: cementoblast namespace: cell alt_id: CL:0000859 def: "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell." [GO_REF:0000034, ISBN:0781733901] comment: Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth. synonym: "cementum secreting cell" EXACT [] xref: CALOHA:TS-1164 xref: FMA:63002 is_a: CL:0000062 ! osteoblast is_a: CL:0000151 ! secretory cell relationship: develops_from CL:0007002 ! precementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ relationship: produces UBERON:0001753 ! cementum [Term] id: CL:0000062 name: osteoblast namespace: cell def: "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell." [GO_REF:0000034, MESH:A11.329.629] comment: non-encoded relationships from VSAO - capable_of_producing VSAO:0000020 xref: BTO:0001593 xref: CALOHA:TS-0720 xref: FMA:66780 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0007010 ! preosteoblast relationship: produces UBERON:0008883 ! osteoid [Term] id: CL:0000063 name: cell by histology namespace: cell def: "A classification of cells by their microscopic appearance." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its microscopic appearance. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000064 name: ciliated cell namespace: cell def: "A cell that has a filiform extrusion of the cell surface." [GOC:tfm] xref: VHOG:0001532 xref: XAO:0000031 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000065 name: ependymal cell namespace: cell def: "A neurectoderm derived cell that lines the neural lumen." [GOC:tfm, JB:jb, PMID:9550134] synonym: "ependymocyte" EXACT [] xref: BTO:0001724 xref: FMA:70550 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000066 name: epithelial cell namespace: cell def: "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina." [FB:ma, GOC:tfm, MESH:A11.436] synonym: "epitheliocyte" EXACT [] xref: BTO:0000414 xref: CALOHA:TS-2026 xref: CARO:0000077 xref: FBbt:00000124 xref: FMA:66768 xref: WBbt:0003672 is_a: CL:0000548 ! animal cell [Term] id: CL:0000067 name: ciliated epithelial cell namespace: cell def: "An epithelial cell that has a cillia." [GOC:tfm] xref: FMA:70605 is_a: CL:0000064 ! ciliated cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: has_plasma_membrane_part GO:0005929 ! cilium relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000068 name: duct epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000069 name: branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell [Term] id: CL:0000070 name: epithelial cell of gland namespace: cell is_obsolete: true [Term] id: CL:0000071 name: blood vessel endothelial cell namespace: cell def: "An endothelial cell that lines the vasculature." [GOC:tfm] synonym: "cuboidal endothelial cell of vascular tree" EXACT [] is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002139 ! endothelial cell of vascular tree intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0004638 ! blood vessel endothelium relationship: develops_from CL:0002546 ! embryonic blood vessel endothelial progenitor cell relationship: part_of UBERON:0004638 ! blood vessel endothelium [Term] id: CL:0000072 name: non-branched duct epithelial cell namespace: cell is_a: CL:0000068 ! duct epithelial cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000073 name: barrier epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000074 name: epithem cell namespace: cell def: "Obsolete. Use PO:0000066 from Plant Ontology instead. A cell that constitutes the mesophyll of a hydathode and is located between the xylem endings and the epidermis. Proposed to be involved in the retrieval of solutes from the xylem sap." [ISBN:0471245208, PMID:12662305] comment: replaced_by: PO:0000066 is_obsolete: true [Term] id: CL:0000075 name: columnar/cuboidal epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000076 name: squamous epithelial cell namespace: cell xref: CALOHA:TS-1249 is_a: CL:0000066 ! epithelial cell [Term] id: CL:0000077 name: mesothelial cell namespace: cell def: "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." [GOC:tfm, ISBN:0721662544] synonym: "mesotheliocyte" EXACT [] xref: FMA:66773 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000213 ! lining cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000078 name: peridermal cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000079 name: stratified epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000357 ! stratified epithelial stem cell [Term] id: CL:0000080 name: circulating cell namespace: cell def: "A cell which moves among different tissues of the body, via blood, lymph, or other medium." [GOC:add] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: part_of UBERON:0000179 ! haemolymphatic fluid relationship: part_of UBERON:0000179 ! haemolymphatic fluid [Term] id: CL:0000081 name: blood cell namespace: cell def: "A cell found predominately in the blood." [GOC:add, GOC:tfm] xref: FMA:62844 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000082 name: epithelial cell of lung namespace: cell xref: BTO:0004299 is_a: CL:0000066 ! epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002048 ! lung relationship: part_of UBERON:0000115 ! lung epithelium relationship: part_of UBERON:0002048 ! lung [Term] id: CL:0000083 name: epithelial cell of pancreas namespace: cell def: "An epithelial cell of the pancreas." [GOC:tfm] xref: BTO:0000028 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001264 ! pancreas relationship: develops_from CL:0000223 ! endodermal cell relationship: part_of UBERON:0001264 ! pancreas [Term] id: CL:0000084 name: T cell namespace: cell alt_id: CL:0000804 alt_id: CL:0000812 def: "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature T cell" RELATED [] synonym: "mature T cell" RELATED [] synonym: "T lymphocyte" EXACT [] synonym: "T-cell" EXACT [] synonym: "T-lymphocyte" EXACT [] xref: BTO:0000782 xref: CALOHA:TS-1001 xref: FMA:62870 xref: VHOG:0001479 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: RO:0002215 GO:0002456 ! capable_of T cell mediated immunity disjoint_from: CL:0000623 ! natural killer cell disjoint_from: CL:0000945 ! lymphocyte of B lineage relationship: develops_from CL:0000827 ! pro-T cell relationship: RO:0002215 GO:0002456 ! capable_of T cell mediated immunity [Term] id: CL:0000085 name: germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000086 name: germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004861 is_a: CL:0000014 ! germ line stem cell [Term] id: CL:0000087 name: male germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004929 is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000088 name: female germ line stem cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004873 is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000086 ! germ line stem cell (sensu Nematoda and Protostomia) [Term] id: CL:0000089 name: male germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000016 ! male germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000090 name: female germ line stem cell (sensu Vertebrata) namespace: cell is_a: CL:0000022 ! female germ line stem cell is_a: CL:0000085 ! germ line stem cell (sensu Vertebrata) [Term] id: CL:0000091 name: Kupffer cell namespace: cell def: "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0517223651, MESH:A11.329.372.588, PMID:15771589, PMID:17105582] comment: Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2. synonym: "hepatic macrophage" EXACT [] synonym: "littoral cell of hepatic sinusoid" EXACT [] synonym: "liver macrophage" EXACT [] synonym: "macrophagocytus stellatus" EXACT [] synonym: "stellate cell of von Kupffer" EXACT [] synonym: "von Kupffer cell" EXACT [] xref: BTO:0000685 xref: FMA:14656 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: part_of UBERON:0001281 ! hepatic sinusoid intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: part_of UBERON:0001281 ! hepatic sinusoid relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000092 name: osteoclast namespace: cell def: "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149, PMID:10428500, PMID:15055519, PMID:17380158] comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid. synonym: "chondroclast" RELATED [] xref: BTO:0000968 xref: CALOHA:TS-0721 xref: FMA:66781 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_part PR:000001850 ! cathepsin K intersection_of: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit intersection_of: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: part_of UBERON:0001474 ! bone element intersection_of: RO:0002215 GO:0045453 ! capable_of bone resorption relationship: develops_from CL:0000576 ! monocyte relationship: has_part PR:000001850 ! cathepsin K relationship: has_part PR:000001937 ! tartrate-resistant acid phosphatase type 5 relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_part PR:000011178 ! nuclear factor NF-kappa-B p100 subunit relationship: has_plasma_membrane_part PR:000001954 ! tumor necrosis factor receptor superfamily member 11A relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: part_of UBERON:0001474 ! bone element relationship: RO:0002215 GO:0045453 ! capable_of bone resorption [Term] id: CL:0000093 name: osteochondroclast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Consider using 'osteoclast ; CL:0000092' instead. is_obsolete: true [Term] id: CL:0000094 name: granulocyte namespace: cell def: "A leukocyte with abundant granules in the cytoplasm." [GOC:amm, GOC:tfm, http://en.wikipedia.org/wiki/Granulocyte, MESH:A11.118.637.415, MESH:D006098] synonym: "granular leucocyte" EXACT [] synonym: "granular leukocyte" EXACT [] synonym: "polymorphonuclear leukocyte" EXACT [] xref: BTO:0000539 xref: BTO:0001026 xref: CALOHA:TS-0422 xref: FMA:62854 is_a: CL:0000081 ! blood cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 intersection_of: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001332 ! carcinoembryonic antigen-related cell adhesion molecule 8 relationship: has_plasma_membrane_part PR:000001969 ! urokinase plasminogen activator surface receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000095 name: neuron associated cell namespace: cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000096 name: mature neutrophil namespace: cell def: "A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive." [GOC:add, GOC:tfm, http://www.cap.org, MESH:A11.118.637.415.583, MESH:D009504, PMID:11138776, PMID:12560239, PMID:15514007, PMID:7880385] comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)). synonym: "mature neutrocyte" EXACT [] synonym: "mature neutrophil leucocyte" EXACT [] synonym: "mature neutrophil leukocyte" EXACT [] synonym: "mature neutrophilic leucocyte" EXACT [] synonym: "mature neutrophilic leukocyte" EXACT [] synonym: "PMN" EXACT [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" EXACT [] synonym: "polynuclear neutrophilic leucocyte" EXACT [] synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000234 ! phagocyte is_a: CL:0000775 {is_inferred="true"} ! neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000775 ! neutrophil intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000025 ! lobed nucleus intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001256 ! high affinity interleukin-8 receptor A intersection_of: has_plasma_membrane_part PR:000001257 ! high affinity interleukin-8 receptor B intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 intersection_of: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010543 ! myeloperoxidase intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein intersection_of: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response intersection_of: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0032637 ! capable_of interleukin-8 production relationship: develops_from CL:0000560 ! band form neutrophil relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000025 ! lobed nucleus relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001256 ! high affinity interleukin-8 receptor A relationship: has_plasma_membrane_part PR:000001257 ! high affinity interleukin-8 receptor B relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001944 ! transcription factor PU.1 relationship: has_plasma_membrane_part PR:000007597 ! proto-oncogene c-Fos relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010543 ! myeloperoxidase relationship: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: RO:0002215 GO:0002536 ! capable_of respiratory burst involved in inflammatory response relationship: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0032637 ! capable_of interleukin-8 production [Term] id: CL:0000097 name: mast cell namespace: cell def: "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development." [GOC:add, GOC:dsd, GOC:tfm, ISBN:068340007X, MESH:A11.329.427, MESH:D008407, PMCID:PMC1312421, PMCID:PMC2855166, PMID:15153310, PMID:16455980, PMID:19671378, PMID:212366338, PMID:9354811] comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5. synonym: "histaminocyte" EXACT [] synonym: "labrocyte" EXACT [ISBN:0721601464] synonym: "mastocyte" EXACT [ISBN:0721601464] synonym: "tissue basophil" RELATED [ISBN:068340007X] xref: BTO:0000830 xref: CALOHA:TS-0603 xref: FMA:66784 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002274 ! histamine secreting cell intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part GO:0030141 ! secretory granule intersection_of: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 intersection_of: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response intersection_of: RO:0002215 GO:0002539 ! capable_of prostaglandin production involved in inflammatory response intersection_of: RO:0002215 GO:0002660 ! capable_of positive regulation of peripheral tolerance induction intersection_of: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0030210 ! capable_of heparin biosynthetic process relationship: develops_from CL:0000831 ! mast cell progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part GO:0030141 ! secretory granule relationship: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 relationship: has_plasma_membrane_part PR:000006169 ! cell surface glycoprotein CD200 receptor 3 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0002349 ! capable_of histamine production involved in inflammatory response relationship: RO:0002215 GO:0002539 ! capable_of prostaglandin production involved in inflammatory response relationship: RO:0002215 GO:0002660 ! capable_of positive regulation of peripheral tolerance induction relationship: RO:0002215 GO:0002690 ! capable_of positive regulation of leukocyte chemotaxis relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0030210 ! capable_of heparin biosynthetic process [Term] id: CL:0000098 name: sensory epithelial cell namespace: cell def: "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] comment: The term "neuroepithelial cell" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 is_a: CL:0000066 ! epithelial cell is_a: CL:0000197 ! receptor cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000099 name: interneuron namespace: cell def: "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions." [GOC:tfm, MESH:A08.663.358] xref: BTO:0003811 xref: FBbt:00005125 xref: FMA:67313 xref: WBbt:0005113 is_a: CL:0000540 ! neuron [Term] id: CL:0000100 name: motor neuron namespace: cell def: "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [MESH:A08.663.655.500, PMID:16875686] synonym: "anterior horn cell" EXACT [] synonym: "motoneuron" EXACT [] xref: BTO:0000312 xref: FMA:83617 xref: WBbt:0005409 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000101 name: sensory neuron namespace: cell def: "Any neuron having a sensory function; an afferent neuron conveying sensory impulses." [ISBN:0721662544] xref: BTO:0001037 xref: FBbt:00005124 xref: FMA:84649 xref: WBbt:0005759 is_a: CL:0000526 ! afferent neuron [Term] id: CL:0000102 name: polymodal neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000103 name: bipolar neuron namespace: cell def: "A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body." [GOC:tfm, ISBN:0444009442] xref: FMA:67282 is_a: CL:0000099 ! interneuron [Term] id: CL:0000104 name: multipolar neuron namespace: cell def: "Neuron with an axon and two or more dendrites." [FMA:67287, GOC:tfm] xref: FMA:67287 is_a: CL:0000540 ! neuron [Term] id: CL:0000105 name: pseudounipolar neuron namespace: cell def: "Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma." [FMA:67305, GOC:tfm] xref: FMA:67305 is_a: CL:0000540 ! neuron [Term] id: CL:0000106 name: unipolar neuron namespace: cell def: "Neuron with one neurite that extends from the cell body." [FMA:67278, GOC:nv] xref: FMA:67278 is_a: CL:0000540 ! neuron [Term] id: CL:0000107 name: autonomic neuron namespace: cell def: "A neruon whose cell body is within an autonomic ganglion." [GOC:tfm] xref: FMA:80121 is_a: CL:0000540 ! neuron [Term] id: CL:0000108 name: cholinergic neuron namespace: cell def: "A neuron that uses acetylcholine as a vesicular neurotransmitter." [GOC:tfm] xref: BTO:0004902 xref: FMA:84796 xref: WBbt:0006840 is_a: CL:0000540 ! neuron [Term] id: CL:0000109 name: adrenergic neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000110 name: peptidergic neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000111 name: peripheral neuron namespace: cell def: "A neuron that is part of nerve found outside the central nervous system." [ISBN:0721662544] xref: FMA:84664 is_a: CL:0000540 ! neuron [Term] id: CL:0000112 name: columnar neuron namespace: cell synonym: "columnar neuron" RELATED [] is_a: CL:0000540 ! neuron [Term] id: CL:0000113 name: mononuclear phagocyte namespace: cell def: "A vertebrate phagocyte with a single nucleus." [GOC:add, GOC:tfm, ISBN:0781735149] xref: BTO:0001433 is_a: CL:0000226 ! single nucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000114 name: surface ectodermal cell namespace: cell synonym: "cell of surface ectoderm" EXACT [] synonym: "surface ectoderm cell" EXACT [] xref: FMA:72552 is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000115 name: endothelial cell namespace: cell def: "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." [GOC:tfm, http://en.wikipedia.org/wiki/Endothelial_cell, https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855, MESH:D042783, PMID:21275341] comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]. synonym: "endotheliocyte" EXACT [] xref: BTO:0001176 xref: CALOHA:TS-0278 xref: FMA:66772 is_a: CL:0000213 ! lining cell is_a: CL:0002078 ! meso-epithelial cell [Term] id: CL:0000116 name: pioneer neuron namespace: cell def: "Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance." [GOC:cvs, GOC:tfm] xref: FBbt:00005128 is_a: CL:0000540 ! neuron [Term] id: CL:0000117 name: CNS neuron (sensu Vertebrata) namespace: cell is_a: CL:0000540 ! neuron relationship: develops_from CL:0000337 ! neuroblast (sensu Vertebrata) [Term] id: CL:0000118 name: basket cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000119 name: Golgi cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000120 name: granule cell namespace: cell xref: BTO:0003393 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000121 name: Purkinje cell namespace: cell def: "The output neuron of the cerebellar cortex." [MESH:A08.186.211.132.810.428.200.212.600] synonym: "Purkinje neuron" EXACT [] synonym: "Purkinje's cell" EXACT [] xref: BTO:0001011 xref: CALOHA:TS-0845 xref: FMA:67969 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000122 name: stellate cell namespace: cell xref: BTO:0002316 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000123 name: neuron associated cell (sensu Vertebrata) namespace: cell is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000124 name: glial cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005144 is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000340 ! glioblast (sensu Nematoda and Protostomia) [Term] id: CL:0000125 name: glial cell namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." [MESH:A08.637] synonym: "neuroglia" RELATED [] synonym: "neuroglial cell" EXACT [] xref: BTO:0002606 xref: CALOHA:TS-0415 xref: FMA:54536 is_a: CL:0000095 ! neuron associated cell relationship: develops_from CL:0000030 {comment="It is unclear that all glial cells develop from a cell type called a glioblast. Radial glial cells develop from neuroepithelial cells and other types of glial cells develop from other precursors. Unless glioblast is meant to describe any cell that can give rise to a glial cell, this relationship needs further investigation."} ! glioblast [Term] id: CL:0000126 name: macroglial cell namespace: cell def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544] synonym: "macrogliocyte" EXACT [] xref: BTO:0000771 xref: CALOHA:TS-2027 xref: FMA:54538 is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000127 name: astrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Astrocyte, MESH:A08.637.200, MESH:D001253, PMID:11746784, PMID:12162730, PMID:12898703, PMID:20942978] comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive. synonym: "astrocytic glia" EXACT [] xref: BTO:0000099 xref: CALOHA:TS-0060 xref: FMA:54537 is_a: CL:0000126 ! macroglial cell [Term] id: CL:0000128 name: oligodendrocyte namespace: cell def: "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system." [http://en.wikipedia.org/wiki/Oligodendrocyte, MESH:A08.637.600, MESH:D009836] comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative. synonym: "oligodendroglia" RELATED [] synonym: "OLs" EXACT [PMID:8734446] xref: BTO:0000962 xref: CALOHA:TS-0709 xref: FMA:54540 is_a: CL:0000126 {is_inferred="true"} ! macroglial cell intersection_of: CL:0000126 ! macroglial cell intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000129 name: microglial cell namespace: cell def: "A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Microglia, ISBN:0721601464, MESH:D017628, PMID:11517395, PMID:12430718, PMID:14561199, PMID:14612429, PMID:16177057, PMID:19461673, PMID:2089275] comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive. synonym: "brain macrophage" BROAD [] synonym: "brain-resident macrophage" EXACT [] synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/] synonym: "MF.microglia.CNS" RELATED [] synonym: "microglia" EXACT [] synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/] xref: BTO:0000078 xref: BTO:0000962 xref: FMA:54539 xref: FMA:54540 is_a: CL:0000243 {is_inferred="true"} ! glial cell (sensu Vertebrata) is_a: CL:0000878 ! central nervous system macrophage intersection_of: CL:0000243 ! glial cell (sensu Vertebrata) intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: part_of UBERON:0001017 ! central nervous system intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: develops_from CL:0002453 ! oligodendrocyte precursor cell relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: part_of UBERON:0001017 ! central nervous system relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000130 name: neuron associated cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000095 ! neuron associated cell [Term] id: CL:0000131 name: gut endothelial cell namespace: cell is_a: CL:0000115 ! endothelial cell relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000132 name: corneal endothelial cell namespace: cell def: "Cell of the single layer of large flattened cells covering the surface of the cornea." [GOC:tfm, MESH:A09.371.060.067.31] xref: CALOHA:TS-0172 xref: FMA:70614 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell [Term] id: CL:0000133 name: neurectodermal cell namespace: cell def: "Ectoderm destined to be nervous tissue." [GOC:tfm, ISBN:068340007X] synonym: "neurectoderm cell" EXACT [] is_a: CL:0000221 ! ectodermal cell [Term] id: CL:0000134 name: mesenchymal cell namespace: cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. This cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814j, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. synonym: "BMSC" NARROW [] synonym: "bone marrow stromal cells" NARROW [] synonym: "CFU-F" RELATED [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED PLURAL [] synonym: "MSC" RELATED [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 xref: FMA:70546 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000219 ! motile cell is_a: CL:0002320 {is_inferred="true"} ! connective tissue cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: RO:0002215 GO:0001649 ! capable_of osteoblast differentiation intersection_of: RO:0002215 GO:0016477 ! capable_of cell migration intersection_of: RO:0002215 GO:0030182 ! capable_of neuron differentiation intersection_of: RO:0002215 GO:0030855 ! capable_of epithelial cell differentiation intersection_of: RO:0002215 GO:0045444 ! capable_of fat cell differentiation intersection_of: RO:0002215 GO:0055007 ! capable_of cardiac muscle cell differentiation intersection_of: RO:0002215 GO:0060591 ! capable_of chondroblast differentiation relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000001800 ! 5'-nucleotidase relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: RO:0002215 GO:0001649 ! capable_of osteoblast differentiation relationship: RO:0002215 GO:0016477 ! capable_of cell migration relationship: RO:0002215 GO:0030182 ! capable_of neuron differentiation relationship: RO:0002215 GO:0030855 ! capable_of epithelial cell differentiation relationship: RO:0002215 GO:0045444 ! capable_of fat cell differentiation relationship: RO:0002215 GO:0055007 ! capable_of cardiac muscle cell differentiation relationship: RO:0002215 GO:0060591 ! capable_of chondroblast differentiation [Term] id: CL:0000135 name: fibrocyte namespace: cell def: "An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes." [GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Fibrocyte, ISBN:0412046911, ISBN:0517223651, PMID:11641248, PMID:15010326, PMID:17607298, PMID:18222966, PMID:8790603, PMID:9551999] comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A. xref: FMA:63879 is_a: CL:0000499 {is_inferred="true"} ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II intersection_of: RO:0002215 GO:0045766 ! capable_of positive regulation of angiogenesis relationship: develops_from CL:0000057 ! fibroblast relationship: RO:0002215 GO:0002495 ! capable_of antigen processing and presentation of peptide antigen via MHC class II relationship: RO:0002215 GO:0045766 ! capable_of positive regulation of angiogenesis [Term] id: CL:0000136 name: fat cell namespace: cell alt_id: CL:0000450 def: "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides." [MESH:A11.329.114] synonym: "adipocyte" EXACT [] synonym: "adipose cell" EXACT [] xref: BTO:0000443 xref: CALOHA:TS-0012 xref: FMA:63880 is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000137 name: osteocyte namespace: cell def: "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." [GOC:tfm, MESH:A11.329.629.500] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 synonym: "bone cell" BROAD [] xref: BTO:0002038 xref: CALOHA:TS-1167 xref: FMA:66779 xref: VSAO:0000124 is_a: CL:0001035 ! bone cell relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0000138 name: chondrocyte namespace: cell def: "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell." [GO_REF:0000034, MESH:A11.329.171] synonym: "cartilage cell" EXACT [] xref: BTO:0000249 xref: CALOHA:TS-0138 xref: FMA:66782 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000667 ! collagen secreting cell relationship: develops_from CL:0000058 ! chondroblast [Term] id: CL:0000140 name: odontocyte namespace: cell def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034] is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000060 ! odontoblast relationship: develops_from CL:0000134 ! mesenchymal cell relationship: produces UBERON:0001751 ! dentine [Term] id: CL:0000141 name: cementocyte namespace: cell def: "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth." [ISBN:0781733901] comment: CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def). xref: FMA:63003 is_a: CL:0000137 ! osteocyte relationship: develops_from CL:0000061 ! cementoblast relationship: part_of UBERON:0005176 ! tooth enamel organ [Term] id: CL:0000142 name: hyalocyte namespace: cell def: "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." [GOC:tfm, PMID:19073178] synonym: "vitreous cell" RELATED [] xref: BTO:0004271 xref: FMA:70620 is_a: CL:0000499 ! stromal cell [Term] id: CL:0000143 name: guidepost cell namespace: cell is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000144 name: cell by function namespace: cell def: "A classification of cells by their primary end goal or behavior." [FB:ma] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its function or behavior. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000145 name: professional antigen presenting cell namespace: cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. synonym: "APC" BROAD [] is_a: CL:0000473 ! defensive cell relationship: RO:0002215 GO:0002504 ! capable_of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: CL:0000146 name: simple columnar epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000147 name: pigment cell namespace: cell def: "A pigment cell is a cell that contains pigment granules." [GOC:tfm] synonym: "chromatocyte" EXACT [] synonym: "chromatophore" EXACT [] xref: VHOG:0001678 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000148 name: melanocyte namespace: cell alt_id: CL:0000572 def: "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance." [SANBI:mhl] synonym: "melanophore" NARROW [] xref: BTO:0000847 xref: CALOHA:TS-0613 xref: FMA:70545 xref: VHOG:0001679 is_a: CL:0000147 {is_inferred="true"} ! pigment cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000147 ! pigment cell intersection_of: has_part GO:0042470 ! melanosome relationship: develops_from CL:0000541 ! melanoblast relationship: has_part GO:0042470 ! melanosome [Term] id: CL:0000149 name: visual pigment cell namespace: cell synonym: "pigment cell" BROAD [] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000150 name: glandular epithelial cell namespace: cell def: "A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules." [GOC:tfm] xref: CALOHA:TS-2085 xref: FMA:86494 is_a: CL:0000066 ! epithelial cell is_a: CL:0000151 ! secretory cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000151 name: secretory cell namespace: cell def: "A cell that specializes in controlled release of one or more substances." [GOC:tfm, ISBN:0721662544] xref: BTO:0003659 xref: FMA:86916 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell [Term] id: CL:0000152 name: exocrine cell namespace: cell def: "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct." [ISBN:0198547684] xref: FMA:16014 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000153 name: GAG secreting cell namespace: cell def: "A cell that secretes glycosaminoglycans." [GOC:tfm] synonym: "hyaluronic acid secreting cell" EXACT [] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000447 ! carbohydrate secreting cell [Term] id: CL:0000154 name: protein secreting cell namespace: cell is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0009306 ! capable_of protein secretion relationship: RO:0002215 GO:0009306 ! capable_of protein secretion [Term] id: CL:0000155 name: peptic cell namespace: cell def: "A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen." [GOC:tfm] synonym: "chief cell of stomach" EXACT [] synonym: "gastric chief cell" EXACT [] synonym: "pepsinogen secreting cell" EXACT [] synonym: "zymogenic cell" EXACT [] xref: FMA:62902 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000156 name: antibody secreting cell namespace: cell def: "OBSOLETE: A cell of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B cells, can be defined, based on the different classes of immunoglobulins that they synthesize." [] comment: Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000157 name: surfactant secreting cell namespace: cell def: "A cell that specializes in secretion of surfactant in the alveoli of the lung." [GOC:tfm, ISBN:0721662544] is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis [Term] id: CL:0000158 name: Clara cell namespace: cell def: "Epithelial progenitor cell of the lung. Clara cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Clara cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium." [GOC:tfm, PMID:12107102, PMID:7905712] synonym: "bronchiolar non-ciliated cell" EXACT [] synonym: "Clara cell of bronchiole" EXACT [] xref: BTO:0004811 xref: FMA:14119 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002328 ! bronchial epithelial cell intersection_of: bearer_of PATO:0001789 ! domed intersection_of: has_plasma_membrane_part GO:0005902 ! microvillus intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: bearer_of PATO:0001789 ! domed relationship: has_plasma_membrane_part GO:0005902 ! microvillus relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis [Term] id: CL:0000159 name: seromucus secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000160 name: goblet cell namespace: cell def: "A cell of the epithelial lining that produce and secrete mucins." [MESH:A03.492.411.369.320] synonym: "chalice cell" EXACT [] xref: BTO:0001540 xref: FMA:13148 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000161 name: acid secreting cell namespace: cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0046717 ! capable_of acid secretion relationship: RO:0002215 GO:0046717 ! capable_of acid secretion [Term] id: CL:0000162 name: parietal cell namespace: cell def: "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." [GOC:tfm, ISBN:0517223651] synonym: "oxyntic cell" EXACT [] xref: BTO:0001780 xref: FMA:62901 is_a: CL:0000161 ! acid secreting cell is_a: CL:0002659 ! glandular cell of stomach [Term] id: CL:0000163 name: endocrine cell namespace: cell def: "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions." [MESH:A06.407] synonym: "endocrinocyte" EXACT [] xref: FMA:83809 is_a: CL:0000151 ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0046879 ! capable_of hormone secretion relationship: RO:0002215 GO:0046879 ! capable_of hormone secretion [Term] id: CL:0000164 name: enteroendocrine cell namespace: cell def: "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas." [GOC:tfm, SANBI:mhl] xref: BTO:0003865 xref: FMA:62930 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000165 name: neuroendocrine cell namespace: cell def: "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." [MESH:A06.688] synonym: "neurosecretory cell" EXACT [] xref: BTO:0002691 xref: FMA:83810 is_a: CL:0000163 ! endocrine cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000166 name: chromaffin cell namespace: cell def: "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system." [MESH:A06.224.161] synonym: "phaeochromocyte" EXACT [] xref: BTO:0000259 xref: FMA:69263 is_a: CL:0000568 ! APUD cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000167 name: peptide hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion relationship: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion [Term] id: CL:0000168 name: insulin secreting cell namespace: cell xref: BTO:0000783 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030073 ! capable_of insulin secretion relationship: RO:0002215 GO:0030073 ! capable_of insulin secretion [Term] id: CL:0000169 name: type B pancreatic cell namespace: cell def: "A cell that secretes insulin and is located towards the center of the islets of Langerhans." [GOC:tfm, http://en.wikipedia.org/wiki/Pancreatic_b_cell, ISBN:0517223651] comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression. synonym: "B-cell of pancreatic islet" EXACT [FMA:70586] synonym: "beta cell" BROAD [ZFA:0009102] synonym: "beta cell islet" RELATED [MA:0002419] synonym: "beta cell of pancreatic islet" EXACT [FMA:70586] synonym: "insulin-secreting cell" EXACT [FMA:70586] synonym: "pancreatic B cell" EXACT [] synonym: "pancreatic B-cell" EXACT [FMA:70586] synonym: "pancreatic beta cell" EXACT [FMA:70586] synonym: "pancreatic islet core" EXACT [MA:0002419] synonym: "type B enteroendocrine cell" EXACT [FMA:70586] xref: BTO:0000783 xref: EV:0200009 xref: FMA:70586 xref: MA:0002419 xref: ncithesaurus:Beta_Cell is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000164 {is_inferred="true"} ! enteroendocrine cell is_a: CL:0000168 {is_inferred="true"} ! insulin secreting cell intersection_of: CL:0000164 ! enteroendocrine cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: RO:0002215 GO:0030073 ! capable_of insulin secretion relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: RO:0002215 GO:0030073 ! capable_of insulin secretion [Term] id: CL:0000170 name: glucagon secreting cell namespace: cell def: "A cell that secretes glucagon." [GOC:tfm] synonym: "glucagon-secreting cell" EXACT [] xref: FMA:84045 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070091 ! capable_of glucagon secretion relationship: RO:0002215 GO:0070091 ! capable_of glucagon secretion [Term] id: CL:0000171 name: pancreatic A cell namespace: cell def: "A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon." [GOC:tfm, ISBN:0721662544] synonym: "alpha cell of iselt of Langerhans" EXACT [] synonym: "pancreatic alpha cell" EXACT [] xref: BTO:0000990 xref: FMA:70585 is_a: CL:0002067 ! type A enterocrine cell relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas relationship: RO:0002215 GO:0070091 ! capable_of glucagon secretion [Term] id: CL:0000172 name: somatostatin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070253 ! capable_of somatostatin secretion relationship: RO:0002215 GO:0070253 ! capable_of somatostatin secretion [Term] id: CL:0000173 name: pancreatic D cell namespace: cell def: "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin." [FMA:0517223651, GOC:tfm] synonym: "D-cell of pancreatic islet" EXACT [] synonym: "delta cell of islet" EXACT [] synonym: "delta cell of pancreatic islet" EXACT [] synonym: "pancreatic D-cell" EXACT [] synonym: "pancreatic delta cell" EXACT [] synonym: "somatostatin-secreting pancreatic cell" EXACT [] xref: BTO:0000803 xref: FMA:70587 is_a: CL:0000502 ! type D enteroendocrine cell relationship: develops_from CL:0002351 ! progenitor cell of endocrine pancreas [Term] id: CL:0000174 name: steroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035929 ! capable_of steroid hormone secretion relationship: RO:0002215 GO:0035929 ! capable_of steroid hormone secretion [Term] id: CL:0000175 name: luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells." [MESH:A05.360.319.114.630.278.400] synonym: "lutein cell" EXACT [] xref: BTO:0003939 xref: FMA:18688 is_a: CL:0000179 ! progesterone secreting cell is_a: CL:0002132 ! stromal cell of ovary relationship: part_of UBERON:0002512 ! corpus luteum relationship: RO:0002215 GO:0042701 ! capable_of progesterone secretion [Term] id: CL:0000176 name: ecdysteroid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045457 ! capable_of ecdysteroid secretion relationship: RO:0002215 GO:0045457 ! capable_of ecdysteroid secretion [Term] id: CL:0000177 name: testosterone secreting cell namespace: cell is_a: CL:0000593 ! androgen secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035936 ! capable_of testosterone secretion relationship: RO:0002215 GO:0035936 ! capable_of testosterone secretion [Term] id: CL:0000178 name: Leydig cell namespace: cell def: "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:tfm, PMID:12050120] comment: Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated synonym: "interstitial cell" BROAD [] synonym: "interstitial cell of Leydig" EXACT [] xref: BTO:0000755 xref: CALOHA:TS-1150 xref: EMAPA:29655 xref: FMA:72297 is_a: CL:0000177 ! testosterone secreting cell relationship: part_of UBERON:0005212 ! testis interstitial tissue [Term] id: CL:0000179 name: progesterone secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0042701 ! capable_of progesterone secretion relationship: RO:0002215 GO:0042701 ! capable_of progesterone secretion [Term] id: CL:0000180 name: estradiol secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035938 ! capable_of estradiol secretion relationship: RO:0002215 GO:0035938 ! capable_of estradiol secretion [Term] id: CL:0000181 name: metabolising cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000182 name: hepatocyte namespace: cell def: "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated." [GOC:tfm, http://en.wikipedia.org/wiki/Hepatocyte, ISBN:0412046911, MESH:A11.436.348, PMID:19717280] comment: Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive. xref: BTO:0000575 xref: CALOHA:TS-0454 xref: FMA:14515 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000181 ! metabolising cell is_a: CL:0000417 ! endopolyploid cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002107 ! liver relationship: develops_from CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000223 ! endodermal cell relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000183 name: contractile cell namespace: cell def: "A cell whose primary function is to shorten." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000185 name: myoepithelial cell namespace: cell def: "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." [GOC:tfm, ISBN:0721662544] synonym: "basket epithelial cell" EXACT [] synonym: "myoepitheliocyte" EXACT [] xref: BTO:0002309 xref: CALOHA:TS-2379 xref: FMA:67799 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000183 ! contractile cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000186 name: myofibroblast cell namespace: cell def: "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell." [GOC:dsd, GOC:tfm, MESH:D058628, PMID:19800625, PMID:20630469] comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha. synonym: "MFB" EXACT [PMID:8731193] is_a: CL:0000183 ! contractile cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000187 name: muscle cell namespace: cell def: "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [MESH:A11.620] synonym: "muscle fiber" EXACT [] synonym: "myocyte" EXACT [] xref: BTO:0000888 xref: BTO:0000902 xref: CALOHA:TS-2032 xref: FBbt:00005074 xref: FMA:67328 xref: WBbt:0003675 is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast [Term] id: CL:0000188 name: skeletal muscle cell namespace: cell def: "A somatic cell located in skeletal muscle." [GOC:tfm] xref: BTO:0004392 xref: CALOHA:TS-2158 xref: FMA:9727 is_a: CL:0000187 {is_inferred="true"} ! muscle cell intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000189 name: slow muscle cell namespace: cell def: "A muscle cell that develops tension more slowly than a fast-twitch fiber." [GOC:tfm, ISBN:0323052908] synonym: "slow muscle fiber" EXACT [ISBN:0815316208] xref: FMA:84448 is_a: CL:0002372 ! myotube relationship: develops_from CL:0000857 ! slow muscle myoblast [Term] id: CL:0000190 name: fast muscle cell namespace: cell def: "A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron ." [GOC:tfm, ISBN:0323052908] synonym: "glycolytic muscle fiber" EXACT [] is_a: CL:0002372 ! myotube relationship: develops_from CL:0000858 ! fast muscle myoblast [Term] id: CL:0000192 name: smooth muscle cell namespace: cell alt_id: CL:0000191 def: "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast)." [http://en.wikipedia.org/wiki/Smooth_muscle_cell, MESH:A11.620.520, MESH:D032389, PMID:9315361] synonym: "myocytes, smooth muscle" EXACT [MESH:D032389] synonym: "non-striated muscle cell" EXACT [] synonym: "SMCs" EXACT [PMID:9315361] synonym: "smooth muscle fiber" EXACT [] xref: BTO:0004576 xref: CALOHA:TS-2159 xref: FMA:14072 is_a: CL:0000187 ! muscle cell relationship: develops_from CL:0000514 ! smooth muscle myoblast [Term] id: CL:0000193 name: cardiac muscle cell (sensu Arthopoda) namespace: cell alt_id: CL:0000466 def: "A striated muscle cell found in the heart. They develop from cardiac myoblasts." [MESH:A11.620.500] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000746 ! cardiac muscle cell relationship: develops_from CL:0000465 ! cardioblast (sensu Arthropoda) [Term] id: CL:0000194 name: nodal cardiac cell namespace: cell comment: Consider CL:0002072. is_obsolete: true [Term] id: CL:0000195 name: Purkinje fiber namespace: cell is_obsolete: true [Term] id: CL:0000196 name: flight muscle cell namespace: cell is_a: CL:0000187 ! muscle cell is_a: CL:0000228 ! multinucleate cell [Term] id: CL:0000197 name: receptor cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000198 name: pain receptor cell namespace: cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:A08.800.550.700.650] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship synonym: "nociceptor" EXACT [] synonym: "nocireceptor" EXACT [] is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000199 name: mechanoreceptor cell namespace: cell def: "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [MESH:A08.800.550.700.500] synonym: "mechanoreceptor" RELATED [MP:0000972] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050974 ! capable_of detection of mechanical stimulus involved in sensory perception relationship: RO:0002215 GO:0050974 ! capable_of detection of mechanical stimulus involved in sensory perception [Term] id: CL:0000200 name: touch receptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050976 ! capable_of detection of mechanical stimulus involved in sensory perception of touch relationship: RO:0002215 GO:0050976 ! capable_of detection of mechanical stimulus involved in sensory perception of touch [Term] id: CL:0000202 name: auditory hair cell namespace: cell alt_id: CL:0000201 def: "A mechanoreceptor cell located in the inner ear that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [MESH:A08.663.650.250] comment: In mammals these cells are located in the organ of Corti. synonym: "auditory receptor cell" EXACT [] synonym: "cochlear hair cell" EXACT [] synonym: "inner ear hair cell" EXACT [GO:0060119] synonym: "inner ear receptor cell" EXACT [GO:0060119] xref: FMA:62364 is_a: CL:0001035 ! bone cell is_a: CL:0002374 ! ear hair cell is_a: CL:0002491 ! auditory epithelial cell relationship: part_of UBERON:0002227 ! spiral organ of cochlea relationship: RO:0002215 GO:0050910 ! capable_of detection of mechanical stimulus involved in sensory perception of sound [Term] id: CL:0000203 name: gravity sensitive cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0070999 ! capable_of detection of mechanical stimulus involved in sensory perception of gravity relationship: RO:0002215 GO:0070999 ! capable_of detection of mechanical stimulus involved in sensory perception of gravity [Term] id: CL:0000204 name: acceleration receptive cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000205 name: thermoreceptor cell namespace: cell def: "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain." [GOC:tfm, MESH:A08.800.550.700.840, MP:0000971] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000006 ! neuronal receptor cell intersection_of: RO:0002215 GO:0050960 ! capable_of detection of temperature stimulus involved in thermoception relationship: RO:0002215 GO:0050960 ! capable_of detection of temperature stimulus involved in thermoception [Term] id: CL:0000206 name: chemoreceptor cell namespace: cell def: "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood." [MESH:A08.800.550.700.120] is_a: CL:0000006 ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050907 ! capable_of detection of chemical stimulus involved in sensory perception relationship: RO:0002215 GO:0050907 ! capable_of detection of chemical stimulus involved in sensory perception [Term] id: CL:0000207 name: olfactory receptor cell namespace: cell synonym: "olfactory receptor neuron" EXACT [] synonym: "olfactory sensory neuron" EXACT [] synonym: "Schultze's cell" EXACT [] xref: BTO:0004185 xref: FMA:67860 is_a: CL:0000206 ! chemoreceptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050911 ! capable_of detection of chemical stimulus involved in sensory perception of smell relationship: RO:0002215 GO:0050911 ! capable_of detection of chemical stimulus involved in sensory perception of smell [Term] id: CL:0000208 name: pH receptor cell namespace: cell is_a: CL:0000206 ! chemoreceptor cell [Term] id: CL:0000209 name: taste receptor cell namespace: cell def: "A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste." [GOC:tfm, ISBN:0618947256] synonym: "taste bud cell" EXACT [] xref: FMA:67910 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000206 {is_inferred="true"} ! chemoreceptor cell is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050912 ! capable_of detection of chemical stimulus involved in sensory perception of taste relationship: RO:0002215 GO:0050912 ! capable_of detection of chemical stimulus involved in sensory perception of taste [Term] id: CL:0000210 name: photoreceptor cell namespace: cell def: "A cell specialized to detect and transduce light." [MESH:A08.663.650.650] xref: BTO:0001060 xref: CALOHA:TS-0868 xref: FBbt:00004211 xref: FMA:86740 is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: RO:0002215 GO:0050962 ! capable_of detection of light stimulus involved in sensory perception relationship: RO:0002215 GO:0050962 ! capable_of detection of light stimulus involved in sensory perception [Term] id: CL:0000211 name: electrically active cell namespace: cell def: "A cell whose function is determined by the generation or the reception of an electric signal." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000212 name: absorptive cell namespace: cell def: "A cell that takes up and metabolizes substances." [CL:CVS] is_a: CL:0000003 ! native cell [Term] id: CL:0000213 name: lining cell namespace: cell def: "A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism." [JB:jb] synonym: "boundary cell" EXACT [] is_a: CL:0000215 ! barrier cell [Term] id: CL:0000214 name: synovial cell namespace: cell def: "A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid." [GOC:tfm, ISBN:0721662544, PMID:17942474] synonym: "hyaluronic acid secreting cell" EXACT [] synonym: "synoviocyte" EXACT [] xref: BTO:0003652 xref: CALOHA:TS-0995 xref: FMA:66786 is_a: CL:0000153 ! GAG secreting cell is_a: CL:0000213 ! lining cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0002018 ! synovial membrane of synovial joint relationship: part_of UBERON:0002018 ! synovial membrane of synovial joint [Term] id: CL:0000215 name: barrier cell namespace: cell def: "A cell whose primary function is to prevent the transport of stuff across compartments." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000216 name: Sertoli cell namespace: cell def: "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier." [MESH:A05.360.444.849.789] xref: BTO:0001238 xref: CALOHA:TS-0922 xref: FMA:72298 xref: VHOG:0001348 is_a: CL:0000511 ! androgen binding protein secreting cell is_a: CL:0000630 {is_inferred="true"} ! supportive cell is_a: CL:0002625 ! seminiferous tubule epithelial cell intersection_of: CL:0000630 ! supportive cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis [Term] id: CL:0000217 name: insulating cell namespace: cell is_a: CL:0000215 ! barrier cell [Term] id: CL:0000218 name: myelinating Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons." [GOC:cvs, GOC:tfm, MESH:A08.637.800] synonym: "neurilemmal cell" EXACT [] synonym: "peripheral neuroglial cell" BROAD [] synonym: "Schwann cell" BROAD [] xref: CALOHA:TS-0898 xref: FMA:62121 is_a: CL:0000217 ! insulating cell is_a: CL:0000328 ! myelin accumulating cell is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell [Term] id: CL:0000219 name: motile cell namespace: cell def: "A cell that moves by its own activities." [FB:ma] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0048870 ! capable_of cell motility relationship: RO:0002215 GO:0048870 ! capable_of cell motility [Term] id: CL:0000220 name: cell by lineage namespace: cell comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell in a multicellular organiam, apart from a zygote, can potentially be classified by its lineage. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000221 name: ectodermal cell namespace: cell def: "A cell of the outer of the three germ layers of the embryo." [MESH:A16.254.425.273] synonym: "ectoderm cell" EXACT [] xref: FMA:72549 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000924 ! ectoderm [Term] id: CL:0000222 name: mesodermal cell namespace: cell def: "A cell of the middle germ layer of the embryo." [MESH:A16.254.425.660] synonym: "mesoblast" EXACT [] synonym: "mesoderm cell" EXACT [] xref: FMA:72554 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000926 ! mesoderm [Term] id: CL:0000223 name: endodermal cell namespace: cell def: "A cell of the inner of the three germ layers of the embryo." [MESH:A16.254.425.407] synonym: "endoderm cell" EXACT [] xref: FMA:72555 is_a: CL:0002321 ! embryonic cell relationship: part_of UBERON:0000925 ! endoderm [Term] id: CL:0000224 name: cell by nuclear number namespace: cell def: "A classification of cells by the number of their nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell can be classified by its nuclear number (note that this term was previously used as a parent class of enucleate cell). If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0001034 [Term] id: CL:0000225 name: anucleate cell namespace: cell def: "A cell that lacks a nucleus." [FB:ma] synonym: "non-nucleated cell" EXACT [] xref: FMA:68647 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001405 ! anucleate [Term] id: CL:0000226 name: single nucleate cell namespace: cell def: "A cell with a single nucleus." [FB:ma, GOC:tfm] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000227 name: binucleate cell namespace: cell is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001406 ! binucleate relationship: bearer_of PATO:0001406 ! binucleate [Term] id: CL:0000228 name: multinucleate cell namespace: cell def: "A cell with more than one nucleus." [FB:ma] synonym: "syncitium" EXACT [] synonym: "syncytial cell" EXACT [] synonym: "syncytium" EXACT [] xref: AEO:0000203 xref: WBbt:0008074 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000229 name: lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature lymphocyte phenotype rather than a distinct cell type; consider using 'lymphocyte ; CL:0000542' or one of its children instead. is_obsolete: true [Term] id: CL:0000230 name: T lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature T lymphocyte phenotype rather than a distinct cell type; consider using 'T cell ; CL:0000084' or one of its children instead. is_obsolete: true [Term] id: CL:0000231 name: B lymphoblast namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Refers to an activated mature B lymphocyte phenotype rather than a distinct cell type; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000232 name: erythrocyte namespace: cell def: "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen." [GOC:tfm, MESH:A11.118.290] synonym: "RBC" EXACT [] synonym: "red blood cell" EXACT [] xref: BTO:0000424 xref: CALOHA:TS-0290 xref: FMA:81100 is_a: CL:0000081 ! blood cell is_a: CL:0000329 ! oxygen accumulating cell is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: bearer_of PATO:0002039 ! biconcave intersection_of: lacks_part GO:0005840 ! ribosome intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation intersection_of: RO:0002215 GO:0015671 ! capable_of oxygen transport relationship: bearer_of PATO:0002039 ! biconcave relationship: develops_from CL:0000558 ! reticulocyte relationship: lacks_part GO:0005840 ! ribosome relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: RO:0002215 GO:0015671 ! capable_of oxygen transport [Term] id: CL:0000233 name: platelet namespace: cell def: "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [GOC:add, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/Platelet, MESH:A11.118.188, MESH:D001792, PMID:11110672, PMID:16987572, PMID:17204662, PMID:17479180, PMID:20414831] comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF. synonym: "anucleate thrombocyte" EXACT [] synonym: "blood platelet" EXACT [] synonym: "enucleate thrombocyte" EXACT [] xref: BTO:0000132 xref: CALOHA:TS-0803 xref: FMA:62851 is_a: CL:0000081 ! blood cell is_a: CL:0000225 ! anucleate cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001405 ! anucleate intersection_of: bearer_of PATO:0001874 ! discoid intersection_of: RO:0002215 GO:0007596 ! capable_of blood coagulation intersection_of: RO:0002215 GO:0008015 ! capable_of blood circulation relationship: bearer_of PATO:0001405 ! anucleate relationship: bearer_of PATO:0001874 ! discoid relationship: develops_from CL:0000556 ! megakaryocyte relationship: RO:0002215 GO:0007596 ! capable_of blood coagulation relationship: RO:0002215 GO:0008015 ! capable_of blood circulation [Term] id: CL:0000234 name: phagocyte namespace: cell def: "Any cell capable of ingesting particulate matter via phagocytosis." [GOC:add, ISBN:0721601464] xref: BTO:0001044 xref: FMA:83806 is_a: CL:0000219 ! motile cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000473 ! defensive cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis [Term] id: CL:0000235 name: macrophage namespace: cell def: "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:16213494, PMID:1919437] comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid. synonym: "histiocyte" EXACT [] xref: BTO:0000801 xref: CALOHA:TS-0587 xref: FMA:63261 xref: FMA:83585 is_a: CL:0000234 ! phagocyte is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0031268 ! capable_of pseudopodium organization relationship: develops_from CL:0000576 ! monocyte relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0031268 ! capable_of pseudopodium organization [Term] id: CL:0000236 name: B cell namespace: cell def: "A lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "B lymphocyte" EXACT [] synonym: "B-cell" EXACT [] synonym: "B-lymphocyte" EXACT [] xref: BTO:0000776 xref: CALOHA:TS-0068 xref: FMA:62869 xref: VHOG:0001480 is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: RO:0002215 GO:0019724 ! capable_of B cell mediated immunity relationship: develops_from CL:0000826 ! pro-B cell relationship: RO:0002215 GO:0019724 ! capable_of B cell mediated immunity [Term] id: CL:0000237 name: keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000238 name: non keratinizing barrier epithelial cell namespace: cell is_a: CL:0000240 ! stratified squamous epithelial cell [Term] id: CL:0000239 name: brush border epithelial cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000240 name: stratified squamous epithelial cell namespace: cell is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000241 name: stratified cuboidal epithelial cell namespace: cell is_a: CL:0000079 ! stratified epithelial cell [Term] id: CL:0000242 name: Merkel cell namespace: cell def: "A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber." [MESH:A08.800.550.700.500.425] synonym: "Merkel's cell" EXACT [] xref: FMA:70548 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000312 {source="PMID:19782676"} ! keratinocyte [Term] id: CL:0000243 name: glial cell (sensu Vertebrata) namespace: cell def: "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear." [MESH:A08.637] is_a: CL:0000125 ! glial cell relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000244 name: transitional epithelial cell namespace: cell def: "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium." [GOC:tfm, ISBN:0721662544] xref: FMA:66778 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000245 name: passage cell namespace: cell def: "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." [ISBN:0471245208] comment: replaced_by: PO:0000353 is_obsolete: true [Term] id: CL:0000246 name: Mauthner neuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000247 name: Rohon-Beard neuron namespace: cell def: "Type of neuron that is a primary mechanosensory cell, with peripheral neurites innervating the skin with free nerve endings." [VHOG:0001484] synonym: "RB neuron" RELATED [VHOG:0001484] synonym: "Rohon Beard cell" EXACT [VHOG:0001484] synonym: "Rohon-Beard cell" EXACT [] xref: AAO:0010316 xref: EFO:0003711 xref: VHOG:0001484 is_a: CL:0000531 ! primary sensory neuron [Term] id: CL:0000248 name: microsporocyte namespace: cell def: "Obsolete. Use PO:0020047 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [ISBN:0471245208] comment: replaced_by: PO:0020047 synonym: "pollen mother cell" EXACT [] synonym: "primary sporogenous cell" EXACT [] is_obsolete: true [Term] id: CL:0000249 name: hatching gland cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000250 name: megaspore namespace: cell def: "Obsolete. Use PO:0020019 from Plant Ontology instead. A haploid (1n) spore developing into a female gametophyte in heterosporous plants." [ISBN:0471245208] comment: replaced_by: PO:0020019 is_obsolete: true [Term] id: CL:0000251 name: extramedullary cell namespace: cell is_a: CL:0000101 ! sensory neuron [Term] id: CL:0000252 name: microspore namespace: cell def: "Obsolete. Use PO:0020048 from Plant Ontology instead. A haploid (1n) spore developing into a male gametophyte in heterosporous plants; the uninucleate pollen grain in seed plants." [ISBN:0471245208] comment: replaced_by: PO:0020048 is_obsolete: true [Term] id: CL:0000253 name: eurydendroid cell namespace: cell is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000254 name: egg cell namespace: cell def: "Obsolete. Use PO:0020094 from Plant Ontology instead. The female gamete of plants." [TAIR:lr] comment: replaced_by: PO:0020094 synonym: "female gametophyte egg cell" EXACT [] is_obsolete: true [Term] id: CL:0000255 name: eukaryotic cell namespace: cell is_a: CL:0000003 ! native cell disjoint_from: CL:0000520 ! prokaryotic cell [Term] id: CL:0000256 name: uric acid accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000257 name: Mycetozoan cell namespace: cell is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000258 name: fiber tracheid namespace: cell def: "Obsolete. Use PO:0000355 from Plant Ontology instead. A fiber like tracheid in the secondary xylem; commonly thick walled, with pointed ends and bordered pits that have lenticular to slit like apertures." [ISBN:0471245208] comment: replaced_by: PO:0000355 is_obsolete: true [Term] id: CL:0000259 name: aggregate cell namespace: cell def: "Differentiating cell composing the aggregate that has acquired adhesive properties." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000260 name: mucilage cell namespace: cell def: "Obsolete. Use PO:0000373 from Plant Ontology instead. Cell containing mucilages or gums or similar carbohydrate material characterized by the property of swelling in water." [ISBN:0471245208] comment: replaced_by: PO:0000373 is_obsolete: true [Term] id: CL:0000261 name: anterior cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000262 name: guard mother cell namespace: cell def: "Obsolete. Use PO:0000351 from Plant Ontology instead. An epidermal cell that divides to produce the guard cells." [ISBN:0471245208] comment: replaced_by: PO:0000351 is_obsolete: true [Term] id: CL:0000263 name: vegetative cell (sensu Mycetozoa) namespace: cell def: "Unicellular haploid myxamoebae that feeds on bacteria and divides by binary fission." [DictyBase:DDB] synonym: "amoeba" EXACT [] is_a: CL:0000257 ! Mycetozoan cell [Term] id: CL:0000264 name: phloem initial namespace: cell def: "Obsolete. Use PO:0000400 from Plant Ontology instead. A cambial cell on the phloem side of the cambial zone that is the source of one or more cells arising by periclinal divisions and differentiating into phloem elements with or without additional divisions in various planes." [ISBN:0471245208] comment: replaced_by: PO:0000400 synonym: "phloem mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000265 name: anterior like cell namespace: cell def: "Cell that has properties of anterior cells (for e.g., accumulate vital dyes in autophagic vesicles) but that is are scattered throughout the rear of the slug. Some but not all these cells express the ecmA gene and/or the ecmB gene. ALCs maintain an amoeboid appearance during culmination. ALCs that express the ecmO promoter have been called pstO/ALC." [DictyBase:DDB] synonym: "ALC" EXACT [] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000266 name: meristemoid namespace: cell def: "Obsolete. Use PO:0004011 from Plant Ontology instead. A cell constituting an active locus of meristematic activity in a tissue composed of somewhat older, differentiating cells." [ISBN:0471245208] comment: replaced_by: PO:0004011 is_obsolete: true [Term] id: CL:0000267 name: prespore cell namespace: cell def: "Cell that is undergoing differentiation to become a spore." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000268 name: sieve element namespace: cell def: "Obsolete. Consult Plant Ontology instead. The cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. Classified into sieve cell and sieve tube member." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000269 name: prestalk cell namespace: cell is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000270 name: subsidiary cell namespace: cell def: "Obsolete. Use PO:0000284 from Plant Ontology instead. An epidermal cell associated with a stoma and at least morphologically distinguishable from the epidermal cells composing the groundmass of the tissue." [ISBN:047124520] comment: replaced_by: PO:0000284 is_obsolete: true [Term] id: CL:0000271 name: prestalk A cell namespace: cell def: "Cell expressing the ecmA marker from a promoter region that is proximal to the ATG (ecmAO promoter). They are located at the anterior-most region of the slug. During culmination pstA cells differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstA" EXACT [] synonym: "pstAO" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000272 name: cambial initial namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell localized in the vascular cambium or phellogen. Its periclinal division can contribute cells either to the outside or to the inside of the axis; in vascular cambium, classified into fusiform initials (source of axial cells of xylem and phloem) and ray initials (source of the ray cells)." [ISBN:0471245208] comment: replaced_by PO:0000295 is_obsolete: true [Term] id: CL:0000273 name: prestalk AB cell namespace: cell def: "Cell that expresses both ecmA and ecmB either simultaneously or sequentially. During culmination pstA differentiate into pstAB cells." [DictyBase:DDB] synonym: "pstAB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000275 name: prestalk B cell namespace: cell def: "Cell expressing ecmB but not ecmA. Most pstB cells are located at the very rear of the slug (rearguard region). These cells form part of the basal disc of the fruiting body. If a migratory slug is formed, these cells are left behind." [DictyBase:DDB] synonym: "pstB" EXACT [] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000276 name: sclerenchyma cell namespace: cell def: "Obsolete. Use PO:0000077 from Plant Ontology instead. Cell variable in form and size, being more or less thick, often lignified, secondary walls. Belongs to the category of subcells and may or may not be devoid of protoplast at maturity." [ISBN:0471245208] comment: replaced_by: PO:0000077 is_obsolete: true [Term] id: CL:0000277 name: obsolete prestalk I cell namespace: cell def: "Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." [DictyBase:DDB] comment: This cell type does not exist in Dictyostelium. it has been long deleted in their anatomy ontology. is_obsolete: true replaced_by: DDANAT:0000406 [Term] id: CL:0000278 name: central cell namespace: cell def: "Obsolete. Use PO:0020090 from Plant Ontology instead. OBSOLETED, use term from Plant Ontology. A cell containing the two polar nuclei which, after double fertilization, will develop into the endosperm." [TAIR:lr] comment: replaced_by: PO:0020090 is_obsolete: true [Term] id: CL:0000279 name: prestalk 0 cell namespace: cell def: "Cell that express ecmA at a very low level. Located at the posterior half of the prestalk zone. Expresses ecmA from the distal region of its promoter (ecmO)." [DictyBase:DDB] is_a: CL:0000269 ! prestalk cell [Term] id: CL:0000280 name: generative cell namespace: cell def: "Obsolete. Use PO:0020097 from Plant Ontology instead. The cell that will give rise to the generative nuclei which will participate in fertilization." [TAIR:lr] comment: replaced_by: PO:0020097 is_obsolete: true [Term] id: CL:0000281 name: pstAB/ALC namespace: cell def: "Anterior-like cell expressing both ecmA and ecmB." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000282 name: trichome namespace: cell def: "Obsolete. Use PO:0000282 from Plant Ontology instead. An outgrowth from the epidermis. Trichomes vary in size and complexity and include hairs, scales, and other structures and may be glandular. In Arabidopsis, patterning of trichome development is not random but does not appear to be lineage-based like stomata." [ISBN:0471245208, PMID:10938806] comment: replaced_by: PO:0000282 is_obsolete: true [Term] id: CL:0000283 name: pstO/ALC namespace: cell def: "Anterior-like cell that expresses the ecmO promoter and that can move to the position normally occupied by the pstO cells." [DictyBase:DDB] is_a: CL:0000265 ! anterior like cell [Term] id: CL:0000284 name: companion cell namespace: cell def: "Obsolete. Use PO:0000071 from Plant Ontology instead. A specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [ISBN:0879015322] comment: replaced_by: PO:0000071 is_obsolete: true [Term] id: CL:0000285 name: stalk cell namespace: cell def: "Vacuolated cell located at the center of the stalk tube that has a cell wall composed of cellulose and that die upon terminal differentiation. Stalk cells provide structural support for the fruiting body." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000286 name: hyphal cell namespace: cell def: "A cell of a filament of a fungal mycelium." [ISBN:08199377X] is_a: CL:0000521 ! fungal cell [Term] id: CL:0000287 name: eye photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000288 name: synergid namespace: cell def: "Obsolete. Use PO:0000191 from Plant Ontology instead. A cell in the micropylar end of the embryo sac associated with the egg in the egg apparatus of angiosperms. Plays a vital role in fertilization." [ISBN:047125208] comment: replaced_by: PO:0000191 is_obsolete: true [Term] id: CL:0000289 name: chemotactic amoeboid cell (sensu Mycetozoa) namespace: cell def: "Starved cell that secretes and responds to chemoattractants (cAMP)." [DictyBase:DDB] is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) is_a: CL:0000732 ! amoeboid cell [Term] id: CL:0000290 name: xylem fiber cell namespace: cell def: "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." [ISBN:0471245208] comment: replaced_by: PO:0000274 is_obsolete: true [Term] id: CL:0000291 name: spore (sensu Mycetozoa) namespace: cell def: "Dormant cell protected by a tri-layer spore coat. The spore has an elliptical shape and is approximately 6-9 microns by 3 microns." [DDB_REF:5048, DictyBase:DDB, PMID:4338436] xref: DDANAT:0000414 is_a: CL:0000263 ! vegetative cell (sensu Mycetozoa) [Term] id: CL:0000292 name: guard cell namespace: cell def: "Obsolete. Use PO:0000293 from Plant Ontology instead. One of a pair of cells flanking the stomatal pore and causing the opening and closing of the pore by changes in turgor." [ISBN:0471245208] comment: replaced_by: PO:0000293 synonym: "stomatal guard cell" EXACT [] is_obsolete: true [Term] id: CL:0000293 name: structural cell namespace: cell def: "A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000294 name: sieve cell namespace: cell def: "Obsolete. Consult Plant Ontology instead. A type of sieve element that has relatively undifferentiated sieve areas (with narrow pores), rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000295 name: somatotropin secreting cell namespace: cell alt_id: CL:0000471 def: "A peptide hormone secreting cell that produces growth hormone, somatotropin." [GOC:tfm, SANBI:mhl] synonym: "growth hormone secreting cell" EXACT [] synonym: "somatotrophin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0030252 ! capable_of growth hormone secretion relationship: RO:0002215 GO:0030252 ! capable_of growth hormone secretion [Term] id: CL:0000296 name: vegetative cell namespace: cell def: "Obsolete. Use PO:0020099 from Plant Ontology instead. Cell type formed after the first mitotic division of the microgametophye, The nucleus of this cell migrates to the tip of the pollen tube after germination and disintegrates when the pollen tube penetrates the nucellus." [ISBN:0140514031, TAIR:lr] comment: replaced_by: PO:0020099 is_obsolete: true [Term] id: CL:0000297 name: socket cell namespace: cell def: "Obsolete. Use PO:0000115 from Plant Ontology instead. A cell that surrounds a trichome and provides support for the trichome." [PMID:10938806] comment: replaced_by: PO:0000115 is_obsolete: true [Term] id: CL:0000298 name: xylem element namespace: cell def: "Obsolete. Use PO:0000273 from Plant Ontology instead. A cell composing the xylem." [ISBN:0471245208] comment: replaced_by: PO:0000273 is_obsolete: true [Term] id: CL:0000299 name: trichoblast namespace: cell def: "OBSOLETED. Commonly used for a cell in root epidermis that gives rise to a root hair. The daughter cell produced by the asymmetric division of a root epidermal cell that gives rise to a root hair." [ISBN:0471245208] comment: Obsoleted. Use trichoblast from the plant ontology (PO:0000262). is_obsolete: true [Term] id: CL:0000300 name: gamete namespace: cell def: "A mature sexual reproductive cell having a single set of unpaired chromosomes." [GOC:tfm, ISBN:0721662544] synonym: "haploid germ cell" RELATED [] synonym: "haploid nucleated cell" EXACT [] xref: CALOHA:TS-0395 xref: FBbt:00005412 xref: FMA:18649 is_a: CL:0000413 ! haploid cell is_a: CL:0000586 {is_inferred="true"} ! germ cell intersection_of: CL:0000586 ! germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0009566 ! capable_of fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: RO:0002215 GO:0009566 ! capable_of fertilization [Term] id: CL:0000301 name: pole cell namespace: cell xref: FBbt:00000092 is_a: CL:0000670 ! primordial germ cell [Term] id: CL:0000302 name: IgM B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000303 name: IgG B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgG isotypes vary by species; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000304 name: IgA B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se, and IgA isotypes vary by species. Consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000305 name: IgE B cell namespace: cell def: "OBSOLETE (was not defined before being made obsolete)." [] comment: Not a differentiation state per se; consider using 'B cell ; CL:0000236' or one of its children instead. is_obsolete: true [Term] id: CL:0000306 name: crystallin accumulating cell namespace: cell synonym: "lens cell" EXACT [] xref: FBbt:00004193 is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000307 name: tracheal epithelial cell namespace: cell alt_id: CL:1000474 def: "An epithelial cell found in the trachea." [GOC:tfm] synonym: "tracheocyte" EXACT [] xref: FBbt:00005038 xref: FMA:74793 is_a: CL:0002202 {is_inferred="true"} ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0003126 ! trachea relationship: develops_from CL:0000377 ! tracheoblast relationship: part_of UBERON:0003126 ! trachea [Term] id: CL:0000308 name: metal ion accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000309 name: copper accumulating cell namespace: cell synonym: "cuprophilic cell" EXACT [] is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000310 name: iron accumulating cell namespace: cell is_a: CL:0000308 ! metal ion accumulating cell [Term] id: CL:0000311 name: keratin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000312 name: keratinocyte namespace: cell alt_id: CL:0002185 def: "An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell." [GOC:dsd, http://en.wikipedia.org/wiki/Keratinocyte, MESH:A11.436.397, MESH:D015603, PMID:15582983, PMID:15749908, PMID:19727116] comment: Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. synonym: "keratinized cell of epidermis" EXACT [] synonym: "malpighian cell" EXACT [] xref: BTO:0000667 xref: CALOHA:TS-0500 xref: FMA:62879 is_a: CL:0000237 {is_inferred="true"} ! keratinizing barrier epithelial cell is_a: CL:0000362 {is_inferred="true"} ! epidermal cell intersection_of: CL:0000237 ! keratinizing barrier epithelial cell intersection_of: part_of UBERON:0001003 ! epidermis intersection_of: RO:0002215 GO:0002775 ! capable_of antimicrobial peptide production intersection_of: RO:0002215 GO:0002776 ! capable_of antimicrobial peptide secretion intersection_of: RO:0002215 GO:0090023 ! capable_of positive regulation of neutrophil chemotaxis relationship: part_of UBERON:0001003 ! epidermis relationship: RO:0002215 GO:0002775 ! capable_of antimicrobial peptide production relationship: RO:0002215 GO:0002776 ! capable_of antimicrobial peptide secretion relationship: RO:0002215 GO:0090023 ! capable_of positive regulation of neutrophil chemotaxis [Term] id: CL:0000313 name: serous secreting cell namespace: cell def: "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid." [GOC:tfm, ISBN:0517223651, ISBN:0721662544] synonym: "serous cell" EXACT [] xref: BTO:0003687 xref: FMA:62511 is_a: CL:0000159 ! seromucus secreting cell [Term] id: CL:0000314 name: milk secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000315 name: tears secreting cell namespace: cell def: "A cell secreting tears, the fluid secreted by the lacrimal glands. This fluid moistens the conjunctiva and cornea." [MESH:A12.200.882] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000316 name: ray initial namespace: cell def: "Obsolete. Use PO:0000082 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. A meristemic ray cell in the vascular cambium that gives rise to ray cells of the secondary xylem and secondary phloem." [ISBN:0471245208] comment: replaced_by: PO:0000082 is_obsolete: true [Term] id: CL:0000317 name: sebum secreting cell namespace: cell def: "A cell secreting sebun, an oily substance secreted by sebaceous glands, composed of keratin, fat, and cellular debris." [MESH:A12.200.702] is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: part_of UBERON:0001821 ! sebaceous gland relationship: part_of UBERON:0001821 ! sebaceous gland [Term] id: CL:0000318 name: sweat secreting cell namespace: cell def: "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." [MESH:A12.200.849] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000319 name: mucus secreting cell namespace: cell synonym: "mucous cell" EXACT [] xref: BTO:0003689 is_a: CL:0000159 ! seromucus secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070254 ! capable_of mucus secretion relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000320 name: megasporocyte namespace: cell def: "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." [ISBN:0471245208] comment: replaced_by: PO:0000431 synonym: "archesporial cell" EXACT [] synonym: "megaspore mother cell" EXACT [] is_obsolete: true [Term] id: CL:0000321 name: seminal fluid secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000322 name: pneumocyte namespace: cell def: "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates." [GOC:tfm, PMID:20054144] synonym: "alveolar epithelial cell" EXACT [] synonym: "pneumonocyte" EXACT [] xref: BTO:0000395 xref: CALOHA:TS-2168 xref: FMA:62499 is_a: CL:0000082 ! epithelial cell of lung intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0002299 ! alveolus of lung relationship: part_of UBERON:0004821 ! pulmonary alveolus epithelium [Term] id: CL:0000323 name: lysozyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000324 name: metanephric mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000325 name: stuff accumulating cell namespace: cell def: "A cell that is specialised to accumulate a particular substance(s)." [FB:ma] subset: ubprop:upper_level is_a: CL:0000003 ! native cell [Term] id: CL:0000326 name: glycogen accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000327 name: extracellular matrix secreting cell namespace: cell is_a: CL:0000151 ! secretory cell is_a: CL:0000499 ! stromal cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070278 ! capable_of extracellular matrix constituent secretion relationship: RO:0002215 GO:0070278 ! capable_of extracellular matrix constituent secretion [Term] id: CL:0000328 name: myelin accumulating cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000329 name: oxygen accumulating cell namespace: cell is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: RO:0002215 GO:0015671 ! capable_of oxygen transport relationship: RO:0002215 GO:0015671 ! capable_of oxygen transport [Term] id: CL:0000330 name: collenchymal cell namespace: cell def: "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." [ISBN:0471245208] comment: replaced_by: PO:0000075 is_obsolete: true [Term] id: CL:0000331 name: tracheid namespace: cell def: "Obsolete. Use PO:0000301 from Plant Ontology instead. A tracheary element of the xylem that has no perforations, as contrasted with a vessel member. May occur in primary and in secondary xylem. May have any kind of secondary wall thickening found in tracheary elements." [ISBN:0471245208] comment: replaced_by: PO:0000301 is_obsolete: true [Term] id: CL:0000332 name: atrichoblast namespace: cell def: "OBSOLETE, use term from Plant Ontology. A cell formed after asymmetric division of root epidermal cell that does not give rise to a root hair." [ISBN:0387987819] comment: replaced_by: PO:0020090 synonym: "non-hair cell" RELATED [] is_obsolete: true [Term] id: CL:0000333 name: migratory neural crest cell namespace: cell def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0002321 ! embryonic cell relationship: develops_from CL:0000133 ! neurectodermal cell relationship: develops_from CL:0007004 ! premigratory neural crest cell [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) namespace: cell synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell [Term] id: CL:0000335 name: mesenchyme condensation cell namespace: cell def: "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors." [GOC:tfm, PMID:5025404] is_a: CL:0000134 ! mesenchymal cell [Term] id: CL:0000336 name: adrenal medulla chromaffin cell namespace: cell alt_id: CL:1000422 def: "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation." [GOC:tfm, http://www.britannica.com/EBchecked/topic/6405/adrenal-gland] synonym: "medullary chromaffin cell of adrenal gland" EXACT [FMA:69262] xref: FMA:69262 is_a: CL:0000457 ! biogenic amine secreting cell is_a: CL:1000426 ! chromaffin cell of adrenal gland intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0001236 ! adrenal medulla [Term] id: CL:0000337 name: neuroblast (sensu Vertebrata) namespace: cell def: "An embryonic cell that develops into a nerve cell or neuron." [FMA:70563] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000338 name: neuroblast (sensu Nematoda and Protostomia) namespace: cell synonym: "neuroblast" BROAD [] is_a: CL:0000031 ! neuroblast [Term] id: CL:0000339 name: glioblast (sensu Vertebrata) namespace: cell def: "An early neural cell developing from the early ependymal cell of the neural tube." [GOC:tfm, ISBN:0618947256] synonym: "spongioblast" EXACT [] xref: FMA:70564 is_a: CL:0000030 ! glioblast is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) [Term] id: CL:0000340 name: glioblast (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000030 ! glioblast is_a: CL:0000130 ! neuron associated cell (sensu Nematoda and Protostomia) [Term] id: CL:0000341 name: pigment cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000147 ! pigment cell [Term] id: CL:0000342 name: pigment cell (sensu Vertebrata) namespace: cell def: "Any animal cell containing pigment granules." [GOC:tfm, ISBN:0721662544] is_a: CL:0000147 ! pigment cell [Term] id: CL:0000343 name: visual pigment cell (sensu Vertebrata) namespace: cell def: "A pigment cell that is capable of detecting light stimulus that is involved in visual perception." [GOC:tfm] xref: FMA:63846 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000342 {is_inferred="true"} ! pigment cell (sensu Vertebrata) intersection_of: CL:0000342 ! pigment cell (sensu Vertebrata) intersection_of: RO:0002215 GO:0050908 ! capable_of detection of light stimulus involved in visual perception relationship: RO:0002215 GO:0050908 ! capable_of detection of light stimulus involved in visual perception [Term] id: CL:0000344 name: non-visual cell (sensu Vertebrata) namespace: cell is_obsolete: true [Term] id: CL:0000345 name: dental papilla cell namespace: cell def: "A small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544] is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001763 ! odontogenic papilla [Term] id: CL:0000346 name: hair follicle dermal papilla cell namespace: cell def: "A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling." [GOC:tfm, PMID:9893172] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000412 ! dermal papilla relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: part_of UBERON:0000412 ! dermal papilla [Term] id: CL:0000347 name: scleral cell namespace: cell def: "A cell of the sclera of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001773 ! sclera relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001773 ! sclera [Term] id: CL:0000348 name: choroidal cell of the eye namespace: cell def: "A cell of the choroid of the eye." [GOC:add] is_a: CL:0000293 ! structural cell intersection_of: CL:0000293 ! structural cell intersection_of: part_of UBERON:0001776 ! optic choroid relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001776 ! optic choroid [Term] id: CL:0000349 name: extraembryonic cell namespace: cell is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0000478 ! extraembryonic structure relationship: part_of UBERON:0000478 ! extraembryonic structure [Term] id: CL:0000350 name: amnioserosal cell namespace: cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0010302 ! amnioserosa relationship: part_of UBERON:0010302 ! amnioserosa [Term] id: CL:0000351 name: trophoblast cell namespace: cell def: "A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface." [GOC:tfm, MESH:A11.936] synonym: "trophoblastic cell" EXACT [] xref: FMA:83028 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: part_of UBERON:0000358 ! blastocyst relationship: part_of UBERON:0000358 ! blastocyst [Term] id: CL:0000352 name: epiblast cell namespace: cell def: "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation." [GOC:tfm, ISBN:0618947256] is_a: CL:0000052 ! totipotent stem cell [Term] id: CL:0000353 name: blastoderm cell namespace: cell def: "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote)." [MESH:A11.104] synonym: "blastomere" EXACT [] xref: BTO:0001473 xref: FMA:72551 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000354 name: blastemal cell namespace: cell synonym: "blastema cell" EXACT [] xref: ncithesaurus:Blastemal_Cell is_a: CL:0000048 ! multi fate stem cell [Term] id: CL:0000355 name: muscle stem cell namespace: cell def: "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types. Distinct cell type from satellite cell." [PMID:18282570] xref: FMA:86767 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000356 name: hair matrix stem cell namespace: cell is_a: CL:0000035 ! single fate stem cell [Term] id: CL:0000357 name: stratified epithelial stem cell namespace: cell is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000358 name: sphincter associated smooth muscle cell namespace: cell def: "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning." [GOC:cjm] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0004590 ! sphincter muscle relationship: part_of UBERON:0004590 ! sphincter muscle [Term] id: CL:0000359 name: vascular associated smooth muscle cell namespace: cell def: "A smooth muscle cell assocatiated with the vasculature." [GOC:dsd, GOC:tfm] synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature [Term] id: CL:0000360 name: morula cell namespace: cell def: "A cell of the early embryo at the developmental stage in which the blastomeres, resulting from repeated mitotic divisions of the fertilized ovum (zygote), form a compact cell mass." [MESH:A16.254.270.550] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0000085 ! morula [Term] id: CL:0000361 name: gastrula cell namespace: cell def: "A cell of the embryo in the early stage following the blastula, characterized by morphogenetic cell movements, cell differentiation, and the formation of the three germ layers." [MESH:A16.254.412] is_a: CL:0000007 ! early embryonic cell relationship: part_of UBERON:0004734 ! gastrula [Term] id: CL:0000362 name: epidermal cell namespace: cell alt_id: CL:1000396 def: "An epithelial cell of the integument (the outer layer of an organism)." [Flybase:dsj, MA:ma] synonym: "cell of epidermis" EXACT [FMA:62411] synonym: "epithelial cell of skin" NARROW [FMA:62411] xref: BTO:0001470 xref: CALOHA:TS-0283 xref: FMA:62411 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis [Term] id: CL:0000363 name: axial cell namespace: cell def: "Obsolete. Use PO:0000081 from Plant Ontology instead. OBSOLETE, use term from the Plant Ontology. A secondary vascular cell that develops from the fusiform cambial initials and oriented with their longest diameter parallel with the main axis of stem or root. These cells make up the axial system, also known as vertical or longitudinal system." [ISBN:0471245208] comment: replaced_by: PO:0000081 is_obsolete: true [Term] id: CL:0000364 name: ray cell namespace: cell def: "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000365 name: zygote namespace: cell def: "Diploid cell produced by the fusion of sperm cell nucleus and egg cell." [ISBN:0471245208] xref: BTO:0000854 xref: EHDAA2:0004546 xref: FMA:72395 is_a: CL:0000007 ! early embryonic cell [Term] id: CL:0000366 name: sperm cell (sensu Viridiplantae) namespace: cell def: "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." [ISBN:0471245208] comment: replaced_by: PO:0000084 synonym: "gametophyte sperm cell" RELATED [] synonym: "male gametophyte sperm cell" RELATED [] synonym: "pollen germ cell " RELATED [] is_obsolete: true [Term] id: CL:0000367 name: sheath cell (sensu Nematoda) namespace: cell synonym: "glial cell (sensu Nematoda)" RELATED [] is_a: CL:0000619 ! support cell (sensu Nematoda) [Term] id: CL:0000368 name: myrosin cell namespace: cell def: "Obsolete. Use PO:0000352 from Plant Ontology instead. Cell containing glucosinolates ('mustard oil glucosides') and myrosinases, enzymes hydrolyzing the glucosinolates. Occurs in eleven dicotyledon families, the two largest of which are the Brassicaceae and Euphorbiaceae." [ISBN:0471245208] comment: replaced_by: PO:0000352 is_obsolete: true [Term] id: CL:0000370 name: transfer cell namespace: cell def: "Obsolete. Use PO:0000078 from Plant Ontology instead. Parenchyma cell with the wall ingrowth (or invaginations) that increase the surface of the plasmalemma. Appears to be specialized for short-distance transfer of solutes." [ISBN:0471245208] comment: replaced_by: PO:0000078 synonym: "intermediary cell" RELATED [] is_obsolete: true [Term] id: CL:0000371 name: protoplast namespace: cell def: "The cell protoplasm after removal of the cell wall." [ISBN:08199377X] is_a: CL:0000578 ! experimentally modified cell in vitro [Term] id: CL:0000372 name: tormogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization that forms a socket around the base of a cuticular specialization produced by a trichogen cell." [ISBN:978-0801481253] synonym: "socket cell" BROAD [ISBN:978-0801481253] xref: FBbt:00005171 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000373 name: histoblast namespace: cell xref: FBbt:00001789 is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000374 name: trichogen cell namespace: cell def: "An epidermal cell that is part of a cell cluster organ of the insect integument (such as a sensillum) and that secretes a cuticular specialization, often in the form of a hair, bristle, peg or scale. The base of this specialization is often surrounded by a socket produced by a closely associated tormogen cell." [ISBN:978-0801481253] synonym: "hair cell" BROAD [] xref: BTO:0004744 xref: FBbt:00005169 is_a: CL:0000463 ! epidermal cell (sensu arthropoda) [Term] id: CL:0000375 name: osteoprogenitor cell namespace: cell xref: BTO:0002051 is_obsolete: true replaced_by: CL:0007010 [Term] id: CL:0000376 name: humidity receptor cell namespace: cell is_a: CL:0000006 ! neuronal receptor cell [Term] id: CL:0000377 name: tracheoblast namespace: cell is_a: CL:0000069 ! branched duct epithelial cell [Term] id: CL:0000378 name: support cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000379 name: sensory processing neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000380 name: thecogen cell namespace: cell def: "The support cell that makes the thecogen dendritic cap - a cuticle-like matrix around the tip of the eo-dendrite and which encloses the soma of the eo-neuron." [Fbbt:00005173] synonym: "fly sheath cell" EXACT [] is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000381 name: neurosecretory neuron namespace: cell xref: FBbt:00005130 is_a: CL:0000527 ! efferent neuron [Term] id: CL:0000382 name: scolopidium namespace: cell synonym: "scolopale cell" EXACT [] xref: FBbt:00005217 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000383 name: nephrogenic mesenchyme stem cell namespace: cell is_a: CL:0000134 ! mesenchymal cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000384 name: ligament cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000385 name: prohemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005062 is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia) [Term] id: CL:0000386 name: attachment cell namespace: cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000387 name: hemocyte (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00005063 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia) relationship: RO:0002215 GO:0035010 {source="PMID:18025161"} ! capable_of encapsulation of foreign target [Term] id: CL:0000388 name: tendon cell namespace: cell def: "A fibrocyte that is part of a tendon." [GOC:tfm] synonym: "muscle attachment cell" EXACT [] synonym: "tenocyte" RELATED [] is_a: CL:0000135 {is_inferred="true"} ! fibrocyte is_a: CL:0000386 ! attachment cell intersection_of: CL:0000135 ! fibrocyte intersection_of: part_of UBERON:0000043 ! tendon relationship: part_of UBERON:0000043 ! tendon [Term] id: CL:0000389 name: socket cell (sensu Nematoda) namespace: cell is_a: CL:0000619 ! support cell (sensu Nematoda) is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000390 name: blood cell (sensu Nematoda and Protostomia) namespace: cell is_a: CL:0000081 ! blood cell [Term] id: CL:0000391 name: podocyte (sensu Diptera) namespace: cell def: "An insect immune cell that develops from plasmatocyte." [PMID:12930778] xref: FBbt:00001688 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) relationship: develops_from CL:0000394 ! plasmatocyte [Term] id: CL:0000392 name: crystal cell namespace: cell xref: FMA:63847 is_a: CL:0000391 ! podocyte (sensu Diptera) [Term] id: CL:0000393 name: electrically responsive cell namespace: cell def: "A cell whose function is determined by its response to an electric signal." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000394 name: plasmatocyte namespace: cell xref: FBbt:00001685 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000395 name: procrystal cell namespace: cell xref: FBbt:00001689 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000396 name: lamellocyte namespace: cell xref: FBbt:00001687 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000397 name: ganglion interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0000045 ! ganglion relationship: part_of UBERON:0000045 ! ganglion [Term] id: CL:0000398 name: polygonal cell namespace: cell xref: FBbt:00001691 is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000399 name: phloem element namespace: cell def: "Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion." [GOC:tfm] is_obsolete: true [Term] id: CL:0000400 name: pavement cell namespace: cell def: "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." [ISBN:087694289] comment: replaced_by: PO:0000332 is_obsolete: true [Term] id: CL:0000401 name: macrophage (sensu Diptera) namespace: cell xref: FBbt:00001686 is_a: CL:0000394 ! plasmatocyte [Term] id: CL:0000402 name: CNS interneuron namespace: cell is_a: CL:0000099 {is_inferred="true"} ! interneuron is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) intersection_of: CL:0000099 ! interneuron intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000404 name: electrically signaling cell namespace: cell def: "A cell that initiates an electrical signal and passes that signal to another cell." [FB:ma] is_a: CL:0000211 ! electrically active cell [Term] id: CL:0000405 name: neuroepidermoblast namespace: cell xref: FBbt:00005148 is_a: CL:0000338 ! neuroblast (sensu Nematoda and Protostomia) [Term] id: CL:0000406 name: CNS short range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000407 name: scolopidial ligament cell namespace: cell xref: FBbt:00005221 is_a: CL:0000384 ! ligament cell [Term] id: CL:0000408 name: male gamete namespace: cell xref: BTO:0001277 xref: CALOHA:TS-0949 is_a: CL:0000015 {is_inferred="true"} ! male germ cell is_a: CL:0000300 {is_inferred="true"} ! gamete intersection_of: CL:0000015 ! male germ cell intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0009566 ! capable_of fertilization relationship: bearer_of PATO:0001375 ! haploid relationship: RO:0002215 GO:0009566 ! capable_of fertilization [Term] id: CL:0000409 name: scolopidial sheath cell namespace: cell xref: FBbt:00005219 is_a: CL:0000618 ! sheath cell [Term] id: CL:0000410 name: CNS long range interneuron namespace: cell is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 name: flatworm hypodermal cell namespace: cell def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] xref: WBbt:0007846 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000412 name: polyploid cell namespace: cell def: "A cell whose nucleus, or nuclei, each contain more than two haploid genomes." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000413 name: haploid cell namespace: cell def: "A cell whose nucleus contains a single haploid genome." [FB:ma, GOC:tfm] is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: bearer_of PATO:0001375 ! haploid relationship: bearer_of PATO:0001375 ! haploid [Term] id: CL:0000414 name: cell by ploidy namespace: cell def: "A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei." [FB:ma, GOC:tfm] comment: This term was made obsolete because there is no difference in meaning between it and 'cell', as any cell with chromosomes can be classified by its ploidy. If you have used this term in annotation, please replace it with cell (CL:0000000), native cell (CL:0000003), eukaryotic cell (CL:0000255) or cell in vitro (CL:0001034) as appropriate. is_obsolete: true consider: CL:0000000 consider: CL:0000003 consider: CL:0000255 consider: CL:0001034 [Term] id: CL:0000415 name: diploid cell namespace: cell def: "A cell whose nucleus has two haploid genomes." [FB:ma] xref: FMA:72300 is_a: CL:0000003 ! native cell [Term] id: CL:0000416 name: polytene cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000417 name: endopolyploid cell namespace: cell is_a: CL:0000412 ! polyploid cell [Term] id: CL:0000418 name: arcade cell namespace: cell def: "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." [GOC:tfm, http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells] xref: WBbt:0005793 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000419 name: seam cell namespace: cell def: "An epithelial fate stem cell found in flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm] xref: BTO:0003039 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000420 name: syncytial epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000421 name: coelomocyte namespace: cell def: "A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids." [GOC:tfm, ISBN:0721662544] xref: BTO:0002856 xref: WBbt:0005751 is_a: CL:0000080 ! circulating cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000422 name: mitogenic signaling cell namespace: cell def: "A cell whose primary function is to cause growth by stimulating cell division in its immediate cellular environment." [FB:ma] is_a: CL:0000003 ! native cell [Term] id: CL:0000423 name: tip cell namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000424 name: excretory cell namespace: cell def: "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids." [GOC:tfm, PMID:19783135] xref: WBbt:0005812 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000425 name: pore cell namespace: cell def: "Forms the terminal part of the cuticle-lined excretory duct of C. elegans." [JB:jb] is_a: CL:0000658 ! cuticle secreting cell [Term] id: CL:0000426 name: scaffold cell namespace: cell is_a: CL:0000445 ! apoptosis fated cell [Term] id: CL:0000427 name: GLR cell namespace: cell def: "A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role." [GOC:tfm, http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm] is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000428 name: yolk cell namespace: cell is_a: CL:0000325 ! stuff accumulating cell is_a: CL:0000349 ! extraembryonic cell [Term] id: CL:0000429 name: imaginal disc cell namespace: cell is_a: CL:0000146 ! simple columnar epithelial cell [Term] id: CL:0000430 name: xanthophore namespace: cell def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005002 ! xanthoblast [Term] id: CL:0000431 name: iridophore namespace: cell def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl] synonym: "guanophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005001 ! iridoblast [Term] id: CL:0000432 name: reticular cell namespace: cell def: "Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum." [GOC:tfm, http://en.wikipedia.org/wiki/Reticular_cell, ISBN:0517223651] synonym: "reticulum cell" EXACT [] xref: FMA:62877 is_a: CL:0000057 ! fibroblast [Term] id: CL:0000433 name: functional megaspore namespace: cell def: "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000244 is_obsolete: true [Term] id: CL:0000434 name: eccrine cell namespace: cell def: "A secretory cell that discharges its product without loss of cytoplasm." [ISBN:0198547684] is_a: CL:0000150 ! glandular epithelial cell [Term] id: CL:0000435 name: alkali secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000436 name: vaginal lubricant secreting cell namespace: cell is_a: CL:0000151 ! secretory cell relationship: part_of UBERON:0000996 ! vagina [Term] id: CL:0000437 name: gonadtroph namespace: cell def: "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH)." [GOC:tfm, http://en.wikipedia.org/wiki/Gonadotroph, ISBN:0517223651] synonym: "delta basophil" EXACT [] synonym: "follicle stimulating hormone secreting cell" EXACT [] synonym: "gonadotrope" EXACT [] synonym: "gonadotrope cell" EXACT [] synonym: "gonadotroph" EXACT [] synonym: "gonadotropic cell" EXACT [] synonym: "pituitary delta cell" EXACT [] xref: BTO:0002482 xref: FMA:83100 is_a: CL:0000438 ! luteinizing hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis [Term] id: CL:0000438 name: luteinizing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell pituitary that produces luteinizing hormone." [GOC:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0032275 ! capable_of luteinizing hormone secretion relationship: RO:0002215 GO:0032275 ! capable_of luteinizing hormone secretion [Term] id: CL:0000439 name: prolactin secreting cell namespace: cell def: "A peptide hormone cell that secretes prolactin." [GOC:tfm, SANBI:mhl] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0070459 ! capable_of prolactin secretion relationship: RO:0002215 GO:0070459 ! capable_of prolactin secretion [Term] id: CL:0000440 name: melanocyte stimulating hormone secreting cell namespace: cell def: "A cell of the intermediate pituitary that produces melanocyte stimulating hormone." [SANBI:mhl] synonym: "melanotrope" EXACT [] synonym: "melanotroph" EXACT [] xref: BTO:0002277 is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036160 ! capable_of melanocyte-stimulating hormone secretion relationship: RO:0002215 GO:0036160 ! capable_of melanocyte-stimulating hormone secretion [Term] id: CL:0000441 name: follicle stem cell namespace: cell xref: FBbt:00004903 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000442 name: follicular dendritic cell namespace: cell def: "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." [ISBN:127520252] comment: Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451. xref: BTO:0004267 xref: FMA:83037 is_a: CL:0000473 ! defensive cell [Term] id: CL:0000443 name: calcitonin secreting cell namespace: cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0036161 ! capable_of calcitonin secretion relationship: RO:0002215 GO:0036161 ! capable_of calcitonin secretion [Term] id: CL:0000444 name: obliquely striated muscle cell namespace: cell is_a: CL:0000737 ! striated muscle cell [Term] id: CL:0000445 name: apoptosis fated cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000446 name: chief cell of parathyroid gland namespace: cell def: "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone." [FMA:69078, GOC:tfm, ISBN:0517223651] synonym: "parathyroid chief cell" EXACT [] synonym: "parathyroid gland chief cell" EXACT [] synonym: "parathyroid hormone secreting cell" EXACT [] synonym: "principal cell of parathyroid gland" EXACT [] xref: BTO:0004712 xref: CALOHA:TS-2140 xref: FMA:69078 is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0002260 ! epithelial cell of parathyroid gland [Term] id: CL:0000447 name: carbohydrate secreting cell namespace: cell is_a: CL:0000151 ! secretory cell [Term] id: CL:0000448 name: white fat cell namespace: cell def: "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." [GOC:tfm, MESH:A11.329.114.500] synonym: "white adipocyte" RELATED [] synonym: "white adipose cell" EXACT [] synonym: "white fat cell" EXACT [] xref: CALOHA:TS-1119 xref: FMA:83434 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002334 ! preadipocyte relationship: part_of UBERON:0001347 ! white adipose tissue [Term] id: CL:0000449 name: brown fat cell namespace: cell def: "A cell from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation." [MESH:A10.165.114.322] synonym: "brown adipocyte" EXACT [] synonym: "brown adipose cell" EXACT [] xref: CALOHA:TS-0099 xref: FMA:83435 is_a: CL:0000136 ! fat cell relationship: develops_from CL:0002335 ! brown preadipocyte relationship: part_of UBERON:0001348 ! brown adipose tissue [Term] id: CL:0000451 name: dendritic cell namespace: cell def: "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative)." [GOC:add, ISBN:0781735149] synonym: "interdigitating cell" RELATED [] synonym: "veiled cell" RELATED [] xref: BTO:0002042 xref: CALOHA:TS-0194 xref: FMA:83036 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation intersection_of: RO:0002215 GO:0045580 ! capable_of regulation of T cell differentiation disjoint_from: CL:0000542 ! lymphocyte relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: RO:0002215 GO:0045580 ! capable_of regulation of T cell differentiation [Term] id: CL:0000452 name: thyroid hormone secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000453 name: Langerhans cell namespace: cell def: "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus." [GO_REF:0000031, GOC:add, GOC:amm, ISBN:0721601464, ISBN:0781735149, PMCID:PMC2346585, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis. synonym: "Langerhans' cell" EXACT [] synonym: "LC" EXACT [] xref: BTO:0000705 xref: CALOHA:TS-2375 xref: FMA:63072 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K intersection_of: RO:0002215 GO:0002828 ! capable_of regulation of type 2 immune response relationship: develops_from CL:0000763 ! myeloid cell relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: RO:0002215 GO:0002828 ! capable_of regulation of type 2 immune response [Term] id: CL:0000454 name: epinephrine secreting cell namespace: cell def: "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types." [GOC:tfm, PMID:12438093] synonym: "adrenaline secreting cell" EXACT [GO:0048242] synonym: "epinephrin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048242 ! capable_of epinephrine secretion relationship: RO:0002215 GO:0048242 ! capable_of epinephrine secretion [Term] id: CL:0000455 name: starch sheath cell namespace: cell def: "Obsolete. Use PO:0004531 from Plant Ontology instead. A cell characterized by conspicuous and rather stable accumulation of starch." [ISBN:044174520] comment: replaced_by: PO:0004531 is_obsolete: true [Term] id: CL:0000456 name: mineralocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035931 ! capable_of mineralocorticoid secretion relationship: RO:0002215 GO:0035931 ! capable_of mineralocorticoid secretion [Term] id: CL:0000457 name: biogenic amine secreting cell namespace: cell is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000458 name: serotonin secreting cell namespace: cell def: "A cell type that secretes 5-Hydroxytryptamine (serotonin)." [GOC:tfm, PMID:19630576] synonym: "5-HT secreting cell" EXACT [] synonym: "5-Hydroxytryptamine secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001820 ! capable_of serotonin secretion relationship: RO:0002215 GO:0001820 ! capable_of serotonin secretion [Term] id: CL:0000459 name: norepinephrin secreting cell namespace: cell def: "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme." [GOC:tfm, ISBN:068340007X] synonym: "noradrenalin secreting cell" EXACT [] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion relationship: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion [Term] id: CL:0000460 name: glucocorticoid secreting cell namespace: cell is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035933 ! capable_of glucocorticoid secretion relationship: RO:0002215 GO:0035933 ! capable_of glucocorticoid secretion [Term] id: CL:0000462 name: adepithelial cell namespace: cell xref: FBbt:00003219 is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000463 name: epidermal cell (sensu arthropoda) namespace: cell def: "An epidermal cell that secretes chitinous cuticle from its apical side." [FlyBase:ds, ISBN:ISBN\:978-0801481253] comment: While insect epidermis is generally columnar/cuboidal, there are certainly well studied cases where it is not (e.g.- Rhodnius prolixus when starved). So it would be safer to add this as a differentium for particular species where this is known. -DSJ. is_a: CL:0000362 ! epidermal cell relationship: develops_from CL:0000464 ! epidermoblast [Term] id: CL:0000464 name: epidermoblast namespace: cell def: "An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions." [GOC:tfm, PMID:7576311] xref: FBbt:00004994 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000114 ! surface ectodermal cell [Term] id: CL:0000465 name: cardioblast (sensu Arthropoda) namespace: cell xref: FBbt:00001666 is_a: CL:0000513 ! cardiac muscle myoblast [Term] id: CL:0000467 name: adrenocorticotropic hormone secreting cell namespace: cell alt_id: CL:0000640 def: "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin." [GOC:tfm, SANBI:mhl] synonym: "ACTH secreting cell" EXACT [GO:0051458] synonym: "adrenocorticotrophic hormone secreting cell" EXACT [] synonym: "corticotrophin hormone secreting cell" EXACT [] synonym: "corticotropin hormone secreting cell" EXACT [] synonym: "corticotropin secreting cell" EXACT [GO:0051458] is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0051458 ! capable_of corticotropin secretion relationship: RO:0002215 GO:0051458 ! capable_of corticotropin secretion [Term] id: CL:0000468 name: neuroglioblast namespace: cell xref: FBbt:00005147 is_a: CL:0000047 ! neuronal stem cell is_a: CL:0000055 ! non-terminally differentiated cell [Term] id: CL:0000469 name: ganglion mother cell namespace: cell xref: FBbt:00005149 is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000470 name: digestive enzyme secreting cell namespace: cell is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000472 name: chlorenchyma cell namespace: cell def: "Obsolete. Use PO:0000076 from Plant Ontology instead. OBSOLETE, use term from Plant Ontology. Parenchyma cells containing chloroplasts; a component of leaf mesophyll and other green parenchyma tissue." [ISBN:0471245208] comment: replaced_by: PO:0000076 is_obsolete: true [Term] id: CL:0000473 name: defensive cell namespace: cell def: "A cell whose primary function is to protect the organism." [JB:jb] is_a: CL:0000003 ! native cell [Term] id: CL:0000474 name: pericardial nephrocyte namespace: cell def: "an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel." [FBbt:00003184, GO:0061320, GOC:tfm, PMID:19783135] synonym: "pericardial cell" NARROW [FBbt:00005058, GO:0061320] xref: FBbt:00005058 is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000475 name: degenerate megaspore namespace: cell def: "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." [TAIR:lr] comment: replaced_by: PO:0000245 is_obsolete: true [Term] id: CL:0000476 name: thyrotroph namespace: cell def: "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center." [ISBN:0517223651, SANBI:mhl] synonym: "beta-basophil" EXACT [] synonym: "thyroid stimulating hormone secreting cell" EXACT [] synonym: "thyrotrope" EXACT [] xref: FMA:83099 is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis relationship: RO:0002215 GO:0070460 ! capable_of thyroid-stimulating hormone secretion [Term] id: CL:0000477 name: follicle cell namespace: cell comment: Editors note: check this. Currently used in goxp synonym: "ovarian follicle cell" EXACT [GO:0007297] xref: FBbt:00004904 is_a: CL:0000075 ! columnar/cuboidal epithelial cell relationship: develops_from CL:0000441 ! follicle stem cell [Term] id: CL:0000478 name: oxytocin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes oxytocin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000479 name: vasopressin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000480 name: secretin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes secretin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000481 name: cholecystokin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000482 name: juvenile hormone secreting cell namespace: cell def: "An endocrine cell that secretes juvenile hormone." [GO:tfm] is_a: CL:0000163 ! endocrine cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0045443 ! capable_of juvenile hormone secretion relationship: RO:0002215 GO:0045443 ! capable_of juvenile hormone secretion [Term] id: CL:0000483 name: bombesin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes cholecystokin stimulating hormone" [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000484 name: connective tissue type mast cell namespace: cell def: "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent." [GOC:add, GOC:dsd, GOC:tfm, PMID:19923473, PMID:9354811] comment: They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(TC)" EXACT [] synonym: "MCTC" EXACT [] synonym: "TC mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue [Term] id: CL:0000485 name: mucosal type mast cell namespace: cell def: "Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype." [GOC:add, GOC:dsd, PMID:19923473, PMID:9354811] comment: They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype. synonym: "MC(T)" EXACT [] synonym: "MCT" EXACT [] synonym: "T mast cells" EXACT [] is_a: CL:0000097 {is_inferred="true"} ! mast cell intersection_of: CL:0000097 ! mast cell intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue intersection_of: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: RO:0002215 GO:0002540 ! capable_of leukotriene production involved in inflammatory response [Term] id: CL:0000486 name: garland cell namespace: cell def: "A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae." [fbbt:00005059, GOC:tfm, PMID:19783135] synonym: "garland nephrocyte" BROAD [GO:0061321] xref: BTO:0004596 xref: FBbt:00005059 is_a: CL:0000227 ! binucleate cell is_a: CL:0000519 ! phagocyte (sensu Nematoda and Protostomia) is_a: CL:0002520 ! nephrocyte [Term] id: CL:0000487 name: oenocyte namespace: cell def: "A large secretory cell found in clusters underlying the epidermis of the abdominal segments of larval abdominal segments." [GOC:bf, PMID:11171397] xref: FBbt:00004995 is_a: CL:0000151 ! secretory cell [Term] id: CL:0000488 name: visible light photoreceptor cell namespace: cell def: "A photoreceptor cell that detects visible light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000489 name: scotopic photoreceptor cell namespace: cell is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000490 name: photopic photoreceptor cell namespace: cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000491 name: cytotoxic T cell namespace: cell def: "OBSOLETE: A cell responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as killer cells (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody." [] comment: This term had an incorrect definition and was overly broad. Consider using 'cytotoxic T cell ; CL:0000910' (in most cases) or another lymphocyte cell type if cytotoxicity is shown to be part of the cell's phenotype in a particular experimental situation. is_obsolete: true [Term] id: CL:0000492 name: CD4-positive helper T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149, MESH:A11.118.637.555.567.569.200.400] synonym: "CD4-positive helper T lymphocyte" EXACT [] synonym: "CD4-positive helper T-cell" EXACT [] synonym: "CD4-positive helper T-lymphocyte" EXACT [] synonym: "CD4-positive T-helper cell" EXACT [] xref: CALOHA:TS-1146 xref: FMA:70572 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000493 name: regulatory T cell namespace: cell def: "OBSOLETE: Subpopulation of CD4+ cells which induce CD8+ suppressor T cells to suppress antibody production by B cells. They also stimulate other cellular immune responses." [] comment: This term was defined too narrowly; consider using the term 'regulatory T cell ; CL:0000815' instead. is_obsolete: true [Term] id: CL:0000494 name: UV sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that detects ultraviolet light." [GOC:tfm] is_a: CL:0000210 ! photoreceptor cell [Term] id: CL:0000495 name: blue sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to blue light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000496 name: green sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to green light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000497 name: red sensitive photoreceptor cell namespace: cell def: "A photoreceptor cell that is sensitive to red light." [GO:tfm] is_a: CL:0000490 ! photopic photoreceptor cell [Term] id: CL:0000498 name: inhibitory interneuron namespace: cell def: "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS)." [GOC:tfm, http://en.wikipedia.org/wiki/Interneuron] xref: FMA:84776 is_a: CL:0000099 ! interneuron [Term] id: CL:0000499 name: stromal cell namespace: cell def: "A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere." [GOC:tfm, MESH:A11.329.830] xref: BTO:0002064 xref: FMA:83624 is_a: CL:0002320 ! connective tissue cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000500 name: follicular epithelial cell namespace: cell is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000501 name: granulosa cell namespace: cell def: "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." [MESH:A05.360.319.114.630.535.200] synonym: "granulosa cell of ovary" EXACT [] xref: BTO:0000542 xref: CALOHA:TS-0729 xref: FMA:18718 is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002174 ! follicular cell of ovary [Term] id: CL:0000502 name: type D enteroendocrine cell namespace: cell def: "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin." [MESH:A03.492.766.440.175] synonym: "D cell" EXACT [] xref: FMA:62935 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000172 ! somatostatin secreting cell [Term] id: CL:0000503 name: theca cell namespace: cell def: "A flattened stroma cell forming a sheath or theca outside the basal lamina lining the mature ovarian follicle. Thecal interstitial or stromal cells are steroidogenic, and produce primarily androgens which serve as precusors of estrogens in the granulosa cells." [MESH:A05.360.319.114.630.535.400] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000499 ! stromal cell is_a: CL:0000593 ! androgen secreting cell [Term] id: CL:0000504 name: enterochromaffin-like cell namespace: cell def: "A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells." [GOC:tfm, MESH:A06.224.365] comment: Consider enterochromaffin cell (CL:0002065). For several years this cell type was "enterochromaffin cell" despite a MESH dbxref and a free text definition that clearly meant enterochromaffin-like cell. synonym: "ECL" EXACT [] xref: BTO:0002692 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell [Term] id: CL:0000505 name: substance P secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes substance P." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000506 name: enkephalin secreting cell namespace: cell def: "An endorphine cell that secretes enkephalin." [GO:tfm] is_a: CL:0000507 ! endorphin secreting cell [Term] id: CL:0000507 name: endorphin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes endorphin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000508 name: type G enteroendocrine cell namespace: cell def: "An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli." [GOC:tfm, ISBN:0517223651, MESH:A03.492.766.440.300] synonym: "G cell " EXACT [] xref: BTO:0004108 xref: FMA:67609 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000506 ! enkephalin secreting cell is_a: CL:0000509 ! gastrin secreting cell [Term] id: CL:0000509 name: gastrin secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin." [GO:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000510 name: paneth cell namespace: cell def: "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." [GOC:tfm, ISBN:0517223651, MESH:A03.492.411.369.700] xref: BTO:0000993 xref: FMA:62897 is_a: CL:0000150 {is_inferred="true"} ! glandular epithelial cell is_a: CL:0000323 ! lysozyme secreting cell is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0000150 ! glandular epithelial cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium relationship: part_of UBERON:0001277 ! intestinal epithelium [Term] id: CL:0000511 name: androgen binding protein secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes androgen binding protein." [GO:tfm] is_a: CL:0000154 ! protein secreting cell [Term] id: CL:0000512 name: paracrine cell namespace: cell def: "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." [GOC:tfm, ISBN:0198529171] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000513 name: cardiac muscle myoblast namespace: cell alt_id: CL:0000714 def: "A precursor cell destined to differentiate into cardiac muscle cell." [GOC:tfm, MESH:A11.635.470] xref: FMA:84797 is_a: CL:0000056 {is_inferred="true"} ! myoblast is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000056 ! myoblast intersection_of: part_of UBERON:0001133 ! cardiac muscle tissue relationship: part_of UBERON:0001133 ! cardiac muscle tissue [Term] id: CL:0000514 name: smooth muscle myoblast namespace: cell def: "A precursor cell destined to differentiate into smooth muscle myocytes." [GOC:tfm, MESH:A11.635.510, MESH:D032390] synonym: "myoblast, smooth muscle" EXACT [MESH:D032390] synonym: "satellite cell" RELATED [] xref: FMA:84798 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: part_of UBERON:0001135 ! smooth muscle tissue relationship: part_of UBERON:0001135 ! smooth muscle tissue [Term] id: CL:0000515 name: skeletal muscle myoblast namespace: cell def: "A myoblast that differentiates into skeletal muscle fibers." [SANBI:mhl] synonym: "skeletal myoblast" EXACT [] xref: FMA:84799 is_a: CL:0000056 {is_inferred="true"} ! myoblast intersection_of: CL:0000056 ! myoblast intersection_of: part_of UBERON:0001134 ! skeletal muscle tissue relationship: part_of UBERON:0001134 ! skeletal muscle tissue [Term] id: CL:0000516 name: perineuronal satellite cell namespace: cell def: "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." [GOC:tfm, MESH:A08.340.685] synonym: "perineural satellite cell" EXACT [] synonym: "perineuronal satellite oligodendroglial cell" EXACT [] synonym: "satellite oligodendrocyte" EXACT [] xref: FMA:54550 is_a: CL:0000123 ! neuron associated cell (sensu Vertebrata) is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) [Term] id: CL:0000517 name: macrophage derived foam cell namespace: cell def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000235 ! macrophage [Term] id: CL:0000518 name: phagocyte (sensu Vertebrata) namespace: cell def: "A phagocyte in vertebrates that is able to phagocytosis." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000519 name: phagocyte (sensu Nematoda and Protostomia) namespace: cell def: "A phagocyte from organisms in the Nematoda or Protostomia clades." [GOC:tfm] is_a: CL:0000234 ! phagocyte [Term] id: CL:0000520 name: prokaryotic cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000521 name: fungal cell namespace: cell is_a: CL:0000255 ! eukaryotic cell disjoint_from: CL:0000548 ! animal cell [Term] id: CL:0000522 name: spore namespace: cell def: "The reproductive structure of bacteria, fungi and cryptograms." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000523 name: mononuclear cytotrophoblast cell namespace: cell def: "A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast." [GOC:tfm, ISBN:0323052908] synonym: "Langhans' cell" EXACT [] xref: FMA:83042 is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000524 name: spheroplast namespace: cell def: "A cell, usually of bacteria or yeast, which has partially lost its cell wall." [MESH:A11.868] synonym: "sphaeroplast" EXACT [] is_a: CL:0000371 ! protoplast [Term] id: CL:0000525 name: syncytiotrophoblast cell namespace: cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo. It It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] synonym: "plasmidotrophoblast" EXACT [] synonym: "syncytial trophoblast" EXACT [] synonym: "syntrophoblast" EXACT [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000351 ! trophoblast cell [Term] id: CL:0000526 name: afferent neuron namespace: cell def: "A neuron which conveys sensory information centrally from the periphery." [GOC:tfm, MESH:A08.663.650] synonym: "input neuron" EXACT [] xref: FMA:87653 is_a: CL:0000540 ! neuron [Term] id: CL:0000527 name: efferent neuron namespace: cell def: "A neuron which sends impulses peripherally to activate muscles or secretory cells." [MESH:A08.663.655] synonym: "output neuron" EXACT [] is_a: CL:0000540 ! neuron [Term] id: CL:0000528 name: nitrergic neuron namespace: cell def: "A nerve cell where transmission is mediated by nitric oxide." [MESH:A08.663.748] xref: FMA:84792 is_a: CL:0000540 ! neuron [Term] id: CL:0000529 name: pigmented epithelial cell namespace: cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000530 name: primary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000531 name: primary sensory neuron namespace: cell is_a: CL:0000101 ! sensory neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000532 name: CAP motoneuron namespace: cell is_a: CL:0000533 ! primary motor neuron [Term] id: CL:0000533 name: primary motor neuron namespace: cell xref: FMA:83619 is_a: CL:0000100 ! motor neuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000534 name: primary interneuron namespace: cell is_a: CL:0000099 ! interneuron is_a: CL:0000530 ! primary neuron [Term] id: CL:0000535 name: secondary neuron namespace: cell is_a: CL:0000540 ! neuron [Term] id: CL:0000536 name: secondary motor neuron namespace: cell xref: FMA:83620 is_a: CL:0000100 ! motor neuron is_a: CL:0000535 ! secondary neuron [Term] id: CL:0000537 name: antipodal cell namespace: cell def: "Obsolete. Use PO:0020093 from Plant Ontology instead. OBSOLETE, use term from plant ontology. A cell located at the chalazal end of the mature embryo sac in angiosperms." [ISBN:047125208] comment: replaced_by: PO:0020093 is_obsolete: true [Term] id: CL:0000538 name: epidermal initial namespace: cell def: "Obsolete. Use PO:0000349 from Plant Ontology instead. A relatively unspecialized cell that will give rise to specialized cell types of the epidermis." [TAIR:lr] comment: replaced_by: PO:0000349 is_obsolete: true [Term] id: CL:0000539 name: idioblast namespace: cell def: "A cell in a tissue that markedly differs in form, size, or contents from other cells in the same tissue." [ISBN:0471245208] is_obsolete: true [Term] id: CL:0000540 name: neuron namespace: cell def: "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [http://en.wikipedia.org/wiki/Neuron, MESH:A08.663, MESH:D009474] comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. synonym: "nerve cell" EXACT [] xref: BTO:0000938 xref: CALOHA:TS-0683 xref: FBbt:00005106 xref: FMA:54527 xref: VHOG:0001483 xref: WBbt:0003679 is_a: CL:0000393 ! electrically responsive cell is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: develops_from CL:0000031 ! neuroblast [Term] id: CL:0000541 name: melanoblast namespace: cell def: "A cell that originates from the neural crest and differentiates into a pigment cell." [GOC:tfm, SANBI:mhl] comment: Derived from UBERON:0002342 neural crest. xref: BTO:0003217 xref: FMA:83377 is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0000710 ! neurecto-epithelial cell relationship: develops_from CL:0000333 ! migratory neural crest cell [Term] id: CL:0000542 name: lymphocyte namespace: cell def: "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [GOC:add, ISBN:0683073696, ISBN:0781735149] comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161) xref: BTO:0000775 xref: CALOHA:TS-0583 xref: FMA:62863 xref: VHOG:0001535 is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000738 ! leukocyte intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: lacks_part GO:0030141 ! secretory granule disjoint_from: CL:0000766 ! myeloid leukocyte relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000792 ! heterochromatin relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000543 name: sieve tube member namespace: cell def: "Obsolete. Use PO:0000289 from Plant Ontology instead. One of the series of cellular components of a sieve tube. It shows a more or less pronounced differentiation between sieve plates (wide pores) and lateral sieve areas (narrow pores). Also sieve tube element and the obsolete sieve tube segment." [ISBN:0471245208] comment: replaced_by: PO:0000289 synonym: "sieve tube element" EXACT [] is_obsolete: true [Term] id: CL:0000544 name: slowly adapting mechanoreceptor cell namespace: cell is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000545 name: T-helper 1 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20303875] synonym: "helper T cell type 1" EXACT [] synonym: "T helper cells type 1" EXACT [PMID:9419219] synonym: "T(H)-1 cell" EXACT [] synonym: "Th1 cell" EXACT [] synonym: "Th1 T cell" EXACT [] synonym: "Th1 T lymphocyte" EXACT [] synonym: "Th1 T-cell" EXACT [] synonym: "Th1 T-lymphocyte" EXACT [] xref: BTO:0001678 xref: FMA:84382 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000546 name: T-helper 2 cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19375293, PMID:20103781] synonym: "helper T cell type 2" EXACT [] synonym: "T helper cells type 2" EXACT [PMID:9419219] synonym: "T(H)-2 cell" EXACT [] synonym: "Th2 cell" EXACT [] synonym: "Th2 T cell" EXACT [] synonym: "Th2 T lymphocyte" EXACT [] synonym: "Th2 T-cell" EXACT [] synonym: "Th2 T-lymphocyte" EXACT [] xref: BTO:0001679 xref: FMA:84385 is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000547 name: proerythroblast namespace: cell def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021] synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] xref: FMA:83518 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005634 ! nucleus intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: develops_from CL:0000038 ! erythroid progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005634 ! nucleus relationship: has_part GO:0005730 ! nucleolus relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G [Term] id: CL:0000548 name: animal cell namespace: cell subset: ubprop:upper_level is_a: CL:0000255 ! eukaryotic cell [Term] id: CL:0000549 name: basophilic erythroblast namespace: cell def: "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers." [GOC:tfm, ISBN:0721601464] synonym: "basophilic normoblast" EXACT [ISBN:0721601464] synonym: "early erythroblast" EXACT [ISBN:0721601464] synonym: "early normoblast" EXACT [ISBN:0721601464] synonym: "prorubricyte" EXACT [ISBN:0721601464] xref: FMA:83505 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000550 name: polychromatophilic erythroblast namespace: cell def: "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers." [ISBN:0721601464] synonym: "intermediate erythroblast" EXACT [ISBN:0721601464] synonym: "intermediate normoblast" EXACT [ISBN:0721601464] synonym: "polychromatic erythroblast" EXACT [ISBN:0721601464] synonym: "polychromatic normoblast" EXACT [ISBN:0721601464] synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464] synonym: "rubricyte" EXACT [ISBN:0721601464] xref: FMA:83506 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000035 ! polychromatophilic cytoplasm intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0000549 ! basophilic erythroblast relationship: has_part CP:0000035 ! polychromatophilic cytoplasm relationship: has_part GO:0000792 ! heterochromatin relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0000551 name: unimodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000552 name: orthochromatic erythroblast namespace: cell def: "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated." [ISBN:0721601464] synonym: "acidophilic erythroblast" EXACT [ISBN:0721601464] synonym: "eosinophilic erythroblast" EXACT [ISBN:0721601464] synonym: "late erythoblast" EXACT [] synonym: "orthochromatic normoblast" EXACT [ISBN:0721601464] synonym: "pyknotic eto enrythroblast" EXACT [ISBN:0721601464] xref: FMA:84646 is_a: CL:0000765 {is_inferred="true"} ! erythroblast intersection_of: CL:0000765 ! erythroblast intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: participates_in GO:0030263 ! apoptotic chromosome condensation relationship: develops_from CL:0000550 ! polychromatophilic erythroblast relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: participates_in GO:0030263 ! apoptotic chromosome condensation [Term] id: CL:0000553 name: megakaryocyte progenitor cell namespace: cell def: "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464] comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative. synonym: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498] synonym: "colony-forming unit-megakaryocyte" EXACT [] synonym: "Meg-CFC" EXACT [PMCID:PMC1794060] synonym: "megacaryoblast" EXACT [] synonym: "megacaryocyte progenitor cell" EXACT [] synonym: "megakaryoblast" EXACT [] synonym: "megakaryocytic progenitor cell" EXACT [PMID:12482498] synonym: "MkP" EXACT [PMID:21116988] synonym: "promegacaryocyte" RELATED [] synonym: "promegakaryocyte" RELATED [] xref: BTO:0001164 xref: CALOHA:TS-0610 xref: FMA:84235 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0007113 ! capable_of endomitotic cell cycle intersection_of: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0007113 ! capable_of endomitotic cell cycle relationship: RO:0002215 GO:0030219 ! capable_of megakaryocyte differentiation [Term] id: CL:0000554 name: gastrin stimulating hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes gastrin stimulating hormone." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000555 name: neuronal brush cell namespace: cell is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000556 name: megakaryocyte namespace: cell def: "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [http://en.wikipedia.org/wiki/Megakaryocyte, ISBN:0721601464, MESH:D008533] comment: Megakaryocytes are reportedly CD181-positive and CD182-positive. synonym: "megacaryocyte" EXACT [] synonym: "megalocaryocyte" EXACT [] synonym: "megalokaryocyte" EXACT [] xref: BTO:0000843 xref: CALOHA:TS-0611 xref: FMA:83555 is_a: CL:0000763 {is_inferred="true"} ! myeloid cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001393 ! euploid intersection_of: part_of UBERON:0002371 ! bone marrow disjoint_from: CL:0000764 ! erythroid lineage cell relationship: bearer_of PATO:0001393 ! euploid relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell relationship: part_of UBERON:0002371 ! bone marrow [Term] id: CL:0000557 name: granulocyte monocyte progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." [GO_REF:0000031, GOC:amm, GOC:dsd, GOC:tfm, http://en.wikipedia.org/wiki/CFU-GM, http://www.copewithcytokines.de, ISBN:0721601464, MESH:D055014, PMCID:PMC2213186, PMCID:PMC548021, PMID:16551251, PMID:16647566] comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_part PR:000007857 ! erythroid transcription factor intersection_of: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: part_of UBERON:0002371 ! bone marrow intersection_of: RO:0002215 GO:0030225 ! capable_of macrophage differentiation intersection_of: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation relationship: develops_from CL:0000049 ! common myeloid progenitor relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_part PR:000007857 ! erythroid transcription factor relationship: lacks_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: part_of UBERON:0002371 ! bone marrow relationship: RO:0002215 GO:0030225 ! capable_of macrophage differentiation relationship: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation [Term] id: CL:0000558 name: reticulocyte namespace: cell def: "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds." [GOC:add, GOC:tfm, PMID:15946868, PMID:2037622] xref: BTO:0001173 xref: CALOHA:TS-0864 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0071971 ! capable_of extracellular vesicular exosome assembly relationship: develops_from CL:0000552 ! orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0071971 ! capable_of extracellular vesicular exosome assembly [Term] id: CL:0000559 name: promonocyte namespace: cell def: "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." [GOC:tfm, ISBN:0721601464] comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. xref: BTO:0004657 xref: FMA:83551 is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell intersection_of: CL:0002194 ! monopoietic cell intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: develops_from CL:0000040 ! monoblast relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation [Term] id: CL:0000560 name: band form neutrophil namespace: cell def: "A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: Found in the Band 1 fraction. synonym: "band" BROAD [] synonym: "band cell" BROAD [] synonym: "band form" BROAD [] synonym: "rod neutrophil" EXACT [] synonym: "stab cell" BROAD [] is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000039 ! banded nucleus intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007597 ! proto-oncogene c-Fos intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 intersection_of: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein intersection_of: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 intersection_of: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase relationship: develops_from CL:0000582 ! neutrophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007597 ! proto-oncogene c-Fos relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001337 ! complement receptor type 1 relationship: has_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010799 ! myb proto-oncogene protein relationship: lacks_plasma_membrane_part PR:000009129 ! integrin alpha-4 relationship: lacks_plasma_membrane_part PR:000010543 ! myeloperoxidase [Term] id: CL:0000561 name: amacrine cell namespace: cell def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:A08.663.358.050] comment: Not clear if this term overlaps with retinal bipolar neuron (CL:0000748). synonym: "amacrine neuron" EXACT [] xref: BTO:0004044 xref: FBbt:00005127 xref: FMA:67766 is_a: CL:0000099 ! interneuron [Term] id: CL:0000562 name: nucleate erythrocyte namespace: cell def: "An erythrocyte having a nucleus." [GOC:add, GOc:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000232 ! erythrocyte intersection_of: has_part GO:0005634 ! nucleus relationship: develops_from CL:0002421 ! nucleated reticulocyte relationship: has_part GO:0005634 ! nucleus [Term] id: CL:0000563 name: endospore namespace: cell def: "A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged." [GOC:tfm, ISBN:0618947256] synonym: "bacterial spore" EXACT [] xref: BTO:0002779 is_a: CL:0000520 ! prokaryotic cell [Term] id: CL:0000564 name: neutrophilic promyelocyte namespace: cell def: "A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0721601464, PMID:12560239, PMID:15514007] comment: These cells are CD11b-negative, CD15-positive, CD16-negative, CD49d-positive, CD68-positive, CD35-negative, and fMLP receptor-negative. They are found in the Band 3 fraction. synonym: "neutrophilic premyelocyte" EXACT [] synonym: "neutrophilic progranulocyte" EXACT [] xref: FMA:84196 is_a: CL:0000834 ! neutrophil progenitor cell is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_part PR:000014362 ! runt-related transcription factor 1 intersection_of: lacks_part PR:000009978 ! lactotransferrin intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000042 ! neutrophilic myeloblast relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_part PR:000014362 ! runt-related transcription factor 1 relationship: lacks_part PR:000009978 ! lactotransferrin relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000565 name: fat body cell namespace: cell def: "A cell whose primary function is intermediary metabolism." [FB:ma] is_a: CL:0000181 ! metabolising cell [Term] id: CL:0000566 name: angioblastic mesenchymal cell namespace: cell def: "A mesenchymal stem cell capable of developing into blood vessel endothelium." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive. synonym: "angioblast" EXACT [] synonym: "chondroplast" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: has_plasma_membrane_part PR:000001444 ! cadherin-5 intersection_of: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 intersection_of: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 relationship: develops_from CL:0000134 ! mesenchymal cell relationship: has_plasma_membrane_part PR:000001444 ! cadherin-5 relationship: has_plasma_membrane_part PR:000002112 ! vascular endothelial growth factor receptor 2 relationship: has_plasma_membrane_part PR:000016043 ! T-cell acute lymphocytic leukemia protein 1 [Term] id: CL:0000567 name: polymodal nocireceptor namespace: cell is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: APUD cell namespace: cell def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A11.070] synonym: "amine precursor uptake and decarboxylation cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000569 name: cardiac mesenchymal cell namespace: cell def: "A mesenchymal cell found in the developing heart." [PMID:18816864] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000948 ! heart relationship: develops_from CL:0000011 ! migratory trunk neural crest cell relationship: part_of UBERON:0000948 ! heart [Term] id: CL:0000570 name: parafollicular cell namespace: cell def: "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine." [GOC:tfm, ISBN:0517223651] synonym: "C cell" EXACT [] synonym: "C cell of thyroid gland" EXACT [FMA:68653] synonym: "clear cell of thyroid gland" EXACT [FMA:68653] synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653] synonym: "thyroid parafollicular cell" EXACT [FMA:68653] xref: FMA:68653 xref: SCTID:176770005 is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: RO:0002215 GO:0001820 ! capable_of serotonin secretion intersection_of: RO:0002215 GO:0014046 ! capable_of dopamine secretion intersection_of: RO:0002215 GO:0036161 ! capable_of calcitonin secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: part_of UBERON:0001747 ! parenchyma of thyroid gland relationship: RO:0002215 GO:0001820 ! capable_of serotonin secretion relationship: RO:0002215 GO:0014046 ! capable_of dopamine secretion relationship: RO:0002215 GO:0036161 ! capable_of calcitonin secretion [Term] id: CL:0000571 name: leucophore namespace: cell def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005003 ! leucoblast [Term] id: CL:0000573 name: retinal cone cell namespace: cell def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:A08.663.650.650.670.100] xref: BTO:0001036 xref: CALOHA:TS-0866 xref: FMA:67748 is_a: CL:0000287 ! eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000574 name: erythrophore namespace: cell def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005004 ! pigment erythroblast [Term] id: CL:0000575 name: corneal epithelial cell namespace: cell alt_id: CL:1000431 def: "An epithelial cell of the cornea." [GOC:tfm] synonym: "epithelial cell of cornea" EXACT [FMA:70551] xref: BTO:0004298 xref: CALOHA:TS-0173 xref: FMA:70551 is_a: CL:0000076 {is_inferred="true"} ! squamous epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000076 ! squamous epithelial cell intersection_of: part_of UBERON:0000964 ! cornea relationship: part_of UBERON:0000964 ! cornea [Term] id: CL:0000576 name: monocyte namespace: cell def: "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, MESH:A11.118.637.555.652] comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid. xref: BTO:0000876 xref: CALOHA:TS-0638 xref: FMA:62864 is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: lacks_part GO:0030141 ! secretory granule intersection_of: RO:0002215 GO:0030225 ! capable_of macrophage differentiation intersection_of: RO:0002215 GO:0030316 ! capable_of osteoclast differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation relationship: develops_from CL:0000559 ! promonocyte relationship: lacks_part GO:0030141 ! secretory granule relationship: RO:0002215 GO:0030225 ! capable_of macrophage differentiation relationship: RO:0002215 GO:0030316 ! capable_of osteoclast differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation [Term] id: CL:0000577 name: type EC enteroendocrine cell namespace: cell alt_id: CL:0002065 def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A03.492.766.440.250, PMID:9505449] synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell is_a: CL:0000506 ! enkephalin secreting cell [Term] id: CL:0000578 name: experimentally modified cell in vitro namespace: cell def: "A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure." [FB:ma, ReO:mhb] comment: This class has been re-labeled to imply reference only to in vitro experimentally modified cells, similarly, the definition has been slightly updated to reflect this. 'experimentally modified cell' refers only to cells in vitro, and not modified in vivo/in environment cells. There is currently no class representing unmodified in vitro cells (other than the parent 'cell in vitro'), or a class representing modified native cells. More granular subclassing of experimentally modified cell can be found in ReO. MHB 1.12.12 is_a: CL:0001034 ! cell in vitro [Term] id: CL:0000579 name: border follicle cell namespace: cell xref: FBbt:00004905 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000580 name: neutrophilic myelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD15-positive, CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. xref: BTO:0003455 xref: FMA:83540 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part GO:0042582 ! azurophil granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000581 name: peritoneal macrophage namespace: cell def: "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive." [MESH:A11.329.372.630, PMID:15771589, PMID:19201820] comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+. xref: BTO:0001034 xref: FMA:83025 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: located_in UBERON:0001179 ! peritoneal cavity intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: located_in UBERON:0001179 ! peritoneal cavity relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium [Term] id: CL:0000582 name: neutrophilic metamyelocyte namespace: cell def: "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." [GOC:add, GOC:dsd, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:10618520, PMID:12560239, PMID:15514007] comment: These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. synonym: "juvenile neutrophil" EXACT [] xref: FMA:84197 is_a: CL:0000776 {is_inferred="true"} ! immature neutrophil is_a: CL:0002192 ! metamyelocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000776 ! immature neutrophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon intersection_of: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin intersection_of: has_part PR:000009978 ! lactotransferrin intersection_of: has_part PR:000010543 ! myeloperoxidase intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor relationship: develops_from CL:0000580 ! neutrophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000005310 ! CCAAT/enhancer-binding protein epsilon relationship: has_part PR:000009725 ! neutrophil gelatinase-associated lipocalin relationship: has_part PR:000009978 ! lactotransferrin relationship: has_part PR:000010543 ! myeloperoxidase relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_plasma_membrane_part PR:000001580 ! fMet-Leu-Phe receptor [Term] id: CL:0000583 name: alveolar macrophage namespace: cell def: "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative." [GO_REF:0000031, GOC:ana, GOC:dsd, GOC:tfm, MESH:A11.329.372.600] comment: Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-. synonym: "dust cell" EXACT [] synonym: "MF.Lu" RELATED [] xref: BTO:0000802 xref: CALOHA:TS-0030 xref: FMA:83023 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: part_of UBERON:0002299 ! alveolus of lung intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001807 ! C-type lectin domain family 7 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: part_of UBERON:0002299 ! alveolus of lung relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation [Term] id: CL:0000584 name: enterocyte namespace: cell def: "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." [SANBI:mhl] xref: BTO:0000398 xref: FMA:62122 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0000677 ! gut absorptive cell is_a: CL:0002563 ! intestinal epithelial cell [Term] id: CL:0000585 name: null cell namespace: cell def: "OBSOLETE: A class of lymphocytes characterized by the lack of surface markers specific for either T or B cells." [] comment: This term is rather archaic; consider using 'natural killer cell ; CL:0000623', 'pro-B cell ; CL:0000826', 'pro-T cell ; CL:0000827', or other appropriate lymphocyte-related term depending on the context. is_obsolete: true [Term] id: CL:0000586 name: germ cell namespace: cell def: "The reproductive cell in multicellular organisms." [MESH:A05.360.490] xref: BTO:0000535 xref: VHOG:0001534 xref: WBbt:0006796 is_a: CL:0000039 {is_inferred="true"} ! germ line cell intersection_of: CL:0000039 ! germ line cell intersection_of: RO:0002215 GO:0048609 ! capable_of multicellular organismal reproductive process relationship: RO:0002215 GO:0048609 ! capable_of multicellular organismal reproductive process [Term] id: CL:0000587 name: cold sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast namespace: cell def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A11.329.679] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 {is_inferred="true"} ! osteoclast intersection_of: CL:0000092 ! osteoclast intersection_of: RO:0002215 GO:0042483 ! capable_of negative regulation of odontogenesis relationship: RO:0002215 GO:0042483 ! capable_of negative regulation of odontogenesis [Term] id: CL:0000589 name: cochlear inner hair cell namespace: cell def: "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated." [MESH:A08.663.650.250.250] synonym: "inner hair cell" BROAD [] xref: BTO:0003667 xref: FMA:62365 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000590 name: small luteal cell namespace: cell def: "A progesterone secreting cell in the corpus luteum that develops from theca cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "small lutein cell" EXACT [] synonym: "theca lutein cell" EXACT [] xref: BTO:0002850 xref: FMA:18690 is_a: CL:0000175 ! luteal cell relationship: develops_from CL:0000503 ! theca cell [Term] id: CL:0000591 name: warmth sensing thermoreceptor cell namespace: cell def: "A thermoreceptor cell that detects reduced temperatures." [GOC:tfm] is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000592 name: large luteal cell namespace: cell def: "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." [GOC:tfm, MESH:A05.360.319.114.630.278.400] synonym: "granulosa lutein cell" EXACT [] synonym: "granulosoluteocytus" RELATED [] xref: FMA:18689 is_a: CL:0000175 ! luteal cell is_a: CL:0000177 ! testosterone secreting cell relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000593 name: androgen secreting cell namespace: cell def: "A steroid hormone secreting cell that secretes androgen." [GOC:tfm] is_a: CL:0000174 ! steroid hormone secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0035935 ! capable_of androgen secretion relationship: RO:0002215 GO:0035935 ! capable_of androgen secretion [Term] id: CL:0000594 name: skeletal muscle satellite cell namespace: cell def: "An elongated, spindle-shaped, quiescent myoblast that are located between the basal lamina and the plasmalemma of the muscle fibres. They are thought to play a role in muscle repair and regeneration." [GOC:tfm, MESH:A11.635.500.700] is_a: CL:0000035 ! single fate stem cell is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0000680 ! muscle precursor cell [Term] id: CL:0000595 name: enucleate erythrocyte namespace: cell def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] synonym: "RBC" BROAD [] synonym: "red blood cell" BROAD [] is_a: CL:0000232 {is_inferred="true"} ! erythrocyte intersection_of: CL:0000232 ! erythrocyte intersection_of: lacks_part GO:0005634 ! nucleus relationship: develops_from CL:0002422 ! enucleated reticulocyte relationship: lacks_part GO:0005634 ! nucleus [Term] id: CL:0000596 name: sexual spore namespace: cell def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000597 name: microconidium namespace: cell def: "The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall." [GOC:tfm, ISBN:0471940526, PMID:8357339, SGD:clt] xref: FAO:0000028 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0000598 name: pyramidal cell namespace: cell def: "A projection neuron in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region." [GOC:tfm, MESH:A08.186.211.577.405.700] synonym: "projection neuron" EXACT [] synonym: "pyramidal neuron" EXACT [] xref: BTO:0003102 xref: FMA:67310 xref: FMA:86775 xref: NIF_Cell:sao862606388 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000599 name: conidium namespace: cell def: "An asexual, nonmotile spore formed by higher fungi; conidia are usually made from the side or tip of specialized sporogenous cells and do not form by progressive cleavage of the cytoplasm." [ISBN:08199377X, PMID:2524423, PMID:9529886, SGD:clt] xref: BTO:0000283 xref: FAO:0000024 is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000600 name: heterokaryon namespace: cell def: "A fungal cell with two or more genetically distinct nuclei." [ISBN:08199377X] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000521 ! fungal cell [Term] id: CL:0000601 name: outer hair cell namespace: cell def: "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." [MESH:A08.663.650.250.315] synonym: "cochlear outer hair cell" EXACT [] xref: BTO:0003666 xref: FMA:62366 is_a: CL:0000202 ! auditory hair cell [Term] id: CL:0000602 name: pressoreceptor cell namespace: cell def: "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls." [MESH:A08.800.050.800.900.700] is_a: CL:1000082 ! stretch receptor cell [Term] id: CL:0000603 name: dikaryon namespace: cell def: "A fungal cell with two genetically distinct haploid nuclei." [ISBN:08199377X] is_a: CL:0000227 ! binucleate cell is_a: CL:0000600 ! heterokaryon [Term] id: CL:0000604 name: retinal rod cell namespace: cell def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:A08.663.650.650.670.650] xref: BTO:0001024 xref: CALOHA:TS-0870 xref: FMA:67747 is_a: CL:0000287 ! eye photoreceptor cell relationship: develops_from CL:0002672 ! retinal progenitor cell [Term] id: CL:0000605 name: fungal asexual spore namespace: cell def: "A spore formed following mitosis or mitoses." [GOC:tfm, PMID:2524423, PMID:9529886, SGD:clt] xref: FAO:0000023 is_a: CL:0002369 ! fungal spore [Term] id: CL:0000606 name: macroconidium namespace: cell def: "The larger of two types of asexual spores formed by some fungi; usually round or oblong." [GOC:tfm, ISBN:0471940526, SGD:clt] xref: FAO:0000038 is_a: CL:0000599 ! conidium [Term] id: CL:0000607 name: ascospore namespace: cell def: "A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete." [GOC:tfm, ISBN:08199377X, SGD:clt] xref: BTO:0000097 xref: FAO:0000020 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000608 name: zygospore namespace: cell def: "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." [ISBN:0471940526, ISBN:08199377X, SGD:clt] xref: FAO:0000040 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000609 name: vestibular hair cell namespace: cell def: "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem." [GOC:tfm, MESH:A08.663.650.250.380] synonym: "vestibular receptor cell" EXACT [] xref: FMA:62351 is_a: CL:0002374 ! ear hair cell [Term] id: CL:0000610 name: plant cell namespace: cell comment: This term was obsoleted as it is redundant with PO:0009002 in the cell ontology (PO) is_obsolete: true consider: PO:0009002 [Term] id: CL:0000611 name: eosinophil progenitor cell namespace: cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). synonym: "CFU-Eo" RELATED [] synonym: "colony forming unit eosinophil" RELATED [] synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_part PR:000001944 ! transcription factor PU.1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000001944 ! transcription factor PU.1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000612 name: eosinophilic myelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." [GOC:add, GOC:dsd, http://www.cap.org, ISBN:0721601464, PMID:19622087] xref: BTO:0003454 xref: FMA:83542 is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002087 ! nongranular leukocyte is_a: CL:0002193 ! myelocyte intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000613 name: basophil progenitor cell namespace: cell def: "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1312421] comment: BaP are also CD13-low and integrin beta-7-low. They are lin-negative (CD2, CD3e, CD4, CD5, CD8, CD11b, CD14, CD19, CD20, ly6g, ly76, and NCAM-1). They also lack expression of mast cell protease 1 (MCP-1) and microphthalmia-associated transcription factor (mitf). synonym: "BaP" EXACT [] synonym: "basophilic stem cell" RELATED [] synonym: "CFU-Bas" RELATED [] synonym: "colony forming unit basophil" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_low_plasma_membrane_amount PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000614 name: basophilic myelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:18466030] xref: BTO:0003456 xref: FMA:83543 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000768 ! immature basophil intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_part GO:0070820 ! tertiary granule intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_part GO:0070820 ! tertiary granule relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III [Term] id: CL:0000615 name: basidiospore namespace: cell def: "A thick walled spore containing one or more haploid nuclei produced by sexual reproduction in an Basidiomycete; formed externally on extrusions of the basidium." [GOC:clt, ISBN:0471940526, ISBN:08199377X] xref: BTO:0002166 xref: FAO:0000021 is_a: CL:0000596 ! sexual spore [Term] id: CL:0000616 name: sporangiospore namespace: cell def: "A walled spore produced in a sporangium." [ISBN:08199377X] is_obsolete: true [Term] id: CL:0000617 name: GABAergic neuron namespace: cell def: "A neuron that uses GABA as a vesicular neurotransmitter" [GOC:tfm] synonym: "GABA-ergic neuron" EXACT [] xref: FMA:84788 xref: WBbt:0005190 is_a: CL:0000540 ! neuron [Term] id: CL:0000618 name: sheath cell namespace: cell is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000619 name: support cell (sensu Nematoda) namespace: cell is_a: CL:0000124 ! glial cell (sensu Nematoda and Protostomia) is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000620 name: zoospore namespace: cell def: "A sporangiospore that is motile, having flagella." [ISBN:08199377X] xref: FAO:0000039 is_obsolete: true [Term] id: CL:0000621 name: fusion competent myoblast namespace: cell is_a: CL:0000056 ! myoblast [Term] id: CL:0000622 name: acinar cell namespace: cell def: "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus)." [GOC:tfm, http://www.copewithcytokines.de] synonym: "acinic cell" EXACT [] synonym: "acinous cell" EXACT [] xref: FMA:83625 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000154 ! protein secreting cell relationship: part_of UBERON:0009842 ! acinus [Term] id: CL:0000623 name: natural killer cell namespace: cell def: "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "large granular lymphocyte" BROAD [] synonym: "NK cell" EXACT [] synonym: "null cell" BROAD [] xref: BTO:0000914 xref: BTO:0004716 xref: CALOHA:TS-0664 xref: FMA:63147 xref: FMA:83601 xref: VHOG:0001697 is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: RO:0002215 GO:0002228 ! capable_of natural killer cell mediated immunity intersection_of: RO:0002215 GO:0050776 ! capable_of regulation of immune response relationship: develops_from CL:0000825 ! pro-NK cell relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: RO:0002215 GO:0002228 ! capable_of natural killer cell mediated immunity relationship: RO:0002215 GO:0050776 ! capable_of regulation of immune response [Term] id: CL:0000624 name: CD4-positive, alpha-beta T cell namespace: cell def: "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor." [GOC:add, ISBN:0781735149] synonym: "CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta T-cell" EXACT [] synonym: "CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule disjoint_from: CL:0000625 ! CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000625 name: CD8-positive, alpha-beta T cell namespace: cell def: "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta T-cell" EXACT [] synonym: "CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000626 name: olfactory granule cell namespace: cell def: "Granule cell that is part of the olfactory bulb." [GOC:mah] is_a: CL:0000120 ! granule cell [Term] id: CL:0000627 name: transporting cell namespace: cell def: "A cell involved in transporting nutrients, minerals, water, gases and other chemicals between cells for a variety of purposes including conveying nutrition to other tissues, removing waste products from the tissues, conveying gases for respiration, distributing heat and repelling invasion of foreign substances." [TAIR:sr] is_a: CL:0000003 ! native cell [Term] id: CL:0000628 name: photosynthetic cell namespace: cell def: "A cell that can perform photosynthesis, in which carbohydrates are synthesized from carbon dioxide and water, using light as the energy source." [TAIR:sr] comment: see PMID:21177950, The making of a photosynthetic animal. is_a: CL:0000003 ! native cell [Term] id: CL:0000629 name: storage cell namespace: cell def: "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." [FB:ma] is_a: CL:0000325 ! stuff accumulating cell [Term] id: CL:0000630 name: supportive cell namespace: cell def: "A cell whose primary function is to support other cell types." [FB:ma, GOC:tfm] xref: BTO:0002315 xref: FMA:86947 xref: ZFA:0000688 is_a: CL:0000003 ! native cell [Term] id: CL:0000631 name: labyrinth supporting cell namespace: cell def: "Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen." [MESH:A09.246.631.246.577.543] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000632 name: hepatic stellate cell namespace: cell def: "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, http://en.wikipedia.org/wiki/Hepatic_stellate_cell, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] comment: Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. synonym: "fat-storing cell" RELATED [] synonym: "hepatic perisinusoidal cell" EXACT [] synonym: "Ito cell" EXACT [] synonym: "lipocyte" RELATED [] synonym: "perisinusoidal cell" EXACT [] synonym: "vitamin A-storing cells" RELATED [PMID:12808230] xref: BTO:0002741 xref: CALOHA:TS-0452 xref: FMA:67763 is_a: CL:0000057 ! fibroblast is_a: CL:0000327 ! extracellular matrix secreting cell intersection_of: CL:0002320 ! connective tissue cell intersection_of: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein intersection_of: part_of UBERON:0002107 ! liver relationship: has_plasma_membrane_part PR:000007939 ! glial fibrillary acidic protein relationship: part_of UBERON:0002107 ! liver [Term] id: CL:0000633 name: Hensen cell namespace: cell def: "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Hensen" EXACT [] synonym: "external limiting cell of organ of Corti" EXACT [] synonym: "Hensen's cell" EXACT [] xref: FMA:79799 is_a: CL:0002490 ! organ of Corti supporting cell [Term] id: CL:0000634 name: Claudius cell namespace: cell def: "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti." [GOC:tfm, ISBN:0721662544] synonym: "cell of Claudius" EXACT [] synonym: "external supporting cell of Claudius" EXACT [] synonym: "external supporting cell of vestibular epithelium" EXACT [] xref: FMA:79802 is_a: CL:0002315 ! supporting cell of cochlea [Term] id: CL:0000635 name: Deiter's cell namespace: cell def: "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression." [GOC:tfm, http://www.britannica.com/EBchecked/topic/156177/Deiters-cell, ISBN:0721662544] synonym: "Deiters cell" EXACT [] synonym: "outer phalangeal cell" EXACT [] xref: FMA:75725 is_a: CL:0002165 ! phalangeal cell [Term] id: CL:0000636 name: Mueller cell namespace: cell xref: BTO:0003064 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000637 name: chromophil cell of anterior pituitary gland namespace: cell def: "A cell that stains readily in the anterior pituitary gland." [GOC:tfm, ISBN:0618947256] xref: FMA:83089 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000167 ! peptide hormone secreting cell intersection_of: CL:0000166 ! chromaffin cell intersection_of: part_of UBERON:0002196 ! adenohypophysis relationship: part_of UBERON:0002196 ! adenohypophysis relationship: RO:0002215 GO:0030072 ! capable_of peptide hormone secretion [Term] id: CL:0000638 name: acidophil cell of pars distalis of adenohypophysis namespace: cell def: "An acidophilic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "acidophil cell of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars anterior of adenohypophysis" EXACT [] synonym: "acidophil of pars distalis of adenohypophysis" EXACT [] synonym: "pituitary alpha cell" EXACT [] xref: FMA:83093 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000639 name: basophil cell of pars distalis of adenohypophysis namespace: cell def: "A basophillic chromophil cell that of the anterior pituitary gland." [GOC:tfm] synonym: "basophil cell of anterior lobe of hypophysis" EXACT [] synonym: "beta cell" RELATED [] synonym: "pituitary beta cell" RELATED [] xref: FMA:83094 is_a: CL:0000637 ! chromophil cell of anterior pituitary gland [Term] id: CL:0000641 name: chromophobe cell namespace: cell def: "A cell that is resistant to stains." [GOC:tfm] synonym: "chromophobic cell" EXACT [] xref: FMA:83626 is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000642 name: folliculostellate cell namespace: cell def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb] is_a: CL:0000163 ! endocrine cell is_a: CL:0000630 ! supportive cell [Term] id: CL:0000644 name: Bergmann glial cell namespace: cell def: "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses." [GOC:tfm, http://www.neurolex.org/wiki/Category\:Bergmann_Glial_Cell] synonym: "Bergmann astrocyte" EXACT [] synonym: "Bergmann glial cell of cerebellum" EXACT [] xref: FMA:54559 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000645 name: pituicyte namespace: cell def: "A cell with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment." [http://en.wikipedia.org/wiki/Pituicyte, ISBN:0412046911, ISBN:0517223651] xref: BTO:0003793 xref: FMA:83503 is_a: CL:0000127 ! astrocyte [Term] id: CL:0000646 name: basal cell namespace: cell def: "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." [GOC:tfm, ISBN:0517223651] xref: BTO:0000939 xref: FMA:62516 is_a: CL:0000036 ! epithelial fate stem cell [Term] id: CL:0000647 name: multinucleated giant cell namespace: cell def: "A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:0702024783] comment: Role or process: Chronic infection, granulomatous inflammation. Consider also megakaryocyte (CL:0000556) as sometimes multinucleated giant cell is used to refer to this. synonym: "foreign body giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "Langerhans giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "macrophage polykaryon" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "multinucleate giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] synonym: "syncytial giant cell" EXACT [ISBN:0702022918, ISBN:0702024783] xref: BTO:0003107 xref: FMA:83035 is_a: CL:0000228 ! multinucleate cell is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001908 ! multinucleate intersection_of: participates_in GO:0002432 ! granuloma formation intersection_of: participates_in GO:0002544 ! chronic inflammatory response relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000235 ! macrophage relationship: participates_in GO:0002432 ! granuloma formation relationship: participates_in GO:0002544 ! chronic inflammatory response [Term] id: CL:0000648 name: kidney granular cell namespace: cell alt_id: CL:0000461 def: "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation." [GOC:cvs, GOC:tfm, PMID:11457727] synonym: "JG cell" EXACT [] synonym: "juxtaglomerular cell" BROAD [] synonym: "renin secreting cell" EXACT [] xref: FMA:84138 is_a: CL:0000154 ! protein secreting cell is_a: CL:0000192 ! smooth muscle cell is_a: CL:1000618 ! juxtaglomerular complex cell [Term] id: CL:0000649 name: prickle cell namespace: cell alt_id: CL:0002186 def: "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer. A function of this cell is to generate keratin." [GOC:tfm, ISBN:0721662544, ISBN:0815332181] synonym: "prickle cell of epidermis" EXACT [] xref: FMA:69059 is_a: CL:0000312 ! keratinocyte [Term] id: CL:0000650 name: mesangial cell namespace: cell def: "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells] xref: BTO:0000853 xref: CALOHA:TS-0617 xref: FMA:70972 is_a: CL:0000669 ! pericyte cell relationship: develops_from CL:0000134 ! mesenchymal cell [Term] id: CL:0000651 name: neck cell namespace: cell def: "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" [GOC:tfm] synonym: "mucous neck cell" EXACT [] is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000319 ! mucus secreting cell relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion [Term] id: CL:0000652 name: pinealocyte namespace: cell def: "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation." [GOC:tfm, http://en.wikipedia.org/wiki/Pinealocyte, ISBN:0517223651, PMID:16687276] xref: BTO:0001068 xref: FMA:83417 is_a: CL:0000163 ! endocrine cell is_a: CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000653 name: glomerular visceral epithelial cell namespace: cell def: "A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:tfm] comment: GO has podocyte as a related synonym due to concern this may refer to more than one cell type. However, this did not turn up in my search. If podocyte does refer to more than one cell type, then we should classify the synonym to 'related'[tfm]. synonym: "epithelial cell of visceral layer of glomerular capsule" BROAD [FMA:70967] synonym: "glomerular podocyte" EXACT [FMA:70967] synonym: "podocyte" EXACT [] xref: BTO:0002295 is_a: CL:0002522 ! renal filtration cell is_a: CL:1000451 ! epithelial cell of visceral layer of glomerular capsule relationship: part_of UBERON:0005751 ! visceral layer of glomerular capsule [Term] id: CL:0000654 name: primary oocyte namespace: cell def: "A primary oocyte is an oocyte that has not completed female meosis I." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0000512 xref: FMA:18645 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007126 ! meiosis relationship: develops_from CL:0000024 ! oogonial cell relationship: has_not_completed GO:0007126 ! meiosis [Term] id: CL:0000655 name: secondary oocyte namespace: cell def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:tfm, ISBN:0721662544] synonym: "primary oogonium" RELATED [] xref: BTO:0003094 xref: FMA:18646 is_a: CL:0000023 {is_inferred="true"} ! oocyte intersection_of: CL:0000023 ! oocyte intersection_of: has_not_completed GO:0007147 ! female meiosis II relationship: develops_from CL:0000654 ! primary oocyte relationship: has_not_completed GO:0007147 ! female meiosis II [Term] id: CL:0000656 name: primary spermatocyte namespace: cell def: "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes." [GOC:tfm, ISBN:0721662544] xref: BTO:0001115 xref: CALOHA:TS-2194 xref: FMA:72292 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001394 ! diploid intersection_of: RO:0002215 GO:0007140 ! capable_of male meiosis relationship: bearer_of PATO:0001394 ! diploid relationship: RO:0002215 GO:0007140 ! capable_of male meiosis [Term] id: CL:0000657 name: secondary spermatocyte namespace: cell def: "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids." [GOC:tfm, ISBN:0721662544] xref: BTO:0000709 xref: CALOHA:TS-2195 xref: FBbt:00004941 xref: FMA:72293 is_a: CL:0000017 {is_inferred="true"} ! spermatocyte is_a: CL:0000413 ! haploid cell intersection_of: CL:0000017 ! spermatocyte intersection_of: bearer_of PATO:0001375 ! haploid intersection_of: RO:0002215 GO:0007142 ! capable_of male meiosis II relationship: bearer_of PATO:0001375 ! haploid relationship: develops_from CL:0000656 ! primary spermatocyte relationship: RO:0002215 GO:0007142 ! capable_of male meiosis II [Term] id: CL:0000658 name: cuticle secreting cell namespace: cell def: "An epithelial cell that secretes cuticle." [GOC:tfm] is_a: CL:0000066 ! epithelial cell is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000659 name: eggshell secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes eggshell." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell is_a: CL:0000500 ! follicular epithelial cell [Term] id: CL:0000660 name: glycocalyx secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes glycocalyx." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000661 name: distal tip cell (sensu Nematoda) namespace: cell is_a: CL:0000422 ! mitogenic signaling cell [Term] id: CL:0000662 name: neuroglioblast (sensu Nematoda) namespace: cell is_a: CL:0000468 ! neuroglioblast [Term] id: CL:0000663 name: valve cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000664 name: closable valve cell namespace: cell is_a: CL:0000185 ! myoepithelial cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000665 name: permanently open valve cell namespace: cell is_a: CL:0000663 ! valve cell [Term] id: CL:0000666 name: fenestrated cell namespace: cell synonym: "window cell" EXACT [] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000667 name: collagen secreting cell namespace: cell def: "An extracellular matrix secreting cell that secretes collagen." [GOC:tfm] is_a: CL:0000327 ! extracellular matrix secreting cell [Term] id: CL:0000668 name: obsolete parenchymal cell namespace: cell def: "The cell characteristic of an organ, as distinguished from associated connective or supporting tissues." [ISBN:0471245208] comment: OBSOLETE: Term was made obsolete to avoid confusion with plant parenchymal cell. Cell type has a similar but slightly different meaning in botany (plants): see PO:0000074. xref: BTO:0002174 xref: FMA:84638 is_obsolete: true [Term] id: CL:0000669 name: pericyte cell namespace: cell alt_id: CL:0000184 def: "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells." [GOC:dsd, GOC:tfm, ISBN:0721662544, MESH:D020286, PMID:16807374, PMID:17986482, PMID:20024907] comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A. synonym: "adventitial cell" RELATED [] synonym: "adventitial reticular cell" EXACT [] synonym: "ARC" EXACT [PMID:17986482] synonym: "cell of Rouget" EXACT [] synonym: "pericyte" EXACT [] synonym: "pericyte of Rouget" EXACT [] xref: BTO:0002441 xref: FMA:63174 is_a: CL:0000183 ! contractile cell is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell [Term] id: CL:0000670 name: primordial germ cell namespace: cell def: "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells." [GOC:tfm, PMID:1381289] synonym: "gonocyte" EXACT [] synonym: "primitive germ cell" EXACT [] xref: FMA:70567 is_a: CL:0000039 {is_inferred="true"} ! germ line cell is_a: CL:0000219 {is_inferred="true"} ! motile cell intersection_of: CL:0000039 ! germ line cell intersection_of: part_of UBERON:0000922 ! embryo intersection_of: RO:0002215 GO:0048870 ! capable_of cell motility relationship: part_of UBERON:0000922 ! embryo relationship: RO:0002215 GO:0048870 ! capable_of cell motility [Term] id: CL:0000671 name: centripetally migrating follicle cell namespace: cell xref: FBbt:00004906 is_a: CL:0000477 ! follicle cell [Term] id: CL:0000672 name: tracheary element namespace: cell def: "Obsolete. Use PO:0000290 from Plant Ontology instead. A water conducting cell, tracheid or vessel member." [ISBN:0471245208] comment: replaced_by: PO:0000290 is_obsolete: true [Term] id: CL:0000673 name: Kenyon cell namespace: cell is_a: CL:0000028 ! CNS neuron (sensu Nematoda and Protostomia) [Term] id: CL:0000674 name: interfollicle cell namespace: cell synonym: "fly stalk cell" EXACT [] xref: FBbt:00004910 is_a: CL:0000075 ! columnar/cuboidal epithelial cell [Term] id: CL:0000675 name: female gamete namespace: cell def: "A mature sexual reproductive cell of the female germline." [GOC:tfm] is_a: CL:0000021 {is_inferred="true"} ! female germ cell is_a: CL:0000300 ! gamete intersection_of: CL:0000021 ! female germ cell intersection_of: bearer_of PATO:0001375 ! haploid relationship: bearer_of PATO:0001375 ! haploid [Term] id: CL:0000676 name: cap cell namespace: cell xref: BTO:0001033 is_a: CL:0000378 ! support cell (sensu Nematoda and Protostomia) [Term] id: CL:0000677 name: gut absorptive cell namespace: cell def: "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules." [JB:jb] is_a: CL:0000212 ! absorptive cell [Term] id: CL:0000678 name: commisural neuron namespace: cell is_a: CL:0000372 ! tormogen cell [Term] id: CL:0000679 name: glutamatergic neuron namespace: cell xref: WBbt:0006829 is_a: CL:0000540 ! neuron [Term] id: CL:0000680 name: muscle precursor cell namespace: cell is_a: CL:0000055 ! non-terminally differentiated cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000222 ! mesodermal cell [Term] id: CL:0000681 name: radial glial cell namespace: cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life. synonym: "forebrain radial glial cell" NARROW [] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000710 ! neurecto-epithelial cell [Term] id: CL:0000682 name: M cell namespace: cell def: "An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes." [GOC:jb, GOC:tfm] synonym: "M-cell" EXACT [] synonym: "microfold cell" EXACT [] xref: BTO:0003600 xref: FMA:62929 is_a: CL:0000066 ! epithelial cell is_a: CL:0000473 ! defensive cell is_a: CL:0000627 ! transporting cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000683 name: ependymoglial cell namespace: cell def: "A cell that transports hormones from neurosecretory cells. This nerve cell is characterized by bipolar shape and endfeet that contact a basal lamina around blood vessels, and/or the pia mater or vitreous body of the eye and additionally contact the ventricular surface or sub-retinal space." [http://neurolex.org/wiki/Category\:Ependymoglial_Cell, JB:jb] synonym: "ependymal astrocyte" EXACT [] is_a: CL:0000127 ! astrocyte [Term] id: CL:0000684 name: littoral cell of liver namespace: cell is_a: CL:0000077 ! mesothelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000685 name: meristematic cell namespace: cell def: "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." [PO:0004010] comment: replaced_by: PO:0004010 is_obsolete: true [Term] id: CL:0000686 name: cerebrospinal fluid secreting cell namespace: cell def: "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid." [GOC:tfm] is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0000151 {is_inferred="true"} ! secretory cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0033326 ! capable_of cerebrospinal fluid secretion relationship: develops_from CL:0000333 ! migratory neural crest cell relationship: RO:0002215 GO:0033326 ! capable_of cerebrospinal fluid secretion [Term] id: CL:0000687 name: R1 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000688 name: perijunctional fibroblast namespace: cell def: "A fibroblast-like cell that provides support at neuromuscular junctions in vertebrates and are localized outside the synaptic basal lamina." [JB:jb] is_a: CL:0000057 ! fibroblast is_a: CL:0000630 ! supportive cell [Term] id: CL:0000689 name: myoendocrine cell namespace: cell def: "A cell with both myofibrils and secretory granules." [JB:jb] is_a: CL:0000163 ! endocrine cell [Term] id: CL:0000690 name: R2 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000691 name: stellate interneuron namespace: cell is_a: CL:0000099 ! interneuron [Term] id: CL:0000692 name: terminal Schwann cell namespace: cell def: "A neuroglial cell of the peripheral nervous system inside the basal lamina of the neuromuscular junction providing chemical and physical support to the synapse." [JB:jb, PMID:16136171] synonym: "Schwann cell" BROAD [] is_a: CL:0000630 ! supportive cell is_a: CL:0002376 ! non-myelinating Schwann cell [Term] id: CL:0000693 name: neuroglioform cell namespace: cell def: "A stellate interneuron having 7-10 dendrites that may branch." [JB:jb] synonym: "spiderweb cell" EXACT [] is_a: CL:0000691 ! stellate interneuron [Term] id: CL:0000694 name: R3 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000695 name: Cajal-Retzius cell namespace: cell def: "One of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [PMID:10600995, PMID:9728912] is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000696 name: PP cell namespace: cell def: "A cell that stores and secretes pancreatic polypeptide hormone." [GOC:tfm, JB:jb, PMID:15153415] synonym: "type F enteroendocrine cell" EXACT [] xref: FMA:62938 xref: FMA:83409 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell [Term] id: CL:0000697 name: R4 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000698 name: paraganglial cell namespace: cell is_obsolete: true [Term] id: CL:0000699 name: paraganglial type 1 cell namespace: cell def: "A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines." [GOC:tfm] is_a: CL:0000165 ! neuroendocrine cell [Term] id: CL:0000700 name: dopaminergic neuron namespace: cell def: "A neuron that releases dopamine as a neurotransmitter." [GOC:dhill] synonym: "dopaminergic cell" EXACT [] xref: BTO:0004032 xref: FMA:84787 xref: WBbt:0006746 is_a: CL:0000540 ! neuron [Term] id: CL:0000701 name: paraganglia type 2 cell namespace: cell def: "Supports paraganglial type 1 cell." [JB:jb] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000702 name: R5 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000703 name: sustentacular cell namespace: cell def: "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors." [JB:jb] xref: BTO:0002315 is_a: CL:0000630 ! supportive cell [Term] id: CL:0000704 name: endothelial tip cell namespace: cell def: "A specialized endothelial cell that senses extracellular signals and guides the directed growth of blood vessels." [PMID:15376331] is_a: CL:0000071 ! blood vessel endothelial cell [Term] id: CL:0000705 name: R6 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000706 name: choroid plexus epithelial cell namespace: cell alt_id: CL:1000430 def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell intersection_of: CL:0000065 ! ependymal cell intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: part_of UBERON:0001886 ! choroid plexus [Term] id: CL:0000707 name: R7 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000494 ! UV sensitive photoreceptor cell [Term] id: CL:0000708 name: leptomeningeal cell namespace: cell def: "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus." [JB:jb] synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier [Term] id: CL:0000709 name: R8 photoreceptor cell namespace: cell is_a: CL:0000287 ! eye photoreceptor cell is_a: CL:0000488 ! visible light photoreceptor cell [Term] id: CL:0000710 name: neurecto-epithelial cell namespace: cell def: "Epithelial cells derived from neural plate and neural crest." [GOC:tfm] comment: The term "neuroepithelial cell" is used to describe both this cell type and sensory epithelial cell (CL:0000098). synonym: "neuroepithelial cell" BROAD [] xref: BTO:0004301 xref: FMA:70557 is_a: CL:0000075 ! columnar/cuboidal epithelial cell is_a: CL:0002077 ! ecto-epithelial cell relationship: develops_from CL:0000133 ! neurectodermal cell [Term] id: CL:0000711 name: cumulus cell namespace: cell def: "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." [GOC:tfm, http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells] xref: BTO:0002236 is_a: CL:0000154 ! protein secreting cell is_a: CL:0002174 ! follicular cell of ovary relationship: develops_from CL:0000501 ! granulosa cell [Term] id: CL:0000712 name: stratum granulosum cell namespace: cell is_a: CL:0000362 ! epidermal cell [Term] id: CL:0000713 name: corona radiata cell namespace: cell is_a: CL:0000711 ! cumulus cell [Term] id: CL:0000715 name: embryonic crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000716 name: lymph gland crystal cell namespace: cell is_a: CL:0000392 ! crystal cell is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000717 name: fusimotor neuron namespace: cell def: "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." [PMID:15582775] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000718 name: cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000306 ! crystallin accumulating cell [Term] id: CL:0000719 name: posterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000720 name: anterior cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000721 name: equatorial cone cell (sensu Endopterygota) namespace: cell is_a: CL:0000718 ! cone cell (sensu Endopterygota) [Term] id: CL:0000722 name: cystoblast namespace: cell is_a: CL:0000586 ! germ cell [Term] id: CL:0000723 name: somatic stem cell namespace: cell def: "A stem cell that can give rise to cell types of the body other than those of the germ-line." [GO:0048103] xref: CALOHA:TS-2086 xref: FMA:63368 is_a: CL:0000034 {is_inferred="true"} ! stem cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000034 ! stem cell intersection_of: RO:0002215 GO:0048103 ! capable_of somatic stem cell division relationship: RO:0002215 GO:0048103 ! capable_of somatic stem cell division [Term] id: CL:0000724 name: heterocyst namespace: cell def: " A differentiated cell that functions as a site of nitrogen fixation under aerobic conditions." [MA:ma] xref: BTO:0000600 is_a: CL:0000520 ! prokaryotic cell is_a: CL:0000725 ! nitrogen fixing cell [Term] id: CL:0000725 name: nitrogen fixing cell namespace: cell is_a: CL:0000003 ! native cell [Term] id: CL:0000726 name: chlamydospore namespace: cell def: "An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material." [GOC:tfm, ISBN:085199377X] comment: Considering obsoleting as sometimes used to refer to protozoans too. But reference indicates term was intended for fungus. is_a: CL:0000605 ! fungal asexual spore [Term] id: CL:0000727 name: primary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000728 name: secondary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000729 name: tertiary pigment cell namespace: cell is_a: CL:0001658 ! visual pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0000730 name: leading edge cell namespace: cell def: "A cell at the front of a migrating epithelial sheet." [MA:ma] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000731 name: urothelial cell namespace: cell def: "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [GOC:tfm, MA:ma] synonym: "bladder transitional cell" NARROW [] synonym: "transitional epithelial cell of urinary bladder" NARROW [] synonym: "urinary tract transitional epithelial cell" NARROW [] xref: FMA:84127 is_a: CL:0000244 {is_inferred="true"} ! transitional epithelial cell intersection_of: CL:0000244 ! transitional epithelial cell intersection_of: part_of UBERON:0000365 ! urothelium relationship: part_of UBERON:0000365 ! urothelium [Term] id: CL:0000732 name: amoeboid cell namespace: cell is_a: CL:0000219 ! motile cell [Term] id: CL:0000733 name: lymph gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000735 ! lymph gland hemocyte [Term] id: CL:0000734 name: embryonic gland plasmatocyte namespace: cell is_a: CL:0000394 ! plasmatocyte is_a: CL:0000736 ! embryonic gland hemocyte [Term] id: CL:0000735 name: lymph gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000736 name: embryonic gland hemocyte namespace: cell is_a: CL:0000387 ! hemocyte (sensu Nematoda and Protostomia) [Term] id: CL:0000737 name: striated muscle cell namespace: cell def: "Muscle cell which has as its direct parts myofilaments organized into sarcomeres." [GOC:tfm, ISBN:0721662544] xref: BTO:0002916 xref: CALOHA:TS-2157 xref: FMA:86936 is_a: CL:0000187 ! muscle cell [Term] id: CL:0000738 name: leukocyte namespace: cell def: "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [GOC:add, GOC:tfm, ISBN:978-0-323-05290-0] synonym: "immune cell" EXACT [] synonym: "leucocyte" EXACT [] synonym: "white blood cell" EXACT [] xref: BTO:0000751 xref: CALOHA:TS-0549 xref: FMA:62852 is_a: CL:0000219 ! motile cell is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: RO:0002215 GO:0001667 ! capable_of ameboidal cell migration relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: RO:0002215 GO:0001667 ! capable_of ameboidal cell migration [Term] id: CL:0000740 name: retinal ganglion cell namespace: cell def: "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve." [GOC:dph] synonym: "gangliocyte" EXACT [] synonym: "ganglion cell of retina" EXACT [] synonym: "RGC" EXACT [] xref: BTO:0001800 xref: FMA:67765 is_a: CL:0000117 ! CNS neuron (sensu Vertebrata) [Term] id: CL:0000741 name: spinal accessory motor neuron namespace: cell def: "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." [PMID:16267219] synonym: "SACMN" EXACT [] is_a: CL:0000100 ! motor neuron [Term] id: CL:0000742 name: periarticular chondrocyte namespace: cell def: "A round chondrocyte that first differentiates in the late embryonic growth plate of bone." [PMID:15951842] is_a: CL:0000138 {is_inferred="true"} ! chondrocyte intersection_of: CL:0000138 ! chondrocyte intersection_of: part_of UBERON:0010996 ! articular cartilage of joint relationship: part_of UBERON:0010996 ! articular cartilage of joint [Term] id: CL:0000743 name: hypertrophic chondrocyte namespace: cell def: "Chondrocyte that is terminally differentiated, produces type X collagen, is large in size, and often associated with the replacement of cartilage by bone (endochondral ossification)." [GO_REF:0000034, PMID:15951842] comment: is hypertrophic pathological or normal? and can it be described using a pato term? is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000744 name: columnar chondrocyte namespace: cell def: "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." [PMID:15951842] is_a: CL:0000138 ! chondrocyte [Term] id: CL:0000745 name: horizontal cell namespace: cell def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433] xref: BTO:0004120 is_a: CL:0000099 ! interneuron [Term] id: CL:0000746 name: cardiac muscle cell namespace: cell alt_id: FMA:83808 def: "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei." [GOC:mtg_cardiacconduct_nov11, GOC:tfm, ISBN:0323052908] synonym: "cardiac muscle fiber" EXACT [GO:0048739] synonym: "cardiac myocyte" EXACT [] synonym: "cardiocyte" BROAD [] synonym: "cardiomyocyte" EXACT [] synonym: "heart muscle cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:14067 is_a: CL:0000737 {is_inferred="true"} ! striated muscle cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000737 ! striated muscle cell intersection_of: part_of UBERON:0007100 ! circulatory organ relationship: develops_from CL:0000513 ! cardiac muscle myoblast relationship: part_of UBERON:0007100 ! circulatory organ [Term] id: CL:0000747 name: cyanophore namespace: cell def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl] synonym: "blue chromatophore" RELATED [] is_a: CL:0000147 ! pigment cell relationship: develops_from CL:0005005 ! cyanoblast [Term] id: CL:0000748 name: retinal bipolar neuron namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000103 ! bipolar neuron [Term] id: CL:0000749 name: ON-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000750 name: OFF-bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the outer half of the inner plexiform layer. These cells hyperpolarize in response to light stimulation of their corresponding photoreceptors." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000751 name: rod bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [GOC:tfm, PMID:14689473] xref: FMA:67750 is_a: CL:0000749 ! ON-bipolar cell [Term] id: CL:0000752 name: cone retinal bipolar cell namespace: cell def: "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer." [PMID:14689473] is_a: CL:0000748 ! retinal bipolar neuron [Term] id: CL:0000753 name: type 1 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." [PMID:14689473] synonym: "DB1 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000754 name: type 2 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is not well filled and the dendrites are more delicate than in type 1 cells. The axon terminal is bushier and exhibits a dense plexus of varicosities in the inner part of sublamina 1." [PMID:14689473] synonym: "FMB cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000755 name: type 3 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The dendritic tree is delicate and the dendritic tips appear small when compared with type 1 cells. The axon terminal is stratified and restricted to sublamina 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB2 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000756 name: type 4 cone bipolar cell (sensu Mus) namespace: cell def: "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." [PMID:14689473] synonym: "DB3 cone bipolar cell" EXACT [] is_a: CL:0000750 ! OFF-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000757 name: type 5 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." [PMID:14689473] synonym: "DB4 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000758 name: type 6 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The cell has a loose, delicate axon terminal that opens in sublamina 3 of the inner plexiform layer and descends into sublamina 4." [PMID:14689473] synonym: "DB5 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000759 name: type 7 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is narrowly stratified and are found just below a calretinin-expressing band in sublamina 4 of the inner plexiform layer." [PMID:14689473] synonym: "IMB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000760 name: type 8 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." [PMID:14689473] synonym: "DB6 cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000761 name: type 9 cone bipolar cell (sensu Mus) namespace: cell def: "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The dendritic tree is wide and the dendritic convergence indicates cone selectivity. The axon terminal is sparsely branched and terminates in sublamina 5 of the inner plexiform layer." [PMID:14689473] synonym: "BB cone bipolar cell" EXACT [] is_a: CL:0000749 ! ON-bipolar cell is_a: CL:0000752 ! cone retinal bipolar cell [Term] id: CL:0000762 name: nucleated thrombocyte namespace: cell def: "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:16360205] comment: Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000763 {is_inferred="true"} ! myeloid cell intersection_of: CL:0000763 ! myeloid cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: RO:0002215 GO:0007596 ! capable_of blood coagulation relationship: bearer_of PATO:0001407 ! mononucleate relationship: develops_from CL:0000828 ! thromboblast relationship: RO:0002215 GO:0007596 ! capable_of blood coagulation [Term] id: CL:0000763 name: myeloid cell namespace: cell def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [GOC:add] xref: BTO:0001441 xref: CALOHA:TS-0647 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000764 name: erythroid lineage cell namespace: cell alt_id: CL:0002156 def: "A immature or mature cell in the lineage leading to and including erythrocytes." [GOC:add, GOC:tfm] comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes. synonym: "erythropoietic cell" EXACT [] xref: CALOHA:TS-0290 xref: FMA:62845 xref: FMA:83516 is_a: CL:0000763 ! myeloid cell [Term] id: CL:0000765 name: erythroblast namespace: cell def: "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." [GOC:add, ISBN:0721601464, PMID:18174176] synonym: "normoblast" EXACT [] xref: BTO:0001571 xref: CALOHA:TS-0289 xref: FMA:83504 is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000764 ! erythroid lineage cell intersection_of: has_part GO:0005634 ! nucleus intersection_of: lacks_part GO:0005730 ! nucleolus intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation relationship: develops_from CL:0000547 ! proerythroblast relationship: has_part GO:0005634 ! nucleus relationship: lacks_part GO:0005730 ! nucleolus relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: RO:0002215 GO:0030218 ! capable_of erythrocyte differentiation [Term] id: CL:0000766 name: myeloid leukocyte namespace: cell def: "A cell of the monocyte, granulocyte, or mast cell lineage." [GOC:add] is_a: CL:0000738 {is_inferred="true"} ! leukocyte is_a: CL:0000763 ! myeloid cell intersection_of: CL:0000738 ! leukocyte intersection_of: develops_from CL:0000049 ! common myeloid progenitor relationship: develops_from CL:0000049 ! common myeloid progenitor [Term] id: CL:0000767 name: basophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, MESH:D001491, PMCID:PMC2626675, PMID:11927641, PMID:19741522, PMID:21236338, PMID:9933081] comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive. synonym: "basophilic leucocyte" EXACT [] synonym: "basophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000129 xref: CALOHA:TS-0073 xref: FMA:62862 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_high_plasma_membrane_amount PR:000001255 ! chemokine receptor CCR3 intersection_of: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 intersection_of: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 relationship: has_high_plasma_membrane_amount PR:000001255 ! chemokine receptor CCR3 relationship: has_high_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001344 ! ectonucleotide pyrophosphatase/phosphodiesterase family member 3 relationship: has_plasma_membrane_part PR:000001950 ! tumor necrosis factor ligand superfamily member 5 [Term] id: CL:0000768 name: immature basophil namespace: cell def: "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature basophilic leucocyte" EXACT [] synonym: "immature basophilic leukocyte" EXACT [] is_a: CL:0000767 {is_inferred="true"} ! basophil intersection_of: CL:0000767 ! basophil intersection_of: lacks_part CP:0000025 ! lobed nucleus relationship: develops_from CL:0000830 ! basophilic promyelocyte relationship: lacks_part CP:0000025 ! lobed nucleus [Term] id: CL:0000769 name: basophilic metamyelocyte namespace: cell def: "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." [GOC:tfm, ISBN:0721601464, PMID:18466030] xref: FMA:84198 is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002192 ! metamyelocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000614 ! basophilic myelocyte relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000770 name: band form basophil namespace: cell def: "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, http://www.cap.org, ISBN:0721601464, PMID:18466030] is_a: CL:0000768 {is_inferred="true"} ! immature basophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000768 ! immature basophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000769 ! basophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000771 name: eosinophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive." [GOC:add, GOC:amm, GOC:dsd, GOC:tfm, ISBN:0721601464, PMCID:PMC2626675, PMID:10914487, PMID:1662676] comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. synonym: "eosinocyte" EXACT [] synonym: "eosinophilic granulocyte" EXACT [] synonym: "eosinophilic leucocyte" EXACT [] synonym: "eosinophilic leukocyte" EXACT [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] xref: BTO:0000399 xref: CALOHA:TS-0279 xref: FMA:62861 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001254 ! chemokine receptor CCR1 intersection_of: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000001254 ! chemokine receptor CCR1 relationship: has_plasma_membrane_part PR:000001255 ! chemokine receptor CCR3 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule [Term] id: CL:0000772 name: immature eosinophil namespace: cell def: "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immature eosinocyte" EXACT [] synonym: "immature eosinophilic leucocyte" EXACT [] synonym: "immature eosinophilic leukocyte" EXACT [] is_a: CL:0000771 {is_inferred="true"} ! eosinophil intersection_of: CL:0000771 ! eosinophil intersection_of: lacks_part CP:0000025 ! lobed nucleus relationship: develops_from CL:0000833 ! eosinophilic promyelocyte relationship: lacks_part CP:0000025 ! lobed nucleus [Term] id: CL:0000773 name: eosinophilic metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative." [GOC:add, GOC:tfm, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002192 ! metamyelocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000027 ! acidophilic cytoplasm intersection_of: has_part CP:0000040 ! reniform nucleus intersection_of: has_part GO:0000792 ! heterochromatin intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_part GO:0070820 ! tertiary granule intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002031 ! aminopeptidase N relationship: develops_from CL:0000612 ! eosinophilic myelocyte relationship: has_part CP:0000027 ! acidophilic cytoplasm relationship: has_part CP:0000040 ! reniform nucleus relationship: has_part GO:0000792 ! heterochromatin relationship: has_part GO:0042582 ! azurophil granule relationship: has_part GO:0070820 ! tertiary granule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002031 ! aminopeptidase N [Term] id: CL:0000774 name: band form eosinophil namespace: cell def: "A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." [GOC:add, GOC:tfm, http://www.cap.org, ISBN:0721601464, PMID:19622087] is_a: CL:0000772 {is_inferred="true"} ! immature eosinophil is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000772 ! immature eosinophil intersection_of: has_part CP:0000039 ! banded nucleus relationship: develops_from CL:0000773 ! eosinophilic metamyelocyte relationship: has_part CP:0000039 ! banded nucleus [Term] id: CL:0000775 name: neutrophil namespace: cell def: "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [GOC:add, GOC:amm, GOC:tfm, ISBN:0721601464] synonym: "neutrocyte" EXACT [] synonym: "neutrophil leucocyte" EXACT [] synonym: "neutrophil leukocyte" EXACT [] synonym: "neutrophilic leucocyte" EXACT [] synonym: "neutrophilic leukocyte" EXACT [] synonym: "PMN" BROAD [] synonym: "poly" BROAD [] synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] synonym: "polymorphonuclear neutrophil" BROAD [] synonym: "polynuclear neutrophilic leucocyte" BROAD [] synonym: "polynuclear neutrophilic leukocyte" BROAD [] xref: BTO:0000130 xref: CALOHA:TS-0688 xref: FMA:62860 is_a: CL:0000094 {is_inferred="true"} ! granulocyte intersection_of: CL:0000094 ! granulocyte intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000776 name: immature neutrophil namespace: cell def: "Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking." [GOC:add, ISBN:0721601464] synonym: "immatuer neutrophilic leukocyte" EXACT [] synonym: "immature neutrocyte" EXACT [] synonym: "immature neutrophil leucocyte" EXACT [] synonym: "immature neutrophil leukocyte" EXACT [] synonym: "immature neutrophilic leucocyte" EXACT [] is_a: CL:0000775 {is_inferred="true"} ! neutrophil intersection_of: CL:0000775 ! neutrophil intersection_of: lacks_part CP:0000025 ! lobed nucleus relationship: develops_from CL:0000564 ! neutrophilic promyelocyte relationship: lacks_part CP:0000025 ! lobed nucleus [Term] id: CL:0000777 name: mesangial phagocyte namespace: cell def: "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling." [GOC:add, GOC:tfm, ISBN:0702022918, ISBN:3540536663, PMID:1600140, PMID:16146841] synonym: "mesangial cell" BROAD [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0002681 ! kidney cortical cell is_a: CL:1000500 ! kidney interstitial cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0002320 ! glomerular mesangium intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation intersection_of: RO:0002215 GO:0048771 ! capable_of tissue remodeling relationship: part_of UBERON:0002320 ! glomerular mesangium relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: RO:0002215 GO:0048771 ! capable_of tissue remodeling [Term] id: CL:0000778 name: mononuclear osteoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts." [GOC:add, GOC:tfm, PMID:12713016, PMID:15055519, PMID:17380158, PMID:9415452] comment: Morphology: mononuclear, highly vesicular. is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000226 ! single nucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000779 name: multinuclear osteoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of bone." [GOC:add, PMID:12713016, PMID:9415452] comment: Morphology: multinucleated, highly vesicular. synonym: "multinucleated osteoclast" EXACT [] is_a: CL:0000092 {is_inferred="true"} ! osteoclast is_a: CL:0000228 ! multinucleate cell intersection_of: CL:0000092 ! osteoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000778 ! mononuclear osteoclast [Term] id: CL:0000780 name: multinuclear odontoclast namespace: cell def: "A specialized multinuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth. synonym: "multinucleated odontoclast" EXACT [] is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000779 ! multinuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate relationship: develops_from CL:0000781 ! mononuclear odontoclast [Term] id: CL:0000781 name: mononuclear odontoclast namespace: cell def: "A specialized mononuclear osteoclast associated with the absorption and removal of cementum." [GOC:add, PMID:9415452] comment: Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth. is_a: CL:0000588 {is_inferred="true"} ! odontoclast is_a: CL:0000778 {is_inferred="true"} ! mononuclear osteoclast intersection_of: CL:0000588 ! odontoclast intersection_of: bearer_of PATO:0001407 ! mononucleate relationship: bearer_of PATO:0001407 ! mononucleate [Term] id: CL:0000782 name: myeloid dendritic cell namespace: cell def: "A dendritic cell of the myeloid lineage." [GOC:add, PMID:10449155, PMID:17332250, PMID:9521319] comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8). synonym: "CD11c+CD123- DC" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "mDC" EXACT [] synonym: "veiled cell" BROAD [] xref: BTO:0004721 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: develops_from CL:0000763 ! myeloid cell intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0000576 ! monocyte relationship: develops_from CL:0000763 ! myeloid cell relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain [Term] id: CL:0000783 name: multinucleated phagocyte namespace: cell def: "A phagocyte formed by the fusion of mononuclear phagocytes." [GOC:add, GOC:tfm] is_a: CL:0000228 ! multinucleate cell is_a: CL:0000518 {is_inferred="true"} ! phagocyte (sensu Vertebrata) intersection_of: CL:0000518 ! phagocyte (sensu Vertebrata) intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: bearer_of PATO:0001908 ! multinucleate [Term] id: CL:0000784 name: plasmacytoid dendritic cell namespace: cell def: "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection." [GOC:add, GOC:dsd, PMCID:PMC2118448, PMCID:PMC538703, PMID:15549123, PMID:17332250, PMID:17850486, PMID:20304825] synonym: "DC2" EXACT [] synonym: "interferon-producing cell" EXACT [] synonym: "IPC" EXACT [] synonym: "lymphoid dendritic cell" EXACT [] synonym: "pDC" EXACT [] synonym: "plasmacytoid monocyte" EXACT [] synonym: "plasmacytoid T cell" EXACT [] synonym: "T-associated plasma cell" EXACT [] synonym: "type 2 DC" EXACT [] xref: BTO:0004625 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production [Term] id: CL:0000785 name: mature B cell namespace: cell def: "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen." [GOC:add, GOC:dsd, ISBN:0781735149] comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive. synonym: "mature B lymphocyte" EXACT [] synonym: "mature B-cell" EXACT [] synonym: "mature B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_completed GO:0002335 ! mature B cell differentiation intersection_of: RO:0002215 GO:0042113 ! capable_of B cell activation disjoint_from: CL:0000816 ! immature B cell disjoint_from: CL:0000817 ! precursor B cell disjoint_from: CL:0000818 ! transitional stage B cell relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_completed GO:0002335 ! mature B cell differentiation relationship: RO:0002215 GO:0002504 ! capable_of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: RO:0002215 GO:0042113 ! capable_of B cell activation [Term] id: CL:0000786 name: plasma cell namespace: cell def: "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Plasma_cell, ISBN:0721601464, ISBN:0781735149, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20951740] comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. synonym: "effector B cell" RELATED [] synonym: "effector B-cell" RELATED [] synonym: "plasma B cell" EXACT [] synonym: "plasma B-cell" EXACT [] synonym: "plasmacyte" EXACT [] synonym: "plasmocyte" EXACT [] xref: BTO:0000392 xref: FMA:70574 is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell intersection_of: CL:0000946 ! antibody secreting cell intersection_of: has_part CP:0000043 ! cartwheel heterochromatin intersection_of: has_part GO:0005794 ! Golgi apparatus intersection_of: has_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: develops_from CL:0000980 ! plasmablast relationship: has_part CP:0000043 ! cartwheel heterochromatin relationship: has_part GO:0005794 ! Golgi apparatus relationship: has_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex [Term] id: CL:0000787 name: memory B cell namespace: cell def: "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, http://en.wikipedia.org/wiki/Memory_B_cell, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive. synonym: "memory B lymphocyte" EXACT [] synonym: "memory B-cell" EXACT [] synonym: "memory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: has_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000788 name: naive B cell namespace: cell def: "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD27-negative and that has not yet been activated by antigen in the periphery." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676, PMID:20081059, PMID:20839338, PMID:20933013] comment: Naïve B-cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. synonym: "naive B lymphocyte" EXACT [] synonym: "naive B-cell" EXACT [] synonym: "naive B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_not_completed GO:0002344 ! B cell affinity maturation intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_not_completed GO:0002344 ! B cell affinity maturation relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000789 name: alpha-beta T cell namespace: cell def: "A T cell that expresses an alpha-beta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta T lymphocyte" EXACT [] synonym: "alpha-beta T-cell" EXACT [] synonym: "alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex disjoint_from: CL:0000798 ! gamma-delta T cell relationship: has_plasma_membrane_part GO:0042105 ! alpha-beta T cell receptor complex [Term] id: CL:0000790 name: immature alpha-beta T cell namespace: cell def: "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "immature alpha-beta T lymphocyte" EXACT [] synonym: "immature alpha-beta T-cell" EXACT [] synonym: "immature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000791 name: mature alpha-beta T cell namespace: cell def: "A alpha-beta T cell that has a mature phenotype." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature alpha-beta T lymphocyte" EXACT [] synonym: "mature alpha-beta T-cell" EXACT [] synonym: "mature alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000789 {is_inferred="true"} ! alpha-beta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000789 ! alpha-beta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000790 ! immature alpha-beta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000792 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149, PMID:19464985] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: FMA:84070 is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000793 name: CD4-positive, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: develops_from CL:0000810 ! CD4-positive, alpha-beta thymocyte relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000794 name: CD8-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] comment: Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo. synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] synonym: "cytotoxic T cell" BROAD [] synonym: "cytotoxic T lymphocyte" BROAD [] synonym: "cytotoxic T-cell" BROAD [] synonym: "cytotoxic T-lymphocyte" BROAD [] synonym: "killer T cell" BROAD [] synonym: "killer T lymphocyte" BROAD [] synonym: "killer T-cell" BROAD [] synonym: "killer T-lymphocyte" BROAD [] xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003466 ! perforin-1 intersection_of: has_part PR:000003499 ! granzyme B intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity intersection_of: RO:0002215 GO:0033380 ! capable_of granzyme B localization to T cell secretory granule relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003466 ! perforin-1 relationship: has_part PR:000003499 ! granzyme B relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: RO:0002215 GO:0033380 ! capable_of granzyme B localization to T cell secretory granule [Term] id: CL:0000795 name: CD8-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8+ regulatory T cell" EXACT [] synonym: "CD8+ T(reg)" EXACT [] synonym: "CD8+ Treg" EXACT [] synonym: "CD8-positive T(reg)" EXACT [] synonym: "CD8-positive Treg" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta Treg" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: FMA:84070 is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000796 name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell namespace: cell def: "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, ISBN:0781735149] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000625 ! CD8-positive, alpha-beta T cell is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000797 name: alpha-beta intraepithelial T cell namespace: cell def: "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "alpha-beta intraepithelial T-cell" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000798 name: gamma-delta T cell namespace: cell def: "A T cell that expresses a gamma-delta T cell receptor complex." [GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] synonym: "gd T cell" RELATED [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex [Term] id: CL:0000799 name: immature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has an immature phenotype." [GOC:add, ISBN:0781735149] comment: Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways. synonym: "immature gamma-delta T lymphocyte" EXACT [] synonym: "immature gamma-delta T-cell" EXACT [] synonym: "immature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002420 ! immature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_not_completed GO:0042492 ! gamma-delta T cell differentiation intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_not_completed GO:0042492 ! gamma-delta T cell differentiation relationship: has_not_completed GO:0045058 ! T cell selection [Term] id: CL:0000800 name: mature gamma-delta T cell namespace: cell def: "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "mature gamma-delta T lymphocyte" EXACT [] synonym: "mature gamma-delta T-cell" EXACT [] synonym: "mature gamma-delta T-lymphocyte" EXACT [] is_a: CL:0000798 {is_inferred="true"} ! gamma-delta T cell is_a: CL:0002419 ! mature T cell intersection_of: CL:0000798 ! gamma-delta T cell intersection_of: has_completed GO:0045058 ! T cell selection relationship: develops_from CL:0000799 ! immature gamma-delta T cell relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000801 name: gamma-delta intraepithelial T cell namespace: cell def: "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "gamma-delta intraepithelial T-cell" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0002496 ! intraepithelial lymphocyte intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response [Term] id: CL:0000802 name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000803 name: CD4-negative CD8-negative gamma-delta intraepithelial T cell namespace: cell def: "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative." [GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte" EXACT [] synonym: "IEL" BROAD [] synonym: "intraepithelial lymphocyte" BROAD [] is_a: CL:0000801 {is_inferred="true"} ! gamma-delta intraepithelial T cell intersection_of: CL:0000801 ! gamma-delta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000805 name: immature single positive thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages. synonym: "immature single positive T cell" EXACT [] synonym: "immature single positive T lymphocyte" EXACT [] synonym: "immature single positive T-lymphocyte" EXACT [] synonym: "ISP" EXACT [] synonym: "T.ISP.th" EXACT [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000808 ! DN4 thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000806 name: DN2 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. synonym: "DN2 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN2 alpha-beta immature T-cell" EXACT [] synonym: "DN2 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN2 cell" EXACT [] synonym: "DN2 immature T cell" EXACT [] synonym: "double negative 2" EXACT [] synonym: "preT.DN2.Th" EXACT [] synonym: "TN2 cell" EXACT [] synonym: "TN2 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000807 name: DN3 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "DN3 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN3 alpha-beta immature T-cell" EXACT [] synonym: "DN3 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN3 cell" EXACT [] synonym: "DN3 immature T cell" EXACT [] synonym: "double negative 3" EXACT [] synonym: "preT.DN3.Th" EXACT [] synonym: "TN3 cell" EXACT [] synonym: "TN3 thymocyte" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000806 ! DN2 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000808 name: DN4 thymocyte namespace: cell def: "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. synonym: "DN4 alpha-beta immature T lymphocyte" EXACT [] synonym: "DN4 alpha-beta immature T-lymphocyte" EXACT [] synonym: "DN4 cell" EXACT [] synonym: "DN4 immature T cell" EXACT [] synonym: "DN4 immature T-cell" EXACT [] synonym: "double negative 4" EXACT [] synonym: "T.DN4.th" EXACT [] is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: develops_from CL:0000807 ! DN3 thymocyte relationship: has_plasma_membrane_part GO:0043384 ! pre-T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 [Term] id: CL:0000809 name: double-positive, alpha-beta thymocyte namespace: cell def: "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] comment: Thymocytes of this stage are undergoing positive and negative selection. synonym: "double-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "DP cell" EXACT [] synonym: "DP thymocyte" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000805 ! immature single positive thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000810 name: CD4-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD4-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD4-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD4 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000811 name: CD8-positive, alpha-beta thymocyte namespace: cell def: "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0781735149] synonym: "CD8-positive, alpha-beta immature T cell" RELATED [] synonym: "CD8-positive, alpha-beta immature T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta immature T-cell" EXACT [] synonym: "CD8-positive, alpha-beta immature T-lymphocyte" EXACT [] synonym: "SP CD8 cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000813 name: memory T cell namespace: cell def: "A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, ISBN:0781735149] synonym: "memory T lymphocyte" EXACT [] synonym: "memory T-cell" EXACT [] synonym: "memory T-lymphocyte" EXACT [] xref: BTO:0003435 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha disjoint_from: CL:0000898 ! naive T cell relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000814 name: mature NK T cell namespace: cell def: "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." [GOC:add, ISBN:0781735149] synonym: "mature natural killer T cell" EXACT [] synonym: "mature natural killer T lymphocyte" EXACT [] synonym: "mature natural killer T-cell" EXACT [] synonym: "mature natural killer T-lymphocyte" EXACT [] synonym: "mature NK T lymphocyte" EXACT [] synonym: "mature NK T-cell" EXACT [] synonym: "mature NK T-lymphocyte" EXACT [] synonym: "mature NKT cell" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: develops_from CL:0002042 ! immature NK T cell stage IV relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000815 name: regulatory T cell namespace: cell def: "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release." [GO_REF:0000031, GOC:add] comment: This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta. synonym: "regulatory T lymphocyte" EXACT [] synonym: "regulatory T-cell" EXACT [] synonym: "regulatory T-lymphocyte" EXACT [] synonym: "suppressor T cell" BROAD [] synonym: "suppressor T lymphocyte" BROAD [] synonym: "suppressor T-cell" BROAD [] synonym: "suppressor T-lymphocyte" BROAD [] xref: BTO:0004520 xref: FMA:84070 is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000816 name: immature B cell namespace: cell def: "An immature B cell is a precursor B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:rhs, GOC:tfm, ISBN:0781735149, PMID:20081059, PMID:20839338] comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive. synonym: "immature B lymphocyte" EXACT [] synonym: "immature B-cell" EXACT [] synonym: "immature B-lymphocyte" EXACT [] synonym: "newly formed B cell" EXACT [ISBN:781735149] is_a: CL:0000817 ! precursor B cell intersection_of: CL:0000236 ! B cell intersection_of: has_not_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000954 ! small pre-B-II cell relationship: has_not_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000817 name: precursor B cell namespace: cell def: "A precursor B cell is a B cell with the phenotype CD10-positive." [GO_REF:0000031, GOC:rhs, GOC:tfm] synonym: "pre-B cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin disjoint_from: CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0000818 name: transitional stage B cell namespace: cell def: "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12810111] synonym: "T1 B cell" NARROW [] synonym: "T2 B cell" NARROW [] synonym: "T3 B cell" NARROW [] synonym: "transitional stage B lymphocyte" EXACT [] synonym: "transitional stage B-cell" EXACT [] synonym: "transitional stage B-lymphocyte" EXACT [] is_a: CL:0000236 {is_inferred="true"} ! B cell intersection_of: CL:0000236 ! B cell intersection_of: has_not_completed GO:0002335 ! mature B cell differentiation intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000816 ! immature B cell relationship: has_not_completed GO:0002335 ! mature B cell differentiation relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000819 name: B-1 B cell namespace: cell def: "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." [GO_REF:0000031, GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/B-1_cell, PMID:11861604, PMID:20933013, PMID:21220451] comment: There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low. synonym: "B-1 B lymphocyte" EXACT [] synonym: "B-1 B-cell" EXACT [] synonym: "B-1 B-lymphocyte" EXACT [] synonym: "B-1 cell" EXACT [] synonym: "B1 B cell" EXACT [] synonym: "B1 B lymphocyte" EXACT [] synonym: "B1 B-cell" EXACT [] synonym: "B1 B-lymphocyte" EXACT [] synonym: "B1 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: RO:0002215 GO:0045087 ! capable_of innate immune response [Term] id: CL:0000820 name: B-1a B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-positive." [GOC:add, PMID:11861604] synonym: "B-1a B lymphocyte" EXACT [] synonym: "B-1a B-cell" EXACT [] synonym: "B-1a B-lymphocyte" EXACT [] synonym: "B1a B cell" EXACT [] synonym: "B1a B lymphocyte" EXACT [] synonym: "B1a B-cell" EXACT [] synonym: "B1a B-lymphocyte" EXACT [] synonym: "B1a cell" EXACT [] synonym: "CD5(+) B1 cell" EXACT [] synonym: "CD5+ B1 cell" EXACT [] synonym: "CD5-positive B1 cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000821 name: B-1b B cell namespace: cell def: "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell." [GOC:add, PMID:11861604] synonym: "B-1b B lymphocyte" EXACT [] synonym: "B-1b B-cell" EXACT [] synonym: "B-1b B-lymphocyte" EXACT [] synonym: "B1b B cell" EXACT [] synonym: "B1b B lymphocyte" EXACT [] synonym: "B1b B-cell" EXACT [] synonym: "B1b B-lymphocyte" EXACT [] synonym: "B1b cell" EXACT [] is_a: CL:0000819 {is_inferred="true"} ! B-1 B cell intersection_of: CL:0000819 ! B-1 B cell intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000822 name: B-2 B cell namespace: cell def: "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:11861604, PMID:20933013] comment: B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive. synonym: "B-0 B cell" RELATED [] synonym: "B-2 B lymphocyte" EXACT [] synonym: "B-2 B-cell" EXACT [] synonym: "B-2 B-lymphocyte" EXACT [] synonym: "B2 B cell" EXACT [] synonym: "B2 B lymphocyte" EXACT [] synonym: "B2 B-cell" EXACT [] synonym: "B2 B-lymphocyte" EXACT [] synonym: "B2 cell" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin [Term] id: CL:0000823 name: immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR)." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. synonym: "immature NK cell" EXACT [] synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: bearer_of PATO:0001501 ! immature disjoint_from: CL:0000824 ! mature natural killer cell disjoint_from: CL:0000937 ! pre-natural killer cell relationship: bearer_of PATO:0001501 ! immature relationship: develops_from CL:0000937 ! pre-natural killer cell [Term] id: CL:0000824 name: mature natural killer cell namespace: cell def: "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:14685782] synonym: "LAK cell" BROAD [PMID:14685782] synonym: "lymphokine activated killer cell" BROAD [PMID:14685782] synonym: "mature NK cell" EXACT [] is_a: CL:0000623 ! natural killer cell disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: develops_from CL:0000823 ! immature natural killer cell [Term] id: CL:0000825 name: pro-NK cell namespace: cell def: "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11532393, PMID:12457618, PMID:15032583, PMID:15766674] comment: Most markers only described for human pro NK cells. synonym: "natural killer cell progenitor" EXACT [] synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674] synonym: "null cell" RELATED [PMID:11532393] synonym: "preNK cell" RELATED [PMID:11532393] synonym: "pro-natural killer cell" EXACT [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000826 name: pro-B cell namespace: cell def: "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." [GOC:add, GOC:dsd, ISBN:0781735149, PMID:12633665, PMID:16551251, PMID:18432934] comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative. synonym: "pre-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] synonym: "pre-pro B cell" BROAD [PMID:17582343] synonym: "pro-B lymphocyte" EXACT [] synonym: "pro-B-cell" EXACT [] synonym: "pro-B-lymphocyte" EXACT [] synonym: "progenitor B cell" EXACT [] synonym: "progenitor B lymphocyte" EXACT [] synonym: "progenitor B-cell" EXACT [] synonym: "progenitor B-lymphocyte" EXACT [] xref: BTO:0003104 is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: has_part PR:000001903 ! paired box protein PAX-5 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: participates_in GO:0033152 ! immunoglobulin V(D)J recombination relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: has_part PR:000001903 ! paired box protein PAX-5 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: participates_in GO:0033152 ! immunoglobulin V(D)J recombination [Term] id: CL:0000827 name: pro-T cell namespace: cell def: "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage." [GOC:add, ISBN:0781735149] synonym: "DN1 cell" NARROW [] synonym: "DN1 thymocyte" NARROW [] synonym: "pro-T lymphocyte" EXACT [] synonym: "progenitor T cell" EXACT [] synonym: "TN1 cell" NARROW [] is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030217 ! capable_of T cell differentiation relationship: develops_from CL:0000051 ! common lymphoid progenitor relationship: RO:0002215 GO:0030217 ! capable_of T cell differentiation [Term] id: CL:0000828 name: thromboblast namespace: cell def: "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates." [GOC:add, GOC:tfm, PMID:7758949] comment: Note that this is a non-mammalian cell type. is_a: CL:0000226 ! single nucleate cell is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: RO:0002215 GO:0002574 ! capable_of thrombocyte differentiation relationship: bearer_of PATO:0001407 ! mononucleate relationship: develops_from CL:0000050 ! megakaryocyte-erythroid progenitor cell relationship: RO:0002215 GO:0002574 ! capable_of thrombocyte differentiation [Term] id: CL:0000829 name: basophilic myeloblast namespace: cell def: "A myeloblast committed to the basophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0000613 ! basophil progenitor cell relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000830 name: basophilic promyelocyte namespace: cell def: "A promyelocyte committed to the basophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84208 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: develops_from CL:0000829 ! basophilic myeloblast relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation [Term] id: CL:0000831 name: mast cell progenitor namespace: cell def: "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative." [GOC:add, GOC:dsd, http://www.copewithcytokines.de, PMCID:PMC1183570, PMCID:PMC1312421, PMID:8629001, PMID:9354811] comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa. synonym: "CFU-Mast " RELATED [] synonym: "CFU-MC" RELATED [] synonym: "colony forming unit mast cell" RELATED [] synonym: "MCP" EXACT [] is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: RO:0002215 GO:0060374 ! capable_of mast cell differentiation relationship: develops_from CL:0002028 ! basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: lacks_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: RO:0002215 GO:0060374 ! capable_of mast cell differentiation [Term] id: CL:0000832 name: eosinophilic myeloblast namespace: cell def: "A myeloblast committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] is_a: CL:0000835 {is_inferred="true"} ! myeloblast intersection_of: CL:0000835 ! myeloblast intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000611 ! eosinophil progenitor cell relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000833 name: eosinophilic promyelocyte namespace: cell def: "A promyelocyte committed to the eosinophil lineage." [GOC:add, ISBN:0721601464] xref: FMA:84199 is_a: CL:0000836 {is_inferred="true"} ! promyelocyte intersection_of: CL:0000836 ! promyelocyte intersection_of: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation relationship: develops_from CL:0000832 ! eosinophilic myeloblast relationship: RO:0002215 GO:0030222 ! capable_of eosinophil differentiation [Term] id: CL:0000834 name: neutrophil progenitor cell namespace: cell def: "A progenitor cell of the neutrophil lineage." [GOC:add, GOC:tfm, ISBN:0721601464] synonym: "neutrophil stem cell" RELATED [] is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030223 ! capable_of neutrophil differentiation [Term] id: CL:0000835 name: myeloblast namespace: cell def: "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow." [GOC:add, http://en.wikipedia.org/wiki/Myeloblast, http://www.cap.org, ISBN:0721601464] xref: BTO:0000187 xref: FMA:83524 is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0002191 ! granulocytopoietic cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0000791 ! euchromatin intersection_of: lacks_part GO:0042582 ! azurophil granule relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0000791 ! euchromatin relationship: lacks_part GO:0042582 ! azurophil granule [Term] id: CL:0000836 name: promyelocyte namespace: cell def: "A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative." [GOC:add, GOC:amm, GOC:tfm, http://www.cap.org, ISBN:0721601464] xref: CALOHA:TS-0825 xref: FMA:83530 is_a: CL:0002191 ! granulocytopoietic cell is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_part CP:0000028 ! basophilic cytoplasm intersection_of: has_part CP:0000037 ! increased nucleus size intersection_of: has_part GO:0005730 ! nucleolus intersection_of: has_part GO:0042582 ! azurophil granule intersection_of: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 intersection_of: has_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0000835 ! myeloblast relationship: has_part CP:0000028 ! basophilic cytoplasm relationship: has_part CP:0000037 ! increased nucleus size relationship: has_part GO:0005730 ! nucleolus relationship: has_part GO:0042582 ! azurophil granule relationship: has_plasma_membrane_part PR:000001456 ! alpha-(1,3)-fucosyltransferase FUT4 relationship: has_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0000837 name: hematopoietic multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans." [GOC:add, GOC:tfm, PMID:19022770] comment: Markers differ between mouse and human. synonym: "hemopoietic progenitor cell" EXACT [] synonym: "MPP" EXACT [] xref: BTO:0000725 xref: CALOHA:TS-0448 is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001402 ! multipotent intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001402 ! multipotent relationship: develops_from CL:0000037 ! hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0000838 name: lymphoid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the lymphoid lineage." [GOC:add, GOC:tfm] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "lymphoid progenitor cell" BROAD [] xref: BTO:0004731 xref: CALOHA:TS-2025 xref: FMA:70338 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation disjoint_from: CL:0000839 ! myeloid lineage restricted progenitor cell relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000839 name: myeloid lineage restricted progenitor cell namespace: cell def: "A progenitor cell restricted to the myeloid lineage." [GOC:add, GOC:tfm, PMID:19022770] comment: Note that this is a class of cell types, not an identified single cell type. synonym: "myeloid progenitor cell" BROAD [] xref: BTO:0004730 xref: CALOHA:TS-2099 xref: FMA:70339 is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030099 ! capable_of myeloid cell differentiation relationship: RO:0002215 GO:0030099 ! capable_of myeloid cell differentiation [Term] id: CL:0000840 name: immature conventional dendritic cell namespace: cell def: "An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low." [GOC:add, GOC:tfm, PMID:9521319] synonym: "immature myeloid dendritic cell" NARROW [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000841 name: mature conventional dendritic cell namespace: cell def: "A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node." [GOC:add, GOC:tfm, PMID:9521319] synonym: "mature myeloid dendritic cell" NARROW [] xref: FMA:83038 is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000840 ! immature conventional dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000842 name: mononuclear cell namespace: cell def: "A leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "peripheral blood mononuclear cell" NARROW [] xref: BTO:0000878 xref: CALOHA:TS-0768 xref: FMA:86713 is_a: CL:0000226 ! single nucleate cell is_a: CL:0002087 ! nongranular leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: bearer_of PATO:0001407 ! mononucleate intersection_of: lacks_part GO:0030141 ! secretory granule relationship: bearer_of PATO:0001407 ! mononucleate relationship: lacks_part GO:0030141 ! secretory granule [Term] id: CL:0000843 name: follicular B cell namespace: cell def: "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Follicular_B_Cells, ISBN:0781735149, PMCID:PMC2193793, PMID:20933013] comment: Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "Fo B cell" EXACT [] synonym: "Fo B-cell" EXACT [] synonym: "follicular B lymphocyte" EXACT [] synonym: "follicular B-cell" EXACT [] synonym: "follicular B-lymphocyte" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor [Term] id: CL:0000844 name: germinal center B cell namespace: cell def: "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0781735149, PMID:19447676, PMID:20933013] comment: Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive. synonym: "GC B cell" EXACT [] synonym: "GC B lymphocyte" EXACT [] synonym: "GC B-cell" EXACT [] synonym: "GC B-lymphocyte" EXACT [] synonym: "germinal center B lymphocyte" EXACT [] synonym: "germinal center B-cell" EXACT [] synonym: "germinal center B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: part_of UBERON:0001745 ! secondary nodular lymphoid tissue relationship: develops_from CL:0000843 ! follicular B cell relationship: part_of UBERON:0001745 ! secondary nodular lymphoid tissue [Term] id: CL:0000845 name: marginal zone B cell namespace: cell def: "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high." [GOC:add, GOC:dsd, http://en.wikipedia.org/wiki/Marginal-zone_B_cell, ISBN:0781735149, PMID:10933592, PMID:20933013] comment: MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive. synonym: "marginal zone B lymphocyte" EXACT [] synonym: "marginal zone B-cell" EXACT [] synonym: "marginal zone B-lymphocyte" EXACT [] synonym: "MZ B cell" EXACT [] synonym: "MZ B lymphocyte" EXACT [] synonym: "MZ B-cell" EXACT [] synonym: "MZ B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001251 ! marginal zone of spleen intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: has_high_plasma_membrane_amount GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001251 ! marginal zone of spleen relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium [Term] id: CL:0000846 name: vestibular dark cell namespace: cell def: "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings." [PMID:11223304] is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000847 name: ciliated olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob." [PMID:16841163] synonym: "ciliated olfactory sensory neuron" EXACT [] synonym: "ciliated sensory neuron" EXACT [] is_a: CL:0000064 ! ciliated cell is_a: CL:0000207 ! olfactory receptor cell relationship: has_plasma_membrane_part GO:0005929 ! cilium [Term] id: CL:0000848 name: microvillous olfactory receptor neuron namespace: cell def: "An olfactory receptor cell in which the apical ending of the dendrite is a knob that bears numerous microvilli." [PMID:16841163] synonym: "microvillous olfactory sensory neuron" EXACT [] synonym: "microvillous sensory neuron" RELATED [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000849 name: crypt olfactory receptor neuron namespace: cell def: "An olfactory receptor cell with short cilia growing in an invagination bordered by microvilli." [PMID:16841163] synonym: "crypt cell" EXACT [] synonym: "crypt olfactory sensory neuron" EXACT [] synonym: "crypt sensory neuron" EXACT [] is_a: CL:0000207 ! olfactory receptor cell [Term] id: CL:0000850 name: serotonergic neuron namespace: cell alt_id: CL:0000403 def: "A neuron that releases serotonin as a neurotransmitter." [SANBI:mhl] synonym: "5-HT neuron" EXACT [] synonym: "5-hydroxytryptamine neuron" EXACT [] synonym: "serotinergic neuron" RELATED [] xref: FBbt:00005133 xref: WBbt:0006837 is_a: CL:0000540 ! neuron [Term] id: CL:0000851 name: neuromast mantle cell namespace: cell def: "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." [ISBN:0125296509] is_a: CL:0000151 ! secretory cell [Term] id: CL:0000852 name: neuromast support cell namespace: cell def: "Neuromast support cell is a non-sensory cell of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; neuromast support cells are surrounded by neuromast mantle cells." [ISBN:0125296509] is_a: CL:0000630 ! supportive cell [Term] id: CL:0000853 name: olfactory epithelial support cell namespace: cell def: "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons." [GOC:tfm, ISBN:0517223651, SANBI:mhl] synonym: "olfactory sustentacular cell" EXACT [] synonym: "supporting cell of olfactory epithelium" EXACT [] synonym: "sustentaculocyte of olfactory epithelium" EXACT [] xref: FMA:62302 is_a: CL:0000630 ! supportive cell is_a: CL:0002167 ! olfactory epithelial cell [Term] id: CL:0000854 name: interneuromast cell namespace: cell def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl] is_a: CL:0000133 ! neurectodermal cell relationship: develops_from CL:0000032 ! neuroplacodal cell [Term] id: CL:0000855 name: sensory hair cell namespace: cell def: "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system." [SANBI:mhl] synonym: "hair cell" BROAD [] xref: BTO:0004744 is_a: CL:0000199 ! mechanoreceptor cell [Term] id: CL:0000856 name: neuromast hair cell namespace: cell def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl] is_a: CL:0000855 ! sensory hair cell [Term] id: CL:0000857 name: slow muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into slow muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000858 name: fast muscle myoblast namespace: cell def: "A skeletal muscle myoblast that differentiates into fast muscle fibers." [SANBI:mhl] is_a: CL:0000515 ! skeletal muscle myoblast [Term] id: CL:0000860 name: classical monocyte namespace: cell def: "A type of monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors. This cell type is characterized by high expression of CCR2 in both rodents and humans, and of being larger size than non-classical monocytes." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2+CXCCR1 (human, mouse, rat). synonym: "inflammatory monocyte" EXACT [] is_a: CL:0000234 ! phagocyte is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: RO:0002215 GO:0002548 ! capable_of monocyte chemotaxis intersection_of: RO:0002215 GO:0006909 ! capable_of phagocytosis intersection_of: RO:0002215 GO:0006954 ! capable_of inflammatory response relationship: has_high_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: RO:0002215 GO:0002548 ! capable_of monocyte chemotaxis relationship: RO:0002215 GO:0006909 ! capable_of phagocytosis relationship: RO:0002215 GO:0006954 ! capable_of inflammatory response [Term] id: CL:0000861 name: elicited macrophage namespace: cell def: "A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive." [GO_REF:0000031, GOC:add, GOC:ana, GOC:tfm, PMID:15771589] comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response). synonym: "free macrophage" EXACT [] synonym: "wandering histiocyte" EXACT [] xref: FMA:84643 xref: FMA:84645 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: participates_in GO:0006954 ! inflammatory response relationship: develops_from CL:0000860 ! classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: participates_in GO:0006954 ! inflammatory response [Term] id: CL:0000862 name: suppressor macrophage namespace: cell def: "A macrophage that suppresses immune responses." [GOC:add, GOC:tfm, PMID:20402419] comment: Markers: May express: IL10, TGFbeta. is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000863 name: inflammatory macrophage namespace: cell def: "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." [GO_REF:0000031, GOC:ana, PMID:19132917] comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response). synonym: "classically activated macrophage" EXACT [] synonym: "M1 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: RO:0002215 GO:0032611 ! capable_of interleukin-1 beta production intersection_of: RO:0002215 GO:0032635 ! capable_of interleukin-6 production intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production intersection_of: RO:0002215 GO:0042554 ! capable_of superoxide anion generation intersection_of: RO:0002215 GO:0042742 ! capable_of defense response to bacterium intersection_of: RO:0002215 GO:0051768 ! capable_of nitric-oxide synthase 2 biosynthetic process relationship: RO:0002215 GO:0032611 ! capable_of interleukin-1 beta production relationship: RO:0002215 GO:0032635 ! capable_of interleukin-6 production relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: RO:0002215 GO:0042554 ! capable_of superoxide anion generation relationship: RO:0002215 GO:0042742 ! capable_of defense response to bacterium relationship: RO:0002215 GO:0051768 ! capable_of nitric-oxide synthase 2 biosynthetic process [Term] id: CL:0000864 name: tissue-resident macrophage namespace: cell def: "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:ana, PMID:19770654] synonym: "fixed macrophage" EXACT [] synonym: "resting histiocyte" EXACT [] xref: FMA:84642 xref: FMA:84644 is_a: CL:0000235 {is_inferred="true"} ! macrophage intersection_of: CL:0000235 ! macrophage intersection_of: part_of UBERON:0000479 ! tissue relationship: part_of UBERON:0000479 ! tissue [Term] id: CL:0000865 name: gastrointestinal tract (lamina propria) macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001238 ! lamina propria of small intestine relationship: part_of UBERON:0001238 ! lamina propria of small intestine [Term] id: CL:0000866 name: thymic macrophage namespace: cell def: "A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] comment: Role or process: immune, clearance of apoptotic thymocytes, antigen-presentation. is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0002370 ! thymus intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: part_of UBERON:0002370 ! thymus relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000867 name: secondary lymphoid organ macrophage namespace: cell def: "A tissue-resident macrophage found in a secondary lymphoid organ." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000864 ! tissue-resident macrophage [Term] id: CL:0000868 name: lymph node macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865] comment: Marker was observed on rat cells. synonym: "MF.LN" EXACT [] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0000029 ! lymph node relationship: has_high_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0000029 ! lymph node [Term] id: CL:0000869 name: tonsillar macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in tonsils." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0002372 ! tonsil intersection_of: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0002372 ! tonsil relationship: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000870 name: Peyer's patch macrophage namespace: cell def: "A gut-associated lymphoid tissue macrophage found in the Peyer's patches." [GO_REF:0000031, GOC:ana, GOC:tfm] is_a: CL:0000885 {is_inferred="true"} ! gut-associated lymphoid tissue macrophage intersection_of: CL:0000885 ! gut-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: part_of UBERON:0001211 ! Peyer's patch [Term] id: CL:0000871 name: splenic macrophage namespace: cell def: "A secondary lymphoid organ macrophage found in the spleen." [GO_REF:0000031, PMID:15771589, PMID:16322748] comment: Role or process: immune, clearance of apoptotic and senescent cells. xref: FMA:83026 is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0002106 ! spleen intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: part_of UBERON:0002106 ! spleen relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000872 name: splenic marginal zone macrophage namespace: cell def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066] comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO intersection_of: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II intersection_of: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: part_of UBERON:0001251 ! marginal zone of spleen relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001884 ! macrophage receptor MARCO relationship: has_plasma_membrane_part PR:000001885 ! macrophage scavenger receptor types I and II relationship: has_plasma_membrane_part PR:000006172 ! CD209 molecule-like protein B relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: part_of UBERON:0001251 ! marginal zone of spleen [Term] id: CL:0000873 name: splenic metallophillic macrophage namespace: cell def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690] comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001251 ! marginal zone of spleen intersection_of: RO:0002220 UBERON:0001959 ! adjacent_to white pulp of spleen relationship: has_low_plasma_membrane_amount PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001251 ! marginal zone of spleen relationship: RO:0002220 UBERON:0001959 ! adjacent_to white pulp of spleen [Term] id: CL:0000874 name: splenic red pulp macrophage namespace: cell def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016] comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin intersection_of: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: part_of UBERON:0001250 ! red pulp of spleen intersection_of: RO:0002215 GO:0006955 ! capable_of immune response intersection_of: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001931 ! sialoadhesin relationship: has_plasma_membrane_part PR:000001806 ! C-type lectin domain family 6 member A relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: part_of UBERON:0001250 ! red pulp of spleen relationship: RO:0002215 GO:0006955 ! capable_of immune response relationship: RO:0002215 GO:0034102 ! capable_of erythrocyte clearance [Term] id: CL:0000875 name: non-classical monocyte namespace: cell def: "Subset of monocytes characterized by low expression of CCR2, low responsiveness to monocyte chemoattractant CCL2/MCP1, low phagocytic activity, but increased co-stimulatory activity. May also play a role in tissue repair." [GO_REF:0000031, PMID:16322748, PMID:18303997, PMID:20628149, PMID:20870168] comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/FcgRII-high, MHCII+, CD86+; mouse: CD62L-Ly6C-. synonym: "patrolling monocyte" EXACT [] synonym: "resident monocyte" EXACT [] is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: RO:0002215 GO:0031294 ! capable_of lymphocyte costimulation relationship: has_high_plasma_membrane_amount PR:000001206 ! CX3C chemokine receptor 1 relationship: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: RO:0002215 GO:0031294 ! capable_of lymphocyte costimulation [Term] id: CL:0000876 name: splenic white pulp macrophage namespace: cell def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597] comment: Markers: Mouse: F4/80-, CD68+, macrosialin+. is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage intersection_of: CL:0000871 ! splenic macrophage intersection_of: has_plasma_membrane_part PR:000002064 ! macrosialin intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001959 ! white pulp of spleen relationship: has_plasma_membrane_part PR:000002064 ! macrosialin relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001959 ! white pulp of spleen [Term] id: CL:0000877 name: splenic tingible body macrophage namespace: cell def: "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000876 {is_inferred="true"} ! splenic white pulp macrophage intersection_of: CL:0000876 ! splenic white pulp macrophage intersection_of: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer intersection_of: part_of UBERON:0001249 ! spleen lymphoid follicle intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: has_plasma_membrane_part PR:000010329 ! tyrosine-protein kinase Mer relationship: part_of UBERON:0001249 ! spleen lymphoid follicle relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000878 name: central nervous system macrophage namespace: cell def: "A tissue-resident macrophage found in the central nervous system." [GO_REF:0000031, PMID:16322748] synonym: "CNS macrophage" EXACT [] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: part_of UBERON:0001017 ! central nervous system relationship: part_of UBERON:0001017 ! central nervous system [Term] id: CL:0000879 name: meningeal macrophage namespace: cell def: "A central nervous system macrophage found in the meninges (the three membranes that surround the brain). This macrophage types is highly phagocytic and expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:11591794] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: part_of UBERON:0002360 ! meninx intersection_of: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity relationship: part_of UBERON:0002360 ! meninx relationship: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity [Term] id: CL:0000880 name: choroid-plexus macrophage namespace: cell def: "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." [GO_REF:0000031, GOC:ana, PMID:9550136] is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: located_in UBERON:0001886 ! choroid plexus intersection_of: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity relationship: located_in UBERON:0001886 ! choroid plexus relationship: RO:0002215 GO:0005044 ! capable_of scavenger receptor activity [Term] id: CL:0000881 name: perivascular macrophage namespace: cell def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 intersection_of: part_of UBERON:0001981 ! blood vessel relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: part_of UBERON:0001981 ! blood vessel [Term] id: CL:0000882 name: thymic medullary macrophage namespace: cell def: "A thymic macrophage found in the thymic medulla." [GO_REF:0000031, GOC:ana, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002124 ! medulla of thymus relationship: part_of UBERON:0002124 ! medulla of thymus [Term] id: CL:0000883 name: thymic cortical macrophage namespace: cell def: "A thymic macrophage found in the thymic cortex." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:9048205] is_a: CL:0000866 {is_inferred="true"} ! thymic macrophage intersection_of: CL:0000866 ! thymic macrophage intersection_of: part_of UBERON:0002123 ! cortex of thymus relationship: part_of UBERON:0002123 ! cortex of thymus [Term] id: CL:0000884 name: mucosa-associated lymphoid tissue macrophage namespace: cell def: "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19906191] is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage intersection_of: CL:0000867 ! secondary lymphoid organ macrophage intersection_of: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue relationship: part_of UBERON:0001961 ! mucosa-associated lymphoid tissue [Term] id: CL:0000885 name: gut-associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the mucosa-associated lymphoid tissues of the gut." [GO_REF:0000031, GOC:ana, PMID:19906191] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001962 ! gut-associated lymphoid tissue intersection_of: RO:0002215 GO:0002387 ! capable_of immune response in gut-associated lymphoid tissue relationship: part_of UBERON:0001962 ! gut-associated lymphoid tissue relationship: RO:0002215 GO:0002387 ! capable_of immune response in gut-associated lymphoid tissue [Term] id: CL:0000886 name: nasal and broncial associated lymphoid tissue macrophage namespace: cell def: "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." [GO_REF:0000031, GOC:ana, PMID:16048540] is_a: CL:0000884 {is_inferred="true"} ! mucosa-associated lymphoid tissue macrophage intersection_of: CL:0000884 ! mucosa-associated lymphoid tissue macrophage intersection_of: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue intersection_of: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue relationship: part_of UBERON:0001963 ! bronchial-associated lymphoid tissue relationship: RO:0002215 GO:0002395 ! capable_of immune response in nasopharyngeal-associated lymphoid tissue [Term] id: CL:0000887 name: lymph node subcapsular sinus macrophage namespace: cell def: "A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive." [GO_REF:0000031, GOC:tfm, PMID:14668803, PMID:17934446, PMID:20228797] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: has_plasma_membrane_part PR:000001931 ! sialoadhesin intersection_of: RO:0002215 GO:0032816 ! capable_of positive regulation of natural killer cell activation intersection_of: RO:0002220 UBERON:0002194 ! adjacent_to capsule of lymph node relationship: has_plasma_membrane_part PR:000001931 ! sialoadhesin relationship: RO:0002215 GO:0032816 ! capable_of positive regulation of natural killer cell activation relationship: RO:0002220 UBERON:0002194 ! adjacent_to capsule of lymph node [Term] id: CL:0000888 name: lymph node tingible body macrophage namespace: cell def: "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:19631584] is_a: CL:0000868 {is_inferred="true"} ! lymph node macrophage intersection_of: CL:0000868 ! lymph node macrophage intersection_of: part_of UBERON:0002006 ! cortex of lymph node intersection_of: RO:0002215 GO:0002905 ! capable_of regulation of mature B cell apoptotic process intersection_of: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance relationship: part_of UBERON:0002006 ! cortex of lymph node relationship: RO:0002215 GO:0002905 ! capable_of regulation of mature B cell apoptotic process relationship: RO:0002215 GO:0043277 ! capable_of apoptotic cell clearance [Term] id: CL:0000889 name: myeloid suppressor cell namespace: cell def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559] comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis. is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte intersection_of: CL:0000766 ! myeloid leukocyte intersection_of: bearer_of PATO:0001501 ! immature intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: bearer_of PATO:0001501 ! immature relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000890 name: alternatively activated macrophage namespace: cell def: "An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:20510870] comment: Role or process: tissue remodeling. synonym: "M2 macrophage" RELATED [] is_a: CL:0000861 {is_inferred="true"} ! elicited macrophage intersection_of: CL:0000861 ! elicited macrophage intersection_of: has_part PR:000001844 ! arginase-1 intersection_of: RO:0002215 GO:0048771 ! capable_of tissue remodeling relationship: has_part PR:000001844 ! arginase-1 relationship: RO:0002215 GO:0048771 ! capable_of tissue remodeling [Term] id: CL:0000891 name: foam cell namespace: cell def: "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] xref: BTO:0003872 xref: FMA:83586 is_a: CL:0000003 ! native cell [Term] id: CL:0000892 name: smooth muscle cell derived foam cell namespace: cell def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add] is_a: CL:0000891 ! foam cell relationship: develops_from CL:0000192 ! smooth muscle cell [Term] id: CL:0000893 name: thymocyte namespace: cell def: "An immature T cell located in the thymus." [GO_REF:0000031, GOC:add, GOC:tfm, PMID:12415312] synonym: "immature T cell" BROAD [] synonym: "immature T lymphocyte" BROAD [] synonym: "immature T-cell" BROAD [] synonym: "immature T-lymphocyte" BROAD [] synonym: "thymic lymphocyte" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 xref: FMA:72202 xref: XAO:0003159 is_a: CL:0002420 {is_inferred="true"} ! immature T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection intersection_of: part_of UBERON:0002370 ! thymus relationship: has_not_completed GO:0045058 ! T cell selection relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000894 name: DN1 thymic pro-T cell namespace: cell def: "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:tfm] synonym: "DN1 thymic pro-T lymphocyte" EXACT [] synonym: "DN1 thymic pro-T-cell" EXACT [] synonym: "DN1 thymic pro-T-lymphocyte" EXACT [] synonym: "DN1 thymic progenitor T cell" EXACT [] synonym: "DN1 thymocyte" EXACT [] synonym: "double negative 1" EXACT [] synonym: "preT.DN1.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0002425 ! early T lineage precursor relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000895 name: naive thymus-derived CD4-positive, alpha-beta T cell namespace: cell def: "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19100699] comment: These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. synonym: "naive thymus-derived CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.4Nve.Sp" EXACT [] synonym: "Th0" EXACT [GOC:tfm] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002436 ! mature CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000896 name: activated CD4-positive, alpha-beta T cell namespace: cell def: "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "activated CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD4-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000895 ! naive thymus-derived CD4-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000897 name: CD4-positive, alpha-beta memory T cell namespace: cell def: "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122- high." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] synonym: "CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T4.Mem.Sp" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000898 name: naive T cell namespace: cell def: "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19100699] synonym: "naive T lymphocyte" EXACT [] synonym: "naive T-cell" EXACT [] synonym: "naive T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_completed GO:0045058 ! T cell selection relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000899 name: T-helper 17 cell namespace: cell def: "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20303875, PMID:20969597] synonym: "helper T cell type 17" EXACT [] synonym: "IL-17-producing CD4+ T helper" EXACT [] synonym: "T helper cells type 17" EXACT [] synonym: "T(H)-17 cell" EXACT [] synonym: "Th17 cell" EXACT [] synonym: "Th17 T cell" EXACT [] synonym: "Th17 T lymphocyte" EXACT [] synonym: "Th17 T-cell" EXACT [] synonym: "Th17 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production [Term] id: CL:0000900 name: naive thymus-derived CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149] comment: Additional markers in human are CD45RA. This cell traffics in secondary lymphoid organs and blood. synonym: "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-cell" EXACT [] synonym: "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte" EXACT [] synonym: "T.8Nve.Sp" NARROW [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000898 ! naive T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0002437 ! mature CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_low_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000901 name: Tr1 cell namespace: cell def: "CD4-positive alpha-beta T cell with regulatory function that produces IL-10." [GO_REF:0000031, GOC:add, GOC:pam, PMID:16903904] comment: These cells are reportedly induced by IL-10 and are capable of producing IFN-gamma, IL-5, IL-10, and TGF-beta.) synonym: "T-regulatory T cell type 1" EXACT [] synonym: "Tr1 T cell" EXACT [] synonym: "Tr1 T lymphocyte" EXACT [] synonym: "Tr1 T-cell" EXACT [] synonym: "Tr1 T-lymphocyte" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000815 ! regulatory T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000902 name: induced T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "adaptive Treg" RELATED [] synonym: "aTreg" RELATED [] synonym: "induced regulatory T cell" EXACT [] synonym: "induced regulatory T lymphocyte" EXACT [] synonym: "induced regulatory T-cell" EXACT [] synonym: "induced regulatory T-lymphocyte" EXACT [] synonym: "induced Treg" EXACT [] synonym: "iTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000903 name: natural T-regulatory cell namespace: cell def: "CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19464985] synonym: "natural regulatory T cell" EXACT [] synonym: "natural regulatory T lymphocyte" EXACT [] synonym: "natural regulatory T-cell" EXACT [] synonym: "natural regulatory T-lymphocyte" EXACT [] synonym: "natural Treg" EXACT [] synonym: "nTreg" EXACT [] is_a: CL:0000792 {is_inferred="true"} ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: CL:0000792 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell intersection_of: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001852 ! cytotoxic T-lymphocyte protein 4 [Term] id: CL:0000904 name: central memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam] synonym: "central CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000905 name: effector memory CD4-positive, alpha-beta T cell namespace: cell def: "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "effector CD4-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD4-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD4-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000897 {is_inferred="true"} ! CD4-positive, alpha-beta memory T cell intersection_of: CL:0000897 ! CD4-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000906 name: activated CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "activated CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "activated CD8-positive, alpha-beta T-cell" EXACT [] synonym: "activated CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0000900 ! naive thymus-derived CD8-positive, alpha-beta T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha [Term] id: CL:0000907 name: central memory CD8 positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "central CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "central CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "central memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000908 name: CD8-positive, alpha-beta cytokine secreting effector T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-cell" EXACT [] synonym: "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000909 name: CD8-positive, alpha-beta memory T cell namespace: cell def: "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122- high." [GO_REF:0000031, GOC:tfm, PMID:20146720] synonym: "CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "T.8Mem.Sp" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell is_a: CL:0000813 ! memory T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001017 ! receptor-type tyrosine-protein phosphatase C isoform CD45RO relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000910 name: cytotoxic T cell namespace: cell def: "A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "cytotoxic T lymphocyte" EXACT [] synonym: "cytotoxic T-cell" EXACT [] synonym: "cytotoxic T-lymphocyte" EXACT [] xref: BTO:0000289 xref: CALOHA:TS-0190 xref: FMA:70573 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity [Term] id: CL:0000911 name: effector T cell namespace: cell def: "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response." [GOC:PAM-ADD, GOC:tfm, ISBN:0877799148, PMID:18395547] synonym: "effector T lymphocyte" EXACT [] synonym: "effector T-cell" EXACT [] synonym: "effector T-lymphocyte" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_completed GO:0045058 ! T cell selection relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_completed GO:0045058 ! T cell selection [Term] id: CL:0000912 name: helper T cell namespace: cell def: "A effector T cell that provides help in the form of secreted cytokines to other immune cells." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18395547] synonym: "helper T lymphocyte" EXACT [] synonym: "helper T-cell" EXACT [] synonym: "helper T-lymphocyte" EXACT [] synonym: "T-helper cell" EXACT [] xref: BTO:0002417 is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0000913 name: effector memory CD8-positive, alpha-beta T cell namespace: cell def: "A CD8-positive, alpha beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720] synonym: "effector CD8-positive, alpha-beta memory T cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T lymphocyte" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-cell" EXACT [] synonym: "effector CD8-positive, alpha-beta memory T-lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T lymphocyte" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-cell" EXACT [] synonym: "effector memory CD8-positive, alpha-beta T-lymphocyte" EXACT [] is_a: CL:0000909 {is_inferred="true"} ! CD8-positive, alpha-beta memory T cell intersection_of: CL:0000909 ! CD8-positive, alpha-beta memory T cell intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000914 name: immature NK T cell namespace: cell def: "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17589542, PMID:19169262] synonym: "immature NK T lymphocyte" EXACT [] synonym: "immature NK T-cell" EXACT [] synonym: "immature NK T-lymphocyte" EXACT [] synonym: "immature NKT cell" EXACT [] is_a: CL:0000790 {is_inferred="true"} ! immature alpha-beta T cell intersection_of: CL:0000790 ! immature alpha-beta T cell intersection_of: has_part PR:000003469 ! early growth response protein 2 relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_part PR:000003469 ! early growth response protein 2 [Term] id: CL:0000915 name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell namespace: cell def: "An alpha-beta intraepithelial T cell with the phenotype CD8-alpha-alpha-positive located in the columnar epithelium of the gastrointestinal tract. These cells have a memory phenotype of CD2-negative and CD5-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD8-alpha-alpha-positive, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: develops_from CL:0000811 ! CD8-positive, alpha-beta thymocyte relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 [Term] id: CL:0000916 name: dendritic epidermal T cell namespace: cell def: "A mature gamma-delta T cell located in the epidermis that regulates wound healing." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:11976459] comment: In mice, DETC have an invariant T cell receptor. synonym: "dendritic epidermal T lymphocyte" EXACT [] synonym: "dendritic epidermal T-cell" EXACT [] synonym: "dendritic epidermal T-lymphocyte" EXACT [] synonym: "DETC" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: part_of UBERON:0001003 ! epidermis intersection_of: RO:0002215 GO:0060054 ! capable_of positive regulation of epithelial cell proliferation involved in wound healing relationship: develops_from CL:0002401 ! mature dendritic epithelial T cell precursor relationship: part_of UBERON:0001003 ! epidermis relationship: RO:0002215 GO:0060054 ! capable_of positive regulation of epithelial cell proliferation involved in wound healing [Term] id: CL:0000917 name: Tc1 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing T-bet and eomesodermin and secreting interferon-gamma." [GO_REF:0000031, GOC:add, GOC:pam, PMID:9914231] synonym: "T-cytotoxic T cell type 1" EXACT [] synonym: "Tc1 T cell" EXACT [] synonym: "Tc1 T lymphocyte" EXACT [] synonym: "Tc1 T-cell" EXACT [] synonym: "Tc1 T-lymphocyte" EXACT [] xref: BTO:0004793 xref: BTO:0004888 xref: FMA:84793 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_part PR:000001835 ! T-box transcription factor TBX21 intersection_of: has_part PR:000003463 ! eomesodermin intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: has_part PR:000001835 ! T-box transcription factor TBX21 relationship: has_part PR:000003463 ! eomesodermin relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000918 name: Tc2 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:9914231] synonym: "T-cytotoxic T cell type 2" EXACT [] synonym: "Tc2 T cell" EXACT [] synonym: "Tc2 T lymphocyte" EXACT [] synonym: "Tc2 T-cell" EXACT [] synonym: "Tc2 T-lymphocyte" EXACT [] xref: BTO:0004794 xref: FMA:84794 is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: has_part PR:000001941 ! trans-acting T-cell-specific transcription factor GATA-3 relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000919 name: CD8-positive, CD25-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD25+ T cell" EXACT [] synonym: "CD8+CD25+ T lymphocyte" EXACT [] synonym: "CD8+CD25+ T(reg)" EXACT [] synonym: "CD8+CD25+ T-cell" EXACT [] synonym: "CD8+CD25+ T-lymphocyte " EXACT [] synonym: "CD8+CD25+ Treg" EXACT [] synonym: "CD8-positive, CD25-positive Treg" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD25-positive, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha [Term] id: CL:0000920 name: CD8-positive, CD28-negative, alpha-beta regulatory T cell namespace: cell def: "CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19118505] synonym: "CD8+CD28- T cell" EXACT [] synonym: "CD8+CD28- T lymphocyte" EXACT [] synonym: "CD8+CD28- T(reg)" EXACT [] synonym: "CD8+CD28- T-cell" EXACT [] synonym: "CD8+CD28- T-lymphocyte " EXACT [] synonym: "CD8+CD28- Treg" EXACT [] synonym: "CD8-positive, CD28-negative T(reg)" EXACT [] synonym: "CD8-positive, CD28-negative Treg" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CD28-negative, alpha-beta regulatory T-lymphocyte" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001350 ! forkhead box protein P3 intersection_of: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 relationship: develops_from CL:0000906 ! activated CD8-positive, alpha-beta T cell relationship: has_part PR:000001350 ! forkhead box protein P3 relationship: lacks_plasma_membrane_part PR:000001841 ! T-cell-specific surface glycoprotein CD28 [Term] id: CL:0000921 name: type I NK T cell namespace: cell def: "An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] comment: In mouse the canonical TCR is V-alpha-14, and in humans it is V-alpha 24. synonym: "classical NK T cell" EXACT [] synonym: "invariant NK T cell" RELATED [] synonym: "type I NK T lymphocyte" EXACT [] synonym: "type I NK T-cell" EXACT [] synonym: "type I NK T-lymphocyte" EXACT [] synonym: "type I NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0043208 ! capable_of glycosphingolipid binding relationship: RO:0002215 GO:0043208 ! capable_of glycosphingolipid binding [Term] id: CL:0000922 name: type II NK T cell namespace: cell def: "An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:15039760] synonym: "type II NK T lymphocyte" EXACT [] synonym: "type II NK T-cell" EXACT [] synonym: "type II NK T-lymphocyte" EXACT [] synonym: "type II NKT cell" EXACT [] is_a: CL:0000814 {is_inferred="true"} ! mature NK T cell intersection_of: CL:0000814 ! mature NK T cell intersection_of: RO:0002215 GO:0002288 ! capable_of NK T cell activation involved in immune response relationship: RO:0002215 GO:0002288 ! capable_of NK T cell activation involved in immune response [Term] id: CL:0000923 name: CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T lymphocyte" EXACT [] synonym: "CD4-positive type I NK T-cell" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "CD4-positive type I NKT cell" EXACT [] synonym: "NKT.4+.SP" NARROW [] is_a: CL:0000624 ! CD4-positive, alpha-beta T cell is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule [Term] id: CL:0000924 name: CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has the phenotype CD4-negative and CD8-negative." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18997862] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell" EXACT [] synonym: "NKT.4-.Sp" NARROW [] is_a: CL:0000921 {is_inferred="true"} ! type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0000925 name: activated CD4-positive type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-positive type I NK T lymphocyte" EXACT [] synonym: "activated CD4-positive type I NK T-cell" EXACT [] synonym: "activated CD4-positive type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-positive type I NKT cell" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000923 ! CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000926 name: CD4-positive type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-positive type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-positive type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000927 name: CD4-positive type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm] synonym: "CD4-positive type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-positive type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-positive type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000492 ! CD4-positive helper T cell is_a: CL:0000923 ! CD4-positive type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000925 ! activated CD4-positive type I NK T cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000928 name: activated CD4-negative, CD8-negative type I NK T cell namespace: cell def: "A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "activated CD4-negative, CD8-negative type I NK T lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-cell" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NK T-lymphocyte" EXACT [] synonym: "activated CD4-negative, CD8-negative type I NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002369 ! capable_of T cell cytokine production relationship: develops_from CL:0000924 ! CD4-negative, CD8-negative type I NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002369 ! capable_of T cell cytokine production [Term] id: CL:0000929 name: CD4-negative, CD8-negative type I NK T cell secreting interferon-gamma namespace: cell def: "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IFN-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000930 name: CD4-negative, CD8-negative type I NK T cell secreting interleukin-4 namespace: cell def: "A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17303398] synonym: "CD4-negative, CD8-negative type I NK T cell secreting IL-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-cell secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "CD4-negative, CD8-negative type I NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000924 ! CD4-negative, CD8-negative type I NK T cell intersection_of: CL:0000921 ! type I NK T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000928 ! activated CD4-negative, CD8-negative type I NK T cell relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000931 name: activated type II NK T cell namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "activated type II NK T lymphocyte" EXACT [] synonym: "activated type II NK T-cell" EXACT [] synonym: "activated type II NK T-lymphocyte" EXACT [] synonym: "activated type II NKT cell" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0002369 ! capable_of T cell cytokine production relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0002369 ! capable_of T cell cytokine production [Term] id: CL:0000932 name: type II NK T cell secreting interferon-gamma namespace: cell def: "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, PMID:17964217] synonym: "type II NK T cell secreting IFN-gamma" EXACT [] synonym: "type II NK T lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NK T-cell secreting interferon-gamma" EXACT [] synonym: "type II NK T-lymphocyte secreting interferon-gamma" EXACT [] synonym: "type II NKT cell secreting interferon-gamma" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000933 name: type II NK T cell secreting interleukin-4 namespace: cell def: "A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:17964217] synonym: "type II NK T cell secreting IL-4" EXACT [] synonym: "type II NK T lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NK T-cell secreting interleukin-4" EXACT [] synonym: "type II NK T-lymphocyte secreting interleukin-4" EXACT [] synonym: "type II NKT cell secreting interleukin-4" EXACT [] is_a: CL:0000912 ! helper T cell is_a: CL:0000922 {is_inferred="true"} ! type II NK T cell intersection_of: CL:0000922 ! type II NK T cell intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: develops_from CL:0000931 ! activated type II NK T cell relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production [Term] id: CL:0000934 name: CD4-positive, alpha-beta cytotoxic T cell namespace: cell def: "A CD4-positive, alpha-beta T cell that has cytotoxic function." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:18440213] synonym: "CD4-positive, alpha-beta cytotoxic T lymphocyte" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-cell" EXACT [] synonym: "CD4-positive, alpha-beta cytotoxic T-lymphocyte" EXACT [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell is_a: CL:0000910 ! cytotoxic T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0001913 ! capable_of T cell mediated cytotoxicity [Term] id: CL:0000935 name: CD4-negative, CD8-negative, alpha-beta intraepithelial T cell namespace: cell def: "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." [GO_REF:0000031, GOC:add, GOC:pam, PMID:11685222] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T lymphocyte" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-cell" EXACT [] synonym: "CD4-negative, CD8-negative, alpha-beta intraepithelial T-lymphocyte" EXACT [] is_a: CL:0000797 {is_inferred="true"} ! alpha-beta intraepithelial T cell intersection_of: CL:0000797 ! alpha-beta intraepithelial T cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025403 ! T-cell surface glycoprotein CD8 alpha chain isoform 1 [Term] id: CL:0000936 name: early lymphoid progenitor namespace: cell def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. synonym: "ELP" EXACT [] synonym: "GMLP" RELATED [PMID:18371378] synonym: "LMPP" EXACT [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: RO:0002215 GO:0030098 ! capable_of lymphocyte differentiation [Term] id: CL:0000937 name: pre-natural killer cell namespace: cell def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874] comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. synonym: "pre-NK cell" EXACT [] is_a: CL:0000623 {is_inferred="true"} ! natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor disjoint_from: CL:0002338 ! CD56-positive, CD161-positive immature natural killer cell disjoint_from: CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor [Term] id: CL:0000938 name: CD56-bright cytokine secreting natural killer cell namespace: cell def: "NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19796267] comment: Markers are associated with human cell types. synonym: "CD56-bright cytokine secreting NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production disjoint_from: CL:0000939 ! cytotoxic CD56-dim natural killer cell relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001319 ! SLAM family member 5 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production [Term] id: CL:0000939 name: cytotoxic CD56-dim natural killer cell namespace: cell def: "A mature natural killer cell that has the phenotype CD56-low and CD16-positive and is capable of cytotoxic function and cytokine production." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19796267] comment: This population is mainly found in human. synonym: "cytotoxic CD56-dim NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0042267 ! capable_of natural killer cell mediated cytotoxicity relationship: has_low_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0042267 ! capable_of natural killer cell mediated cytotoxicity [Term] id: CL:0000940 name: mucosal invariant T cell namespace: cell def: "An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19416870] synonym: "mucosal invariant T lymphocyte" EXACT [] synonym: "mucosal invariant T-cell" EXACT [] synonym: "mucosal invariant T-lymphocyte" EXACT [] is_a: CL:0000791 {is_inferred="true"} ! mature alpha-beta T cell is_a: CL:0002127 ! innate effector T cell intersection_of: CL:0000791 ! mature alpha-beta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: RO:0002215 GO:0002227 ! capable_of innate immune response in mucosa intersection_of: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity relationship: has_completed GO:0030217 ! T cell differentiation relationship: RO:0002215 GO:0002227 ! capable_of innate immune response in mucosa relationship: RO:0002215 GO:0032394 ! capable_of MHC class Ib receptor activity [Term] id: CL:0000941 name: thymic conventional dendritic cell namespace: cell def: "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative." [GO_REF:0000031, GOC:add, GOC:pam, PMID:19273629] comment: In the mouse this cell expresses CD8-alpha-alpha. is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: part_of UBERON:0002370 ! thymus relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: part_of UBERON:0002370 ! thymus [Term] id: CL:0000942 name: thymic plasmacytoid dendritic cell namespace: cell def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: develops_from CL:0000894 ! DN1 thymic pro-T cell relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000943 name: Be1 Cell namespace: cell def: "A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be1 cells are also reportedly capable of secreting IL-6, IL-10, and IL-12. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 1 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 1" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production intersection_of: RO:0002215 GO:0032623 ! capable_of interleukin-2 production intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production intersection_of: RO:0002215 GO:0045627 ! capable_of positive regulation of T-helper 1 cell differentiation relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: RO:0002215 GO:0032623 ! capable_of interleukin-2 production relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: RO:0002215 GO:0045627 ! capable_of positive regulation of T-helper 1 cell differentiation [Term] id: CL:0000944 name: Be2 cell namespace: cell def: "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] comment: Be2 cells are also reportedly capable of secreting IL-13 and TNF. They are also reportedly CD11b-negative and B220-positive. synonym: "B effector 2 cell" EXACT [PMID:11101868, PMID:20224569] synonym: "B effector cell type 2" RELATED [] is_a: CL:0000968 {is_inferred="true"} ! Be cell intersection_of: CL:0000968 ! Be cell intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0032623 ! capable_of interleukin-2 production intersection_of: RO:0002215 GO:0032633 ! capable_of interleukin-4 production intersection_of: RO:0002215 GO:0032635 ! capable_of interleukin-6 production intersection_of: RO:0002215 GO:0045630 ! capable_of positive regulation of T-helper 2 cell differentiation relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0032623 ! capable_of interleukin-2 production relationship: RO:0002215 GO:0032633 ! capable_of interleukin-4 production relationship: RO:0002215 GO:0032635 ! capable_of interleukin-6 production relationship: RO:0002215 GO:0045630 ! capable_of positive regulation of T-helper 2 cell differentiation [Term] id: CL:0000945 name: lymphocyte of B lineage namespace: cell def: "A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex." [GO_REF:0000031, GOC:add, GOC:rhs, GOC:tfm, ISBN:0781735149] comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). is_a: CL:0000542 {is_inferred="true"} ! lymphocyte intersection_of: CL:0000542 ! lymphocyte intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: develops_from CL:0000826 ! pro-B cell relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule [Term] id: CL:0000946 name: antibody secreting cell namespace: cell def: "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin." [GO_REF:0000031, GOC:add, GOC:tfm, ISBN:0721601464, ISBN:0781735149] is_a: CL:0000945 {is_inferred="true"} ! lymphocyte of B lineage intersection_of: CL:0000945 ! lymphocyte of B lineage intersection_of: secretes GO:0042571 ! immunoglobulin complex, circulating relationship: secretes GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000947 name: IgE plasma cell namespace: cell def: "A long lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000948 name: IgE memory B cell namespace: cell def: "A class switched memory B cell that expresses IgE on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgE memory B lymphocyte" EXACT [] synonym: "IgE memory B-cell" EXACT [] synonym: "IgE memory B-lymphocyte" EXACT [] synonym: "memory IgE B cell" EXACT [] synonym: "memory IgE B lymphocyte" EXACT [] synonym: "memory IgE B-cell" EXACT [] synonym: "memory IgE B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: has_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex [Term] id: CL:0000949 name: IgD plasmablast namespace: cell def: "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071739 ! IgD immunoglobulin complex, circulating relationship: secretes GO:0071739 ! IgD immunoglobulin complex, circulating [Term] id: CL:0000950 name: IgE plasmablast namespace: cell def: "A plasmablast that secretes IgE." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000951 name: IgE short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgE." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071743 ! IgE immunoglobulin complex, circulating relationship: secretes GO:0071743 ! IgE immunoglobulin complex, circulating [Term] id: CL:0000952 name: preBCR-positive large pre-B-II cell namespace: cell def: "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000953 name: preBCR-negative large pre-B-II cell namespace: cell def: "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes." [GO_REF:0000031, GOC:rhs, GOC:tfm, PMID:9785673] is_a: CL:0000957 {is_inferred="true"} ! large pre-B-II cell intersection_of: CL:0000957 ! large pre-B-II cell intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: lacks_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: lacks_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 [Term] id: CL:0000954 name: small pre-B-II cell namespace: cell def: "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:9785673] comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "small pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: lacks_plasma_membrane_part GO:0019815 ! B cell receptor complex relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: participates_in GO:0071708 ! immunoglobulin light chain V-J recombination [Term] id: CL:0000955 name: pre-B-II cell namespace: cell def: "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:9785673] comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive. synonym: "pre-B-lymphocyte" EXACT [] synonym: "pre-BII cell" EXACT [] xref: BTO:0001133 xref: CALOHA:TS-0819 is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: lacks_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule disjoint_from: CL:0000956 ! pre-B-I cell relationship: develops_from CL:0000826 ! pro-B cell relationship: has_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: lacks_part PR:000006611 ! DNA nucleotidylexotransferase relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule [Term] id: CL:0000956 name: pre-B-I cell namespace: cell def: "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein." [GO_REF:0000031, GOC:dsd, GOC:rhs, GOC:tfm, PMID:16551251, PMID:18432934, PMID:20839338, PMID:9785673] comment: Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive. synonym: "pre-BI cell" EXACT [] synonym: "pro-B cell (Philadelphia nomenclature)" RELATED [PMID:11244048] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: has_part PR:000006611 ! DNA nucleotidylexotransferase intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: develops_from CL:0000826 ! pro-B cell relationship: has_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: has_part PR:000006611 ! DNA nucleotidylexotransferase relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001858 ! immunoglobulin iota chain relationship: has_plasma_membrane_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination [Term] id: CL:0000957 name: large pre-B-II cell namespace: cell def: "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, PMID:16551251, PMID:18432934, PMID:9785673] comment: Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. synonym: "large pre-B cell" BROAD [PMID:11244048] synonym: "large pre-BII cell" EXACT [] is_a: CL:0000955 {is_inferred="true"} ! pre-B-II cell intersection_of: CL:0000955 ! pre-B-II cell intersection_of: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 intersection_of: participates_in GO:0046651 ! lymphocyte proliferation relationship: lacks_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: lacks_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: participates_in GO:0046651 ! lymphocyte proliferation [Term] id: CL:0000958 name: T1 B cell namespace: cell def: "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T1 B lymphocyte" EXACT [] synonym: "T1 B-cell" EXACT [] synonym: "T1 B-lymphocyte" EXACT [] synonym: "transitional stage 1 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000959 name: T2 B cell namespace: cell def: "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2193793, PMID:12810111] comment: T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive. synonym: "T2 B lymphocyte" EXACT [] synonym: "T2 B-cell" EXACT [] synonym: "T2 B-lymphocyte" EXACT [] synonym: "transitional stage 2 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001318 ! L-selectin relationship: develops_from CL:0000958 ! T1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001318 ! L-selectin [Term] id: CL:0000960 name: T3 B cell namespace: cell def: "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM)." [GO_REF:0000031, GOC:msz, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12810111, PMID:17174121] synonym: "An1 B cell" EXACT [PMID:17174121] synonym: "T3 B lymphocyte" EXACT [] synonym: "T3 B-cell" EXACT [] synonym: "T3 B-lymphocyte" EXACT [] synonym: "transitional stage 3 B cell" EXACT [] is_a: CL:0000818 {is_inferred="true"} ! transitional stage B cell intersection_of: CL:0000818 ! transitional stage B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001318 ! L-selectin intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: participates_in GO:0002515 ! B cell anergy relationship: develops_from CL:0000959 ! T2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001318 ! L-selectin relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: participates_in GO:0002515 ! B cell anergy [Term] id: CL:0000961 name: Bm1 B cell namespace: cell def: "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm1 B lymphocyte" EXACT [] synonym: "Bm1 B-cell" EXACT [] synonym: "Bm1 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell is_a: CL:0002056 ! Fraction F mature B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000818 ! transitional stage B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000962 name: Bm2 B cell namespace: cell def: "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:17992590, PMID:18432934, PMID:8006591] comment: These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2 B lymphocyte" EXACT [] synonym: "Bm2 B-cell" EXACT [] synonym: "Bm2 B-lymphocyte" EXACT [] is_a: CL:0000843 {is_inferred="true"} ! follicular B cell intersection_of: CL:0000843 ! follicular B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: develops_from CL:0000961 ! Bm1 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor [Term] id: CL:0000963 name: Bm3-delta B cell namespace: cell def: "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive." [GO_REF:0000031, GOC:add, GOC:msz, GOC:tfm, PMID:9280752] synonym: "Bm3-delta B lymphocyte" EXACT [] synonym: "Bm3-delta B-cell" EXACT [] synonym: "Bm3-delta B-lymphocyte" EXACT [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000965 ! Bm3 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000964 name: Bm2' B cell namespace: cell def: "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:17992590, PMID:18432934, PMID:8006591] comment: Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative. synonym: "Bm2' B lymphocyte" EXACT [] synonym: "Bm2' B-cell" EXACT [] synonym: "Bm2' B-lymphocyte" EXACT [] synonym: "Bm2-prime B cell" EXACT [] synonym: "Bm2-prime B lymphocyte " EXACT [] synonym: "Bm2-prime B-cell " EXACT [] synonym: "Bm2-prime B-lymphocyte " EXACT [] synonym: "germinal center founder cell" RELATED [] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: RO:0002215 GO:0002634 ! capable_of regulation of germinal center formation relationship: develops_from CL:0000962 ! Bm2 B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: RO:0002215 GO:0002634 ! capable_of regulation of germinal center formation [Term] id: CL:0000965 name: Bm3 B cell namespace: cell def: "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive. synonym: "Bm3 B lymphocyte" EXACT [] synonym: "Bm3 B-cell" EXACT [] synonym: "Bm3 B-lymphocyte" EXACT [] synonym: "centroblast" RELATED [PMID:8006591] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: RO:0002215 GO:0016446 ! capable_of somatic hypermutation of immunoglobulin genes relationship: develops_from CL:0000964 ! Bm2' B cell relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: RO:0002215 GO:0016446 ! capable_of somatic hypermutation of immunoglobulin genes [Term] id: CL:0000966 name: Bm4 B cell namespace: cell def: "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor." [GO_REF:0000031, GOC:dsd, GOC:msz, PMID:18432934, PMID:8006591] comment: Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive. synonym: "Bm4 B lymphocyte" EXACT [] synonym: "Bm4 B-cell" EXACT [] synonym: "Bm4 B-lymphocyte" EXACT [] synonym: "centrocyte" RELATED [PMID:17992590] is_a: CL:0000844 {is_inferred="true"} ! germinal center B cell intersection_of: CL:0000844 ! germinal center B cell intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase relationship: develops_from CL:0000963 ! Bm3-delta B cell relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000003516 ! lactosylceramide 4-alpha-galactosyltransferase [Term] id: CL:0000967 name: Bm5 B cell namespace: cell def: "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMID:18432934, PMID:8006591] comment: Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative. synonym: "Bm5 B lymphocyte" EXACT [] synonym: "Bm5 B-cell" EXACT [] synonym: "Bm5 B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0002314 ! germinal center B cell differentiation intersection_of: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: develops_from CL:0000966 ! Bm4 B cell relationship: has_completed GO:0002314 ! germinal center B cell differentiation relationship: has_completed GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000968 name: Be cell namespace: cell def: "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." [GO_REF:0000031, GOC:msz, GOC:tfm, PMID:11101868, PMID:20224569] synonym: "B effector cell" EXACT [] synonym: "effector B cell" EXACT [] synonym: "effector B lymphocyte" EXACT [] synonym: "effector B-cell" EXACT [] synonym: "effector B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0043370 ! capable_of regulation of CD4-positive, alpha-beta T cell differentiation relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0043370 ! capable_of regulation of CD4-positive, alpha-beta T cell differentiation [Term] id: CL:0000969 name: regulatory B cell namespace: cell def: "A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, MESH:D060151, PMID:11869683, PMID:18482568, PMID:20224569, PMID:20809522] comment: Regulatory B cells reportedly represent 1-2% of the spleen and 7-8% of the peritoneal B220-positive cells in mice. They are also found in the bone marrow, lymph node, and blood of mice. These cells are also reportedly capable of secreting IL-10 and are reportedly CD5-positive, CD21-positive, CD24-positive, CD93-negative, B220-positive, IgM-positive, and IgD-positive. synonym: "B(reg)" EXACT [] synonym: "B10 cell" EXACT [] synonym: "Breg" EXACT [] synonym: "regulatory B lymphocyte" EXACT [] synonym: "regulatory B-cell" EXACT [] synonym: "regulatory B-lymphocyte" EXACT [] is_a: CL:0000785 {is_inferred="true"} ! mature B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000002028 ! T-cell surface glycoprotein CD1d intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response relationship: has_plasma_membrane_part PR:000002028 ! T-cell surface glycoprotein CD1d relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0050777 ! capable_of negative regulation of immune response [Term] id: CL:0000970 name: unswitched memory B cell namespace: cell def: "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive and/or IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013] comment: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive. synonym: "unswitched memory B lymphocyte" EXACT [] synonym: "unswitched memory B-cell" EXACT [] synonym: "unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: develops_from CL:0000980 ! plasmablast relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071742 ! IgE immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 [Term] id: CL:0000971 name: IgM memory B cell namespace: cell def: "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:19447676] comment: IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive. synonym: "IgM memory B lymphocyte" EXACT [] synonym: "IgM memory B-cell" EXACT [] synonym: "IgM memory B-lymphocyte" EXACT [] synonym: "memory IgM B cell" EXACT [] synonym: "memory IgM B lymphocyte" EXACT [] synonym: "memory IgM B-cell" EXACT [] synonym: "memory IgM B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0000972 name: class switched memory B cell namespace: cell def: "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are usually CD27-positive and have either IgG, IgE, or IgA on the cell surface." [GO_REF:0000031, GOC:dsd, GOC:rhs, ISBN:0781765196, PMID:20933013] comment: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive. synonym: "class switched memory B lymphocyte" EXACT [] synonym: "class switched memory B-cell" EXACT [] synonym: "class switched memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: has_completed GO:0045190 ! isotype switching intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: develops_from CL:0000970 ! unswitched memory B cell relationship: has_completed GO:0045190 ! isotype switching relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex [Term] id: CL:0000973 name: IgA memory B cell namespace: cell def: "A class switched memory B cell that expresses IgA." [GO_REF:0000031, GOC:dsd, GOC:msz, ISBN:0781765196] comment: IgA memory B cell are also reportedly RORalpha-positive. synonym: "IgA memory B lymphocyte" EXACT [] synonym: "IgA memory B-cell" EXACT [] synonym: "IgA memory B-lymphocyte" EXACT [] synonym: "memory IgA B cell" EXACT [] synonym: "memory IgA B lymphocyte" EXACT [] synonym: "memory IgA B-cell" EXACT [] synonym: "memory IgA B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex relationship: has_plasma_membrane_part GO:0071745 ! IgA immunoglobulin complex [Term] id: CL:0000974 name: long lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow." [GO_REF:0000031, GOC:msz, GOC:tfm, ISBN:9780781765190, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 intersection_of: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0000975 ! short lived plasma cell relationship: has_high_plasma_membrane_amount PR:000001208 ! C-X-C chemokine receptor type 4 relationship: has_high_plasma_membrane_amount PR:000001935 ! syndecan-1 relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part GO:0019814 ! immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0000975 name: short lived plasma cell namespace: cell def: "A fully differentiated plasma cell that lives for months." [GO_REF:0000031, GOC:msz, PMID:16014527] is_a: CL:0000786 {is_inferred="true"} ! plasma cell intersection_of: CL:0000786 ! plasma cell intersection_of: bearer_of PATO:0001604 ! decreased life span relationship: bearer_of PATO:0001604 ! decreased life span relationship: develops_from CL:0000980 ! plasmablast [Term] id: CL:0000976 name: IgA short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000977 name: IgG short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000978 name: IgM short lived plasma cell namespace: cell def: "A short lived plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000975 {is_inferred="true"} ! short lived plasma cell intersection_of: CL:0000975 ! short lived plasma cell intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000979 name: IgG memory B cell namespace: cell def: "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface." [GO_REF:0000031, GOC:rhs, ISBN:0781765196] synonym: "IgG memory B lymphocyte" EXACT [] synonym: "IgG memory B-cell" EXACT [] synonym: "IgG memory B-lymphocyte" EXACT [] synonym: "memory IgG B cell" EXACT [] synonym: "memory IgG B lymphocyte" EXACT [] synonym: "memory IgG B-cell" EXACT [] synonym: "memory IgG B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0000980 name: plasmablast namespace: cell def: "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative." [GO_REF:0000031, GOC:dsd, GOC:msz, GOC:tfm, PMCID:PMC2673126] comment: Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative. xref: FMA:84371 is_a: CL:0000785 {is_inferred="true"} ! mature B cell is_a: CL:0000946 ! antibody secreting cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 intersection_of: secretes GO:0042571 ! immunoglobulin complex, circulating relationship: develops_from CL:0000785 ! mature B cell relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part PR:000001935 ! syndecan-1 relationship: secretes GO:0042571 ! immunoglobulin complex, circulating [Term] id: CL:0000981 name: double negative memory B cell namespace: cell def: "A memory B cell with the phenotype IgD-negative and CD27-negative." [GO_REF:0000031, GOC:msz, GOC:tfm] synonym: "dn memory B cell" EXACT [] synonym: "dn memory B lymphocyte" EXACT [] synonym: "dn memory B-cell" EXACT [] synonym: "dn memory B-lymphocyte" EXACT [] synonym: "double negative memory B lymphocyte" EXACT [] synonym: "double negative memory B-cell" EXACT [] synonym: "double negative memory B-lymphocyte" EXACT [] is_a: CL:0000787 {is_inferred="true"} ! memory B cell intersection_of: CL:0000787 ! memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule [Term] id: CL:0000982 name: IgG plasmablast namespace: cell def: "A plasmablast that secretes IgG." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000983 name: IgM plasmablast namespace: cell def: "A plasmablast that secretes IgM." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000984 name: IgA plasmablast namespace: cell def: "A plasmablast that secretes IgA." [GO_REF:0000031, GOC:msz] is_a: CL:0000980 {is_inferred="true"} ! plasmablast intersection_of: CL:0000980 ! plasmablast intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000985 name: IgG plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgG." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071736 ! IgG immunoglobulin complex, circulating relationship: secretes GO:0071736 ! IgG immunoglobulin complex, circulating [Term] id: CL:0000986 name: IgM plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgM." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071754 ! IgM immunoglobulin complex, circulating relationship: secretes GO:0071754 ! IgM immunoglobulin complex, circulating [Term] id: CL:0000987 name: IgA plasma cell namespace: cell def: "A fully differentiated plasma cell that secretes IgA." [GO_REF:0000031, GOC:msz, ISBN:781735149] is_a: CL:0000974 {is_inferred="true"} ! long lived plasma cell intersection_of: CL:0000974 ! long lived plasma cell intersection_of: secretes GO:0071746 ! IgA immunoglobulin complex, circulating relationship: secretes GO:0071746 ! IgA immunoglobulin complex, circulating [Term] id: CL:0000988 name: hematopoietic cell namespace: cell def: "A cell of a hematopoietic lineage." [GO_REF:0000031, GOC:add] synonym: "haematopoietic cell" EXACT [] synonym: "haemopoietic cell" EXACT [] synonym: "hemopoietic cell" EXACT [] xref: BTO:0000574 xref: CALOHA:TS-2017 xref: FMA:70366 xref: FMA:83598 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell [Term] id: CL:0000989 name: CD11c-low plasmacytoid dendritic cell namespace: cell def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8). is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M [Term] id: CL:0000990 name: conventional dendritic cell namespace: cell def: "Conventional dendritic cell is a dendritic cell that is CD11c-high." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive. synonym: "cDC" EXACT [] synonym: "DC1" EXACT [] synonym: "dendritic reticular cell" EXACT [] synonym: "interdigitating cell" BROAD [] synonym: "type 1 DC" EXACT [] synonym: "veiled cell" BROAD [] xref: FMA:84191 is_a: CL:0000451 {is_inferred="true"} ! dendritic cell intersection_of: CL:0000451 ! dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001013 ! integrin alpha-X [Term] id: CL:0000991 name: CD11c-negative plasmacytoid dendritic cell namespace: cell def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10). synonym: "CD303-positive dendritic cell" EXACT [] is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell intersection_of: CL:0000784 ! plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C intersection_of: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001292 ! C-type lectin domain family 4 member C relationship: has_plasma_membrane_part PR:000001398 ! leukocyte immunoglobulin-like receptor subfamily A member 4 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production [Term] id: CL:0000992 name: immature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000006)(PMID:19243617). is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000993 name: mature CD11c-low plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD83-high and is CD80-positive, CD86-positive, and MHCII-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000007)(PMID:19243617). is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000992 ! immature CD11c-low plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000994 name: immature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000008)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule intersection_of: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation relationship: develops_from CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: lacks_plasma_membrane_part PR:000001438 ! CD80 molecule relationship: RO:0002215 GO:0019882 ! capable_of antigen processing and presentation [Term] id: CL:0000995 name: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617). synonym: "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid" BROAD [] is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor union_of: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor [Term] id: CL:0000996 name: mature CD11c-negative plasmacytoid dendritic cell namespace: cell def: "Mature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000009)(PMID:19243617). is_a: CL:0000991 {is_inferred="true"} ! CD11c-negative plasmacytoid dendritic cell intersection_of: CL:0000991 ! CD11c-negative plasmacytoid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000994 ! immature CD11c-negative plasmacytoid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0000997 name: immature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0000998 name: CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells." [GO_REF:0000031, GOC:amm, http:www.immgen.org/index_content.html, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617). synonym: "DC.8-4-11b-" EXACT [] synonym: "triple negative dendritic cell" EXACT [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0002474 ! capable_of antigen processing and presentation of peptide antigen via MHC class I relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0002474 ! capable_of antigen processing and presentation of peptide antigen via MHC class I [Term] id: CL:0000999 name: CD4-positive CD11b-positive dendritic cell namespace: cell def: "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617). synonym: "DC.4+" EXACT [] is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0050728 ! capable_of negative regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0050728 ! capable_of negative regulation of inflammatory response [Term] id: CL:0001000 name: CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617). synonym: "DC.8+" EXACT [] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production intersection_of: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I intersection_of: RO:0002215 GO:0050729 ! capable_of positive regulation of inflammatory response relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: RO:0002215 GO:0050729 ! capable_of positive regulation of inflammatory response [Term] id: CL:0001001 name: immature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001002 name: mature CD8_alpha-negative CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000998 {is_inferred="true"} ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: CL:0000998 ! CD8_alpha-negative CD11b-negative dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule intersection_of: RO:0002215 GO:0001816 ! capable_of cytokine production relationship: develops_from CL:0001001 ! immature CD8_alpha-negative CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: RO:0002215 GO:0001816 ! capable_of cytokine production [Term] id: CL:0001003 name: mature CD8_alpha-negative CD11b-positive dendritic cell namespace: cell def: "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0000999 {is_inferred="true"} ! CD4-positive CD11b-positive dendritic cell intersection_of: CL:0000999 ! CD4-positive CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0000997 ! immature CD8_alpha-negative CD11b-positive dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001004 name: immature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001005 name: mature CD8_alpha-positive CD11b-negative dendritic cell namespace: cell def: "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001000 {is_inferred="true"} ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: CL:0001000 ! CD8_alpha-positive CD11b-negative dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001004 ! immature CD8_alpha-positive CD11b-negative dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001006 name: dermal dendritic cell namespace: cell def: "Dermal dendritic cell is a conventional dendritic cell that is CD11b-positive, CD205-positive and CD8 alpha-negative." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000019)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD288-positive (TLR8), and CD289-positive (TLR9). xref: BTO:0004812 is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: part_of UBERON:0002067 ! dermis relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001026 ! lymphocyte antigen 75 relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: part_of UBERON:0002067 ! dermis [Term] id: CL:0001007 name: interstitial dendritic cell namespace: cell def: "Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10). is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001300 ! CD209 molecule intersection_of: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001300 ! CD209 molecule relationship: has_plasma_membrane_part PR:000001905 ! platelet glycoprotein 4 relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002972 ! macrophage mannose receptor 1 [Term] id: CL:0001008 name: Kit and Sca1-positive hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:17952047, PMID:19022770] comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617). synonym: "LSK stem cell" EXACT [] synonym: "Sca1-positive hematopoietic stem cell" EXACT [] is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 intersection_of: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 disjoint_from: CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: lacks_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001009 name: immature dermal dendritic cell namespace: cell def: "Immature dermal dendritic cell is a dermal dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000022)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001010 name: mature dermal dendritic cell namespace: cell def: "Mature dermal dendritic cell is a dermal dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: Originally described in the dendritic cell ontology (DC_CL:0000023)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001009 ! immature dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001011 name: immature interstitial dendritic cell namespace: cell def: "Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000024)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001012 name: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617). is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0000557 ! granulocyte monocyte progenitor cell union_of: CL:0001027 ! CD7-negative lymphoid progenitor cell [Term] id: CL:0001013 name: mature interstitial dendritic cell namespace: cell def: "Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000025)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001007 {is_inferred="true"} ! interstitial dendritic cell intersection_of: CL:0001007 ! interstitial dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001011 ! immature interstitial dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001014 name: CD1a-positive Langerhans cell namespace: cell def: "CD1a-positive Langerhans cell is a Langerhans_cell that is CD1a-positive and CD324-positive." [GO_REF:0000031, GOC:amm, PMID:17850486] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000026)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD286-positive (TLR6), CD287-positive (TLR7), and CD290-positive (TLR10). When activated, these cells are capable of producing IL-6, IL-8, and IL-15. synonym: "CD1a-LC" EXACT [] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part PR:000001447 ! epithelial cadherin intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000001447 ! epithelial cadherin relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0001015 name: CD8_alpha-low Langerhans cell namespace: cell def: "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9). is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 intersection_of: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_high_plasma_membrane_amount PR:000001026 ! lymphocyte antigen 75 relationship: has_low_plasma_membrane_amount PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain [Term] id: CL:0001016 name: immature CD1a-positive Langerhans cell namespace: cell def: "Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000028)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001017 name: mature CD1a-positive Langerhans cell namespace: cell def: "Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:17850486] comment: Originally described in the dendritic cell ontology (DC_CL:0000029)(PMID:19243617). When activated, these cells produce IL-6, IL-8, and IL-15. is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001014 {is_inferred="true"} ! CD1a-positive Langerhans cell intersection_of: CL:0001014 ! CD1a-positive Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001016 ! immature CD1a-positive Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001018 name: immature CD8_alpha-low Langerhans cell namespace: cell def: "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low." [GO_REF:0000031, GOC:amm, GOC:tfm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617). is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: develops_from CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0001019 name: CD115-positive monocyte OR common dendritic progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617). is_a: CL:0002031 ! hematopoietic lineage restricted progenitor cell union_of: CL:0001022 ! CD115-positive monocyte union_of: CL:0001029 ! common dendritic progenitor [Term] id: CL:0001020 name: mature CD8_alpha-low Langerhans cell namespace: cell def: "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GO_REF:0000031, GOC:amm, PMCID:PMC2346585] comment: These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617). is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0001015 {is_inferred="true"} ! CD8_alpha-low Langerhans cell intersection_of: CL:0001015 ! CD8_alpha-low Langerhans cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0001018 ! immature CD8_alpha-low Langerhans cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0001021 name: CD34-positive, CD38-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMCID:PMC2346585, PMID:19022770] comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617). synonym: "CD10-positive common lymphocyte precursor" EXACT [] synonym: "CD10-positive common lymphocyte progenitor" EXACT [] synonym: "CD10-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001898 ! neprilysin disjoint_from: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001022 name: CD115-positive monocyte namespace: cell def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617). is_a: CL:0000576 {is_inferred="true"} ! monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor [Term] id: CL:0001023 name: Kit-positive, CD34-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:1261582, PMID:17952047] comment: Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617). synonym: "CD117-positive common myeloid precursor" BROAD [] is_a: CL:0000049 {is_inferred="true"} ! common myeloid progenitor intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: develops_from CL:0002035 ! Slamf1-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_low_plasma_membrane_amount PR:000001481 ! low affinity immunoglobulin gamma Fc region receptor II-b relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 [Term] id: CL:0001024 name: CD34-positive, CD38-negative hematopoietic stem cell namespace: cell def: "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, PMID:10430905, PMID:11750107, PMID:16551251, PMID:20024907, PMID:9389721] comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617). synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871] xref: CALOHA:TS-0448 xref: FMA:86475 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001786 ! prominin-1 intersection_of: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein intersection_of: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001786 ! prominin-1 relationship: has_plasma_membrane_part PR:000001809 ! CD59-like glycoprotein relationship: has_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000001892 ! CD33 molecule relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 [Term] id: CL:0001025 name: Kit-positive, Sca1-positive common lymphoid progenitor namespace: cell def: "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low." [GO_REF:0000031, GOC:add, GOC:amm, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17952047] comment: Markers are associated with mouse cells. synonym: "CD217-positive common lymphocyte precursor" EXACT [] synonym: "CD217-positive common lymphocyte progenitor" EXACT [] synonym: "CD217-positive common lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0000936 ! early lymphoid progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_low_plasma_membrane_amount PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0001026 name: CD34-positive, CD38-positive common myeloid progenitor namespace: cell def: "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative." [GO_REF:0000031, GOC:add, GOC:amm, PMCID:PMC2626675, PMID:16551251] comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617). synonym: "CD71-positive common myeloid precursor" NARROW [] is_a: CL:0000049 {is_inferred="true"} ! common myeloid progenitor intersection_of: CL:0000049 ! common myeloid progenitor intersection_of: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001898 ! neprilysin relationship: develops_from CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: has_low_plasma_membrane_amount PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001898 ! neprilysin [Term] id: CL:0001027 name: CD7-negative lymphoid progenitor cell namespace: cell def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617). synonym: "CD7-negative lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: develops_from CL:0001021 ! CD34-positive, CD38-positive common lymphoid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001836 ! CD7 molecule [Term] id: CL:0001028 name: CD7-positive lymphoid progenitor cell namespace: cell def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395] comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617). synonym: "CD7-positive lymphoid precursor" EXACT [] is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor intersection_of: CL:0000051 ! common lymphoid progenitor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001836 ! CD7 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: develops_from CL:0001027 ! CD7-negative lymphoid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001836 ! CD7 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA [Term] id: CL:0001029 name: common dendritic progenitor namespace: cell def: "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:17922016, PMID:19286519] comment: Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617). synonym: "CDP" EXACT [PMID:21219184] synonym: "common dendritic precursor" EXACT [] synonym: "pro-DCs" EXACT [PMID:21219184] is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002009 ! macrophage dendritic cell progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 [Term] id: CL:0001030 name: CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor namespace: cell comment: Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617). is_a: CL:0002032 ! hematopoietic oligopotent progenitor cell union_of: CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor [Term] id: CL:0001031 name: cerebellar granule cell namespace: cell def: "Granule cell that is part of the cerebellum." [GOC:mah] xref: BTO:0004278 is_a: CL:0000120 {is_inferred="true"} ! granule cell intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0002037 ! cerebellum relationship: part_of UBERON:0002037 ! cerebellum [Term] id: CL:0001032 name: cortical granule cell namespace: cell def: "Granule cell that is part of the cerebral cortex." [GOC:mah] is_a: CL:0000120 ! granule cell is_a: CL:0002609 ! neuron of cerebral cortex intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0000956 ! cerebral cortex relationship: part_of UBERON:0000956 ! cerebral cortex [Term] id: CL:0001033 name: hippocampal granule cell namespace: cell def: "Granule cell that is part of the hippocampus." [GOC:mah] is_a: CL:0001032 ! cortical granule cell is_a: CL:0002608 ! hippocampal neuron intersection_of: CL:0000120 ! granule cell intersection_of: part_of UBERON:0001954 ! Ammon's horn relationship: part_of UBERON:0001954 ! Ammon's horn [Term] id: CL:0001034 name: cell in vitro namespace: cell def: "A cell that has been removed from a natural environment, and placed in a controlled artificial environment for use in some investigation. Includes multicellular organism cells removed from an organism, and unicellular organisms removed from a natural environment." [ReO:mhb] comment: 'In vitro', translating literally to 'in glass', typically refers to a controlled, often sterile, laboratory setting where cells or other specimens are placed by some agent for the purpose of studying or manipulating them as part of some research investigation. This term is intended to contrast with 'native', which refers to cells or other biological entities that are found in a natural setting. is_a: CL:0000000 ! cell created_by: haendel creation_date: 2012-01-12T09:58:38Z [Term] id: CL:0001035 name: bone cell namespace: cell def: "A connective tissue cell found in bone." [GO_REF:0000034, GOC:add] is_a: CL:0000548 {is_inferred="true"} ! animal cell intersection_of: CL:0000548 ! animal cell intersection_of: part_of UBERON:0001474 ! bone element relationship: part_of UBERON:0001474 ! bone element created_by: adiehl creation_date: 2011-11-16T04:28:16Z [Term] id: CL:0001039 name: terminally differentiated osteoblast namespace: cl def: "Osteoblast that is terminally differentiated, located adjacent to acellular or cellular bone tissue within periosteum, and is capable of mineralizing the matrix." [VSAO:curator] xref: VSAO:0000116 is_a: CL:0000062 ! osteoblast [Term] id: CL:0001040 name: non-terminally differentiated osteoblast namespace: cl def: "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." [VSAO:curator] comment: VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118 xref: VSAO:0000117 is_a: CL:0000062 ! osteoblast is_a: CL:0001035 ! bone cell relationship: part_of UBERON:0002481 ! bone tissue [Term] id: CL:0001041 name: CD8-positive, CXCR3-positive, alpha-beta regulatory T cell namespace: cell def: "A CD8-positive alpha-beta-positive T cell with the phenotype CXCR3-positive and having suppressor function. They are capable of producing IL-10, suppressing proliferation, and suppressing IFN-gamma production." [GOC:dsd, PMID:19609979] comment: These cells may be the human equivalent of murine CD8-positive, CD122-positive alpha-beta regulatory T cell. They are also found in the CD45RA-negative and CD62L-positive fraction. synonym: "CD8+CXCR3+ T cell" EXACT [] synonym: "CD8+CXCR3+ T lymphocyte" EXACT [] synonym: "CD8+CXCR3+ T(reg)" EXACT [] synonym: "CD8+CXCR3+ T-cell" EXACT [] synonym: "CD8+CXCR3+ T-lymphocyte " EXACT [] synonym: "CD8+CXCR3+ Treg" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-cell" EXACT [] synonym: "CD8-positive, CXCR3-positive, alpha-beta regulatory T-lymphocyte" EXACT [] synonym: "CD8-positive, CXCR3-positive, T(reg)" EXACT [] synonym: "CD8-positive, CXCR3-positive, Treg" EXACT [] is_a: CL:0000795 {is_inferred="true"} ! CD8-positive, alpha-beta regulatory T cell intersection_of: CL:0000795 ! CD8-positive, alpha-beta regulatory T cell intersection_of: has_part PR:000001207 ! C-X-C chemokine receptor type 3 intersection_of: RO:0002215 GO:0032613 ! capable_of interleukin-10 production intersection_of: RO:0002215 GO:0032689 ! capable_of negative regulation of interferon-gamma production intersection_of: RO:0002215 GO:0042130 ! capable_of negative regulation of T cell proliferation relationship: has_part PR:000001207 ! C-X-C chemokine receptor type 3 relationship: RO:0002215 GO:0032613 ! capable_of interleukin-10 production relationship: RO:0002215 GO:0032689 ! capable_of negative regulation of interferon-gamma production relationship: RO:0002215 GO:0042130 ! capable_of negative regulation of T cell proliferation [Term] id: CL:0001042 name: T-helper 22 cell namespace: cell def: "CD4-positive, alpha-beta T cell that produces IL-22." [GOC:dsd, PMID:19578368, PMID:19578369] comment: TH22 cells are also reportedly CCR4-positive, CCR6-positive, CCR10-positive, CXCR3-negative. TH22 cells are reportedly capable of secreting IL-13. synonym: "helper T cell type 22" EXACT [] synonym: "T(H)-22 cell" EXACT [] synonym: "Th22 cell" EXACT [] synonym: "Th22 T cell" EXACT [] synonym: "Th22 T lymphocyte" EXACT [] synonym: "Th22 T-cell" EXACT [] synonym: "Th22 T-lymphocyte" EXACT [] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: RO:0002215 GO:0032626 ! capable_of interleukin-22 production relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: RO:0002215 GO:0032626 ! capable_of interleukin-22 production [Term] id: CL:0001658 name: visual pigment cell (sensu Nematoda and Protostomia) namespace: cell xref: FBbt:00004230 is_a: CL:0000149 ! visual pigment cell is_a: CL:0000341 ! pigment cell (sensu Nematoda and Protostomia) [Term] id: CL:0002000 name: Kit-positive erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:19805084] comment: Markers found on mouse cells. is_a: CL:0000038 {is_inferred="true"} ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001345 ! endoglin intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001345 ! endoglin relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part GO:0033001 ! Fc-gamma receptor III complex relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T10:14:16Z [Term] id: CL:0002001 name: CD34-positive, CD38-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:19022770] comment: Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0001026 ! CD34-positive, CD38-positive common myeloid progenitor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:19:22Z [Term] id: CL:0002002 name: Kit-positive granulocyte monocyte progenitor namespace: cell def: "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:16322423, PMID:19022770, PMID:19273628] comment: Markers are found on mouse cells. is_a: CL:0000557 {is_inferred="true"} ! granulocyte monocyte progenitor cell intersection_of: CL:0000557 ! granulocyte monocyte progenitor cell intersection_of: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0001023 ! Kit-positive, CD34-positive common myeloid progenitor relationship: has_high_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_high_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:19:28Z [Term] id: CL:0002003 name: CD34-positive, GlyA-negative erythroid progenitor cell namespace: cell def: "An erythroid progenitor cell that is CD34-positive and is GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell markers associated with human cells. xref: FMA:83517 is_a: CL:0000038 {is_inferred="true"} ! erythroid progenitor cell intersection_of: CL:0000038 ! erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:14:30Z [Term] id: CL:0002004 name: CD34-negative, GlyA-negative proerythroblast namespace: cell def: "A proerythoblast that is CD34-negative and GlyA-negative." [GOC:ak, GOC:tfm, PMID:19621348] comment: Cell surface markers are associated with human cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002003 ! CD34-positive, GlyA-negative erythroid progenitor cell relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:31:50Z [Term] id: CL:0002005 name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700] comment: Markers are associated with human cell type. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-13T03:43:10Z [Term] id: CL:0002006 name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell namespace: cell def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell intersection_of: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_low_plasma_membrane_amount GO:0033001 ! Fc-gamma receptor III complex relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-13T03:43:12Z [Term] id: CL:0002007 name: Kit-low, CD34-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell." [GOC:tfm, PMID:17582345] comment: Markers are found on mouse cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-14T03:25:15Z [Term] id: CL:0002008 name: CD34-positive, CD38-positive eosinophil progenitor cell namespace: cell def: "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." [GOC:tfm, PMCID:PMC2626675] comment: Markers are associated with human cells. is_a: CL:0000611 {is_inferred="true"} ! eosinophil progenitor cell intersection_of: CL:0000611 ! eosinophil progenitor cell intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain relationship: develops_from CL:0002001 ! CD34-positive, CD38-positive granulocyte monocyte progenitor relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001865 ! interleukin-3 receptor class 2 alpha chain created_by: tmeehan creation_date: 2010-01-14T03:25:17Z [Term] id: CL:0002009 name: macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages." [GOC:tfm, PMID:19273628] synonym: "MDP" EXACT [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell intersection_of: CL:0002032 ! hematopoietic oligopotent progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation intersection_of: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: RO:0002215 GO:0043011 ! capable_of myeloid dendritic cell differentiation created_by: tmeehan creation_date: 2010-01-19T02:51:58Z [Term] id: CL:0002010 name: pre-conventional dendritic cell namespace: cell def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm] is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell intersection_of: CL:0002031 ! hematopoietic lineage restricted progenitor cell intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 intersection_of: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0001029 ! common dendritic progenitor relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-19T03:39:30Z [Term] id: CL:0002011 name: Kit-positive macrophage dendritic cell progenitor namespace: cell def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628] comment: Markers are associated with mouse cells. synonym: "murine MDP" EXACT [] is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor intersection_of: CL:0002009 ! macrophage dendritic cell progenitor intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: develops_from CL:0002002 ! Kit-positive granulocyte monocyte progenitor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor created_by: tmeehan creation_date: 2010-01-26T02:43:40Z [Term] id: CL:0002012 name: Kit-low proerythroblast namespace: cell def: "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive." [GOC:ak, GOC:tfm, PMID:19805084] comment: Markers are associated with mouse cells. is_a: CL:0000547 {is_inferred="true"} ! proerythroblast intersection_of: CL:0000547 ! proerythroblast intersection_of: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002000 ! Kit-positive erythroid progenitor cell relationship: has_high_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:31:56Z [Term] id: CL:0002013 name: GlyA-positive basophillic erythroblast namespace: cell def: "A basophilic erythroblast that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers are associated with human cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002004 ! CD34-negative, GlyA-negative proerythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T10:41:15Z [Term] id: CL:0002014 name: Kit-negative, Ly-76 high basophilic erythroblast namespace: cell def: "A basophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers are associated with mouse cells. is_a: CL:0000549 {is_inferred="true"} ! basophilic erythroblast intersection_of: CL:0000549 ! basophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002012 ! Kit-low proerythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:41:22Z [Term] id: CL:0002015 name: Kit-negative, Ly-76 high polychromatophilic erythroblast namespace: cell def: "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] synonym: "late basophilic and polychromatophilic erythroblast" BROAD [] is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002014 ! Kit-negative, Ly-76 high basophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T10:53:11Z [Term] id: CL:0002016 name: CD71-low, GlyA-positive polychromatic erythroblast namespace: cell def: "A polychromatiic erythroblast that is Gly-A-positive and CD71-low." [GOC:ak, GOC:tfm, PMID:1638021] comment: Cell surface markers are associated with human cells. is_a: CL:0000550 {is_inferred="true"} ! polychromatophilic erythroblast intersection_of: CL:0000550 ! polychromatophilic erythroblast intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002013 ! GlyA-positive basophillic erythroblast relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T10:53:16Z [Term] id: CL:0002017 name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts namespace: cell def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084] comment: Cell surface markers associated with mouse cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 intersection_of: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002015 ! Kit-negative, Ly-76 high polychromatophilic erythroblast relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: has_low_plasma_membrane_amount PR:000001945 ! transferrin receptor protein 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T11:04:15Z [Term] id: CL:0002018 name: CD71-negative, GlyA-positive orthochromatic erythroblast namespace: cell def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers associated with human cells. is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast intersection_of: CL:0000552 ! orthochromatic erythroblast intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A intersection_of: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 relationship: develops_from CL:0002016 ! CD71-low, GlyA-positive polychromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: lacks_plasma_membrane_part PR:000001945 ! transferrin receptor protein 1 created_by: tmeehan creation_date: 2010-04-26T11:04:21Z [Term] id: CL:0002019 name: Ly-76 high reticulocyte namespace: cell def: "A reticulocyte that is Ly76-high and is Kit-negative." [GOC:ak, GOC:tfm, PMID:18539294] comment: Marker associated with mouse cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002017 ! Kit-negative, Ly-76 high orthochromatophilic erythroblasts relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:37:00Z [Term] id: CL:0002020 name: GlyA-positive reticulocytes namespace: cell def: "A reticulocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:1638021] comment: Markers is associated with human cells. is_a: CL:0002422 {is_inferred="true"} ! enucleated reticulocyte intersection_of: CL:0002422 ! enucleated reticulocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002018 ! CD71-negative, GlyA-positive orthochromatic erythroblast relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:48:25Z [Term] id: CL:0002021 name: GlyA-positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094] comment: Marker is associated with human cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_plasma_membrane_part PR:000001460 ! glycophorin-A relationship: develops_from CL:0002020 ! GlyA-positive reticulocytes relationship: has_plasma_membrane_part PR:000001460 ! glycophorin-A created_by: tmeehan creation_date: 2010-04-26T11:51:22Z [Term] id: CL:0002022 name: Ly-76 high positive erythrocyte namespace: cell def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084] comment: Marker is associated with mouse cell types. is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 relationship: develops_from CL:0002019 ! Ly-76 high reticulocyte relationship: has_high_plasma_membrane_amount PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-04-26T11:51:27Z [Term] id: CL:0002023 name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell namespace: cell def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are associated with human cell type. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002025 ! CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-26T02:39:09Z [Term] id: CL:0002024 name: Kit-positive megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553] comment: Markers are associated with mouse cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002006 ! Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell relationship: has_low_plasma_membrane_amount PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_low_plasma_membrane_amount PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-26T02:39:15Z [Term] id: CL:0002025 name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell intersection_of: CL:0000553 ! megakaryocyte progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: develops_from CL:0002005 ! CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain created_by: tmeehan creation_date: 2010-04-26T03:52:47Z [Term] id: CL:0002026 name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell namespace: cell def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614] comment: Markers are commonly associated with human cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002023 ! CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000001907 ! platelet glycoprotein Ib alpha chain relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-04-26T03:59:22Z [Term] id: CL:0002027 name: CD9-positive, CD41-positive megakaryocyte cell namespace: cell def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm] comment: Markers are commonly associated with mouse cells. is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte intersection_of: CL:0000556 ! megakaryocyte intersection_of: has_plasma_membrane_part PR:000005178 ! CD9 molecule intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002024 ! Kit-positive megakaryocyte progenitor cell relationship: has_plasma_membrane_part PR:000005178 ! CD9 molecule relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-04-27T10:39:07Z [Term] id: CL:0002028 name: basophil mast progenitor cell namespace: cell def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421] comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low. synonym: "BMCP" EXACT [] is_a: CL:0002191 ! granulocytopoietic cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha intersection_of: has_part PR:000007857 ! erythroid transcription factor intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 intersection_of: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 intersection_of: RO:0002215 GO:0030221 ! capable_of basophil differentiation intersection_of: RO:0002215 GO:0060374 ! capable_of mast cell differentiation relationship: develops_from CL:0000557 ! granulocyte monocyte progenitor cell relationship: has_part PR:000005307 ! CCAAT/enhancer-binding protein alpha relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 relationship: has_plasma_membrane_part PR:000001867 ! interleukin-5 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000016401 ! transmembrane emp24 domain-containing protein 1 relationship: RO:0002215 GO:0030221 ! capable_of basophil differentiation relationship: RO:0002215 GO:0060374 ! capable_of mast cell differentiation created_by: tmeehan creation_date: 2010-04-27T12:46:33Z [Term] id: CL:0002029 name: Fc-epsilon RIalpha-low mast cell progenitor namespace: cell def: "A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low." [GOC:tfm, PMCID:PMC1312421] is_a: CL:0000831 {is_inferred="true"} ! mast cell progenitor intersection_of: CL:0000831 ! mast cell progenitor intersection_of: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000009143 ! integrin beta-7 intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_low_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000009143 ! integrin beta-7 relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:19Z [Term] id: CL:0002030 name: Fc-epsilon RIalpha-high basophil progenitor cell namespace: cell def: "A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high." [GOC:tfm, PMCID:PMC1312421] comment: Markers are associated with mouse cells. is_a: CL:0000613 {is_inferred="true"} ! basophil progenitor cell intersection_of: CL:0000613 ! basophil progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: develops_from CL:0002044 ! Kit-positive, integrin beta7-high basophil mast progenitor cell relationship: has_high_plasma_membrane_amount PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:32Z [Term] id: CL:0002031 name: hematopoietic lineage restricted progenitor cell namespace: cell def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770] is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001400 ! unipotent disjoint_from: CL:0002032 ! hematopoietic oligopotent progenitor cell relationship: bearer_of PATO:0001400 ! unipotent relationship: develops_from CL:0002032 ! hematopoietic oligopotent progenitor cell created_by: tmeehan creation_date: 2010-01-06T03:43:20Z [Term] id: CL:0002032 name: hematopoietic oligopotent progenitor cell namespace: cell def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers." [GOC:tfm, PMID:19022770] is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell intersection_of: CL:0000988 ! hematopoietic cell intersection_of: bearer_of PATO:0001401 ! oligopotent intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G intersection_of: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 relationship: bearer_of PATO:0001401 ! oligopotent relationship: develops_from CL:0000837 ! hematopoietic multipotent progenitor cell relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002978 ! lymphocyte antigen 6G relationship: lacks_plasma_membrane_part PR:000002981 ! lymphocyte antigen 76 created_by: tmeehan creation_date: 2010-01-06T03:43:27Z [Term] id: CL:0002033 name: short term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." [GOC:tfm, PMID:15572596, PMID:19022770] comment: Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low. synonym: "ST stem cell" EXACT [] synonym: "ST-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: develops_from CL:0002034 ! long term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor created_by: tmeehan creation_date: 2010-01-08T09:19:25Z [Term] id: CL:0002034 name: long term hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." [GOC:tfm, PMID:15572596, PMID:17582345] comment: Markers are associated with mouse cells. synonym: "LT stem cell" EXACT [] synonym: "LT-HSC" EXACT [] is_a: CL:0001008 {is_inferred="true"} ! Kit and Sca1-positive hematopoietic stem cell intersection_of: CL:0001008 ! Kit and Sca1-positive hematopoietic stem cell intersection_of: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: has_low_plasma_membrane_amount PR:000001843 ! Thy-1 membrane glycoprotein relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor created_by: tmeehan creation_date: 2010-01-08T09:19:28Z [Term] id: CL:0002035 name: Slamf1-negative multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor relationship: develops_from CL:0002036 ! Slamf1-positive multipotent progenitor cell relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: lacks_plasma_membrane_part PR:000002001 ! FL cytokine receptor created_by: tmeehan creation_date: 2010-01-08T11:16:33Z [Term] id: CL:0002036 name: Slamf1-positive multipotent progenitor cell namespace: cell def: "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive." [GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. synonym: "KSL cell" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 disjoint_from: CL:0002043 ! CD34-positive, CD38-negative multipotent progenitor cell relationship: develops_from CL:0002033 ! short term hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-01-08T11:16:35Z [Term] id: CL:0002037 name: CD2-positive, CD5-positive, CD44-positive alpha-beta intraepithelial T cell namespace: cell def: "Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive." [GOC:tfm, PMID:16048545] synonym: "memory alpha beta IEL" EXACT [PMID:16048545] is_a: CL:0000793 {is_inferred="true"} ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: CL:0000793 ! CD4-positive, alpha-beta intraepithelial T cell intersection_of: has_plasma_membrane_part PR:000001083 ! CD2 molecule intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001083 ! CD2 molecule relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 created_by: tmeehan creation_date: 2009-10-20T02:20:43Z [Term] id: CL:0002038 name: T follicular helper cell namespace: cell def: "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production." [GOC:tfm, PMID:19855402, PMID:20107805, PMID:22043829] synonym: "follicular B helper T cell" RELATED [PMID:22043829] synonym: "follicular helper T cell" RELATED [PMID:22649468] synonym: "follicular helper T-cell" RELATED [PMID:22508770] synonym: "follicular T cell" RELATED [PMID:20107805, PMID:21914188] synonym: "follicular T-cell" RELATED [] synonym: "follicular T-helper cell" RELATED [PMID:22552227] synonym: "T(FH)" EXACT [PMID:20207847] synonym: "Tfh" EXACT [PMID:20107805, PMID:20383172] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_part PR:000003450 ! B-cell lymphoma 6 protein intersection_of: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 intersection_of: RO:0002215 GO:0045830 ! capable_of positive regulation of isotype switching intersection_of: RO:0002215 GO:0051024 ! capable_of positive regulation of immunoglobulin secretion relationship: develops_from CL:0000896 ! activated CD4-positive, alpha-beta T cell relationship: has_part PR:000003450 ! B-cell lymphoma 6 protein relationship: has_plasma_membrane_part PR:000001209 ! C-X-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: lacks_plasma_membrane_part PR:000001203 ! C-C chemokine receptor type 7 relationship: RO:0002215 GO:0045830 ! capable_of positive regulation of isotype switching relationship: RO:0002215 GO:0051024 ! capable_of positive regulation of immunoglobulin secretion created_by: tmeehan creation_date: 2009-10-29T04:01:27Z [Term] id: CL:0002039 name: immature NK T cell stage I namespace: cell def: "A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, PMID:17589542] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0000809 ! double-positive, alpha-beta thymocyte relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:09:16Z [Term] id: CL:0002040 name: immature NK T cell stage II namespace: cell def: "A CD24-low, CD44-negative, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org. synonym: "NKT.44-NK1.1-.Th" EXACT [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002039 ! immature NK T cell stage I relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:13:43Z [Term] id: CL:0002041 name: immature NK T cell stage III namespace: cell def: "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." [PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002040 ! immature NK T cell stage II relationship: has_low_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:14:48Z [Term] id: CL:0002042 name: immature NK T cell stage IV namespace: cell def: "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:17589542] synonym: "NKT.44+.NK1.1-.Th" BROAD [] is_a: CL:0000914 {is_inferred="true"} ! immature NK T cell intersection_of: CL:0000914 ! immature NK T cell intersection_of: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: develops_from CL:0002041 ! immature NK T cell stage III relationship: has_high_plasma_membrane_amount PR:000001008 ! integrin alpha-2 relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: lacks_plasma_membrane_part PR:000001874 ! KLRB1-like protein created_by: tmeehan creation_date: 2009-10-29T04:17:38Z [Term] id: CL:0002043 name: CD34-positive, CD38-negative multipotent progenitor cell namespace: cell def: "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative." [GOC:tfm, PMID:18371405, PMID:19022770] comment: Cell markers are associated with human hematopoietic multipotent progenitor cells. is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell intersection_of: CL:0000837 ! hematopoietic multipotent progenitor cell intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein relationship: develops_from CL:0001024 ! CD34-positive, CD38-negative hematopoietic stem cell relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001843 ! Thy-1 membrane glycoprotein created_by: tmeehan creation_date: 2010-01-12T11:14:15Z [Term] id: CL:0002044 name: Kit-positive, integrin beta7-high basophil mast progenitor cell namespace: cell def: "A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative." [GOC:ak, GOC:tfm] comment: Markers are associated with mouse cells. is_a: CL:0002028 {is_inferred="true"} ! basophil mast progenitor cell intersection_of: CL:0002028 ! basophil mast progenitor cell intersection_of: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 intersection_of: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_high_plasma_membrane_amount PR:000009143 ! integrin beta-7 relationship: has_plasma_membrane_part PR:000001479 ! low affinity immunoglobulin gamma Fc region receptor II relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: lacks_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-04-27T01:22:38Z [Term] id: CL:0002045 name: Fraction A pre-pro B cell namespace: cell def: "A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive." [GOC:ak, GOC:tfm, http://www.immgen.org/index_content.html, PMID:12633665, PMID:17582343] comment: Markers associated with mouse cells. synonym: "fraction A" EXACT [] synonym: "pre pro B cell" RELATED [] is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C created_by: tmeehan creation_date: 2010-04-28T10:50:07Z [Term] id: CL:0002046 name: early pro-B cell namespace: cell def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000826 {is_inferred="true"} ! pro-B cell intersection_of: CL:0000826 ! pro-B cell intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 intersection_of: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001289 ! membrane-spanning 4-domains subfamily A member 1 relationship: lacks_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: participates_in GO:0071707 ! immunoglobulin heavy chain V-D-J recombination created_by: tmeehan creation_date: 2010-04-28T11:19:11Z [Term] id: CL:0002047 name: Fraction B precursor B cell namespace: cell def: "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." [GOC:ak, GOC:tfm, PMID:18432934] comment: Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive. synonym: "Fr. B" EXACT [] synonym: "Fraction B" EXACT [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002045 ! Fraction A pre-pro B cell relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T11:56:21Z [Term] id: CL:0002048 name: late pro-B cell namespace: cell def: "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive." [GOC:dsd, GOC:tfm, PMID:18432934] comment: Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive. is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002046 ! early pro-B cell relationship: has_low_plasma_membrane_amount PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T12:06:06Z [Term] id: CL:0002049 name: Fraction C precursor B cell namespace: cell def: "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." [GOC:tfm, PMID:17582343] synonym: "Fraction C" RELATED [] is_a: CL:0002400 {is_inferred="true"} ! Fraction B/C precursor B cell intersection_of: CL:0002400 ! Fraction B/C precursor B cell intersection_of: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination intersection_of: has_part PR:000001858 ! immunoglobulin iota chain intersection_of: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 intersection_of: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 relationship: develops_from CL:0002047 ! Fraction B precursor B cell relationship: has_not_completed GO:0071707 ! immunoglobulin heavy chain V-D-J recombination relationship: has_part PR:000001858 ! immunoglobulin iota chain relationship: has_part PR:000001859 ! immunoglobulin lambda-like polypeptide 1 relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: has_plasma_membrane_part PR:000003457 ! V(D)J recombination-activating protein 1 relationship: has_plasma_membrane_part PR:000003460 ! V(D)J recombination-activating protein 2 created_by: tmeehan creation_date: 2010-04-28T02:04:01Z [Term] id: CL:0002050 name: Fraction C' precursor B cell namespace: cell def: "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." [GOC:tfm, PMID:17582343] synonym: "Fr. C'" EXACT [] synonym: "Fraction C-prime" EXACT [] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: develops_from CL:0002049 ! Fraction C precursor B cell relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase created_by: tmeehan creation_date: 2010-04-28T02:13:46Z [Term] id: CL:0002051 name: CD38-high pre-BCR positive cell namespace: cell def: "A pre-BCR positive T cell that is CD38-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cells. synonym: "large pre-B cell type I" RELATED [] is_a: CL:0000952 {is_inferred="true"} ! preBCR-positive large pre-B-II cell intersection_of: CL:0000952 ! preBCR-positive large pre-B-II cell intersection_of: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002048 ! late pro-B cell relationship: has_high_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T02:27:47Z [Term] id: CL:0002052 name: Fraction D precursor B cell namespace: cell def: "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:17582343, PMID:18432934] comment: Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative. synonym: "Fr. D" EXACT [] synonym: "Fraction D pre-B cell" EXACT [GOC:tfm] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase intersection_of: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex relationship: develops_from CL:0002050 ! Fraction C' precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_not_completed GO:0071708 ! immunoglobulin light chain V-J recombination relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002039 ! glutamyl aminopeptidase relationship: lacks_plasma_membrane_part GO:0035369 ! pre-B cell receptor complex created_by: tmeehan creation_date: 2010-04-28T02:55:16Z [Term] id: CL:0002053 name: CD22-positive, CD38-low small pre-B cell namespace: cell def: "A small pre-B cell that is CD22-positive and CD38-low." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell. RAG expression maybe diminishing. synonym: "small pre-B cell" EXACT [] is_a: CL:0000954 {is_inferred="true"} ! small pre-B-II cell intersection_of: CL:0000954 ! small pre-B-II cell intersection_of: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 intersection_of: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 relationship: develops_from CL:0002051 ! CD38-high pre-BCR positive cell relationship: has_low_plasma_membrane_amount PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001288 ! B-cell receptor CD22 created_by: tmeehan creation_date: 2010-04-28T03:04:48Z [Term] id: CL:0002054 name: Fraction E immature B cell namespace: cell def: "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive." [GOC:ak, GOC:dsd, GOC:tfm, PMID:17582343, PMID:18432934] comment: Markers associated with mouse cells. These cells are also reportedly sIgD-negative. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_low_plasma_membrane_amount PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: develops_from CL:0002052 ! Fraction D precursor B cell relationship: has_low_plasma_membrane_amount PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: lacks_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha created_by: tmeehan creation_date: 2010-04-28T03:13:47Z [Term] id: CL:0002055 name: CD38-negative immature B cell namespace: cell def: "An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high." [GOC:tfm, PMID:18432934] comment: Markers are associated with human cell type. is_a: CL:0000816 {is_inferred="true"} ! immature B cell intersection_of: CL:0000816 ! immature B cell intersection_of: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 intersection_of: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000001898 ! neprilysin intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: develops_from CL:0002053 ! CD22-positive, CD38-low small pre-B cell relationship: has_high_plasma_membrane_amount PR:000001288 ! B-cell receptor CD22 relationship: has_low_plasma_membrane_amount PR:000001338 ! complement receptor type 2 relationship: has_low_plasma_membrane_amount PR:000001898 ! neprilysin relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 created_by: tmeehan creation_date: 2010-04-28T03:19:14Z [Term] id: CL:0002056 name: Fraction F mature B cell namespace: cell def: "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative." [GOC:tfm, PMID:17582343] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: develops_from CL:0002054 ! Fraction E immature B cell relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000001880 ! low affinity immunoglobulin epsilon Fc receptor relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor created_by: tmeehan creation_date: 2010-04-30T03:01:48Z [Term] id: CL:0002057 name: CD14-positive, CD16-negative classical monocyte namespace: cell def: "A monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive," [GOC:tfm, PMID:15615263, PMID:1706877, PMID:19689341] comment: Markers are associated with human monocytes. is_a: CL:0000860 {is_inferred="true"} ! classical monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 relationship: has_plasma_membrane_part PR:000001465 ! high affinity immunoglobulin gamma Fc receptor I relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001925 ! scavenger receptor cysteine-rich type 1 protein M130 created_by: tmeehan creation_date: 2010-06-05T08:25:41Z [Term] id: CL:0002058 name: Gr1-low non-classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive." [GOC:tfm, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. Also, this cell-type is sometimes described as being Gr1-negative. is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: develops_from CL:0002398 ! Gr1-positive, CD43-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001199 ! C-C chemokine receptor type 2 relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R created_by: tmeehan creation_date: 2010-06-05T08:25:44Z [Term] id: CL:0002059 name: CD8alpha-positive thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-positive." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "CD8alpha-alpha-positive thymic conventional dendritic cell" EXACT [] synonym: "DC.8+.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-06-07T02:48:36Z [Term] id: CL:0002060 name: melanophage namespace: cell def: "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes." [GOC:tfm, PMID:20479296, PMID:2943821] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_part CHEBI:25179 ! melanin intersection_of: part_of UBERON:0002097 ! skin of body relationship: has_part CHEBI:25179 ! melanin relationship: part_of UBERON:0002097 ! skin of body created_by: tmeehan creation_date: 2010-06-22T10:46:12Z [Term] id: CL:0002061 name: T-helper 9 cell namespace: cell def: "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." [GOC:tfm, PMID:18931678, PMID:19604299, PMID:20154671] synonym: "T helper cells type 9" EXACT [] synonym: "T(H)-9 cell" EXACT [] synonym: "Th9" EXACT [PMID:18931678] is_a: CL:0000492 {is_inferred="true"} ! CD4-positive helper T cell intersection_of: CL:0000492 ! CD4-positive helper T cell intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B intersection_of: RO:0002215 GO:0002215 ! capable_of defense response to nematode intersection_of: RO:0002215 GO:0032638 ! capable_of interleukin-9 production relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: RO:0002215 GO:0002215 ! capable_of defense response to nematode relationship: RO:0002215 GO:0032638 ! capable_of interleukin-9 production created_by: tmeehan creation_date: 2010-06-22T11:18:44Z [Term] id: CL:0002062 name: type I pneumocyte namespace: cell def: "A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange." [GOC:tfm, http://www.copewithcytokines.de, PMID:20054144] synonym: "AT1" EXACT [] synonym: "ATI" EXACT [] synonym: "lung type 1 cells" EXACT [] synonym: "membranous pneumocytes" EXACT [] synonym: "pulmonary alveolar type I cell" EXACT [] synonym: "small alveolar cells" EXACT [] synonym: "squamous alveolar cell" EXACT [] synonym: "squamous alveolar lining cell" EXACT [] synonym: "type 1 alveolar epithelial cells" EXACT [] synonym: "type 1 pneumocyte" EXACT [] synonym: "type I alveolar cells" EXACT [] synonym: "type I alveolar epithelial cells" EXACT [] xref: BTO:0000780 xref: FMA:62500 is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0007585 ! capable_of respiratory gaseous exchange relationship: RO:0002215 GO:0007585 ! capable_of respiratory gaseous exchange created_by: tmeehan creation_date: 2010-06-23T04:37:54Z [Term] id: CL:0002063 name: type II pneumocyte namespace: cell def: "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." [GOC:tfm, http://www.copewithcytokines.de, ISBN:0412046911, PMID:8540632] synonym: "AT2" EXACT [] synonym: "ATII" EXACT [] synonym: "cuboidal type II cell" EXACT [] synonym: "granular pneumocyte" EXACT [] synonym: "great alveolar cell" EXACT [] synonym: "lung type 2 cell" EXACT [] synonym: "lung type II cell" RELATED [] synonym: "TII" EXACT [] synonym: "type 2 alveolar epithelial cell" EXACT [] synonym: "type 2 alveolocyte" EXACT [] synonym: "type 2 pneumocyte" EXACT [] synonym: "type II alveolar cell" EXACT [] synonym: "type II alveolar epithelial cell" EXACT [] synonym: "type II alveolocyte" EXACT [] xref: BTO:0000538 xref: FMA:62501 is_a: CL:0000157 ! surfactant secreting cell is_a: CL:0000322 ! pneumocyte intersection_of: CL:0000322 ! pneumocyte intersection_of: RO:0002215 GO:0032940 ! capable_of secretion by cell intersection_of: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis relationship: RO:0002215 GO:0032940 ! capable_of secretion by cell relationship: RO:0002215 GO:0043129 ! capable_of surfactant homeostasis created_by: tmeehan creation_date: 2010-06-24T12:04:13Z [Term] id: CL:0002064 name: pancreatic acinar cell namespace: cell def: "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells, ISBN:0517223651, PMID:20395539] synonym: "acinar cell of pancreas" EXACT [] xref: BTO:0000028 xref: CALOHA:TS-0737 xref: FMA:63032 is_a: CL:0000622 {is_inferred="true"} ! acinar cell is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000622 ! acinar cell intersection_of: part_of UBERON:0001263 ! pancreatic acinus relationship: has_part GO:0042589 ! zymogen granule membrane relationship: part_of UBERON:0001263 ! pancreatic acinus created_by: tmeehan creation_date: 2010-06-24T03:16:29Z [Term] id: CL:0002066 name: Feyrter cell namespace: cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] synonym: "P cell" BROAD [] synonym: "respiratory enterochromaffin cell " EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell created_by: tmeehan creation_date: 2010-06-28T08:24:30Z [Term] id: CL:0002067 name: type A enterocrine cell namespace: cell def: "An enterocrine cell that produces glucagon." [GOC:tfm, ISBN:0412046911] xref: FMA:62939 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000170 ! glucagon secreting cell created_by: tmeehan creation_date: 2010-09-10T10:48:54Z [Term] id: CL:0002068 name: Purkinje myocyte namespace: cell def: "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." [FMA:0412046911, GOC:tfm, PMID:19939742] synonym: "myocytus conducens cardiacus" EXACT [] synonym: "Purkinje cell fiber" EXACT [] synonym: "Purkinje muscle cell" EXACT [] xref: BTO:0001032 xref: FMA:14146 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-28T08:36:15Z [Term] id: CL:0002069 name: type II vestibular sensory cell namespace: cell def: "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices." [GOC:tfm, ISBN:0517223651] synonym: "type 2 vestibular hair cell" EXACT [] synonym: "type 2 vestibular sensory cell" EXACT [] synonym: "type II hair cell" EXACT [] xref: FMA:67909 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:13Z [Term] id: CL:0002070 name: type I vestibular sensory cell namespace: cell def: "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending." [GOC:tfm, ISBN:0517223651] synonym: "type 1 vestibular hair cell" EXACT [] synonym: "type 1 vestibular sensory cell" EXACT [] synonym: "type I hair cell" EXACT [] xref: FMA:62352 is_a: CL:0000609 ! vestibular hair cell created_by: tmeehan creation_date: 2010-06-29T09:58:19Z [Term] id: CL:0002071 name: enterocyte of epithelium of large intestine namespace: cell def: "Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type." [GOC:tfm, ISBN:0517223651] synonym: "columnar cell" BROAD [] synonym: "columnar cell of the colon" EXACT [] synonym: "vacuolar absorptive cell" EXACT [] xref: BTO:0002484 xref: FMA:63638 xref: FMA:66771 is_a: CL:0000584 ! enterocyte is_a: CL:0002253 {is_inferred="true"} ! epithelial cell of large intestine intersection_of: CL:0000584 ! enterocyte intersection_of: part_of UBERON:0001278 ! epithelium of large intestine relationship: part_of UBERON:0001278 ! epithelium of large intestine created_by: tmeehan creation_date: 2010-06-29T11:07:25Z [Term] id: CL:0002072 name: nodal myocyte namespace: cell def: "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery." [FMA:67101, GOC:tfm] synonym: "cardiac pacemaker cell" EXACT [GOC:pr] synonym: "myocytus nodalis" EXACT [] synonym: "P cell" EXACT [] synonym: "pacemaker cell" BROAD [] xref: BTO:0004190 xref: FMA:67101 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:41:37Z [Term] id: CL:0002073 name: transitional myocyte namespace: cell def: "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes." [FMA:67142, GOC:tfm] xref: FMA:67142 is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T02:39:32Z [Term] id: CL:0002074 name: myocardial endocrine cell namespace: cell def: "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." [FMA:67111, GOC:tfm] xref: FMA:67111 is_a: CL:0000163 ! endocrine cell is_a: CL:0002086 ! specialized cardiac myocyte created_by: tmeehan creation_date: 2010-06-29T11:50:47Z [Term] id: CL:0002075 name: brush cell of trachebronchial tree namespace: cell def: "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "pulmonary brush cell" RELATED [] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0002204 ! brush cell intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-06-29T03:22:46Z [Term] id: CL:0002076 name: endo-epithelial cell namespace: cell def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm] xref: FMA:69075 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000223 ! endodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:14Z [Term] id: CL:0002077 name: ecto-epithelial cell namespace: cell def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm] xref: FMA:69074 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000221 ! ectodermal cell created_by: tmeehan creation_date: 2010-06-29T03:38:22Z [Term] id: CL:0002078 name: meso-epithelial cell namespace: cell def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm] synonym: "epithelial mesenchymal cell" EXACT [] xref: FMA:69076 is_a: CL:0000066 ! epithelial cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000222 ! mesodermal cell created_by: tmeehan creation_date: 2010-06-29T03:49:14Z [Term] id: CL:0002079 name: pancreatic ductal cell namespace: cell def: "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH." [FMA:63099, GOC:tfm, PMID:14740223] xref: FMA:63099 is_a: CL:1000488 ! cholangiocyte is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: part_of UBERON:0001064 ! ventral pancreatic duct intersection_of: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001064 ! ventral pancreatic duct relationship: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity created_by: tmeehan creation_date: 2010-06-30T08:49:43Z [Term] id: CL:0002080 name: pancreatic centro-acinar cell namespace: cell def: "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." [GOC:tfm, PMID:12142741, PMID:20018761, PMID:8185160] synonym: "centroacinar cell of Langerhans" EXACT [] synonym: "pancreatic centroacinar cell" EXACT [] xref: FMA:62455 is_a: CL:1001433 ! epithelial cell of exocrine pancreas intersection_of: CL:0000083 ! epithelial cell of pancreas intersection_of: part_of UBERON:0001263 ! pancreatic acinus intersection_of: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity relationship: part_of UBERON:0001263 ! pancreatic acinus relationship: RO:0002215 GO:0015106 ! capable_of bicarbonate transmembrane transporter activity created_by: tmeehan creation_date: 2010-06-30T08:49:52Z [Term] id: CL:0002081 name: type II cell of carotid body namespace: cell def: "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery." [GOC:tfm, http://en.wikipedia.org/wiki/Carotid_body, PMID:7938227] synonym: "sheath cell of carotid body" EXACT [] xref: FMA:84187 is_a: CL:0000703 ! sustentacular cell is_a: CL:0002256 ! supporting cell of carotid body created_by: tmeehan creation_date: 2010-06-30T04:23:42Z [Term] id: CL:0002082 name: type II cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces epinephrine." [GOC:tfm] synonym: "adremergic chromaffin cell" EXACT [] synonym: "adrenal secreting cell of the adrenal medulla" EXACT [] synonym: "epiniphrine secreting cell of the adrenal medulla" EXACT [] xref: FMA:69322 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000454 ! epinephrine secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla intersection_of: RO:0002215 GO:0048242 ! capable_of epinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla relationship: RO:0002215 GO:0048242 ! capable_of epinephrine secretion created_by: tmeehan creation_date: 2010-07-14T09:41:42Z [Term] id: CL:0002083 name: type I cell of adrenal medulla namespace: cell def: "A chromaffin cell of the adrenal medulla that produces norepinephrine." [GOC:tfm, ISBN:068340007X] synonym: "noradrenergic chromaffin cell" EXACT [] xref: FMA:69321 is_a: CL:0000336 {is_inferred="true"} ! adrenal medulla chromaffin cell is_a: CL:0000459 ! norepinephrin secreting cell intersection_of: CL:0000336 ! adrenal medulla chromaffin cell intersection_of: part_of UBERON:0001236 ! adrenal medulla intersection_of: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion relationship: part_of UBERON:0001236 ! adrenal medulla relationship: RO:0002215 GO:0048243 ! capable_of norepinephrine secretion created_by: tmeehan creation_date: 2010-07-14T10:12:24Z [Term] id: CL:0002084 name: Boettcher cell namespace: cell def: "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." [GOC:tfm, http://en.wikipedia.org/wiki/Boettcher_cell] synonym: "Boettcher's cell" EXACT [] synonym: "Bottcher cell" EXACT [] synonym: "Bottcher's cell" EXACT [] is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-07-14T03:22:02Z [Term] id: CL:0002085 name: tanycyte namespace: cell alt_id: CL:0000643 def: "Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle." [GOC:tfm, http://neurolex.org/wiki/Category\:Tanycyte] synonym: "stretch cell" EXACT [] xref: BTO:0001953 xref: FMA:54560 is_a: CL:0000683 ! ependymoglial cell created_by: tmeehan creation_date: 2010-07-15T11:21:11Z [Term] id: CL:0002086 name: specialized cardiac myocyte namespace: cell def: "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." [FMA:67968, GOC:tfm] xref: FMA:67968 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-07-21T01:33:38Z [Term] id: CL:0002087 name: nongranular leukocyte namespace: cell def: "A leukocyte that lacks granules." [GOC:tfm] synonym: "agranular leukocyte" EXACT [] xref: FMA:62855 is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: lacks_part GO:0030141 ! secretory granule relationship: lacks_part GO:0030141 ! secretory granule created_by: tmeehan creation_date: 2010-07-22T11:30:33Z [Term] id: CL:0002088 name: interstitial cell of Cajal namespace: cell def: "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise." [GOC:tfm, PMID:16460275, PMID:19520112] comment: Some argue this cell type is of mesenchymal origin. synonym: "ICC" EXACT [] synonym: "intestinal pacemaker cell" EXACT [GOC:pr] xref: BTO:0003914 xref: FMA:86573 is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: RO:0002215 GO:0043134 ! capable_of regulation of hindgut contraction relationship: RO:0002215 GO:0043134 ! capable_of regulation of hindgut contraction created_by: tmeehan creation_date: 2010-07-22T03:26:00Z [Term] id: CL:0002089 name: nuocyte namespace: cell def: "A leukocyte cell capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:tfm, PMID:20200518] is_a: CL:0000738 {is_inferred="true"} ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B intersection_of: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 intersection_of: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 intersection_of: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha intersection_of: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response intersection_of: RO:0002215 GO:0032616 ! capable_of interleukin-13 production relationship: has_plasma_membrane_part PR:000001860 ! inducible T-cell costimulator relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000008982 ! interleukin-17 receptor B relationship: has_plasma_membrane_part PR:000008994 ! interleukin-1 receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001326 ! bone marrow stromal antigen 2 relationship: lacks_plasma_membrane_part PR:000001893 ! natural cytotoxicity triggering receptor 1 relationship: lacks_plasma_membrane_part PR:000001927 ! sialic acid-binding Ig-like lectin 5 relationship: lacks_plasma_membrane_part PR:000007431 ! high affinity immunoglobulin epsilon receptor subunit alpha relationship: RO:0002215 GO:0002830 ! capable_of positive regulation of type 2 immune response relationship: RO:0002215 GO:0032616 ! capable_of interleukin-13 production created_by: tmeehan creation_date: 2010-08-12T02:22:19Z [Term] id: CL:0002090 name: polar body namespace: cell def: "One of two small cells formed by the first and second meiotic division of oocytes." [GOC:tfm, http://en.wikipedia.org/wiki/Polar_body, ISBN:068340007X] xref: EHDAA2:0004716 xref: FMA:85543 xref: WBbt:0008429 xref: XAO:0000262 is_a: CL:0000021 ! female germ cell created_by: tmeehan creation_date: 2010-08-23T09:49:53Z [Term] id: CL:0002091 name: primary polar body namespace: cell def: "A small cell formed by the first meiotic division of oocytes." [GOC:tfm, ISBN:068340007X] synonym: "first polar body" EXACT [EHDAA2:0000541] synonym: "polocytus primarius" EXACT [FMA:18650] xref: EHDAA2:0000541 xref: EMAPA:16032 xref: FMA:18650 xref: VHOG:0000464 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:49:58Z [Term] id: CL:0002092 name: bone marrow cell namespace: cell def: "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." [GOC:tfm, ISBN:0618947256] comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense. xref: BTO:0004850 xref: FMA:83621 is_a: CL:0001035 {is_inferred="true"} ! bone cell intersection_of: CL:0001035 ! bone cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-07-22T04:48:15Z [Term] id: CL:0002093 name: secondary polar body namespace: cell def: "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." [GOC:tfm, ISBN:068340007X] synonym: "polocytus secundarius" EXACT [FMA:18651] synonym: "second polar body" EXACT [EHDAA2:0001820] xref: EHDAA2:0001820 xref: EMAPA:16034 xref: EMAPA:16045 xref: FMA:18651 is_a: CL:0002090 ! polar body created_by: tmeehan creation_date: 2010-08-23T09:50:01Z [Term] id: CL:0002094 name: interstitial cell of ovary namespace: cell def: "A cell that makes up the loose connective tissue of the ovary." [GOC:tfm] xref: FMA:18709 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:11:34Z [Term] id: CL:0002095 name: hilus cell of ovary namespace: cell def: "A cell in the hilum of the ovary that produces androgens." [GOC:tfm, ISBN:068340007X] synonym: "hilar cell of ovary" EXACT [] xref: FMA:18710 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T11:18:18Z [Term] id: CL:0002096 name: internodal tract myocyte namespace: cell def: "A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals." [GOC:tfm, ISBN:0781729300] xref: FMA:223275 is_a: CL:0002086 ! specialized cardiac myocyte intersection_of: CL:0000187 ! muscle cell intersection_of: part_of UBERON:0009966 ! internodal tract relationship: part_of UBERON:0009966 ! internodal tract created_by: tmeehan creation_date: 2010-08-23T11:24:11Z [Term] id: CL:0002097 name: cortical cell of adrenal gland namespace: cell def: "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol." [GOC:tfm] synonym: "adrenal cortex cell" EXACT [] synonym: "adrenocortical cell" EXACT [] xref: FMA:69545 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000174 ! steroid hormone secreting cell is_a: CL:0002078 {is_inferred="true"} ! meso-epithelial cell intersection_of: CL:0002078 ! meso-epithelial cell intersection_of: part_of UBERON:0001235 ! adrenal cortex relationship: part_of UBERON:0001235 ! adrenal cortex created_by: tmeehan creation_date: 2010-08-24T01:37:44Z [Term] id: CL:0002098 name: regular cardiac myocyte namespace: cell def: "A cardiac myocyte that is connected together by transverse intercalated discs at a regular interval." [GOC:tfm] synonym: "regular cardiac muscle cell" EXACT [] synonym: "regular cardiac muscle fiber" EXACT [] xref: FMA:67967 is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-08-23T11:33:10Z [Term] id: CL:0002099 name: type I cell of adrenal cortex namespace: cell alt_id: CL:1000423 def: "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." [GOC:tfm, ISBN:0517223651] synonym: "epithelial cell of zona glomerulosa of adrenal gland" EXACT [] xref: FMA:69273 is_a: CL:0000456 ! mineralocorticoid secreting cell is_a: CL:0002097 {is_inferred="true"} ! cortical cell of adrenal gland intersection_of: CL:0002097 ! cortical cell of adrenal gland intersection_of: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland relationship: part_of UBERON:0002053 ! zona glomerulosa of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:42:02Z [Term] id: CL:0002100 name: regular interventricular cardiac myocyte namespace: cell def: "A regular cardiac myocyte of the interventricular region of the heart." [GOC:tfm] xref: FMA:228792 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:40:52Z [Term] id: CL:0002101 name: CD38-positive naive B cell namespace: cell def: "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ naive B cell" EXACT [] synonym: "CD38+ naive B lymphocyte" EXACT [] synonym: "CD38+ naive B-cell" EXACT [] synonym: "CD38+ naive B-lymphocyte" EXACT [] synonym: "CD38-positive naive B lymphocyte" EXACT [] synonym: "CD38-positive naive B-cell" EXACT [] synonym: "CD38-positive naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002102 name: CD38-negative naive B cell namespace: cell def: "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- naive B cell" EXACT [] synonym: "CD38- naive B lymphocyte" EXACT [] synonym: "CD38- naive B-cell" EXACT [] synonym: "CD38- naive B-lymphocyte" EXACT [] synonym: "CD38-negative naive B lymphocyte" EXACT [] synonym: "CD38-negative naive B-cell" EXACT [] synonym: "CD38-negative naive B-lymphocyte" EXACT [] is_a: CL:0000788 {is_inferred="true"} ! naive B cell intersection_of: CL:0000788 ! naive B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002103 name: IgG-positive double negative memory B cell namespace: cell def: "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG+ dn memory B cell" EXACT [] synonym: "IgG+ dn memory B lymphocyte" EXACT [] synonym: "IgG+ dn memory B-cell" EXACT [] synonym: "IgG+ dn memory B-lymphocyte" EXACT [] synonym: "IgG+ double negative memory B cell" EXACT [] synonym: "IgG+ double negative memory B lymphocyte" EXACT [] synonym: "IgG+ double negative memory B-cell" EXACT [] synonym: "IgG+ double negative memory B-lymphocyte" EXACT [] synonym: "IgG-positive dn memory B cell" EXACT [] synonym: "IgG-positive dn memory B lymphocyte" EXACT [] synonym: "IgG-positive dn memory B-cell" EXACT [] synonym: "IgG-positive dn memory B-lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B lymphocyte" EXACT [] synonym: "IgG-positive double negative memory B-cell" EXACT [] synonym: "IgG-positive double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: has_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002104 name: IgG-negative double negative memory B cell namespace: cell def: "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- dn memory B cell" EXACT [] synonym: "IgG- dn memory B lymphocyte" EXACT [] synonym: "IgG- dn memory B-cell" EXACT [] synonym: "IgG- dn memory B-lymphocyte" EXACT [] synonym: "IgG- double negative memory B cell" EXACT [] synonym: "IgG- double negative memory B lymphocyte" EXACT [] synonym: "IgG- double negative memory B-cell" EXACT [] synonym: "IgG- double negative memory B-lymphocyte" EXACT [] synonym: "IgG-negative dn memory B cell" EXACT [] synonym: "IgG-negative dn memory B lymphocyte" EXACT [] synonym: "IgG-negative dn memory B-cell" EXACT [] synonym: "IgG-negative dn memory B-lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B lymphocyte" EXACT [] synonym: "IgG-negative double negative memory B-cell" EXACT [] synonym: "IgG-negative double negative memory B-lymphocyte" EXACT [] is_a: CL:0000981 {is_inferred="true"} ! double negative memory B cell intersection_of: CL:0000981 ! double negative memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002105 name: CD38-positive IgG memory B cell namespace: cell def: "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ IgG memory B cell" EXACT [] synonym: "CD38+ IgG memory B lymphocyte" EXACT [] synonym: "CD38+ IgG memory B-cell" EXACT [] synonym: "CD38+ IgG memory B-lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B lymphocyte" EXACT [] synonym: "CD38-positive IgG memory B-cell" EXACT [] synonym: "CD38-positive IgG memory B-lymphocyte" EXACT [] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002106 name: IgD-positive CD38-positive IgG memory B cell namespace: cell def: "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: has_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002107 name: IgD-negative CD38-positive IgG memory B cell namespace: cell def: "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002105 {is_inferred="true"} ! CD38-positive IgG memory B cell intersection_of: CL:0002105 ! CD38-positive IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex [Term] id: CL:0002108 name: CD38-negative IgG memory B cell namespace: cell def: "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0000979 {is_inferred="true"} ! IgG memory B cell intersection_of: CL:0000979 ! IgG memory B cell intersection_of: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part GO:0071738 ! IgD immunoglobulin complex relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002109 name: B220-positive CD38-positive naive B cell namespace: cell def: "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "B220+CD38+ naive B cell" EXACT [] synonym: "B220+CD38+ naive B lymphocyte" EXACT [] synonym: "B220+CD38+ naive B-cell" EXACT [] synonym: "B220+CD38+ naive B-lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B lymphocyte" EXACT [] synonym: "B220-positive CD38-positive naive B-cell" EXACT [] synonym: "B220-positive CD38-positive naive B-lymphocyte" EXACT [] synonym: "CD38+B220+ naive B cell" EXACT [] synonym: "CD38+B220+ naive B lymphocyte" EXACT [] synonym: "CD38+B220+ naive B-cell" EXACT [] synonym: "CD38+B220+ naive B-lymphocyte" EXACT [] is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002110 name: B220-low CD38-positive naive B cell namespace: cell def: "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002101 {is_inferred="true"} ! CD38-positive naive B cell intersection_of: CL:0002101 ! CD38-positive naive B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002111 name: CD38-negative unswitched memory B cell namespace: cell def: "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38- unswitched memory B cell" EXACT [] synonym: "CD38- unswitched memory B lymphocyte" EXACT [] synonym: "CD38- unswitched memory B-cell" EXACT [] synonym: "CD38- unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B lymphocyte" EXACT [] synonym: "CD38-negative unswitched memory B-cell" EXACT [] synonym: "CD38-negative unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002112 name: B220-positive CD38-negative unswitched memory B cell namespace: cell def: "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002113 name: B220-low CD38-negative unswitched memory B cell namespace: cell def: "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002111 {is_inferred="true"} ! CD38-negative unswitched memory B cell intersection_of: CL:0002111 ! CD38-negative unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002114 name: CD38-positive unswitched memory B cell namespace: cell def: "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "CD38+ unswitched memory B cell" EXACT [] synonym: "CD38+ unswitched memory B lymphocyte" EXACT [] synonym: "CD38+ unswitched memory B-cell" EXACT [] synonym: "CD38+ unswitched memory B-lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B lymphocyte" EXACT [] synonym: "CD38-positive unswitched memory B-cell" EXACT [] synonym: "CD38-positive unswitched memory B-lymphocyte" EXACT [] is_a: CL:0000970 {is_inferred="true"} ! unswitched memory B cell intersection_of: CL:0000970 ! unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002115 name: B220-positive CD38-positive unswitched memory B cell namespace: cell def: "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002116 name: B220-low CD38-positive unswitched memory B cell namespace: cell def: "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002114 {is_inferred="true"} ! CD38-positive unswitched memory B cell intersection_of: CL:0002114 ! CD38-positive unswitched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002117 name: IgG-negative class switched memory B cell namespace: cell def: "A class switched memory B cell that lacks IgG on the cell surface." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] synonym: "IgG- class switched memory B cell" EXACT [] synonym: "IgG- class switched memory B lymphocyte" EXACT [] synonym: "IgG- class switched memory B-cell" EXACT [] synonym: "IgG- class switched memory B-lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B lymphocyte" EXACT [] synonym: "IgG-negative class switched memory B-cell" EXACT [] synonym: "IgG-negative class switched memory B-lymphocyte" EXACT [] is_a: CL:0000972 {is_inferred="true"} ! class switched memory B cell intersection_of: CL:0000972 ! class switched memory B cell intersection_of: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex relationship: lacks_plasma_membrane_part GO:0071735 ! IgG immunoglobulin complex [Term] id: CL:0002118 name: CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: lacks_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002119 name: CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002117 {is_inferred="true"} ! IgG-negative class switched memory B cell intersection_of: CL:0002117 ! IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 relationship: has_plasma_membrane_part PR:000001408 ! ADP-ribosyl cyclase 1 [Term] id: CL:0002120 name: CD24-positive CD38-negative IgG-negative class switched memory B cell namespace: cell def: "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002121 name: CD24-negative CD38-negative IgG-negative class switched memory B cell namespace: cell def: "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002118 {is_inferred="true"} ! CD38-negative IgG-negative class switched memory B cell intersection_of: CL:0002118 ! CD38-negative IgG-negative class switched memory B cell intersection_of: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: lacks_plasma_membrane_part PR:000001932 ! signal transducer CD24 [Term] id: CL:0002122 name: B220-positive CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002123 name: B220-low CD38-positive IgG-negative class switched memory B cell namespace: cell def: "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive." [GOC:dsd, GOC:rhs, GOC:tfm, PMID:20123131] is_a: CL:0002119 {is_inferred="true"} ! CD38-positive IgG-negative class switched memory B cell intersection_of: CL:0002119 ! CD38-positive IgG-negative class switched memory B cell intersection_of: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_low_plasma_membrane_amount PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R [Term] id: CL:0002124 name: CD27-positive gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta27-positive" EXACT [] synonym: "gd27-positive" EXACT [] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production created_by: tmeehan creation_date: 2010-08-18T09:57:19Z [Term] id: CL:0002125 name: CD27-negative gamma-delta T cell namespace: cell def: "A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion." [GOC:dsd, GOC:tfm, PMID:19270712] synonym: "gammadelta-17 cells" EXACT [PMID:21976777] is_a: CL:0000800 {is_inferred="true"} ! mature gamma-delta T cell is_a: CL:0000912 ! helper T cell intersection_of: CL:0000800 ! mature gamma-delta T cell intersection_of: has_completed GO:0030217 ! T cell differentiation intersection_of: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 intersection_of: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: develops_from CL:0002126 ! CD25-positive, CD27-positive immature gamma-delta T cell relationship: has_completed GO:0030217 ! T cell differentiation relationship: has_part PR:000003455 ! nuclear receptor ROR-gamma isoform 2 relationship: lacks_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production created_by: tmeehan creation_date: 2010-08-18T09:57:29Z [Term] id: CL:0002126 name: CD25-positive, CD27-positive immature gamma-delta T cell namespace: cell def: "A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low)." [GOC:tfm, PMID:19270712] is_a: CL:0000799 {is_inferred="true"} ! immature gamma-delta T cell is_a: CL:0000893 ! thymocyte intersection_of: CL:0000799 ! immature gamma-delta T cell intersection_of: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule intersection_of: has_high_plasma_membrane_amount PR:000001318 ! L-selectin intersection_of: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 intersection_of: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule intersection_of: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 intersection_of: part_of UBERON:0002370 ! thymus relationship: has_high_plasma_membrane_amount PR:000001307 ! CD44 molecule relationship: has_high_plasma_membrane_amount PR:000001318 ! L-selectin relationship: has_high_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: has_low_plasma_membrane_amount PR:000001083 ! CD2 molecule relationship: has_low_plasma_membrane_amount PR:000001839 ! T-cell surface glycoprotein CD5 relationship: has_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001919 ! programmed cell death protein 1 relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-08-18T10:35:37Z [Term] id: CL:0002127 name: innate effector T cell namespace: cell def: "A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation." [GOC:tfm, PMID:20581831] is_a: CL:0000911 {is_inferred="true"} ! effector T cell intersection_of: CL:0000911 ! effector T cell intersection_of: RO:0002215 GO:0045087 ! capable_of innate immune response relationship: RO:0002215 GO:0045087 ! capable_of innate immune response created_by: tmeehan creation_date: 2010-08-20T02:14:25Z [Term] id: CL:0002128 name: Tc17 cell namespace: cell def: "A CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg." [GOC:dsd, GOC:tfm, PMID:19201830] comment: Found in the CD27-positive CD28-positive or CD27-negative CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative. synonym: "Tc17 T cell" EXACT [] synonym: "Tc17 T lymphocyte" EXACT [] synonym: "Tc17 T-cell" EXACT [] synonym: "Tc17 T-lymphocyte" EXACT [] is_a: CL:0000908 {is_inferred="true"} ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: CL:0000908 ! CD8-positive, alpha-beta cytokine secreting effector T cell intersection_of: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 intersection_of: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 intersection_of: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA intersection_of: RO:0002215 GO:0032620 ! capable_of interleukin-17 production relationship: has_high_plasma_membrane_amount PR:000001201 ! C-C chemokine receptor type 5 relationship: has_plasma_membrane_part PR:000001202 ! C-C chemokine receptor type 6 relationship: lacks_plasma_membrane_part PR:000001015 ! receptor-type tyrosine-protein phosphatase C isoform CD45RA relationship: RO:0002215 GO:0032620 ! capable_of interleukin-17 production [Term] id: CL:0002129 name: regular atrial cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac atrium." [GOC:tfm] synonym: "atrial cardiac muscle cell" EXACT [GOC:pr] synonym: "atrial myocyte" EXACT [] synonym: "regular atrial cardiac muscle fiber" EXACT [] synonym: "regular cardiac muscle cell of atrium" EXACT [] xref: FMA:83108 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:03Z [Term] id: CL:0002130 name: regular interatrial cardiac myocyte namespace: cell def: "A cardiac myocyte of the interatrial region of the heart." [GOC:tfm] xref: FMA:228790 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:09Z [Term] id: CL:0002131 name: regular ventricular cardiac myocyte namespace: cell def: "Regular cardiac myocyte of a cardiac ventricle." [GOC:tfm] synonym: "regular cardiac muscle cell of ventricle" EXACT [] synonym: "regular ventricular cardiac muscle fiber" EXACT [] synonym: "ventricular cardiac muscle cell" BROAD [GOC:pr] synonym: "ventricular myocyte" EXACT [] xref: FMA:83109 is_a: CL:0002098 ! regular cardiac myocyte created_by: tmeehan creation_date: 2010-08-23T11:41:13Z [Term] id: CL:0002132 name: stromal cell of ovary namespace: cell def: "A stomal cell of the ovary" [GOC:tfm] synonym: "ovarian stromal cell" EXACT [GOC:cjm] xref: FMA:72299 is_a: CL:0000499 ! stromal cell intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0000992 ! female gonad relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-08-23T12:10:31Z [Term] id: CL:0002133 name: stromal cell of ovorain cortex namespace: cell def: "A stromal cell of the ovarian cortex." [GOC:tfm] xref: FMA:256169 is_a: CL:0002132 ! stromal cell of ovary created_by: tmeehan creation_date: 2010-08-23T12:12:15Z [Term] id: CL:0002134 name: stromal cell of ovarian medulla namespace: cell def: "A stromal cell of the ovarian medulla." [GOC:tfm] xref: FMA:256171 is_a: CL:0002132 {is_inferred="true"} ! stromal cell of ovary intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0013192 ! ovarian medulla relationship: part_of UBERON:0013192 ! ovarian medulla created_by: tmeehan creation_date: 2010-08-23T12:12:17Z [Term] id: CL:0002135 name: nonkeratinized cell of epidermis namespace: cell def: "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." [GO:tfm, PMID:1987287] xref: FMA:62880 is_a: CL:0000362 ! epidermal cell created_by: tmeehan creation_date: 2010-08-24T08:43:27Z [Term] id: CL:0002136 name: type II cell of adrenal cortex namespace: cell def: "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." [GOC:tfm, ISBN:0517223651] synonym: "type II cortical cell of adrenal gland" EXACT [] xref: FMA:69547 is_a: CL:0000460 ! glucocorticoid secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:42Z [Term] id: CL:0002137 name: type III cell of adrenal cortex namespace: cell def: "A cell in the zona reticularis that produce sex hormones." [GOC:tfm, ISBN:0517223651] xref: FMA:69564 is_a: CL:0000593 ! androgen secreting cell is_a: CL:0002097 ! cortical cell of adrenal gland created_by: tmeehan creation_date: 2010-08-24T01:50:44Z [Term] id: CL:0002138 name: endothelial cell of lymphatic vessel namespace: cell alt_id: CL:1000421 def: "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions." [GOC:tfm, PMID:17846148] synonym: "LEC" EXACT [] synonym: "lymphatic endothelial cell" EXACT [] xref: BTO:0004167 xref: FMA:68458 is_a: CL:0002139 {is_inferred="true"} ! endothelial cell of vascular tree intersection_of: CL:0002139 ! endothelial cell of vascular tree intersection_of: develops_from CL:0005022 ! vascular lymphangioblast intersection_of: part_of UBERON:0001473 ! lymphatic vessel relationship: develops_from CL:0005022 ! vascular lymphangioblast relationship: part_of UBERON:0001473 ! lymphatic vessel created_by: tmeehan creation_date: 2010-08-24T02:05:28Z [Term] id: CL:0002139 name: endothelial cell of vascular tree namespace: cell def: "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [GOC:dsd, GOC:tfm, PMID:12768659] comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive. synonym: "cubodial endothelial cell of vascular tree" NARROW [] synonym: "vascular endothelial cell" EXACT [] xref: BTO:0001854 xref: CALOHA:TS-1106 xref: FMA:67755 is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-08-24T02:06:40Z [Term] id: CL:0002140 name: acinar cell of sebaceous gland namespace: cell alt_id: CL:0002587 def: "A sebum secreting cell of the skin that secretes sebum into the hair follicles." [GOC:tfm] synonym: "sebocyte" EXACT [] xref: BTO:0004613 xref: FMA:70953 is_a: CL:0000317 {is_inferred="true"} ! sebum secreting cell is_a: CL:0000622 ! acinar cell is_a: CL:1000448 ! epithelial cell of sweat gland intersection_of: CL:0000317 ! sebum secreting cell intersection_of: part_of UBERON:0003487 ! skin sebaceous gland relationship: part_of UBERON:0003487 ! skin sebaceous gland created_by: tmeehan creation_date: 2010-08-24T09:27:52Z [Term] id: CL:0002141 name: active chief cell of parathyroid gland namespace: cell def: "A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1" [FMA:0517223651, GOC:tfm] xref: FMA:69082 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T09:30:15Z [Term] id: CL:0002142 name: dark cell of eccrine sweat gland namespace: cell def: "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." [ISBN:0517223651] xref: FMA:70659 is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell created_by: tmeehan creation_date: 2010-08-24T02:15:16Z [Term] id: CL:0002143 name: dark chief cell of parathyroid cell namespace: cell def: "A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69080 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T02:18:36Z [Term] id: CL:0002144 name: capillary endothelial cell namespace: cell def: "An endothelial cell found in capillaries." [GOC:tfm] xref: BTO:0004956 xref: CALOHA:TS-0112 xref: FMA:67756 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001915 ! endothelium of capillary relationship: part_of UBERON:0001915 ! endothelium of capillary created_by: tmeehan creation_date: 2010-08-24T10:15:00Z [Term] id: CL:0002145 name: ciliated columnar cell of tracheobronchial tree namespace: cell def: "A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree." [GOC:tfm, ISBN:0517223651] xref: FMA:70542 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree is_a: CL:0005012 ! multi-ciliated epithelial cell relationship: develops_from CL:0002209 ! intermediate epitheliocyte created_by: tmeehan creation_date: 2010-08-24T03:38:29Z [Term] id: CL:0002146 name: clear cell of eccrine sweat gland namespace: cell def: "A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin." [GOC:tfm, ISBN:0517223651] xref: FMA:70658 is_a: CL:0000318 ! sweat secreting cell is_a: CL:0000434 ! eccrine cell created_by: tmeehan creation_date: 2010-08-24T10:33:02Z [Term] id: CL:0002147 name: clear chief cell of parathyroid cell namespace: cell def: "A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells." [GOC:tfm, ISBN:0618947256] xref: FMA:69081 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-08-24T10:39:42Z [Term] id: CL:0002148 name: dental pulp cell namespace: cell def: "A cell found within the dental pulp." [GOC:tfm, PMID:11087820] xref: BTO:0000339 xref: CALOHA:TS-0195 xref: FMA:87170 is_a: CL:0002159 ! general ecto-epithelial cell is_a: CL:0002320 ! connective tissue cell relationship: part_of UBERON:0001754 ! dental pulp created_by: tmeehan creation_date: 2010-08-24T02:52:09Z [Term] id: CL:0002149 name: epithelial cell of uterus namespace: cell alt_id: CL:1000294 def: "An epithelial cell of the uterus." [GOC:tfm] xref: FMA:256161 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000995 ! uterus relationship: part_of UBERON:0000995 ! uterus created_by: tmeehan creation_date: 2010-08-24T10:45:54Z [Term] id: CL:0002150 name: epithelioid macrophage namespace: cell def: "Epithelioid macrophage is an activated macrophage that resembles an epithelial cell with finely granular, pale eosinophilic cytoplasm and central, ovoid nucleus (oval or elongate). This cell type is able to merge into one another to form aggregates. The presence of such aggregates may characterize some pathologic conditions, mainly granulomatous inflammation." [MESH:A11.329.372.300, PMID:12673090] synonym: "epithelioid cell" BROAD [] synonym: "epithelioid histocyte" EXACT [MESH:A11.329.372.300, PMID:12673090] synonym: "epitheloid macrophage" EXACT [] xref: FMA:83514 is_a: CL:0000235 ! macrophage relationship: develops_from CL:0000861 ! elicited macrophage created_by: tmeehan creation_date: 2010-08-24T03:48:30Z [Term] id: CL:0002151 name: late promyelocyte namespace: cell def: "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." [ISBN:0412046911] xref: FMA:83534 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:50Z [Term] id: CL:0002152 name: columnar cell of endocervix namespace: cell def: "A columnar cell of the cervix uteri." [GOC:tfm, ISBN:0721662544] xref: FMA:86486 is_a: CL:0002149 ! epithelial cell of uterus relationship: part_of UBERON:0000458 ! endocervix created_by: tmeehan creation_date: 2010-08-24T10:47:47Z [Term] id: CL:0002153 name: corneocyte namespace: cell def: "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." [GOC:tfm, ISBN:068340007X] xref: BTO:0001943 xref: FMA:68650 is_a: CL:0000225 ! anucleate cell is_a: CL:0000311 ! keratin accumulating cell relationship: develops_from CL:0000312 ! keratinocyte relationship: part_of UBERON:0002027 ! stratum corneum of epidermis created_by: tmeehan creation_date: 2010-08-24T10:53:03Z [Term] id: CL:0002154 name: early promyelocyte namespace: cell def: "A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages." [FMA:0412046911, GOC:tfm] xref: FMA:83533 is_a: CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-24T03:07:53Z [Term] id: CL:0002155 name: echinocyte namespace: cell def: "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." [GOC:tfm] synonym: "burr cell" EXACT [] xref: FMA:81099 is_a: CL:0000595 ! enucleate erythrocyte created_by: tmeehan creation_date: 2010-08-24T03:15:21Z [Term] id: CL:0002157 name: endosteal cell namespace: cell def: "A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones." [FMA:0618947256, GOC:tfm] xref: FMA:86495 is_a: CL:0001035 ! bone cell is_a: CL:0002078 ! meso-epithelial cell relationship: part_of UBERON:0009859 ! endosteum created_by: tmeehan creation_date: 2010-08-24T03:33:58Z [Term] id: CL:0002158 name: external epithelial cell of tympanic membrane namespace: cell def: "Epithelial cell found on the external side of the tympanic membrane" [GOC:tfm, PMID:5686391] xref: FMA:70558 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-25T10:25:31Z [Term] id: CL:0002159 name: general ecto-epithelial cell namespace: cell def: "Epithelial cells derived from general body ectoderm and ectoderm placodes." [GOC:tfm] xref: FMA:70556 is_a: CL:0002077 ! ecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T08:31:08Z [Term] id: CL:0002160 name: basal external epithelial cell of tympanic membrane namespace: cell def: "A cell type found in the basal epithelial layer on the external side of the tympanic membrane. Cell type is flattened with intracellular spaces of variable dimensions." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:44Z [Term] id: CL:0002161 name: superficial external epithelial cell of tympanic membrane namespace: cell def: "A cell type found on the superficial layer of the external side of the tympanic membrane. This cell-type lacks a nucleus." [PMID:5686391] is_a: CL:0002158 ! external epithelial cell of tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:28:48Z [Term] id: CL:0002162 name: internal epithelial cell of tympanic membrane namespace: cell def: "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." [FMA:5686391, GOC:tfm] xref: FMA:70626 is_a: CL:0002076 ! endo-epithelial cell relationship: part_of UBERON:0002364 ! tympanic membrane created_by: tmeehan creation_date: 2010-08-25T10:49:46Z [Term] id: CL:0002163 name: internal pillar cell of cochlea namespace: cell def: "A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75722 xref: FMA:75726 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:21Z [Term] id: CL:0002164 name: external pillar cell of cochlea namespace: cell def: "A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells." [GOC:tfm, http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html] xref: FMA:75727 is_a: CL:1000191 ! pillar cell created_by: tmeehan creation_date: 2010-08-25T11:05:23Z [Term] id: CL:0002165 name: phalangeal cell namespace: cell def: "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells." [GOC:tfm, ISBN:0618947256] xref: FMA:79800 is_a: CL:0002490 ! organ of Corti supporting cell created_by: tmeehan creation_date: 2010-08-25T01:29:07Z [Term] id: CL:0002166 name: epithelial cell of Malassez namespace: cell def: "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth." [GOC:tfm, ISBN:0517223651, ISBN:0815129521] synonym: "epithelial cell rests of Malassez " EXACT [] synonym: "epithelial debris of Malassez" EXACT [] xref: FMA:62987 is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: part_of UBERON:0001708 ! jaw skeleton relationship: part_of UBERON:0001708 ! jaw skeleton created_by: tmeehan creation_date: 2010-08-26T08:51:27Z [Term] id: CL:0002167 name: olfactory epithelial cell namespace: cell def: "A specialized cell involved in sensory perception of smell." [GOC:tfm, PMID:7143026] xref: FMA:67870 is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-08-26T01:47:13Z [Term] id: CL:0002168 name: border cell of cochlea namespace: cell def: "A border cell is a slender columnar cell on the medial portion of the basilar membrane." [FMA:0412046911, GOC:tfm] xref: FMA:79798 is_a: CL:0002315 ! supporting cell of cochlea created_by: tmeehan creation_date: 2010-08-25T01:47:12Z [Term] id: CL:0002169 name: basal cell of olfactory epithelium namespace: cell alt_id: CL:1000395 def: "An epithelial cell located on the basal lamina of the olfactory epithelium." [GOC:tfm, PMID:7143026] xref: FMA:62303 is_a: CL:0002167 {is_inferred="true"} ! olfactory epithelial cell intersection_of: CL:0002167 ! olfactory epithelial cell intersection_of: part_of UBERON:0001997 ! olfactory epithelium relationship: part_of UBERON:0001997 ! olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:58:54Z [Term] id: CL:0002170 name: keratinized cell of the oral mucosa namespace: cell def: "A keratinized cell located in the hard palate or gingiva." [GOC:tfm, PMID:12014572] is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002251 ! epithelial cell of alimentary canal is_a: CL:0002336 ! buccal mucosa cell relationship: part_of UBERON:0003729 ! mouth mucosa created_by: tmeehan creation_date: 2010-08-26T02:51:30Z [Term] id: CL:0002171 name: globose cell of olfactory epithelium namespace: cell def: "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium." [GOC:tfm, PMID:17468753] synonym: "blastema cell of olfactory epithelium" EXACT [] xref: FMA:67874 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:18Z [Term] id: CL:0002172 name: interdental cell of cochlea namespace: cell def: "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph." [GOC:tfm, MP:0004482, PMID:2111803] synonym: "interdental cell" EXACT [] xref: FMA:79797 is_a: CL:0001035 ! bone cell is_a: CL:0002315 ! supporting cell of cochlea relationship: part_of UBERON:0002276 ! lamina of spiral limbus created_by: tmeehan creation_date: 2010-08-25T02:02:48Z [Term] id: CL:0002173 name: extraglomerular mesangial cell namespace: cell def: "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells." [GOC:tfm, http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells, ISBN:0412046911] synonym: "Goormaghtigh cell" EXACT [] synonym: "lacis cell" RELATED [] synonym: "polar cushion cells" EXACT [] xref: FMA:84143 xref: KUPO:0001033 is_a: CL:0000650 ! mesangial cell is_a: CL:1000500 ! kidney interstitial cell is_a: CL:1000618 {is_inferred="true"} ! juxtaglomerular complex cell is_a: CL:1001318 ! renal interstitial pericyte intersection_of: CL:0002320 ! connective tissue cell intersection_of: part_of UBERON:0002321 ! extraglomerular mesangium relationship: part_of UBERON:0002321 ! extraglomerular mesangium created_by: tmeehan creation_date: 2010-08-25T02:20:55Z [Term] id: CL:0002174 name: follicular cell of ovary namespace: cell def: "A cell within the follicle of an ovary." [GOC:tfm] xref: EMAPA:31247 xref: FMA:70589 is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-08-25T03:01:27Z [Term] id: CL:0002175 name: primary follicular cell of ovary namespace: cell def: "A cell within the primary follicle of the ovary." [GOC:tfm] xref: FMA:70590 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:42Z [Term] id: CL:0002176 name: secondary follicular cell of ovary namespace: cell def: "A cell of a secondary follicile within the ovary." [GOC:tfm] xref: FMA:70591 is_a: CL:0002174 ! follicular cell of ovary created_by: tmeehan creation_date: 2010-08-25T03:03:48Z [Term] id: CL:0002177 name: folliculostellate cell of pars distalis of adenohypophysis namespace: cell def: "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature." [GOC:tfm] synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT [] xref: FMA:83102 is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell is_a: CL:0000710 ! neurecto-epithelial cell intersection_of: CL:0000642 ! folliculostellate cell intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis relationship: part_of UBERON:0006964 ! pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-08-25T03:10:10Z [Term] id: CL:0002178 name: epithelial cell of stomach namespace: cell alt_id: CL:1000399 def: "An epithelial cell found in the lining of the stomach." [GOC:tfm] xref: FMA:62948 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000945 ! stomach relationship: part_of UBERON:0000945 ! stomach created_by: tmeehan creation_date: 2010-08-25T03:22:08Z [Term] id: CL:0002179 name: foveolar cell of stomach namespace: cell def: "An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop ." [GOC:tfm, http://www.merriam-webster.com/medical/foveolar] xref: FMA:86552 is_a: CL:0002178 ! epithelial cell of stomach created_by: tmeehan creation_date: 2010-08-25T03:23:22Z [Term] id: CL:0002180 name: mucous cell of stomach namespace: cell alt_id: CL:1000404 def: "A mucous cell in the epithelium of the stomach." [GOC:tfm] xref: FMA:63464 is_a: CL:0002659 ! glandular cell of stomach intersection_of: CL:0002178 ! epithelial cell of stomach intersection_of: part_of UBERON:0001199 ! mucosa of stomach relationship: part_of UBERON:0001199 ! mucosa of stomach created_by: tmeehan creation_date: 2010-08-25T03:38:51Z [Term] id: CL:0002181 name: mucus neck cell of gastric gland namespace: cell alt_id: CL:1000401 def: "A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach." [GOC:tfm, ISBN:0517223651] xref: FMA:62954 is_a: CL:0000651 {is_inferred="true"} ! neck cell is_a: CL:0002180 {is_inferred="true"} ! mucous cell of stomach intersection_of: CL:0000651 ! neck cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:41:30Z [Term] id: CL:0002182 name: surface mucosal cell of stomach namespace: cell def: "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall." [GOC:tfm, ISBN:0517223651] xref: FMA:62949 is_a: CL:0000319 ! mucus secreting cell is_a: CL:0002180 ! mucous cell of stomach relationship: RO:0002215 GO:0070254 ! capable_of mucus secretion created_by: tmeehan creation_date: 2010-08-25T03:45:10Z [Term] id: CL:0002183 name: stem cell of gastric gland namespace: cell alt_id: CL:1000400 def: "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit." [GOC:tfm, ISBN:0517223651] xref: FMA:62953 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell is_a: CL:0002180 ! mucous cell of stomach intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0000325 ! gastric gland relationship: part_of UBERON:0000325 ! gastric gland created_by: tmeehan creation_date: 2010-08-25T03:57:08Z [Term] id: CL:0002184 name: basal proper cell of olfactory epithelium namespace: cell def: "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium." [GOC:tfm, PMID:0517223651, PMID:11891623] synonym: "horizontal basal cells" EXACT [] xref: FMA:62304 is_a: CL:0002169 ! basal cell of olfactory epithelium created_by: tmeehan creation_date: 2010-08-26T01:59:22Z [Term] id: CL:0002187 name: basal cell of epidermis namespace: cell alt_id: CL:1000439 def: "A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane." [GOC:tfm, ISBN:0517223651] xref: FMA:70571 is_a: CL:0000312 ! keratinocyte is_a: CL:0000646 {is_inferred="true"} ! basal cell is_a: CL:1000428 ! stem cell of epidermis intersection_of: CL:0000646 ! basal cell intersection_of: part_of UBERON:0001003 ! epidermis relationship: part_of UBERON:0001003 ! epidermis created_by: tmeehan creation_date: 2010-08-26T03:12:49Z [Term] id: CL:0002188 name: glomerular endothelial cell namespace: cell def: "An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate." [GOC:tfm, PMID:15840009] xref: BTO:0004632 xref: FMA:70970 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell is_a: CL:0000666 ! fenestrated cell is_a: CL:1000746 ! glomerular cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0000074 ! renal glomerulus relationship: part_of UBERON:0000074 ! renal glomerulus created_by: tmeehan creation_date: 2010-08-26T10:59:44Z [Term] id: CL:0002189 name: granular cell of epidermis namespace: cell def: "A keratinocyte of the epidermis that is characterized by containing granules of keratohyalin and lamellar granules." [ISBN:1416031855] xref: FMA:70543 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:19:00Z [Term] id: CL:0002190 name: squamous cell of epidermis namespace: cell def: "A flat keratinocyte immediately below the cornified layer." [GOC:tfm, ISBN:0517223651] xref: FMA:86925 is_a: CL:0000312 ! keratinocyte created_by: tmeehan creation_date: 2010-08-26T03:37:02Z [Term] id: CL:0002191 name: granulocytopoietic cell namespace: cell def: "A cell involved in the formation of a granulocyte." [GOC:tfm] xref: FMA:83519 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation relationship: RO:0002215 GO:0030851 ! capable_of granulocyte differentiation created_by: tmeehan creation_date: 2010-08-30T12:54:27Z [Term] id: CL:0002192 name: metamyelocyte namespace: cell def: "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare." [GOC:tfm, http://en.wikipedia.org/wiki/Metamyelocyte, ISBN:0721601464] xref: FMA:83541 is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0002193 ! myelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:15Z [Term] id: CL:0002193 name: myelocyte namespace: cell def: "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." [GOC:tfm, http://en.wikipedia.org/wiki/Myelocyte, ISBN:0323052908] xref: BTO:0000734 xref: FMA:83525 is_a: CL:0002191 ! granulocytopoietic cell relationship: develops_from CL:0000836 ! promyelocyte created_by: tmeehan creation_date: 2010-08-30T01:08:19Z [Term] id: CL:0002194 name: monopoietic cell namespace: cell def: "A cell involved in the formation of a monocyte (monopoiesis)." [GOC:tfm] xref: FMA:83552 is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell intersection_of: CL:0000839 ! myeloid lineage restricted progenitor cell intersection_of: RO:0002215 GO:0030224 ! capable_of monocyte differentiation relationship: RO:0002215 GO:0030224 ! capable_of monocyte differentiation created_by: tmeehan creation_date: 2010-08-30T01:27:48Z [Term] id: CL:0002195 name: hepatic stem cell namespace: cell def: "A stem cell that can give rise to the cells of the liver." [GOC:tfm] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: part_of UBERON:0002107 ! liver relationship: part_of UBERON:0002107 ! liver created_by: tmeehan creation_date: 2010-08-30T02:00:42Z [Term] id: CL:0002196 name: hepatic oval stem cell namespace: cell alt_id: CL:1000036 def: "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue." [PMID:17901986] synonym: "hepatic oval cell" EXACT [] xref: BTO:0004270 xref: FMA:86576 is_a: CL:0002195 ! hepatic stem cell created_by: tmeehan creation_date: 2010-08-30T02:01:49Z [Term] id: CL:0002197 name: inactive chief cell of parathyoid gland namespace: cell def: "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." [GOC:tfm, ISBN:0517223651] is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:14:01Z [Term] id: CL:0002198 name: oncocyte namespace: cell def: "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands." [GOC:tfm, ISBN:0721662544, PMID:20013317] synonym: "oxyphil" EXACT [] xref: FMA:67606 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T11:26:49Z [Term] id: CL:0002199 name: oxyphil cell of parathyroid gland namespace: cell def: "An oncocyte located in the parathyroid gland." [PMID:20013317] xref: FMA:69084 is_a: CL:0002198 ! oncocyte is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:23Z [Term] id: CL:0002200 name: oxyphil cell of thyroid namespace: cell def: "An oncocyte located in the thyroid." [GOC:tfm, PMID:20013317] synonym: "Askanazy cells" EXACT [] synonym: "Hurthle cells" EXACT [] xref: FMA:87169 is_a: CL:0002198 ! oncocyte is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-02T11:33:26Z [Term] id: CL:0002201 name: renal beta-intercalated cell namespace: cell def: "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." [GOC:tfm, PMID:11781354] is_a: CL:0005010 ! renal intercalated cell created_by: tmeehan creation_date: 2010-09-02T01:43:55Z [Term] id: CL:0002202 name: epithelial cell of tracheobronchial tree namespace: cell alt_id: CL:1000407 def: "An epithelial cell of the tracheobronchial tree." [GOC:tfm] xref: FMA:66816 is_a: CL:0002632 ! epithelial cell of lower respiratory tract intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0007196 ! tracheobronchial tree relationship: part_of UBERON:0007196 ! tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:09:14Z [Term] id: CL:0002203 name: Brush cell of epithelium proper of large intestine namespace: cell alt_id: CL:1000387 def: "Brush cell found in the epithelial layer of the colon." [GOC:tfm] comment: Brush cells are a distinct cell type from brush border cell-types. xref: FMA:263222 is_a: CL:0002204 ! brush cell is_a: CL:0002253 ! epithelial cell of large intestine created_by: tmeehan creation_date: 2010-09-02T02:20:50Z [Term] id: CL:0002204 name: brush cell namespace: cell def: "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." [GOC:tfm, ISBN:0517223651, PMID:15817800] synonym: "caveolated cell" EXACT [] synonym: "fibrillovesicular cell" EXACT [] synonym: "multivesicular cell" EXACT [] synonym: "tuft cell" EXACT [] xref: FMA:67978 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-02T02:28:53Z [Term] id: CL:0002205 name: brush cell of lobular bronchiole namespace: cell alt_id: CL:1000386 def: "A brush cell found in the epithelium of lobular bronchiole." [GOC:tfm] xref: FMA:263220 is_a: CL:0000082 ! epithelial cell of lung is_a: CL:0002208 ! brush cell of bronchus intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002051 ! epithelium of bronchiole relationship: part_of UBERON:0002051 ! epithelium of bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:34Z [Term] id: CL:0002206 name: brush cell of terminal bronchiole namespace: cell alt_id: CL:1000390 def: "A brush cell of the epithelium in the terminal bronchiole." [GOC:tfm] xref: FMA:263228 is_a: CL:0002205 ! brush cell of lobular bronchiole intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0001958 ! epithelium of terminal bronchiole relationship: part_of UBERON:0001958 ! epithelium of terminal bronchiole created_by: tmeehan creation_date: 2010-09-02T02:38:36Z [Term] id: CL:0002207 name: brush cell of trachea namespace: cell alt_id: CL:1000388 def: "Brush cell of the epithelium in the trachea." [GOC:tfm] xref: FMA:263224 is_a: CL:0000307 {is_inferred="true"} ! tracheal epithelial cell is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree intersection_of: CL:0002204 ! brush cell intersection_of: part_of UBERON:0001901 ! epithelium of trachea relationship: part_of UBERON:0001901 ! epithelium of trachea created_by: tmeehan creation_date: 2010-09-02T02:38:37Z [Term] id: CL:0002208 name: brush cell of bronchus namespace: cell alt_id: CL:1000389 def: "A brush cell found in the epithelium of bronchus." [GOC:tfm] xref: FMA:263226 is_a: CL:0002075 {is_inferred="true"} ! brush cell of trachebronchial tree is_a: CL:0002328 {is_inferred="true"} ! bronchial epithelial cell intersection_of: CL:0002075 ! brush cell of trachebronchial tree intersection_of: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus created_by: tmeehan creation_date: 2010-09-02T02:38:42Z [Term] id: CL:0002209 name: intermediate epitheliocyte namespace: cell def: "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells." [GOC:tfm, ISBN:0517223651] synonym: "undifferentiated columnar cell of tracheobronchial tree" EXACT [] xref: FMA:69060 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-02T02:53:59Z [Term] id: CL:0002210 name: red muscle cell namespace: cell def: "A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance." [GOC:tfm, ISBN:0517223651] synonym: "oxidative muscle fiber" EXACT [] synonym: "red muscle fiber" EXACT [] xref: FMA:84448 is_a: CL:0002372 ! myotube created_by: tmeehan creation_date: 2010-09-02T03:20:03Z [Term] id: CL:0002211 name: type I muscle cell namespace: cell def: "A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue." [GOC:tfm, ISBN:0517223651] synonym: "intermediate muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow twitch fiber" EXACT [] synonym: "slow twitch muscle cell" EXACT [] synonym: "slow twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "slow-twitch muscle fiber" RELATED [MESH:A02.633.565.700] synonym: "type 1 muscle cell" EXACT [] synonym: "type 1 muscle fiber" EXACT [] synonym: "type I muscle fiber" EXACT [] xref: BTO:0001812 xref: CALOHA:TS-0940 xref: FMA:84413 xref: MESH:A02.633.565.700 is_a: CL:0000189 ! slow muscle cell is_a: CL:0002210 ! red muscle cell created_by: tmeehan creation_date: 2010-09-02T03:24:05Z [Term] id: CL:0002212 name: type II muscle cell namespace: cell def: "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." [GOC:tfm] synonym: "type 2 muscle cell" EXACT [] synonym: "type 2 muscle fiber" EXACT [] synonym: "type II muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84414 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:45Z [Term] id: CL:0002213 name: white muscle cell namespace: cell def: "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." [GOC:tfm, ISBN:0517223651] xref: FMA:84449 is_a: CL:0000190 ! fast muscle cell created_by: tmeehan creation_date: 2010-09-02T03:28:48Z [Term] id: CL:0002214 name: type IIa muscle cell namespace: cell def: "A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue." [GOC:tfm] synonym: "fast twitch A" EXACT [] synonym: "fatigue resistant fast twitch muscle cell" EXACT [] synonym: "type 2a muscle cell" EXACT [] synonym: "type 2a muscle fiber" EXACT [] synonym: "type IIa muscle fiber" EXACT [] xref: BTO:0001813 xref: FMA:84415 is_a: CL:0002210 ! red muscle cell is_a: CL:0002212 ! type II muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:38Z [Term] id: CL:0002215 name: type IIb muscle cell namespace: cell def: "A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity." [GOC:tfm, http://en.wikipedia.org/wiki/Skeletal_muscle, ISBN:0517223651] synonym: "type 2b muscle cell" EXACT [] synonym: "type 2b muscle fiber" EXACT [] synonym: "type IIb muscle fiber" EXACT [] xref: FMA:84416 is_a: CL:0002212 ! type II muscle cell is_a: CL:0002213 ! white muscle cell created_by: tmeehan creation_date: 2010-09-02T03:31:42Z [Term] id: CL:0002216 name: intermediate muscle cell namespace: cell def: "An intermediate muscle cell that has characteristics of both fast and slow muscle cells." [GOC:tfm] xref: FMA:84450 is_a: CL:0002372 ! myotube created_by: tmeehan creation_date: 2010-09-02T03:51:17Z [Term] id: CL:0002217 name: intermediate trophoblast cell namespace: cell def: "A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] xref: BTO:0002366 xref: FMA:86564 is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:04:36Z [Term] id: CL:0002218 name: immature dendritic epithelial T cell precursor namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "immature DEC precursor" EXACT [] synonym: "immature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T01:58:00Z [Term] id: CL:0002219 name: anchoring trophoblasts namespace: cell def: "A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua." [GOC:tfm, http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-09-02T04:14:28Z [Term] id: CL:0002220 name: interstitial cell of pineal gland namespace: cell def: "A cell located between the pinealocytes." [GOC:tfm, ISBN:0517223651] xref: FMA:86575 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-02T04:28:41Z [Term] id: CL:0002221 name: keratinized squamous cell of esophagus namespace: cell def: "A squamous cell that has keratin in the esophagus." [GOC:tfm, PMID:11694559] xref: FMA:86549 is_a: CL:0000237 ! keratinizing barrier epithelial cell is_a: CL:0002252 ! epithelial cell of esophagus created_by: tmeehan creation_date: 2010-09-07T10:11:06Z [Term] id: CL:0002222 name: vertebrate lens cell namespace: cell def: "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye." [GOC:tfm, ISBN:0721662544] xref: FMA:70950 is_a: CL:0000066 ! epithelial cell is_a: CL:0000306 ! crystallin accumulating cell is_a: CL:0002371 ! somatic cell relationship: part_of UBERON:0000965 ! lens of camera-type eye created_by: tmeehan creation_date: 2010-09-07T10:38:03Z [Term] id: CL:0002223 name: anterior lens cell namespace: cell def: "A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s)." [GOC:tfm, ISBN:0517223651] xref: FMA:63181 is_a: CL:0002224 ! lens epithelial cell created_by: tmeehan creation_date: 2010-09-07T10:45:45Z [Term] id: CL:0002224 name: lens epithelial cell namespace: cell def: "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544] xref: FMA:67559 is_a: CL:0000075 {is_inferred="true"} ! columnar/cuboidal epithelial cell is_a: CL:0002222 ! vertebrate lens cell intersection_of: CL:0000075 ! columnar/cuboidal epithelial cell intersection_of: part_of UBERON:0001803 ! epithelium of lens relationship: part_of UBERON:0001803 ! epithelium of lens created_by: tmeehan creation_date: 2010-09-07T10:45:47Z [Term] id: CL:0002225 name: secondary lens fiber namespace: cell def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651] synonym: "secondary lens fibre" EXACT [] is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002228 ! primary lens fiber created_by: tmeehan creation_date: 2010-09-07T10:53:39Z [Term] id: CL:0002226 name: non-nucleated secondary lens fiber namespace: cell def: "A secondary lens fiber cell that lacks a nucleus." [GOC:tfm] synonym: "non-nucleated secondary lens fibre" EXACT [] xref: FMA:67561 is_a: CL:0002225 ! secondary lens fiber relationship: develops_from CL:0002227 ! nucleated secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:23Z [Term] id: CL:0002227 name: nucleated secondary lens fiber namespace: cell def: "A secondary fiber cell that contains a nucleus." [GOC:tfm] synonym: "nucleated secondary lens fibre" EXACT [] xref: FMA:70949 is_a: CL:0002225 ! secondary lens fiber created_by: tmeehan creation_date: 2010-09-07T11:15:26Z [Term] id: CL:0002228 name: primary lens fiber namespace: cell def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers." [GOC:tfm, PMID:10711704] synonym: "primary lens fibre" EXACT [] xref: FMA:70613 is_a: CL:0011004 ! lens fiber cell relationship: develops_from CL:0002223 ! anterior lens cell created_by: tmeehan creation_date: 2010-09-07T11:19:01Z [Term] id: CL:0002229 name: light chief cell of parathyroid gland namespace: cell def: "A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules." [GOC:tfm, ISBN:0721662544] xref: FMA:69079 is_a: CL:0000446 ! chief cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-07T11:46:54Z [Term] id: CL:0002231 name: epithelial cell of prostate namespace: cell alt_id: CL:1000295 alt_id: CL:1000408 def: "An epithelial cell of the prostate." [GOC:tfm] synonym: "prostate epithelial cell" EXACT [] xref: FMA:256163 xref: FMA:66817 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-07T01:49:29Z [Term] id: CL:0002232 name: epithelial cell of prostatic duct namespace: cell alt_id: CL:1000462 def: "An epithelial cell of prostatic duct." [GOC:tfm] synonym: "ductal epithelial cell of prostate" EXACT [FMA:74224] xref: FMA:74224 is_a: CL:0000072 {is_inferred="true"} ! non-branched duct epithelial cell is_a: CL:0002231 ! epithelial cell of prostate intersection_of: CL:0000072 ! non-branched duct epithelial cell intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:55:51Z [Term] id: CL:0002233 name: epithelial cell of prostatic acinus namespace: cell alt_id: CL:1000461 def: "An epithelial cell of the prostatic acinus." [GOC:tfm, PMCID:PMC2673349] synonym: "acinar epithelial cell of prostate" EXACT [FMA:74223] xref: FMA:74223 is_a: CL:0002231 {is_inferred="true"} ! epithelial cell of prostate intersection_of: CL:0002231 ! epithelial cell of prostate intersection_of: part_of UBERON:0004179 ! prostate glandular acinus relationship: part_of UBERON:0004179 ! prostate glandular acinus created_by: tmeehan creation_date: 2010-09-07T01:55:53Z [Term] id: CL:0002234 name: basal cell of prostatic acinus namespace: cell alt_id: CL:1000464 def: "A cell of the basal layer of the epithelium in the prostatic acinus." [GOC:tfm] synonym: "basal epithelial cell of prostatic acinus" EXACT [FMA:74265] xref: FMA:74265 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002341 ! basal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:08Z [Term] id: CL:0002235 name: luminal cell of prostatic acinus namespace: cell def: "A cell of the luminal layer of the epithelium in the prostatic acinus." [GOC:tfm] xref: FMA:74266 is_a: CL:0002233 ! epithelial cell of prostatic acinus is_a: CL:0002340 ! luminal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:10Z [Term] id: CL:0002236 name: basal epithelial cell of prostatic duct namespace: cell alt_id: CL:1000463 def: "A cell that constitutes the basal layer of epithelium in the prostatic duct." [GOC:tfm, PMID:15226377] xref: FMA:74226 is_a: CL:0002232 ! epithelial cell of prostatic duct is_a: CL:0002341 {is_inferred="true"} ! basal cell of prostate epithelium intersection_of: CL:0002341 ! basal cell of prostate epithelium intersection_of: part_of UBERON:0002485 ! prostate duct relationship: part_of UBERON:0002485 ! prostate duct created_by: tmeehan creation_date: 2010-09-07T01:59:12Z [Term] id: CL:0002237 name: luminal epithelial cell of prostatic duct namespace: cell def: "A cell that constitutes the luminal layer of epithelium of prostatic duct." [GOC:tfm] xref: FMA:74225 is_a: CL:0002232 ! epithelial cell of prostatic duct is_a: CL:0002340 ! luminal cell of prostate epithelium created_by: tmeehan creation_date: 2010-09-07T01:59:16Z [Term] id: CL:0002238 name: male gonocyte namespace: cell def: "A primordial germ cell that is destined to become a male germ cell." [GOC:tfm] synonym: "male primordial germ cell" EXACT [] synonym: "testis primordial germ cell" EXACT [VHOG:0000662] xref: EHDAA2:0001053 xref: EMAPA:18686 xref: FMA:84771 xref: VHOG:0000662 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000473 ! testis created_by: tmeehan creation_date: 2010-09-07T02:11:13Z [Term] id: CL:0002239 name: ooblast namespace: cell def: "A primordial cell from which an oocyte (ovum) ultimately is developed." [GOC:tfm] synonym: "ovary primordial germ cell" EXACT [VHOG:0000661] synonym: "ovigerm" EXACT [FMA:84772] xref: EHDAA2:0000505 xref: EMAPA:17965 xref: FMA:84772 xref: ISBN:0721662544 xref: VHOG:0000661 is_a: CL:0000670 ! primordial germ cell relationship: part_of UBERON:0000992 ! female gonad created_by: tmeehan creation_date: 2010-09-07T02:11:16Z [Term] id: CL:0002240 name: marrow fibroblast namespace: cell def: "A fibroblast in the bone marrow." [GOC:tfm] xref: FMA:84377 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-07T02:25:18Z [Term] id: CL:0002241 name: pulmonary interstitial fibroblast namespace: cell def: "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." [GOC:tfm] synonym: "pulmonary myofibroblast" EXACT [] synonym: "pulmonary septal cell" EXACT [] xref: FMA:84467 is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0005169 ! interstitial tissue relationship: part_of UBERON:0005169 ! interstitial tissue created_by: tmeehan creation_date: 2010-09-07T02:29:38Z [Term] id: CL:0002242 name: nucleate cell namespace: cell def: "A cell containing at least one nucleus." [GOC:tfm] xref: FMA:67513 is_a: CL:0000003 ! native cell intersection_of: CL:0000003 ! native cell intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-09-07T03:32:33Z [Term] id: CL:0002243 name: smooth muscle cell of sphincter of pupil namespace: cell def: "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." [GOC:tfm, ISBN:0721662544, ISBN:0721694128] synonym: "smooth muscle fiber of sphincter of pupil" EXACT [] synonym: "smooth muscle fibre of sphincter of pupil" RELATED [] xref: FMA:70611 is_a: CL:0000358 {is_inferred="true"} ! sphincter associated smooth muscle cell is_a: CL:0000359 ! vascular associated smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001607 ! sphincter pupillae relationship: develops_from CL:0000133 ! neurectodermal cell relationship: part_of UBERON:0001607 ! sphincter pupillae created_by: tmeehan creation_date: 2010-09-08T08:53:42Z [Term] id: CL:0002244 name: squamous cell of ectocervix namespace: cell def: "A nonstratified squamous cell located in the ectocervix." [GOC:tfm, http://www.bu.edu/histology/p/19404loa.htm] synonym: "ectocervical squamous cell" EXACT [] xref: FMA:86483 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0002149 ! epithelial cell of uterus created_by: tmeehan creation_date: 2010-09-08T09:12:23Z [Term] id: CL:0002245 name: null lymphocyte namespace: cell def: "A lymphocyte that lacks T or B cell surface markers." [GOC:tfm, ISBN:068340007X] xref: FMA:83601 is_obsolete: true created_by: tmeehan creation_date: 2010-09-07T03:43:42Z [Term] id: CL:0002246 name: peripheral blood stem cell namespace: cell def: "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells)." [GOC:tfm] synonym: "PBSC" EXACT [] xref: BTO:0002669 xref: FMA:86711 is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell is_a: CL:0000080 ! circulating cell intersection_of: CL:0000037 ! hematopoietic stem cell intersection_of: part_of UBERON:0000178 ! blood relationship: part_of UBERON:0000178 ! blood created_by: tmeehan creation_date: 2010-09-07T03:57:09Z [Term] id: CL:0002247 name: pleural macrophage namespace: cell def: "A tissue macrophage that is in the pleural space." [GOC:tfm] xref: FMA:83024 is_a: CL:0000864 ! tissue-resident macrophage created_by: tmeehan creation_date: 2010-09-07T04:16:43Z [Term] id: CL:0002248 name: pluripotent stem cell namespace: cell def: "A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta." [GOC:tfm, PMID:19343304] xref: FMA:70570 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-07T04:26:06Z [Term] id: CL:0002249 name: primitive cardiac myocyte namespace: cell def: "A stem cell that can differentiate into a cardiac myocyte." [GOC:tfm, PMID:16938308] xref: FMA:75620 is_a: CL:0000035 ! single fate stem cell is_a: CL:0002078 ! meso-epithelial cell created_by: tmeehan creation_date: 2010-09-07T04:40:32Z [Term] id: CL:0002250 name: intestinal crypt stem cell namespace: cell def: "A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells." [GOC:tfm, ISBN:0517223651] synonym: "stem cell of intestinal crypt of lieberkuhn" EXACT [] xref: FMA:63379 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002563 ! intestinal epithelial cell intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0001983 ! crypt of Lieberkuhn relationship: part_of UBERON:0001983 ! crypt of Lieberkuhn created_by: tmeehan creation_date: 2010-09-08T09:21:22Z [Term] id: CL:0002251 name: epithelial cell of alimentary canal namespace: cell def: "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." [GOC:tfm, ISBN:0721662544] is_a: CL:0002076 ! endo-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001555 ! digestive tract relationship: part_of UBERON:0001555 ! digestive tract created_by: tmeehan creation_date: 2010-09-08T09:26:53Z [Term] id: CL:0002252 name: epithelial cell of esophagus namespace: cell alt_id: CL:1000402 def: "An epithelial cell of the esophagus." [GOC:tfm] xref: FMA:63071 is_a: CL:0002251 {is_inferred="true"} ! epithelial cell of alimentary canal intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001043 ! esophagus relationship: part_of UBERON:0001043 ! esophagus created_by: tmeehan creation_date: 2010-09-08T09:28:20Z [Term] id: CL:0002253 name: epithelial cell of large intestine namespace: cell alt_id: CL:1000292 def: "An epithelial cell of the large intestine." [GOC:tfm] synonym: "epithelial cell of colon" RELATED [] xref: BTO:0004297 xref: FMA:256157 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0000059 ! large intestine relationship: part_of UBERON:0000059 ! large intestine created_by: tmeehan creation_date: 2010-09-08T09:28:22Z [Term] id: CL:0002254 name: epithelial cell of small intestine namespace: cell alt_id: CL:1000293 def: "An epithelial cell of the small intestine." [GOC:tfm] xref: FMA:256159 is_a: CL:0002563 {is_inferred="true"} ! intestinal epithelial cell intersection_of: CL:0002563 ! intestinal epithelial cell intersection_of: part_of UBERON:0002108 ! small intestine relationship: part_of UBERON:0002108 ! small intestine created_by: tmeehan creation_date: 2010-09-08T09:41:46Z [Term] id: CL:0002255 name: stromal cell of endometrium namespace: cell def: "An epithelial cell that regulates growth and differentiation of the overlying epithelium." [GOC:tfm, PMID:11331626] xref: CALOHA:TS-1266 xref: FMA:86490 is_a: CL:0000499 {is_inferred="true"} ! stromal cell is_a: CL:0002149 ! epithelial cell of uterus intersection_of: CL:0000499 ! stromal cell intersection_of: part_of UBERON:0001295 ! endometrium relationship: part_of UBERON:0001295 ! endometrium created_by: tmeehan creation_date: 2010-09-08T09:50:04Z [Term] id: CL:0002256 name: supporting cell of carotid body namespace: cell def: "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." [GOC:tfm, http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells, PMID:8985136] synonym: "carotid body sustentacular cell" EXACT [] xref: FMA:84188 is_a: CL:0000630 ! supportive cell is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-08T10:34:45Z [Term] id: CL:0002257 name: epithelial cell of thyroid gland namespace: cell alt_id: CL:1000297 def: "An epithelial cell of thyroid gland." [GOC:tfm] xref: FMA:256167 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002046 ! thyroid gland relationship: part_of UBERON:0002046 ! thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:46:51Z [Term] id: CL:0002258 name: thyroid follicular cell namespace: cell def: "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." [GOC:tfm, ISBN:0517223651] synonym: "follicular cell of thyroid gland" EXACT [] synonym: "principal cell of thyroid gland" EXACT [] synonym: "thyroid gland follicular cell" EXACT [] xref: BTO:0003736 xref: CALOHA:TS-1285 xref: FMA:68782 is_a: CL:0002257 ! epithelial cell of thyroid gland created_by: tmeehan creation_date: 2010-09-08T01:50:08Z [Term] id: CL:0002259 name: neuroepithelial stem cell namespace: cell def: "The stem cell from which glial precursor cell arises from." [GOC:tfm, PMID:11687496] synonym: "totipotent neuroepithelial stem cell" NARROW [] xref: FMA:87171 is_a: CL:0000723 ! somatic stem cell created_by: tmeehan creation_date: 2010-09-08T02:14:14Z [Term] id: CL:0002260 name: epithelial cell of parathyroid gland namespace: cell alt_id: CL:1000429 def: "An epithelial cell of the parathyroid gland." [GOC:tfm] xref: FMA:70547 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0001132 ! parathyroid gland relationship: part_of UBERON:0001132 ! parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:29:38Z [Term] id: CL:0002261 name: endothelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000446 def: "An endothelial cell found in the mucosa associated with the facial skeleton." [GOC:tfm, ISBN:0618947256] xref: FMA:70627 is_a: CL:0002076 ! endo-epithelial cell created_by: tmeehan creation_date: 2010-09-14T10:40:12Z [Term] id: CL:0002262 name: endothelial cell of sinusoid namespace: cell alt_id: CL:1000403 def: "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver." [GOC:tfm, ISBN:0618947256] xref: FMA:63134 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0003909 ! sinusoid relationship: part_of UBERON:0003909 ! sinusoid created_by: tmeehan creation_date: 2010-09-14T10:57:26Z [Term] id: CL:0002263 name: transitional cell of parathyroid gland namespace: cell def: "One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage." [GOC:tfm, ISBN:0412046911] xref: FMA:69324 is_a: CL:0002260 ! epithelial cell of parathyroid gland created_by: tmeehan creation_date: 2010-09-08T02:33:50Z [Term] id: CL:0002264 name: type A cell of stomach namespace: cell def: "A type of enteroendocrine cell found in the stomach that secretes glucagon." [GOC:tfm] xref: FMA:83411 is_a: CL:0002067 ! type A enterocrine cell is_a: CL:0002659 ! glandular cell of stomach created_by: tmeehan creation_date: 2010-09-10T10:54:42Z [Term] id: CL:0002265 name: type D cell of colon namespace: cell def: "A D cell located in the colon." [GOC:tfm] xref: FMA:268744 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002658 ! glandular cell of the large intestine is_a: CL:1001516 ! intestinal enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T11:37:35Z [Term] id: CL:0002266 name: type D cell of small intestine namespace: cell def: "A type D cell of the small intestine." [GOC:tfm] xref: FMA:268736 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002254 ! epithelial cell of small intestine is_a: CL:1001516 ! intestinal enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T01:34:22Z [Term] id: CL:0002267 name: type D cell of stomach namespace: cell def: "A type D cell found in the stomach." [GOC:tfm] xref: FMA:83410 is_a: CL:0000502 ! type D enteroendocrine cell is_a: CL:0002659 ! glandular cell of stomach created_by: tmeehan creation_date: 2010-09-10T01:36:03Z [Term] id: CL:0002268 name: P/D1 enteroendocrine cell namespace: cell def: "An enteroendocrine cell that stores and secretes Ghrelin." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63207 xref: FMA:63418 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002269 ! vasoactive intestinal peptide secreting cell created_by: tmeehan creation_date: 2010-09-10T01:47:45Z [Term] id: CL:0002269 name: vasoactive intestinal peptide secreting cell namespace: cell def: "An endocrine cell that secretes vasoactive intestinal peptide." [GOC:tfm] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T01:52:20Z [Term] id: CL:0002270 name: type EC2 enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:62941 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-09-10T02:13:47Z [Term] id: CL:0002271 name: type EC1 enteroendocrine cell namespace: cell def: "A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine." [GOC:tfm, ISBN:0517223651] xref: FMA:62940 is_a: CL:0000505 ! substance P secreting cell is_a: CL:0000577 ! type EC enteroendocrine cell created_by: tmeehan creation_date: 2010-09-10T02:13:49Z [Term] id: CL:0002272 name: motilin secreting cell namespace: cell def: "A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect." [GOC:tfm, MESH:D06.472.317.525] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T02:31:13Z [Term] id: CL:0002273 name: type ECL enteroendocrine cell namespace: cell def: "A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine." [GOC:tfm, ISBN:0517223651, PMID:15153415] xref: FMA:63208 is_a: CL:0000577 ! type EC enteroendocrine cell is_a: CL:0002274 ! histamine secreting cell created_by: tmeehan creation_date: 2010-09-10T02:35:17Z [Term] id: CL:0002274 name: histamine secreting cell namespace: cell def: "A cell type that secretes histamine." [GOC:tfm] is_a: CL:0000457 ! biogenic amine secreting cell intersection_of: CL:0000151 ! secretory cell intersection_of: RO:0002215 GO:0001821 ! capable_of histamine secretion relationship: RO:0002215 GO:0001821 ! capable_of histamine secretion created_by: tmeehan creation_date: 2010-09-10T03:04:42Z [Term] id: CL:0002275 name: pancreatic PP cell namespace: cell def: "A PP cell located in the islets of the pancreas." [GOC:tfm] comment: The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell. synonym: "pancreatic polypeptide-secreting cell" EXACT [] synonym: "PP cell of pancreatic islet" EXACT [] synonym: "PP-cell of pancreatic islet" EXACT [] xref: BTO:0000805 xref: FMA:70588 is_a: CL:0000083 ! epithelial cell of pancreas is_a: CL:0000696 ! PP cell intersection_of: CL:0000696 ! PP cell intersection_of: part_of UBERON:0000006 ! islet of Langerhans intersection_of: part_of UBERON:0001264 ! pancreas relationship: part_of UBERON:0000006 ! islet of Langerhans relationship: part_of UBERON:0001264 ! pancreas created_by: tmeehan creation_date: 2010-09-10T03:30:31Z [Term] id: CL:0002276 name: PP cell of pancreatic acinus namespace: cell def: "A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus." [GOC:tfm] synonym: "type F cell of pancreatic acinus" EXACT [] xref: FMA:85400 is_obsolete: true created_by: tmeehan creation_date: 2010-09-10T03:30:33Z [Term] id: CL:0002277 name: type I enteroendocrine cell namespace: cell def: "An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile." [GOC:tfm] synonym: "CCK cell" EXACT [] xref: FMA:62937 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:44:36Z [Term] id: CL:0002278 name: GIP cell namespace: cell def: "An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide." [GOC:tfm] synonym: "type K enteroendocrine cell" EXACT [] xref: FMA:62942 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:51:47Z [Term] id: CL:0002279 name: type L enteroendocrine cell namespace: cell def: "A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY." [ISBN:0517223651, PMID:15153415] xref: FMA:62944 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T03:59:09Z [Term] id: CL:0002280 name: type N enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." [GOC:tfm] synonym: "N cell" EXACT [] xref: FMA:62943 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-10T04:08:29Z [Term] id: CL:0002281 name: type S enteroendocrine cell namespace: cell def: "Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin." [GOC:tfm, PMID:15153415] xref: FMA:62936 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000167 ! peptide hormone secreting cell is_a: CL:0000458 ! serotonin secreting cell created_by: tmeehan creation_date: 2010-09-10T04:44:46Z [Term] id: CL:0002282 name: type TG enteroendocrine cell namespace: cell def: "An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide." [DOI:10.1007/978-3-211-99390-3, GOC:tfm, PMID:7013499] xref: FMA:63421 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000509 ! gastrin secreting cell created_by: tmeehan creation_date: 2010-09-13T09:48:34Z [Term] id: CL:0002283 name: ecto-epithelial cell of viscerocranial mucosa namespace: cell alt_id: CL:1000440 def: "An epithelial cell of the mucosa associated with facial skeleton." [GOC:tfm, ISBN:0323052908] xref: FMA:70581 is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T11:04:02Z [Term] id: CL:0002284 name: type X enteroendocrine cell namespace: cell def: "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." [GOC:tfm, PMID:20616512] synonym: "A-like" EXACT [] synonym: "X/A-like" EXACT [] xref: FMA:63209 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0005018 ! ghrelin secreting cell created_by: tmeehan creation_date: 2010-09-13T10:12:12Z [Term] id: CL:0002285 name: type III taste bud cell namespace: cell def: "A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM." [GOC:tfm, ISBN:0517223651, PMID:15738192] synonym: "taste bud basal cell" BROAD [] synonym: "type 3 taste cell" EXACT [] xref: FMA:67940 is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:21Z [Term] id: CL:0002286 name: type II taste cell namespace: cell def: "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." [GOC:tfm, PMID:15738192] synonym: "type 2 taste cell" EXACT [] xref: FMA:62381 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:26Z [Term] id: CL:0002287 name: type IV taste receptor cell namespace: cell def: "A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally." [GOC:tfm, ISBN:0517223651, PMID:15738192] comment: There is debate about the exact lineage of these cell types from this progenitor. See PMID:15738192. synonym: "taste bud basal cell" BROAD [] synonym: "type 4 taste cell" EXACT [] xref: FMA:62380 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:29Z [Term] id: CL:0002288 name: type V taste receptor cell namespace: cell def: "A cell type that forms the boundary with the surrounding epithelium." [GOC:tfm, ISBN:0517223651] xref: FMA:67941 is_a: CL:0000209 ! taste receptor cell created_by: tmeehan creation_date: 2010-09-13T10:57:31Z [Term] id: CL:0002289 name: type I taste bud cell namespace: cell def: "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." [GOC:tfm, ISBN:0412046911, ISBN:0517223651, PMID:15738192] synonym: "dark tongue cell" EXACT [] synonym: "type I taste cell" EXACT [] synonym: "type taste 1 cell" EXACT [] xref: FMA:62356 is_a: CL:0000209 ! taste receptor cell is_a: CL:0000703 ! sustentacular cell created_by: tmeehan creation_date: 2010-09-13T10:57:35Z [Term] id: CL:0002290 name: Y chromosome-bearing sperm cell namespace: cell def: "A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "Y bearing sperm" EXACT [] synonym: "Y-bearing sperm" EXACT [] xref: FMA:84058 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:24Z [Term] id: CL:0002291 name: X chromosome-bearing sperm cell namespace: cell def: "A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum." [GOC:tfm, ISBN:0721669743] synonym: "X bearing sperm" EXACT [] synonym: "X-bearing sperm" EXACT [] xref: FMA:84057 is_a: CL:0000019 ! sperm created_by: tmeehan creation_date: 2010-09-13T11:35:26Z [Term] id: CL:0002292 name: type I cell of carotid body namespace: cell def: "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters." [GOC:tfm, ISBN:0517223651] synonym: "glomus cell" EXACT [] xref: FMA:84186 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-13T01:40:21Z [Term] id: CL:0002293 name: epithelial cell of thymus namespace: cell alt_id: CL:1000459 def: "An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies." [FMA:72208, GOC:tfm] synonym: "epithelial cell of thymus gland" EXACT [] synonym: "epithelial reticular cell" EXACT [] synonym: "epithelial reticular cell of thymus" EXACT [] synonym: "thymic epithelial cell" EXACT [] xref: CALOHA:TS-1040 xref: FMA:72208 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0002370 ! thymus relationship: part_of UBERON:0002370 ! thymus created_by: tmeehan creation_date: 2010-09-13T02:34:22Z [Term] id: CL:0002294 name: type-1 epithelial cell of thymus namespace: cell def: "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." [GOC:tfm, PMID:9264335] synonym: "subcapsular thymic epithelial cell" EXACT [] xref: FMA:72209 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:23Z [Term] id: CL:0002295 name: type-6 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections." [GOC:tfm, PMID:19721455, PMID:9264335] synonym: "cystic thymic epithelial cells" EXACT [] synonym: "large medullary thymic epithelial cells" EXACT [] synonym: "large mTEC" EXACT [] xref: FMA:72214 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:26Z [Term] id: CL:0002296 name: type-4 epithelial cell of thymus namespace: cell def: "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." [FMA:0412046911, GOC:tfm, PMID:9264335] synonym: "dark thymic epithelial cell" EXACT [] xref: FMA:72212 is_a: CL:0002364 ! cortical thymic epithelial cell is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:45Z [Term] id: CL:0002297 name: type-3 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell with moderate nuclear and cytoplasmic electron-density. Scattered in the cortex, this cell type is predominant in the mid and deep cortex." [PMID:9264335] synonym: "intermediate thymic epithelial cell" EXACT [] xref: FMA:72211 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:51Z [Term] id: CL:0002298 name: type-5 epithelial cell of thymus namespace: cell def: "A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla." [GOC:tfm, ISBN:0412046911, PMID:19721455, PMID:9264335] synonym: "undifferentiated medullary thymic epithelial cell" EXACT [] synonym: "undifferentiated mTEC" EXACT [] synonym: "undifferentiated thymic epithelial cell" EXACT [] xref: FMA:72213 is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:54Z [Term] id: CL:0002299 name: type-2 epithelial cell of thymus namespace: cell def: "An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus." [GOC:tfm, ISBN:0412046911, PMID:9264335] synonym: "pale thymic epithelial cell" EXACT [] xref: FMA:72210 is_a: CL:0002364 ! cortical thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T02:37:58Z [Term] id: CL:0002300 name: type-7 epithelial cell of thymus namespace: cell def: "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." [GOC:tfm, PMID:19721455] synonym: "spindle shaped medullary thymic epithelial cell" EXACT [] synonym: "spindle shaped mTEC" EXACT [] is_a: CL:0002365 ! medullary thymic epithelial cell created_by: tmeehan creation_date: 2010-09-13T03:23:25Z [Term] id: CL:0002301 name: type B synovial cell namespace: cell def: "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." [GOC:tfm, ISBN:0517223651] xref: FMA:66788 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:14Z [Term] id: CL:0002302 name: type A synovial cell namespace: cell def: "A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum." [GOC:tfm, ISBN:0517223651] synonym: "type A synoviocyte" EXACT [] xref: FMA:66787 is_a: CL:0000214 ! synovial cell created_by: tmeehan creation_date: 2010-09-13T03:39:17Z [Term] id: CL:0002303 name: pigmented ciliary epithelial cell namespace: cell def: "A ciliated epithelial cell of the retina, this cell type uptakes sodium chloride and passes it to non-pigmented ciliary epithelial cells." [PMID:15106942] synonym: "PE" EXACT [] xref: FMA:70606 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell created_by: tmeehan creation_date: 2010-09-13T04:09:27Z [Term] id: CL:0002304 name: non-pigmented ciliary epithelial cell namespace: cell def: "A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells." [GOC:tfm, PMID:15106942] synonym: "NPE" EXACT [] xref: FMA:70607 is_a: CL:0000067 ! ciliated epithelial cell is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell is_a: CL:0005012 ! multi-ciliated epithelial cell intersection_of: CL:0000710 ! neurecto-epithelial cell intersection_of: part_of UBERON:0001778 ! ciliary epithelium relationship: part_of UBERON:0001778 ! ciliary epithelium created_by: tmeehan creation_date: 2010-09-13T04:09:31Z [Term] id: CL:0002305 name: epithelial cell of distal tubule namespace: cell def: "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH." [GOC:tfm, ISBN:0517223651] synonym: "kidney distal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70981 xref: KUPO:0001055 is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004135 ! distal tubule relationship: part_of UBERON:0004135 ! distal tubule [Term] id: CL:0002306 name: epithelial cell of proximal tubule namespace: cell def: "An epithelial cell of the proximal tubule of the kidney." [GOC:tfm, ISBN:1-4160-2328-3] synonym: "kidney proximal tubule epithelial cell" EXACT [] xref: FMA:62125 xref: FMA:70973 xref: KUPO:0001044 is_a: CL:0000239 ! brush border epithelial cell is_a: CL:0002078 ! meso-epithelial cell is_a: CL:1000615 ! kidney cortex tubule cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0004134 ! proximal tubule relationship: part_of UBERON:0004134 ! proximal tubule [Term] id: CL:0002307 name: brush border cell of the proximal tubule namespace: cell def: "A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow." [GOC:tfm, ISBN:1-4160-2328-3] is_a: CL:0002306 ! epithelial cell of proximal tubule created_by: tmeehan creation_date: 2010-09-14T11:29:20Z [Term] id: CL:0002308 name: epithelial cell of skin gland namespace: cell def: "An epithelial cell of a skin gland." [GOC:tfm] synonym: "epithelial cell of gland of skin" EXACT [] xref: FMA:70657 is_a: CL:0002159 ! general ecto-epithelial cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002419 ! skin gland relationship: part_of UBERON:0002419 ! skin gland created_by: tmeehan creation_date: 2010-09-14T12:00:07Z [Term] id: CL:0002309 name: corticotroph namespace: cell def: "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;" [GOC:tfm, ISBN:0517223651] xref: BTO:0002509 xref: FMA:83098 is_a: CL:0000467 ! adrenocorticotropic hormone secreting cell is_a: CL:0000639 ! basophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:08:23Z [Term] id: CL:0002310 name: mammosomatotroph namespace: cell def: "An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone." [GOC:tfm] xref: FMA:83097 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:25:34Z [Term] id: CL:0002311 name: mammotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces prolactin." [SANBI:mhl] synonym: "epsilon-acidophil" EXACT [] synonym: "lactotrope" EXACT [] synonym: "lactotroph" EXACT [] synonym: "lactotropic cell" EXACT [] synonym: "mammotrope" EXACT [] synonym: "mammotrophic cell" EXACT [] synonym: "mammotropic cell" EXACT [] xref: FMA:83096 is_a: CL:0000439 ! prolactin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:30:57Z [Term] id: CL:0002312 name: somatotroph namespace: cell def: "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [SANBI:mhl] synonym: "somatotrope" EXACT [] synonym: "somatotropic cell" EXACT [] synonym: "somatrophic cell" EXACT [] xref: FMA:83095 is_a: CL:0000295 ! somatotropin secreting cell is_a: CL:0000638 ! acidophil cell of pars distalis of adenohypophysis created_by: tmeehan creation_date: 2010-09-14T02:33:09Z [Term] id: CL:0002313 name: endocrine-paracrine cell of prostate gland namespace: cell def: "An ecto-epithelial cell of the prostate gland that secretes hormones." [GOC:tfm] synonym: "glandular cell of prostate" EXACT [] synonym: "neuro-epithelial cell of prostate gland" EXACT [] xref: CALOHA:TS-1280 xref: FMA:74390 xref: FMA:86774 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0002159 ! general ecto-epithelial cell created_by: tmeehan creation_date: 2010-09-14T03:01:58Z [Term] id: CL:0002314 name: external supporting cell of vestibular epithelium namespace: cell def: "An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein." [GOC:tfm, PMID:20837532] xref: FMA:75809 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:20:01Z [Term] id: CL:0002315 name: supporting cell of cochlea namespace: cell def: "An epithelial supporting cell located in the cochlea." [GOC:tfm] xref: FMA:79796 is_a: CL:0005014 ! auditory epithelial support cell created_by: tmeehan creation_date: 2010-09-14T03:31:38Z [Term] id: CL:0002316 name: supporting cell of vestibular epithelium namespace: cell def: "A supporting cell of the vestibular epithelium." [GOC:tfm, PMID:20837532] xref: FMA:75607 is_a: CL:0005014 ! auditory epithelial support cell created_by: tmeehan creation_date: 2010-09-14T03:31:44Z [Term] id: CL:0002317 name: external limiting cell of vestibular epithelium namespace: cell def: "An external limiting cell found in the vestibular epithelium." [GOC:tfm] xref: FMA:75808 is_a: CL:0002316 ! supporting cell of vestibular epithelium created_by: tmeehan creation_date: 2010-09-14T03:33:50Z [Term] id: CL:0002318 name: periperhal blood mesothelial cell namespace: cell def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528] xref: FMA:86712 is_a: CL:0000081 ! blood cell relationship: develops_from CL:0000077 ! mesothelial cell created_by: tmeehan creation_date: 2010-09-15T10:47:11Z [Term] id: CL:0002319 name: neural cell namespace: cell def: "A cell that is part of the nervous system." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2040 xref: FMA:70333 is_a: CL:0000548 ! animal cell is_a: CL:0002371 ! somatic cell created_by: tmeehan creation_date: 2010-09-15T01:34:57Z [Term] id: CL:0002320 name: connective tissue cell namespace: cell alt_id: CL:1000406 def: "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." [GOC:tfm, ISBN:0618947256] xref: CALOHA:TS-2096 xref: FMA:63875 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0002384 ! connective tissue relationship: part_of UBERON:0002384 ! connective tissue created_by: tmeehan creation_date: 2010-09-15T03:01:54Z [Term] id: CL:0002321 name: embryonic cell namespace: cell def: "A cell of the embryo." [FMA:0618947256] xref: CALOHA:TS-0263 xref: FMA:82840 xref: FMA:82841 xref: WBbt:0007028 is_a: CL:0000548 ! animal cell created_by: tmeehan creation_date: 2010-09-15T03:39:21Z [Term] id: CL:0002322 name: embryonic stem cell namespace: cell def: "A stem cell of embryonic origin." [GOC:dsd, GOC:tfm, ISBN:068340007X, PMID:18179856] comment: This is an in vitro cell type and may be removed in future releases. These cells are reportedly SSEA-4-positive, CD73-negative, and CD324-positive. synonym: "ESC" EXACT [] xref: BTO:0001086 xref: CALOHA:TS-0263 xref: FMA:82841 is_a: CL:0000034 ! stem cell is_a: CL:0002321 ! embryonic cell created_by: tmeehan creation_date: 2010-09-15T03:44:35Z [Term] id: CL:0002323 name: amniocyte namespace: cell def: "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." [BFO:0000066, GOC:tfm, PMID:3211847] xref: BTO:0000066 is_a: CL:0000349 {is_inferred="true"} ! extraembryonic cell intersection_of: CL:0000349 ! extraembryonic cell intersection_of: located_in UBERON:0000173 ! amniotic fluid relationship: located_in UBERON:0000173 ! amniotic fluid created_by: tmeehan creation_date: 2010-09-20T10:13:37Z [Term] id: CL:0002324 name: myoepithelial cell of mammary gland namespace: cell def: "A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative." [GOC:tfm, PMID:11250738, PMID:19022771] is_a: CL:1000416 ! myoepithelial cell of lactiferous gland created_by: tmeehan creation_date: 2010-09-20T11:42:14Z [Term] id: CL:0002325 name: mammary alveolar cell namespace: cell alt_id: CL:0002230 alt_id: CL:1000476 def: "The milk-producing cell of the alveolar unit that emerges during pregnancy." [GOC:tfm, PMID:19022771] synonym: "epithelial cell of lactiferous gland" EXACT [] synonym: "luminal cell of alveolus of lactiferous gland" EXACT [] xref: FMA:74506 xref: FMA:79866 is_a: CL:0000150 ! glandular epithelial cell is_a: CL:0000314 ! milk secreting cell is_a: CL:0002159 {is_inferred="true"} ! general ecto-epithelial cell is_a: CL:0002327 {is_inferred="true"} ! mammary epithelial cell intersection_of: CL:0002159 ! general ecto-epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2010-09-20T01:30:57Z [Term] id: CL:0002326 name: luminal epithelial cell of mammary gland namespace: cell def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771] xref: FMA:73280 is_a: CL:0000069 ! branched duct epithelial cell is_a: CL:0002327 ! mammary epithelial cell created_by: tmeehan creation_date: 2010-09-20T01:37:53Z [Term] id: CL:0002327 name: mammary epithelial cell namespace: cell def: "An epithelial cell of the mammary gland." [GOC:tfm, PMID:19022771] synonym: "breast epithelial cell" EXACT [] xref: BTO:0004300 is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0001911 ! mammary gland relationship: part_of UBERON:0001911 ! mammary gland created_by: tmeehan creation_date: 2010-09-20T01:49:37Z [Term] id: CL:0002328 name: bronchial epithelial cell namespace: cell def: "An epithelial cell of the bronchus." [GOC:tfm] xref: BTO:0002922 is_a: CL:0002202 ! epithelial cell of tracheobronchial tree intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002031 ! epithelium of bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:00:00Z [Term] id: CL:0002329 name: basal epithelial cell of tracheobronchial tree namespace: cell def: "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury." [GOC:tfm] is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-20T02:10:36Z [Term] id: CL:0002330 name: undifferentiated cell of bronchus epithelium namespace: cell def: "An undifferentiated columnar cell of the bronchus epithelium" [GOC:tfm, PMID:18757316] is_a: CL:0002328 ! bronchial epithelial cell created_by: tmeehan creation_date: 2010-09-20T02:17:58Z [Term] id: CL:0002332 name: ciliated cell of the bronchus namespace: cell def: "A ciliated cell of the bronchus." [GOC:tfm, PMID:18757316] is_a: CL:0002145 ! ciliated columnar cell of tracheobronchial tree is_a: CL:0002328 ! bronchial epithelial cell intersection_of: CL:0000064 ! ciliated cell intersection_of: part_of UBERON:0002185 ! bronchus relationship: part_of UBERON:0002185 ! bronchus created_by: tmeehan creation_date: 2010-09-20T02:21:12Z [Term] id: CL:0002333 name: neural crest derived fat cell namespace: cell def: "A fat cell derived from a neural crest cell." [GOC:tfm, PMID:17507398] is_a: CL:0000136 ! fat cell relationship: develops_from CL:0000005 ! fibroblast neural crest derived created_by: tmeehan creation_date: 2010-09-20T02:25:25Z [Term] id: CL:0002334 name: preadipocyte namespace: cell def: "An undifferentiated fibroblast that can be stimulated to form a fat cell." [GOC:tfm, PMID:18793119] xref: BTO:0001107 is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-09-20T02:31:53Z [Term] id: CL:0002335 name: brown preadipocyte namespace: cell def: "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha)." [GOC:tfm, PMID:18719589] is_a: CL:0002334 ! preadipocyte created_by: tmeehan creation_date: 2010-09-20T02:38:38Z [Term] id: CL:0002336 name: buccal mucosa cell namespace: cell def: "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." [GOC:tfm, MESH:A10.615.550.599] is_a: CL:0002261 ! endothelial cell of viscerocranial mucosa created_by: tmeehan creation_date: 2010-09-20T02:52:54Z [Term] id: CL:0002337 name: keratinocyte stem cell namespace: cell def: "A stem cell located in the bulge of the hair follicle that can give rise to regenerate the new follicle with each hair cycle and to reepithelialize the epidermis during wound repair." [PMID:15339667] synonym: "bulge keratinocyte" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0000312 ! keratinocyte is_a: CL:1000428 ! stem cell of epidermis created_by: tmeehan creation_date: 2010-09-20T03:07:03Z [Term] id: CL:0002338 name: CD56-positive, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: develops_from CL:0002344 ! CD56-negative, CD161-positive immature natural killer cell relationship: has_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule created_by: tmeehan creation_date: 2010-09-21T10:06:53Z [Term] id: CL:0002339 name: prostate stem cell namespace: cell def: "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium." [GOC:tfm, PMID:15226377] synonym: "CD133-positive prostate epithelial cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell is_a: CL:0002341 ! basal cell of prostate epithelium intersection_of: CL:0000034 ! stem cell intersection_of: part_of UBERON:0002367 ! prostate gland relationship: part_of UBERON:0002367 ! prostate gland created_by: tmeehan creation_date: 2010-09-20T03:21:06Z [Term] id: CL:0002340 name: luminal cell of prostate epithelium namespace: cell def: "The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival." [GOC:tfm] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:05Z [Term] id: CL:0002341 name: basal cell of prostate epithelium namespace: cell def: "An undifferentiated cell of the prostate epithelium that lacks secretory activity." [GOC:tfm, PMCID:PMC2673349] is_a: CL:0002231 ! epithelial cell of prostate created_by: tmeehan creation_date: 2010-09-20T03:34:10Z [Term] id: CL:0002342 name: circulating endothelial cell namespace: cell def: "A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage." [GOC:tfm, PMID:19652886] is_a: CL:0000115 ! endothelial cell created_by: tmeehan creation_date: 2010-09-20T03:49:58Z [Term] id: CL:0002343 name: decidual natural killer cell namespace: cell def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965] synonym: "decidual NK cell" EXACT [] synonym: "dNK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 intersection_of: has_plasma_membrane_part PR:000009766 ! galectin-1 intersection_of: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_high_plasma_membrane_amount PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000009766 ! galectin-1 relationship: lacks_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-09-20T04:00:02Z [Term] id: CL:0002344 name: CD56-negative, CD161-positive immature natural killer cell namespace: cell def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618] comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily). synonym: "p-NK" RELATED [PMID:12457618] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta intersection_of: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule intersection_of: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 relationship: has_plasma_membrane_part PR:000001381 ! interleukin-2 receptor subunit beta relationship: has_plasma_membrane_part PR:000001874 ! KLRB1-like protein relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001003 ! CD34 molecule relationship: lacks_plasma_membrane_part PR:000001024 ! neural cell adhesion molecule 1 created_by: tmeehan creation_date: 2010-09-20T04:33:11Z [Term] id: CL:0002345 name: CD27-low, CD11b-low immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422] comment: Markers are associated with mouse cells. synonym: "preNK.BM" BROAD [] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 relationship: develops_from CL:0002346 ! Dx5-negative, NK1.1-positive immature natural killer cell relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000009616 ! T-cell surface glycoprotein YE1/48 created_by: tmeehan creation_date: 2010-09-20T04:41:01Z [Term] id: CL:0002346 name: Dx5-negative, NK1.1-positive immature natural killer cell namespace: cell def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763] is_a: CL:0000823 {is_inferred="true"} ! immature natural killer cell intersection_of: CL:0000823 ! immature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C intersection_of: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: lacks_plasma_membrane_part PR:000001008 ! integrin alpha-2 created_by: tmeehan creation_date: 2010-09-21T10:11:44Z [Term] id: CL:0002347 name: CD27-high, CD11b-high natural killer cell namespace: cell def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: RO:0002215 GO:0032609 ! capable_of interferon-gamma production relationship: develops_from CL:0002349 ! CD27-high, CD11b-low natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: RO:0002215 GO:0032609 ! capable_of interferon-gamma production created_by: tmeehan creation_date: 2010-09-21T10:19:49Z [Term] id: CL:0002348 name: CD27-low, CD11b-high natural killer cell namespace: cell def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: develops_from CL:0002347 ! CD27-high, CD11b-high natural killer cell relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-09-21T10:19:54Z [Term] id: CL:0002349 name: CD27-high, CD11b-low natural killer cell namespace: cell def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922] is_a: CL:0002426 ! CD11b-positive, CD27-positive natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: develops_from CL:0002345 ! CD27-low, CD11b-low immature natural killer cell relationship: has_high_plasma_membrane_amount PR:000001963 ! CD27 molecule relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-09-21T10:20:00Z [Term] id: CL:0002350 name: endocardial cell namespace: cell alt_id: CL:1000475 def: "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin." [GOC:tfm, ISSN:0452-3458] synonym: "endocardial endothelial cell" EXACT [] synonym: "endothelial cell of endocardium" EXACT [FMA:75621] xref: FMA:75621 is_a: CL:0000115 {is_inferred="true"} ! endothelial cell is_a: CL:0002494 ! cardiocyte intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0002165 ! endocardium relationship: part_of UBERON:0002165 ! endocardium created_by: tmeehan creation_date: 2010-09-21T04:33:05Z [Term] id: CL:0002351 name: progenitor cell of endocrine pancreas namespace: cell def: "A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1." [GOC:tfm, PMID:20025937, PMID:20217494] synonym: "pancreatic endocrine progenitor" EXACT [] synonym: "pancreatic islet progenitor cell" EXACT [] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-09-21T04:41:06Z [Term] id: CL:0002352 name: gestational hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell that exists during embryogenesis." [GOC:tfm, ISBN:978-60327-246-6] is_a: CL:0000037 ! hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T09:05:13Z [Term] id: CL:0002353 name: fetal liver hematopoietic progenitor cell namespace: cell def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 intersection_of: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule intersection_of: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 relationship: has_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001833 ! SLAM family member 1 relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: has_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: lacks_plasma_membrane_part PR:000001308 ! CD48 molecule relationship: lacks_plasma_membrane_part PR:000001896 ! natural killer cell receptor 2B4 created_by: tmeehan creation_date: 2010-09-22T09:08:32Z [Term] id: CL:0002354 name: yolk sac hematopoietic stem cell namespace: cell def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm] synonym: "hemangioblast precursor" EXACT [] is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell intersection_of: CL:0002352 ! gestational hematopoietic stem cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex intersection_of: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0042611 ! MHC protein complex relationship: lacks_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000002979 ! lymphocyte antigen 6A-2/6E-1 created_by: tmeehan creation_date: 2010-09-22T09:08:34Z [Term] id: CL:0002355 name: primitive red blood cell namespace: cell def: "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." [DOI:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "primitive erythroblast" EXACT [] synonym: "primitive erythrocyte" EXACT [] synonym: "primitive erythroid cell" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: has_part PR:000008467 ! hemoglobin subunit zeta intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002361 ! primitive erythroid progenitor relationship: has_part PR:000008467 ! hemoglobin subunit zeta relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:27:05Z [Term] id: CL:0002356 name: primitive reticulocyte namespace: cell def: "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm, PMID:11495698] synonym: "megalocyte" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T09:35:16Z [Term] id: CL:0002357 name: fetal derived definitive erythrocyte namespace: cell def: "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins." [GOC:tfm, PMID:11495698] synonym: "macrocyte" EXACT [] is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte intersection_of: CL:0000595 ! enucleate erythrocyte intersection_of: has_part PR:000008857 ! hemoglobin subunit beta-1 intersection_of: part_of UBERON:0000922 ! embryo relationship: develops_from CL:0002353 ! fetal liver hematopoietic progenitor cell relationship: has_part PR:000008857 ! hemoglobin subunit beta-1 relationship: part_of UBERON:0000922 ! embryo created_by: tmeehan creation_date: 2010-09-22T09:38:32Z [Term] id: CL:0002358 name: pyrenocyte namespace: cell def: "Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte." [GOC:tfm] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: bearer_of PATO:0000587 ! decreased size intersection_of: develops_from CL:0002355 ! primitive red blood cell relationship: bearer_of PATO:0000587 ! decreased size relationship: develops_from CL:0002355 ! primitive red blood cell created_by: tmeehan creation_date: 2010-09-22T10:02:37Z [Term] id: CL:0002359 name: placental hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:30:02Z [Term] id: CL:0002360 name: AGM hematopoietic stem cell namespace: cell def: "A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC." [GOC:tfm, ISBN:978-1-60327-346-6] is_a: CL:0002352 ! gestational hematopoietic stem cell created_by: tmeehan creation_date: 2010-09-22T10:31:49Z [Term] id: CL:0002361 name: primitive erythroid progenitor namespace: cell def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979] synonym: "EryP-CFC" EXACT [] synonym: "inner blood island hemangioblast" EXACT [] is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell intersection_of: CL:0002417 ! primitive erythroid lineage cell intersection_of: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb relationship: develops_from CL:0002418 ! hemangioblast relationship: has_plasma_membrane_part PR:000009127 ! integrin alpha-IIb created_by: tmeehan creation_date: 2010-09-22T10:47:28Z [Term] id: CL:0002362 name: granule cell precursor namespace: cell def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007] is_a: CL:0000337 ! neuroblast (sensu Vertebrata) created_by: tmeehan creation_date: 2010-09-22T01:40:44Z [Term] id: CL:0002363 name: keratocyte namespace: cell def: "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate." [GOC:tfm, ISBN:978-0-7020-2958-5] synonym: "corneal fibroblast" EXACT [] synonym: "corneal keratocyte" EXACT [] is_a: CL:0000057 {is_inferred="true"} ! fibroblast intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001777 ! substantia propria of cornea relationship: develops_from CL:0000008 ! migratory cranial neural crest cell relationship: part_of UBERON:0001777 ! substantia propria of cornea created_by: tmeehan creation_date: 2010-09-22T01:57:40Z [Term] id: CL:0002364 name: cortical thymic epithelial cell namespace: cell def: "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells." [GOC:tfm, PMID:18403190] synonym: "cTEC" EXACT [] xref: BTO:0004562 is_a: CL:0002293 ! epithelial cell of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:12Z [Term] id: CL:0002365 name: medullary thymic epithelial cell namespace: cell def: "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output." [GOC:tfm, PMID:18180458] synonym: "mTEC" EXACT [] xref: BTO:0004563 is_a: CL:0002293 ! epithelial cell of thymus created_by: tmeehan creation_date: 2010-09-23T03:17:14Z [Term] id: CL:0002366 name: myometrial cell namespace: cell def: "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin." [GOC:tfm, PMID:11429640] synonym: "myometrium smooth muscle cell" EXACT [] xref: BTO:0004519 is_a: CL:0002601 ! uterine smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0001296 ! myometrium relationship: part_of UBERON:0001296 ! myometrium created_by: tmeehan creation_date: 2010-09-23T03:46:34Z [Term] id: CL:0002367 name: trabecular meshwork cell namespace: cell def: "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." [GOC:tfm, PMID:14500801] synonym: "trabeculocyte" EXACT [] is_a: CL:0000115 {is_inferred="true"} ! endothelial cell intersection_of: CL:0000115 ! endothelial cell intersection_of: part_of UBERON:0005969 ! reticulum trabeculare relationship: part_of UBERON:0005969 ! reticulum trabeculare created_by: tmeehan creation_date: 2010-09-23T04:18:50Z [Term] id: CL:0002368 name: respiratory epithelial cell namespace: cell def: "An endo-epithelial cell of the respiratory tract." [GOC:tfm] synonym: "airway epithelial cell" EXACT [] xref: BTO:0004533 is_a: CL:0002076 {is_inferred="true"} ! endo-epithelial cell intersection_of: CL:0002076 ! endo-epithelial cell intersection_of: part_of UBERON:0000065 ! respiratory tract relationship: part_of UBERON:0000065 ! respiratory tract created_by: tmeehan creation_date: 2010-09-23T04:38:49Z [Term] id: CL:0002369 name: fungal spore namespace: cell def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] is_a: CL:0000521 ! fungal cell created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002370 name: respiratory goblet cell namespace: cell def: "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion." [GOC:tfm, ISBN:0721662544] synonym: "respiratory mucosa goblet cells" EXACT [MP:0010863] is_a: CL:0000160 ! goblet cell is_a: CL:0002202 ! epithelial cell of tracheobronchial tree created_by: tmeehan creation_date: 2010-09-23T04:42:27Z [Term] id: CL:0002371 name: somatic cell namespace: cell def: "A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell)." [GOC:tfm, ISBN:0721662544] subset: ubprop:upper_level xref: BTO:0001268 xref: FMA:72300 xref: WBbt:0008378 is_a: CL:0000003 ! native cell created_by: tmeehan creation_date: 2010-09-24T09:44:42Z [Term] id: CL:0002372 name: myotube namespace: cell alt_id: CL:0000369 def: "A myotube is a multinucleated cells that is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:tfm, ISBN:0323052908] synonym: "myotubule" EXACT [] synonym: "single cell sarcomere" EXACT [] synonym: "skeletal muscle fiber" EXACT [] is_a: CL:0000188 ! skeletal muscle cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0000737 ! striated muscle cell relationship: develops_from CL:0000515 ! skeletal muscle myoblast created_by: tmeehan creation_date: 2010-09-24T01:13:01Z [Term] id: CL:0002373 name: growth hormone releasing hormone secreting cell namespace: cell def: "A peptide hormone secreting cell that secretes growth hormone releasing hormone." [GOC:dph, GOC:tfm] synonym: "GHRH secreting cell" EXACT [] synonym: "somatocrinin secreting cell" EXACT [] is_a: CL:0000167 ! peptide hormone secreting cell created_by: tmeehan creation_date: 2010-09-24T01:36:44Z [Term] id: CL:0002374 name: ear hair cell namespace: cell def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023] synonym: "ear receptor cell" EXACT [] is_a: CL:0000855 ! sensory hair cell created_by: tmeehan creation_date: 2010-09-24T01:49:31Z [Term] id: CL:0002375 name: Schwann cell precursor namespace: cell def: "A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19." [GOC:tfm] synonym: "Schwann cell precursor cell" EXACT [] is_a: CL:0000030 ! glioblast relationship: develops_from CL:0000333 ! migratory neural crest cell created_by: tmeehan creation_date: 2010-09-24T02:06:10Z [Term] id: CL:0002376 name: non-myelinating Schwann cell namespace: cell def: "A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002377 ! immature Schwann cell created_by: tmeehan creation_date: 2010-09-24T02:10:26Z [Term] id: CL:0002377 name: immature Schwann cell namespace: cell def: "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons." [GOC:cvs, GOC:tfm, ISBN:0721662544] synonym: "Schwann cell" BROAD [] xref: ZFA:0001725 is_a: CL:0002573 ! Schwann cell relationship: develops_from CL:0002375 ! Schwann cell precursor created_by: tmeehan creation_date: 2010-09-24T02:10:31Z [Term] id: CL:0002378 name: immature Vgamma2-positive fetal thymocyte namespace: cell def: "A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive and is found in the fetal thymus." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2+ thymocyte" BROAD [] is_a: CL:0002404 ! fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:21:07Z [Term] id: CL:0002379 name: meningothelial cell namespace: cell def: "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." [GOC:tfm, http://www.aippg.net/forum/viewtopic.php?t=62590] synonym: "arachnoid cap cell" EXACT [] xref: FMA:86588 is_a: CL:0000710 ! neurecto-epithelial cell created_by: tmeehan creation_date: 2010-09-28T02:23:46Z [Term] id: CL:0002380 name: oospore namespace: cell def: "An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere." [GOC:tfm, ISBN:0851988857, SGD:clt] xref: FAO:0000039 is_a: CL:0000605 ! fungal asexual spore created_by: tmeehan creation_date: 2010-10-01T09:22:45Z [Term] id: CL:0002381 name: uninucleate conidium namespace: cell def: "A conidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000025 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:26:39Z [Term] id: CL:0002382 name: multinucleate conidium namespace: cell def: "A conidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000033 is_a: CL:0000599 ! conidium created_by: tmeehan creation_date: 2010-10-01T09:31:28Z [Term] id: CL:0002383 name: conidium of conidiophore head namespace: cell def: "A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head." [GOC:tfm, PMID:9529886, SGD:clt] xref: FAO:0000033 is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002384 name: uninucleate macroconidium namespace: cell def: "A macroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000029 is_a: CL:0000606 ! macroconidium is_a: CL:0002381 ! uninucleate conidium [Term] id: CL:0002385 name: blastoconidium namespace: cell def: "An oblong or round asexual spore formed from conidial chains." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "blastospore" RELATED [] xref: BTO:0000127 xref: FAO:0000042 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002386 name: multinucleate macroconidium namespace: cell def: "A macroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000035 is_a: CL:0000606 ! macroconidium is_a: CL:0002382 ! multinucleate conidium [Term] id: CL:0002387 name: arthroconidium namespace: cell def: "Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores." [GOC:tfm, PMID:2524423, SGD:clt] synonym: "arthrospore" RELATED [] xref: FAO:0000041 is_a: CL:0000606 ! macroconidium [Term] id: CL:0002388 name: multinucleate arthroconidium namespace: cell def: "An arthroconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000037 is_a: CL:0002386 ! multinucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002389 name: uninucleate arthroconidium namespace: cell def: "An arthroconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000031 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002387 ! arthroconidium [Term] id: CL:0002390 name: uninucleate blastconidium namespace: cell def: "A blastoconidium that has only one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000030 is_a: CL:0002384 ! uninucleate macroconidium is_a: CL:0002385 ! blastoconidium [Term] id: CL:0002391 name: multinucleate blastoconidium namespace: cell def: "A blastoconidium that has more than one nucleus." [GOC:tfm, SGD:clt] xref: FAO:0000036 is_a: CL:0002385 ! blastoconidium is_a: CL:0002386 ! multinucleate macroconidium [Term] id: CL:0002392 name: plant spore namespace: cell def: "Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte." [GOC:tfm, PO:0025017] comment: replaced_by: PO:0025017 is_obsolete: true [Term] id: CL:0002393 name: intermediate monocyte namespace: cell def: "A monocyte that has characteristics of both patrolling and inflammatory monocytes." [GOC:tfm, PMID:20628149, PMID:20870168] is_a: CL:0000576 ! monocyte created_by: tmeehan creation_date: 2010-10-04T10:52:03Z [Term] id: CL:0002394 name: CD141-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." [GOC:dsd, GOC:tfm, PMCID:PMC2882828, PMCID:PMC2882837, PMID:17332250, PMID:20628149] comment: Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell is_a: CL:0000784 ! plasmacytoid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002105 ! thrombomodulin intersection_of: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response intersection_of: RO:0002215 GO:0032606 ! capable_of type I interferon production intersection_of: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I relationship: has_plasma_membrane_part PR:000002105 ! thrombomodulin relationship: RO:0002215 GO:0002827 ! capable_of positive regulation of T-helper 1 type immune response relationship: RO:0002215 GO:0032606 ! capable_of type I interferon production relationship: RO:0002215 GO:0042590 ! capable_of antigen processing and presentation of exogenous peptide antigen via MHC class I created_by: tmeehan creation_date: 2010-10-04T02:38:58Z [Term] id: CL:0002395 name: Gr1-high classical monocyte namespace: cell def: "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:20628149, PMID:8890901] comment: Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product. is_a: CL:0000860 {is_inferred="true"} ! classical monocyte is_a: CL:0001022 ! CD115-positive monocyte intersection_of: CL:0000860 ! classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001206 ! CX3C chemokine receptor 1 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin created_by: tmeehan creation_date: 2010-10-04T11:26:18Z [Term] id: CL:0002396 name: CD14-low, CD16-positive monocyte namespace: cell def: "A patrolling monocyte that is CD14-low and CD16-positive." [GOC:tfm, PMID:20870168] comment: Markers are associated with human monocytes. is_a: CL:0000875 {is_inferred="true"} ! non-classical monocyte intersection_of: CL:0000875 ! non-classical monocyte intersection_of: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: develops_from CL:0002397 ! CD14-positive, CD16-positive monocyte relationship: has_low_plasma_membrane_amount PR:000001889 ! CD14 molecule relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III created_by: tmeehan creation_date: 2010-10-04T12:25:42Z [Term] id: CL:0002397 name: CD14-positive, CD16-positive monocyte namespace: cell def: "An intermediate monocyte that is CD14-positive, CD16-positive." [GOC:tfm, PMID:20628149] comment: Markers are associated with human cells. is_a: CL:0002393 {is_inferred="true"} ! intermediate monocyte intersection_of: CL:0002393 ! intermediate monocyte intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: develops_from CL:0002057 ! CD14-positive, CD16-negative classical monocyte relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule created_by: tmeehan creation_date: 2010-10-04T12:49:47Z [Term] id: CL:0002398 name: Gr1-positive, CD43-positive monocyte namespace: cell def: "An intermediate monocyte that is Gr1-positive, CD43-positive." [GOC:tfm, PMID:20628149] is_a: CL:0001022 ! CD115-positive monocyte is_a: CL:0002393 ! intermediate monocyte intersection_of: CL:0000576 ! monocyte intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C relationship: develops_from CL:0002395 ! Gr1-high classical monocyte relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: has_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C created_by: tmeehan creation_date: 2010-10-04T12:49:49Z [Term] id: CL:0002399 name: CD1c-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD1c-positive." [GOC:dsd, GOC:tfm, PMID:20204387, PMID:20628149] comment: Normally represent 10-20% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10) [PMID:20204387]. Upon TLR stimulation, these cells were potent producers of CXCL8 (IL-8), while producing little TNF-alpha. is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c intersection_of: RO:0002215 GO:0032637 ! capable_of interleukin-8 production relationship: has_plasma_membrane_part PR:000002027 ! T-cell surface glycoprotein CD1c relationship: RO:0002215 GO:0032637 ! capable_of interleukin-8 production created_by: tmeehan creation_date: 2010-10-04T02:39:01Z [Term] id: CL:0002400 name: Fraction B/C precursor B cell namespace: cell def: "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000817 {is_inferred="true"} ! precursor B cell intersection_of: CL:0000817 ! precursor B cell intersection_of: has_plasma_membrane_part PR:000001002 ! CD19 molecule intersection_of: has_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 intersection_of: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001002 ! CD19 molecule relationship: has_plasma_membrane_part PR:000001879 ! leukosialin relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: has_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: lacks_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex created_by: tmeehan creation_date: 2010-10-05T10:11:38Z [Term] id: CL:0002401 name: mature dendritic epithelial T cell precursor namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "mature DEC precursor" EXACT [] synonym: "mature DETC precursor" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002218 ! immature dendritic epithelial T cell precursor created_by: tmeehan creation_date: 2010-10-07T02:05:46Z [Term] id: CL:0002402 name: Peyer's patch B cell namespace: cell def: "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Peyers patch B cell" EXACT [] is_a: CL:0000822 ! B-2 B cell intersection_of: CL:0000785 ! mature B cell intersection_of: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 intersection_of: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 intersection_of: lacks_plasma_membrane_part PR:000001879 ! leukosialin intersection_of: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor intersection_of: part_of UBERON:0001211 ! Peyer's patch relationship: has_plasma_membrane_part GO:0071753 ! IgM immunoglobulin complex relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: has_plasma_membrane_part PR:000001338 ! complement receptor type 2 relationship: lacks_plasma_membrane_part PR:000001839 ! T-cell surface glycoprotein CD5 relationship: lacks_plasma_membrane_part PR:000001879 ! leukosialin relationship: lacks_plasma_membrane_part PR:000002037 ! complement component C1q receptor relationship: part_of UBERON:0001211 ! Peyer's patch created_by: tmeehan creation_date: 2010-10-05T11:18:03Z [Term] id: CL:0002403 name: mature Vgamma2-positive fetal thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "fetal Vgamma2-positive" EXACT [] is_a: CL:0002404 ! fetal thymocyte relationship: develops_from CL:0002378 ! immature Vgamma2-positive fetal thymocyte created_by: tmeehan creation_date: 2010-10-07T02:24:36Z [Term] id: CL:0002404 name: fetal thymocyte namespace: cell def: "A thymocyte found in the fetal thymus." [GOC:tfm] is_a: CL:0000893 ! thymocyte created_by: tmeehan creation_date: 2010-10-07T02:28:25Z [Term] id: CL:0002405 name: gamma-delta thymocyte namespace: cell def: "A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative)." [GOC:tfm, PMID:20725107] synonym: "gammadelta thymocyte" EXACT [] synonym: "gd thymocyte" EXACT [] is_a: CL:0000798 ! gamma-delta T cell is_a: CL:0002489 ! double negative thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part GO:0042106 ! gamma-delta T cell receptor complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-10-07T02:33:39Z [Term] id: CL:0002406 name: immature Vgamma2-positive thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:44Z [Term] id: CL:0002407 name: mature Vgamma2-positive thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-positive" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002406 ! immature Vgamma2-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T02:53:48Z [Term] id: CL:0002408 name: immature Vgamma2-negative thymocyte namespace: cell def: "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-positive." [GOC:tfm, http://www.immgen.org] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative thymocyte" BROAD [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:05Z [Term] id: CL:0002409 name: mature Vgamma2-negative thymocyte namespace: cell def: "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4- negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus." [GOC:tfm, http://www.immgen.org/index_content.html] comment: NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments. synonym: "Vgamma2-negative" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte relationship: develops_from CL:0002408 ! immature Vgamma2-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T02:59:08Z [Term] id: CL:0002410 name: pancreatic stellate cell namespace: cell def: "A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast." [GOC:mah, GOC:tfm, PMID:17200706] synonym: "PaSC" EXACT [] is_a: CL:0000057 ! fibroblast created_by: tmeehan creation_date: 2010-11-10T09:40:33Z [Term] id: CL:0002411 name: Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1-positive, Vd6.3-negative T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:07:44Z [Term] id: CL:0002412 name: Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002405 ! gamma-delta thymocyte created_by: tmeehan creation_date: 2010-10-07T03:03:00Z [Term] id: CL:0002413 name: mature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org] synonym: "mature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:32Z [Term] id: CL:0002414 name: immature Vgamma1.1-positive, Vdelta6.3-negative thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1-positive, Vd6.3-negative T cell" RELATED [] is_a: CL:0002411 ! Vgamma1.1-positive, Vdelta6.3-negative thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:35Z [Term] id: CL:0002415 name: immature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "immature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:39Z [Term] id: CL:0002416 name: mature Vgamma1.1-positive, Vdelta6.3-positive thymocyte namespace: cell def: "A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "mature Vg1.1+Vd6.3+ T cell" EXACT [] is_a: CL:0002412 ! Vgamma1.1-positive, Vdelta6.3-positive thymocyte created_by: tmeehan creation_date: 2010-10-07T03:10:41Z [Term] id: CL:0002417 name: primitive erythroid lineage cell namespace: cell def: "An immature or mature cell of the first erythroid lineage to arise during embryonic development." [GOC:tfm] is_a: CL:0000764 ! erythroid lineage cell created_by: tmeehan creation_date: 2010-10-12T11:22:41Z [Term] id: CL:0002418 name: hemangioblast namespace: cell def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698] is_a: CL:0000222 ! mesodermal cell relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell created_by: tmeehan creation_date: 2010-10-12T12:21:16Z [Term] id: CL:0002419 name: mature T cell namespace: cell def: "A T cell that expresses a T cell receptor complex and has completed T cell selection." [GOC:tfm] synonym: "CD3e-positive T cell" EXACT [] synonym: "CD3epsilon T cell" RELATED [] synonym: "mature T-cell" EXACT [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_completed GO:0045058 ! T cell selection intersection_of: has_plasma_membrane_part GO:0042101 ! T cell receptor complex relationship: has_completed GO:0045058 ! T cell selection relationship: has_plasma_membrane_part GO:0042101 ! T cell receptor complex created_by: tmeehan creation_date: 2010-10-12T01:56:15Z [Term] id: CL:0002420 name: immature T cell namespace: cell def: "A T cell that has not completed T cell selection." [GOC:tfm] synonym: "immature T-cell" EXACT [] xref: BTO:0001372 xref: CALOHA:TS-1042 is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: has_not_completed GO:0045058 ! T cell selection relationship: has_not_completed GO:0045058 ! T cell selection created_by: tmeehan creation_date: 2010-10-12T01:56:17Z [Term] id: CL:0002421 name: nucleated reticulocyte namespace: cell def: "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles." [GOC:tfm, PMID:18182572, PMID:9011180, PMID:9046052] is_a: CL:0000558 {is_inferred="true"} ! reticulocyte is_a: CL:0002242 ! nucleate cell intersection_of: CL:0000558 ! reticulocyte intersection_of: has_part GO:0005634 ! nucleus relationship: has_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-10-15T09:24:05Z [Term] id: CL:0002422 name: enucleated reticulocyte namespace: cell def: "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes." [GOC:tfm, ISBN:0-12203-052-4, ISBN:0721601464] xref: CALOHA:TS-0864 xref: FMA:66785 is_a: CL:0000558 {is_inferred="true"} ! reticulocyte intersection_of: CL:0000558 ! reticulocyte intersection_of: has_part GO:0005840 ! ribosome intersection_of: lacks_part GO:0005634 ! nucleus relationship: has_part GO:0005840 ! ribosome relationship: lacks_part GO:0005634 ! nucleus created_by: tmeehan creation_date: 2010-10-15T09:24:08Z [Term] id: CL:0002423 name: DN2a thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-hi." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: has_high_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:05Z [Term] id: CL:0002424 name: DN2b thymocyte namespace: cell def: "A DN2 thymocyte that is Kit-low." [GOC:tfm, PMID:20595614] comment: Observed in mice. is_a: CL:0000806 {is_inferred="true"} ! DN2 thymocyte intersection_of: CL:0000806 ! DN2 thymocyte intersection_of: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor relationship: develops_from CL:0002423 ! DN2a thymocyte relationship: has_low_plasma_membrane_amount PR:000002065 ! mast/stem cell growth factor receptor created_by: tmeehan creation_date: 2010-10-21T10:12:08Z [Term] id: CL:0002425 name: early T lineage precursor namespace: cell def: "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive." [GOC:dsd, GOC:tfm, http://www.immgen.org/index_content.html, PMID:16551251] comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative. synonym: "ETP" EXACT [] synonym: "preT.ETP.Th" EXACT [] is_a: CL:0000827 {is_inferred="true"} ! pro-T cell intersection_of: CL:0000827 ! pro-T cell intersection_of: has_plasma_membrane_part PR:000001307 ! CD44 molecule intersection_of: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha intersection_of: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor intersection_of: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha relationship: has_plasma_membrane_part PR:000001307 ! CD44 molecule relationship: has_plasma_membrane_part PR:000001869 ! interleukin-7 receptor subunit alpha relationship: has_plasma_membrane_part PR:000002065 ! mast/stem cell growth factor receptor relationship: lacks_plasma_membrane_part PR:000001380 ! interleukin-2 receptor subunit alpha created_by: tmeehan creation_date: 2010-10-21T01:16:24Z [Term] id: CL:0002426 name: CD11b-positive, CD27-positive natural killer cell namespace: cell def: "A mature natural killer cell that is CD11b-positive and CD27-positive." [GOC:tfm, http://www.immgen.org/index_content.html] comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive. is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001963 ! CD27 molecule relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001963 ! CD27 molecule created_by: tmeehan creation_date: 2010-10-25T03:07:59Z [Term] id: CL:0002427 name: resting double-positive thymocyte namespace: cell def: "A double-positive, alpha-beta thymocyte that is small and not proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP.sm.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000587 ! decreased size relationship: bearer_of PATO:0000587 ! decreased size created_by: tmeehan creation_date: 2010-10-21T01:59:06Z [Term] id: CL:0002428 name: double-positive blast namespace: cell def: "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "activated double-positive thymocyte" EXACT [] synonym: "T.DPb.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: participates_in GO:0008283 ! cell proliferation relationship: bearer_of PATO:0000586 ! increased size relationship: develops_from CL:0002427 ! resting double-positive thymocyte relationship: participates_in GO:0008283 ! cell proliferation created_by: tmeehan creation_date: 2010-10-21T01:59:11Z [Term] id: CL:0002429 name: CD69-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is CD69-positive and has begun positive selection." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.DP69+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002428 ! double-positive blast relationship: has_low_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:11:52Z [Term] id: CL:0002430 name: CD4-intermediate, CD8-positive double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.Th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:19Z [Term] id: CL:0002431 name: CD4-positive, CD8-intermediate double-positive thymocyte namespace: cell def: "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4int8+.th" EXACT [] is_a: CL:0000809 {is_inferred="true"} ! double-positive, alpha-beta thymocyte intersection_of: CL:0000809 ! double-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule intersection_of: participates_in GO:0043368 ! positive T cell selection relationship: develops_from CL:0002429 ! CD69-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000025402 ! T cell receptor co-receptor CD8 relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: participates_in GO:0043368 ! positive T cell selection created_by: tmeehan creation_date: 2010-10-21T02:29:23Z [Term] id: CL:0002432 name: CD24-positive, CD4 single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD4 single-positive semimature thymocyte" EXACT [] synonym: "T.4SP24int.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002433 ! CD69-positive, CD4-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:43:52Z [Term] id: CL:0002433 name: CD69-positive, CD4-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD4-single-positive" EXACT [] synonym: "T.4SP69+.Th" EXACT [] is_a: CL:0000810 {is_inferred="true"} ! CD4-positive, alpha-beta thymocyte intersection_of: CL:0000810 ! CD4-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002431 ! CD4-positive, CD8-intermediate double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:46:02Z [Term] id: CL:0002434 name: CD24-positive, CD8 single-positive thymocyte namespace: cell def: "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] comment: Described in the immgene database as being CD24-intermediate. synonym: "CD24-positive, CD8 single-positive semimature thymocyte" EXACT [] synonym: "T.8SP24int.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002435 ! CD69-positive, CD8-positive single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T02:59:10Z [Term] id: CL:0002435 name: CD69-positive, CD8-positive single-positive thymocyte namespace: cell def: "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "intermediate CD8-single-positive" EXACT [] synonym: "T.8SP69+.Th" EXACT [] is_a: CL:0000811 {is_inferred="true"} ! CD8-positive, alpha-beta thymocyte intersection_of: CL:0000811 ! CD8-positive, alpha-beta thymocyte intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_plasma_membrane_part PR:000001343 ! CD69 molecule relationship: develops_from CL:0002430 ! CD4-intermediate, CD8-positive double-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_plasma_membrane_part PR:000001343 ! CD69 molecule created_by: tmeehan creation_date: 2010-10-21T02:59:14Z [Term] id: CL:0002436 name: mature CD4 single-positive thymocyte namespace: cell def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "T.4SP24-.Th" RELATED [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002432 ! CD24-positive, CD4 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:31:19Z [Term] id: CL:0002437 name: mature CD8 single-positive thymocyte namespace: cell def: "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http:www.immgen.org/index_content.html] synonym: "T.8SP24-.Th" EXACT [] is_a: CL:0000625 {is_inferred="true"} ! CD8-positive, alpha-beta T cell intersection_of: CL:0000625 ! CD8-positive, alpha-beta T cell intersection_of: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex intersection_of: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 relationship: develops_from CL:0002434 ! CD24-positive, CD8 single-positive thymocyte relationship: has_high_plasma_membrane_amount GO:0042105 ! alpha-beta T cell receptor complex relationship: has_low_plasma_membrane_amount PR:000001932 ! signal transducer CD24 created_by: tmeehan creation_date: 2010-10-21T03:51:50Z [Term] id: CL:0002438 name: NK1.1-positive natural killer cell namespace: cell def: "A mature NK cell that is NK1.1-positive." [GOC:tfm] comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice. synonym: "NK.sp" EXACT [] synonym: "NK1.1-positive NK cell" EXACT [] is_a: CL:0000824 {is_inferred="true"} ! mature natural killer cell intersection_of: CL:0000824 ! mature natural killer cell intersection_of: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C relationship: has_plasma_membrane_part PR:000002977 ! killer cell lectin-like receptor subfamily B member 1C created_by: tmeehan creation_date: 2010-10-25T03:18:04Z [Term] id: CL:0002439 name: NKGA2-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is NKGA2-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.G2A+.SP" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein relationship: has_plasma_membrane_part PR:000002023 ! NKG2-A/NKG2-B type II integral membrane protein created_by: tmeehan creation_date: 2010-10-25T03:31:09Z [Term] id: CL:0002440 name: Ly49D-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: has_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:36:19Z [Term] id: CL:0002441 name: CD94-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:36:28Z [Term] id: CL:0002442 name: CD94-negative, Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "CD94- Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-94-.Sp" EXACT [] is_a: CL:0002446 ! Ly49CI-negative natural killer cell is_a: CL:0002447 ! CD94-negative natural killer cell intersection_of: CL:0000623 ! natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:21Z [Term] id: CL:0002443 name: Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-positive NK cell" EXACT [] synonym: "NK.49Cl+.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:36:38Z [Term] id: CL:0002444 name: Ly49H-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-positive" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: has_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:36:43Z [Term] id: CL:0002445 name: Ly49D-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49D-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49D-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 relationship: lacks_plasma_membrane_part PR:000009619 ! killer cell lectin-like receptor 4 created_by: tmeehan creation_date: 2010-10-25T03:39:02Z [Term] id: CL:0002446 name: Ly49CI-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49Cl-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Ly49I-negative NK cell" EXACT [] synonym: "NK.49Cl-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: lacks_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:52:04Z [Term] id: CL:0002447 name: CD94-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.94-.Sp" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: lacks_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 created_by: tmeehan creation_date: 2010-10-25T03:54:18Z [Term] id: CL:0002448 name: Ly49H-negative natural killer cell namespace: cell def: "A NK1.1-positive T cell that is Ly49H-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "LyH49H-negative" EXACT [] is_a: CL:0002438 {is_inferred="true"} ! NK1.1-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 relationship: lacks_plasma_membrane_part PR:000009623 ! killer cell lectin-like receptor 8 created_by: tmeehan creation_date: 2010-10-25T03:42:42Z [Term] id: CL:0002449 name: CD94-positive Ly49CI-positive natural killer cell namespace: cell def: "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "NK.49Cl+94+.Sp" EXACT [] is_a: CL:0002441 ! CD94-positive natural killer cell is_a: CL:0002443 ! Ly49CI-positive natural killer cell intersection_of: CL:0002438 ! NK1.1-positive natural killer cell intersection_of: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 intersection_of: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 relationship: has_plasma_membrane_part PR:000001402 ! killer cell lectin-like receptor subfamily D member 1 relationship: has_plasma_membrane_part PR:000009618 ! killer cell lectin-like receptor 3 created_by: tmeehan creation_date: 2010-10-25T03:56:27Z [Term] id: CL:0002450 name: tether cell namespace: cell def: "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." [GOC:cvs, GOC:tfm, PMID:9398434] is_a: CL:0002374 ! ear hair cell created_by: tmeehan creation_date: 2010-11-10T01:41:00Z [Term] id: CL:0002451 name: mammary stem cell namespace: cell def: "A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi." [GOC:hjd, GOC:tfm, PMID:15987436, PMID:16397499, PMID:17851544] is_a: CL:0000048 ! multi fate stem cell created_by: tmeehan creation_date: 2010-11-10T01:46:51Z [Term] id: CL:0002453 name: oligodendrocyte precursor cell namespace: cell def: "The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:20142420] is_a: CL:0000123 {is_inferred="true"} ! neuron associated cell (sensu Vertebrata) intersection_of: CL:0000123 ! neuron associated cell (sensu Vertebrata) intersection_of: part_of UBERON:0001017 ! central nervous system relationship: develops_from CL:0000339 ! glioblast (sensu Vertebrata) relationship: part_of UBERON:0001017 ! central nervous system created_by: tmeehan creation_date: 2010-11-10T02:51:34Z [Term] id: CL:0002454 name: Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell namespace: cell def: "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.8-4-11b+" EXACT [] synonym: "spleen double-negative dendritic cell" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:10:28Z [Term] id: CL:0002455 name: CD8_alpha-negative plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8-" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:27:37Z [Term] id: CL:0002456 name: CD8_alpha-positive plasmactyoid dendritic cell namespace: cell def: "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.pDC.8+" EXACT [] is_a: CL:0000989 {is_inferred="true"} ! CD11c-low plasmacytoid dendritic cell intersection_of: CL:0000989 ! CD11c-low plasmacytoid dendritic cell intersection_of: has_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: has_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-22T01:23:07Z [Term] id: CL:0002457 name: epidermal Langerhans cell namespace: cell def: "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000453 {is_inferred="true"} ! Langerhans cell is_a: CL:0002465 ! CD11b-positive dendritic cell intersection_of: CL:0000453 ! Langerhans cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: part_of UBERON:0001003 ! epidermis relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: part_of UBERON:0001003 ! epidermis created_by: tmeehan creation_date: 2010-11-22T03:57:57Z [Term] id: CL:0002458 name: langerin-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-positive, CD103-positive, and CD11b-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-22T04:06:22Z [Term] id: CL:0002459 name: langerin-negative dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part CL:0002458 ! langerin-positive dermal dendritic cell relationship: lacks_plasma_membrane_part CL:0002507 ! langerin-positive lymph node dendritic cell relationship: lacks_plasma_membrane_part CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-22T04:09:44Z [Term] id: CL:0002460 name: CD8alpha-negative thymic conventional dendritic cell namespace: cell def: "A conventional thymic dendritic cell that is CD8alpha-negative." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:19273629] synonym: "DC.8-.Th" EXACT [] is_a: CL:0000941 {is_inferred="true"} ! thymic conventional dendritic cell intersection_of: CL:0000941 ! thymic conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2010-11-23T10:58:53Z [Term] id: CL:0002461 name: CD103-positive dendritic cell namespace: cell def: "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T01:32:43Z [Term] id: CL:0002462 name: adipose dendritic cell namespace: cell def: "A F4/80-negative dendritic cell located in adipose tissue." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell is_a: CL:0002320 ! connective tissue cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: part_of UBERON:0001013 ! adipose tissue relationship: develops_from CL:0002010 ! pre-conventional dendritic cell relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: part_of UBERON:0001013 ! adipose tissue created_by: tmeehan creation_date: 2010-11-23T01:38:21Z [Term] id: CL:0002463 name: SIRPa-positive adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa+.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:44Z [Term] id: CL:0002464 name: SIRPa-negative adipose dendritic cell namespace: cell def: "An adipose dendritic cell that is SIRPa-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.SIRPa-.Ad" EXACT [] is_a: CL:0002462 ! adipose dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: lacks_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T01:40:46Z [Term] id: CL:0002465 name: CD11b-positive dendritic cell namespace: cell def: "A conventional dendritic cell that expresses CD11b (ITGAM)." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2010-11-23T01:50:05Z [Term] id: CL:0002466 name: small intestine serosal dendritic cell namespace: cell def: "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "DC.11cloSer.SI" EXACT [] is_a: CL:0002465 {is_inferred="true"} ! CD11b-positive dendritic cell intersection_of: CL:0002465 ! CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2010-11-23T02:00:21Z [Term] id: CL:0002467 name: Gr1-high myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-high and CD11c-negative." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1hi" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:15:12Z [Term] id: CL:0002468 name: Gr1-low myeloid suppressor cell namespace: cell def: "A myeloid suppressor cell that is Gr1-low and CD11c-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MDS.Gr1lo" EXACT [] is_a: CL:0000889 {is_inferred="true"} ! myeloid suppressor cell intersection_of: CL:0000889 ! myeloid suppressor cell intersection_of: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_low_plasma_membrane_amount PR:000002980 ! lymphocyte antigen 6C relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T02:19:43Z [Term] id: CL:0002469 name: MHC-II-negative classical monocyte namespace: cell def: "Gr1-high monocyte that lacks MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C+II-" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:27:12Z [Term] id: CL:0002470 name: MHC-II-positive classical monocyte namespace: cell def: "Gr1-high monocyte that has a MHC-II receptor complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6c+II" EXACT [] is_a: CL:0002395 {is_inferred="true"} ! Gr1-high classical monocyte intersection_of: CL:0002395 ! Gr1-high classical monocyte intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:30:21Z [Term] id: CL:0002471 name: MHC-II-negative non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that lacks expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II-" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:38:15Z [Term] id: CL:0002472 name: MHC-II-low non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-IIint" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:53Z [Term] id: CL:0002473 name: MHC-II-high non-classical monocyte namespace: cell def: "Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "Mo.6C-II+" EXACT [] is_a: CL:0002058 {is_inferred="true"} ! Gr1-low non-classical monocyte intersection_of: CL:0002058 ! Gr1-low non-classical monocyte intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T03:47:55Z [Term] id: CL:0002474 name: lymphoid MHC-II-negative classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 {is_inferred="true"} ! MHC-II-negative classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part PR:000001013 ! integrin alpha-X created_by: tmeehan creation_date: 2010-11-23T04:00:52Z [Term] id: CL:0002475 name: lymphoid MHC-II-negative non-classical monocyte namespace: cell def: "A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002469 ! MHC-II-negative classical monocyte is_a: CL:0002471 ! MHC-II-negative non-classical monocyte intersection_of: CL:0002469 ! MHC-II-negative classical monocyte intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:09:09Z [Term] id: CL:0002476 name: bone marrow macrophage namespace: cell def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.BM" RELATED [] xref: BTO:0004732 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor intersection_of: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R intersection_of: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon intersection_of: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part PR:000002062 ! macrophage colony-stimulating factor 1 receptor relationship: lacks_plasma_membrane_part PR:000001014 ! receptor-type tyrosine-protein phosphatase C isoform CD45R relationship: lacks_plasma_membrane_part PR:000001020 ! CD3 epsilon relationship: lacks_plasma_membrane_part PR:000002980 ! lymphocyte antigen 6C relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2010-11-23T04:19:25Z [Term] id: CL:0002477 name: adipose macrophage namespace: cell def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm] is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage intersection_of: CL:0000864 ! tissue-resident macrophage intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001013 ! integrin alpha-X intersection_of: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001013 ! integrin alpha-X relationship: has_plasma_membrane_part PR:000001968 ! tyrosine-protein phosphatase non-receptor type substrate 1 created_by: tmeehan creation_date: 2010-11-23T04:31:28Z [Term] id: CL:0002478 name: F4/80-negative adipose macrophage namespace: cell def: "An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.Autofl.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 created_by: tmeehan creation_date: 2010-11-23T04:40:50Z [Term] id: CL:0002479 name: F4/80-positive adipose macrophage namespace: cell def: "An adipose macrophage that does not express MHC-II but is F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "MF.F480+.Ad" EXACT [] is_a: CL:0002477 {is_inferred="true"} ! adipose macrophage intersection_of: CL:0002477 ! adipose macrophage intersection_of: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 intersection_of: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001813 ! EGF-like module-containing mucin-like hormone receptor-like 1 relationship: lacks_plasma_membrane_part GO:0042613 ! MHC class II protein complex created_by: tmeehan creation_date: 2010-11-23T04:35:53Z [Term] id: CL:0002480 name: nasal mucosa goblet cell namespace: cell def: "A goblet cell located in the nasal epithelium." [GOC:cjm, GOC:tfm] xref: MP:0002262 is_a: CL:0000160 {is_inferred="true"} ! goblet cell intersection_of: CL:0000160 ! goblet cell intersection_of: part_of UBERON:0005384 ! nasal cavity epithelium relationship: part_of UBERON:0005384 ! nasal cavity epithelium created_by: tmeehan creation_date: 2010-12-03T03:03:02Z [Term] id: CL:0002481 name: peritubular myoid cell namespace: cell def: "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule." [GOC:cjm, GOC:tfm, MP:0006420] is_a: CL:0000185 {is_inferred="true"} ! myoepithelial cell intersection_of: CL:0000185 ! myoepithelial cell intersection_of: part_of UBERON:0001343 ! seminiferous tubule of testis relationship: part_of UBERON:0001343 ! seminiferous tubule of testis created_by: tmeehan creation_date: 2010-12-03T03:11:48Z [Term] id: CL:0002482 name: dermal melanocyte namespace: cell def: "A melanocyte that produces pigment in the dermis." [GOC:cjm, GOC:tfm, MP:0009386] is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002067 ! dermis relationship: part_of UBERON:0002067 ! dermis created_by: tmeehan creation_date: 2010-12-03T03:17:05Z [Term] id: CL:0002483 name: hair follicle melanocyte namespace: cell def: "A melanocyte that produces pigment within the hair follicle." [GOC:tfm, MP:0004381] is_a: CL:0000362 ! epidermal cell is_a: CL:0002484 ! epithelial melanocyte is_a: CL:0002559 ! hair follicle cell is_a: CL:1000458 ! melanocyte of skin intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002073 ! hair follicle relationship: part_of UBERON:0002073 ! hair follicle created_by: tmeehan creation_date: 2010-12-03T03:17:09Z [Term] id: CL:0002484 name: epithelial melanocyte namespace: cell def: "A melanocyte that produces pigment in the epithelium." [GOC:tfm, MP:0009388] is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000483 ! epithelium relationship: part_of UBERON:0000483 ! epithelium created_by: tmeehan creation_date: 2010-12-03T03:17:14Z [Term] id: CL:0002485 name: retinal melanocyte namespace: cell def: "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium." [GOC:tfm, MP:0010190] is_a: CL:0000148 {is_inferred="true"} ! melanocyte intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0000966 ! retina relationship: part_of UBERON:0000966 ! retina created_by: tmeehan creation_date: 2010-12-03T03:25:32Z [Term] id: CL:0002486 name: strial intermediate cell namespace: cell def: "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) ." [GOC:tfm, MP:0000048] is_a: CL:0000148 {is_inferred="true"} ! melanocyte is_a: CL:0001035 ! bone cell is_a: CL:0002491 ! auditory epithelial cell intersection_of: CL:0000148 ! melanocyte intersection_of: part_of UBERON:0002282 ! stria vascularis of cochlear duct relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-03T03:29:15Z [Term] id: CL:0002487 name: cutaneous/subcutaneous mechanoreceptor cell namespace: cell def: "A neuronal receptor that respond to mechanical pressure or distortion in the skin." [GOC:tfm, MP:0000973] is_a: CL:0000199 ! mechanoreceptor cell created_by: tmeehan creation_date: 2010-12-06T02:53:30Z [Term] id: CL:0002488 name: trophoblast giant cell namespace: cell def: "A trophoblast cell that has a large volume of cytoplasm, is polyploidy and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta." [GOC:tfm, MP:0001714, MP:19876834] synonym: "giant trophoblast cell" EXACT [] is_a: CL:0000351 {is_inferred="true"} ! trophoblast cell intersection_of: CL:0000351 ! trophoblast cell intersection_of: bearer_of PATO:0000586 ! increased size intersection_of: RO:0002215 GO:0001974 ! capable_of blood vessel remodeling relationship: bearer_of PATO:0000586 ! increased size relationship: RO:0002215 GO:0001974 ! capable_of blood vessel remodeling created_by: tmeehan creation_date: 2010-12-06T02:55:24Z [Term] id: CL:0002489 name: double negative thymocyte namespace: cell def: "A thymocyte that lacks expression of CD4 and CD8." [GOC:tfm, MP:0002407] synonym: "double negative T cell" BROAD [] is_a: CL:0000893 {is_inferred="true"} ! thymocyte intersection_of: CL:0000893 ! thymocyte intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000025402 ! T cell receptor co-receptor CD8 created_by: tmeehan creation_date: 2010-12-06T03:03:38Z [Term] id: CL:0002490 name: organ of Corti supporting cell namespace: cell def: "A supporting cell of the organ of Corti." [GOC:tfm, MP:0004300] is_a: CL:0001035 ! bone cell is_a: CL:0002315 ! supporting cell of cochlea intersection_of: CL:0005014 ! auditory epithelial support cell intersection_of: part_of UBERON:0002227 ! spiral organ of cochlea relationship: part_of UBERON:0002227 ! spiral organ of cochlea created_by: tmeehan creation_date: 2010-12-06T03:09:01Z [Term] id: CL:0002491 name: auditory epithelial cell namespace: cell def: "A specialized cell involved in auditory sensory perception." [GOC:tfm] is_a: CL:0000098 ! sensory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:18:43Z [Term] id: CL:0002492 name: strial marginal cell namespace: cell def: "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria." [GOC:tfm, MP:0004366] is_a: CL:0002491 ! auditory epithelial cell created_by: tmeehan creation_date: 2010-12-06T03:20:41Z [Term] id: CL:0002493 name: strial basal cell namespace: cell def: "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions." [GOC:tfm, MP:0004365] comment: Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863] is_a: CL:0001035 ! bone cell is_a: CL:0002491 ! auditory epithelial cell relationship: part_of UBERON:0002282 ! stria vascularis of cochlear duct created_by: tmeehan creation_date: 2010-12-06T03:26:53Z [Term] id: CL:0002494 name: cardiocyte namespace: cell def: "A cell located in the heart, including both muscle and non muscle cells." [GOC:tfm] comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart. synonym: "heart cell" EXACT [] xref: BTO:0001539 xref: CALOHA:TS-0115 xref: FMA:83808 xref: FMA:84791 is_a: CL:0000548 ! animal cell is_a: CL:0002371 {is_inferred="true"} ! somatic cell intersection_of: CL:0002371 ! somatic cell intersection_of: part_of UBERON:0000948 ! heart relationship: part_of UBERON:0000948 ! heart created_by: tmeehan creation_date: 2010-12-07T09:37:22Z [Term] id: CL:0002495 name: fetal cardiomyocyte namespace: cell def: "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte." [GOC:tfm, MP:0008788] synonym: "embryonic cardiomyocyte" EXACT [] synonym: "neonatal cardiomyocyte" EXACT [] is_a: CL:0000746 ! cardiac muscle cell created_by: tmeehan creation_date: 2010-12-07T09:50:41Z [Term] id: CL:0002496 name: intraepithelial lymphocyte namespace: cell def: "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response." [GOC:tfm, MP:0008894] synonym: "IEL" EXACT [] synonym: "intraepithelial T cell" EXACT [] synonym: "intraepithelial T-cell" EXACT [] is_a: CL:0002419 {is_inferred="true"} ! mature T cell intersection_of: CL:0002419 ! mature T cell intersection_of: part_of UBERON:0001277 ! intestinal epithelium intersection_of: RO:0002215 GO:0002385 ! capable_of mucosal immune response relationship: part_of UBERON:0001277 ! intestinal epithelium relationship: RO:0002215 GO:0002385 ! capable_of mucosal immune response created_by: tmeehan creation_date: 2010-12-07T09:54:50Z [Term] id: CL:0002497 name: primary trophoblast giant cell namespace: cell def: "A trophoblast giant cell derived from the mural trophectoderm." [GOC:tfm, PMCID:PMC85124] xref: EMAPA:16066 is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:47Z [Term] id: CL:0002498 name: secondary trophoblast giant cell namespace: cell def: "A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast." [GOC:tfm, PMCID:PMC85124] is_a: CL:0002488 ! trophoblast giant cell created_by: tmeehan creation_date: 2010-12-07T10:07:52Z [Term] id: CL:0002499 name: spongiotrophoblast cell namespace: cell def: "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." [GOC:tfm, MP:0008959] is_a: CL:0000351 ! trophoblast cell created_by: tmeehan creation_date: 2010-12-07T12:56:56Z [Term] id: CL:0002500 name: P enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide." [FMA:63418, GOC:tfm] is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:06Z [Term] id: CL:0002501 name: type D1 enteroendocrine cell namespace: cell def: "A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide." [FMA:63207, GOC:tfm] xref: FMA:63207 is_a: CL:0002268 ! P/D1 enteroendocrine cell created_by: tmeehan creation_date: 2010-12-07T03:42:09Z [Term] id: CL:0002502 name: type M enteroendocrine cell namespace: cell def: "An enteroendocrine cell of the small intestine that secretes motilin." [GOC:tfm, PMID:15153415] synonym: "Mo enteroendocrine cell" BROAD [] xref: FMA:63420 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0002272 ! motilin secreting cell created_by: tmeehan creation_date: 2010-12-07T03:55:49Z [Term] id: CL:0002503 name: adventitial cell namespace: cell def: "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc" [GOC:tfm] xref: BTO:0002441 xref: FMA:84639 is_a: CL:0000630 ! supportive cell is_a: CL:0002320 ! connective tissue cell created_by: tmeehan creation_date: 2010-12-07T04:03:56Z [Term] id: CL:0002504 name: enteric smooth muscle cell namespace: cell def: "A smooth muscle cell of the intestine." [GOC:tfm] synonym: "intestinal smooth muscle cell" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0000160 ! intestine relationship: part_of UBERON:0000160 ! intestine created_by: tmeehan creation_date: 2011-01-17T03:39:38Z [Term] id: CL:0002505 name: liver CD103-negative dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103-11b+.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: part_of UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:41Z [Term] id: CL:0002506 name: liver CD103-positive dendritic cell namespace: cell def: "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver." [GOC:tfm, http:http\://www.immgen.org/index_content.html] synonym: "DC.103+11b-.Lv" EXACT [] is_a: CL:0002454 {is_inferred="true"} ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is_a: CL:0002461 ! CD103-positive dendritic cell intersection_of: CL:0002454 ! Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: part_of UBERON:0001281 ! hepatic sinusoid relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001006 ! receptor-type tyrosine-protein phosphatase C relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: part_of UBERON:0001281 ! hepatic sinusoid created_by: tmeehan creation_date: 2011-01-21T01:27:45Z [Term] id: CL:0002507 name: langerin-positive lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: has_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain created_by: tmeehan creation_date: 2011-01-21T01:57:00Z [Term] id: CL:0002508 name: langerin-negative, CD103-negative lymph node dendritic cell namespace: cell def: "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0000990 {is_inferred="true"} ! conventional dendritic cell intersection_of: CL:0000990 ! conventional dendritic cell intersection_of: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex intersection_of: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E intersection_of: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain intersection_of: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K relationship: has_plasma_membrane_part GO:0042613 ! MHC class II protein complex relationship: lacks_plasma_membrane_part PR:000001004 ! CD4 molecule relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: lacks_plasma_membrane_part PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain relationship: lacks_plasma_membrane_part PR:000001293 ! C-type lectin domain family 4 member K created_by: tmeehan creation_date: 2011-01-21T02:13:58Z [Term] id: CL:0002509 name: CD103-positive, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002461 ! CD103-positive dendritic cell is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: has_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:07:54Z [Term] id: CL:0002510 name: CD103-negative, langerin-positive lymph node dendritic cell namespace: cell def: "A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002507 {is_inferred="true"} ! langerin-positive lymph node dendritic cell intersection_of: CL:0002507 ! langerin-positive lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M intersection_of: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: lacks_plasma_membrane_part PR:000001010 ! integrin alpha-E created_by: tmeehan creation_date: 2011-01-21T02:11:14Z [Term] id: CL:0002511 name: CD11b-low, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_low_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:22:15Z [Term] id: CL:0002512 name: CD11b-high, CD103-negative, langerin-negative lymph node dendritic cell namespace: cell def: "A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high." [GOC:tfm, http://www.immgen.org/index_content.html] is_a: CL:0002508 {is_inferred="true"} ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: CL:0002508 ! langerin-negative, CD103-negative lymph node dendritic cell intersection_of: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M relationship: has_high_plasma_membrane_amount PR:000001012 ! integrin alpha-M created_by: tmeehan creation_date: 2011-01-21T02:16:21Z [Term] id: CL:0002513 name: Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5+.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:22:18Z [Term] id: CL:0002514 name: Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell namespace: cell def: "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment." [GOC:tfm, http://www.immgen.org/index_content.html] synonym: "tgd.vg5-.IEL" EXACT [] is_a: CL:0000802 ! CD8-alpha alpha positive, gamma-delta intraepithelial T cell created_by: tmeehan creation_date: 2011-01-24T10:25:44Z [Term] id: CL:0002515 name: interrenal norepinephrine type cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal noradrenaline type cell" EXACT [] synonym: "type n interrenal cell" EXACT [] is_a: CL:0000459 ! norepinephrin secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:11:55Z [Term] id: CL:0002516 name: interrenal chromaffin cell namespace: cell def: "A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish." [GOC:MH, GOC:tfm, PMID:12668625] is_a: CL:0000166 ! chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:21:35Z [Term] id: CL:0002517 name: interrenal epinephrin secreting cell namespace: cell def: "An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo." [GOC:MH, GOC:tfm, PMID:12668625] synonym: "interrenal adrenaline secreting cell" RELATED [] synonym: "type a interrenal cell" EXACT [] is_a: CL:0000454 ! epinephrine secreting cell is_a: CL:0002516 ! interrenal chromaffin cell created_by: tmeehan creation_date: 2011-02-08T10:27:05Z [Term] id: CL:0002518 name: kidney epithelial cell namespace: cell def: "An epithelial cell of the kidney." [GOC:tfm, KUPO:SJ] xref: KUPO:0001019 is_a: CL:0000066 ! epithelial cell is_a: CL:1000497 {is_inferred="true"} ! kidney cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0002113 ! kidney relationship: part_of UBERON:0002113 ! kidney created_by: tmeehan creation_date: 2011-02-08T10:46:34Z [Term] id: CL:0002519 name: interrenal epithelial cell namespace: cell def: "An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type." [GOC:mh, GOC:tfm, PMID:12668625] is_a: CL:0002518 ! kidney epithelial cell created_by: tmeehan creation_date: 2011-02-08T11:03:32Z [Term] id: CL:0002520 name: nephrocyte namespace: cell def: "An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis." [GOC:tfm, PMID:19783135] xref: BTO:0004597 xref: FMA:83807 is_a: CL:0002522 ! renal filtration cell created_by: tmeehan creation_date: 2011-02-08T01:34:56Z [Term] id: CL:0002521 name: subcutaneous fat cell namespace: cell def: "A fat cell that is part of subcutaneous adipose tissue." [GOC:tfm] synonym: "subcutaneous adipocyte" EXACT [] is_a: CL:0000136 {is_inferred="true"} ! fat cell intersection_of: CL:0000136 ! fat cell intersection_of: part_of UBERON:0002190 ! subcutaneous adipose tissue relationship: part_of UBERON:0002190 ! subcutaneous adipose tissue created_by: tmeehan creation_date: 2011-02-21T02:51:22Z [Term] id: CL:0002522 name: renal filtration cell namespace: cell def: "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." [GOC:tfm] is_a: CL:0000424 ! excretory cell created_by: tmeehan creation_date: 2011-02-08T01:37:59Z [Term] id: CL:0002523 name: mesonephric glomerular visceral epithelial cell namespace: cell def: "A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros" [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell created_by: tmeehan creation_date: 2011-02-08T01:58:30Z [Term] id: CL:0002524 name: disseminated nephrocyte namespace: cell def: "A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues." [GOC:tfm, PMID:19783135] is_a: CL:0002520 ! nephrocyte created_by: tmeehan creation_date: 2011-02-08T02:07:33Z [Term] id: CL:0002525 name: metanephric glomerular visceral epithelial cell namespace: cell def: "A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros." [GOC:tfm] is_a: CL:0000653 ! glomerular visceral epithelial cell created_by: tmeehan creation_date: 2011-02-08T02:02:13Z [Term] id: CL:0002526 name: CD14-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-negative and CD14-positive." [GOC:dsd, PMID:19236899, PMID:20309010] comment: They are also CD11c-positive, CD40-positive, CD85j-positive (ILT-2), CD163-positive, CD205-positive (DEC205), CD207-negative (langerin), CD209-positive (DC-SIGN), CD274-positive (PD-L1), CD324-negative (E-cadherin), Factor XIIIa-positive, LOX-I-positive, CLEC6-positive, Dectin-1-positive, and DCIR-positive. Upon stimulation, these cells are capable of producing IL1-beta, IL6, IL8, IL10, IL12p40, IL19, IL20, IL24, TGF-beta, TNF-alpha, GM-CSF, and MCP1. They reside in the dermis. synonym: "CD14+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000001889 ! CD14 molecule intersection_of: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a intersection_of: RO:0002215 GO:0045191 ! capable_of regulation of isotype switching relationship: has_plasma_membrane_part PR:000001889 ! CD14 molecule relationship: lacks_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: RO:0002215 GO:0045191 ! capable_of regulation of isotype switching [Term] id: CL:0002527 name: immature CD14-positive dermal dendritic cell namespace: cell def: "An immature CD14-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002528 name: mature CD14-positive dermal dendritic cell namespace: cell def: "A mature CD14-positive dermal dendritic cell is CD80-high, CD86-high, MHCII-high and is CD83-positive." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002526 {is_inferred="true"} ! CD14-positive dermal dendritic cell intersection_of: CL:0002526 ! CD14-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002527 ! immature CD14-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002529 name: CD1a-positive dermal dendritic cell namespace: cell def: "A dermal dendritic cell that is CD1a-positive and CD14-negative." [GOC:dsd, PMID:20309010] comment: Reside in the dermis. They are also CD11c-positive, CD40-positive, CD207-negative (langerin), CD209-negative (DC-SIGN), and CD324-negative (E-cadherin). When activated, they are capable of producing CXCL8 (IL-8) and IL-15. Possibly a precursor of Langerhans cells or equivalent of langerin-positive dermal DCs in the mouse. synonym: "CD1a+ dermal DC" EXACT [] is_a: CL:0001006 {is_inferred="true"} ! dermal dendritic cell intersection_of: CL:0001006 ! dermal dendritic cell intersection_of: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a relationship: has_plasma_membrane_part PR:000002025 ! T-cell surface glycoprotein CD1a [Term] id: CL:0002530 name: immature CD1a-positive dermal dendritic cell namespace: cell def: "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0001009 ! immature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002531 name: mature CD1a-positive dermal dendritic cell namespace: cell def: "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0001010 ! mature dermal dendritic cell is_a: CL:0002529 {is_inferred="true"} ! CD1a-positive dermal dendritic cell intersection_of: CL:0002529 ! CD1a-positive dermal dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002530 ! immature CD1a-positive dermal dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002532 name: CD16-positive myeloid dendritic cell namespace: cell def: "A myeloid dendritic cell found in the blood that is CD16-positive." [GOC:dsd, PMID:17332250] comment: Normally represent 65-75% of peripheral blood mDCs (human). They are also CD281-positive (TLR1), CD282-positive (TLR2), CD284-positive (TLR4), CD285-positive (TLR5), CD286-positive (TLR6), CD288-positive (TLR8), CD289-positive (TLR9), and CD290-positive (TLR10) by RT-PCR [PMID:17332250]. Upon TLR stimulation, these cells are potent producers of TNF-alpha, while producing little CXCL8 (IL8). synonym: "CD16+ mDC" EXACT [] synonym: "CD16-mDC" EXACT [] is_a: CL:0000782 {is_inferred="true"} ! myeloid dendritic cell intersection_of: CL:0000782 ! myeloid dendritic cell intersection_of: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III intersection_of: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production relationship: has_plasma_membrane_part PR:000001483 ! low affinity immunoglobulin gamma Fc region receptor III relationship: RO:0002215 GO:0032640 ! capable_of tumor necrosis factor production [Term] id: CL:0002533 name: immature CD16-positive myeloid dendritic cell namespace: cell def: "An immature CD16-positive myeloid dendritic cell is CD80-low, CD86-low, and MHCII-low." [GOC:dsd] is_a: CL:0000840 ! immature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_low_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_low_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_low_plasma_membrane_amount PR:000001438 ! CD80 molecule [Term] id: CL:0002534 name: mature CD16-positive myeloid dendritic cell namespace: cell def: "A mature CD16-positive myeloid dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." [GOC:dsd] is_a: CL:0000841 ! mature conventional dendritic cell is_a: CL:0002532 {is_inferred="true"} ! CD16-positive myeloid dendritic cell intersection_of: CL:0002532 ! CD16-positive myeloid dendritic cell intersection_of: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex intersection_of: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule intersection_of: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule intersection_of: has_plasma_membrane_part PR:000001310 ! CD83 molecule relationship: develops_from CL:0002533 ! immature CD16-positive myeloid dendritic cell relationship: has_high_plasma_membrane_amount GO:0042613 ! MHC class II protein complex relationship: has_high_plasma_membrane_amount PR:000001412 ! CD86 molecule relationship: has_high_plasma_membrane_amount PR:000001438 ! CD80 molecule relationship: has_plasma_membrane_part PR:000001310 ! CD83 molecule [Term] id: CL:0002535 name: epithelial cell of cervix namespace: cell def: "An epithelial cell of the cervix." [GOC:tfm] synonym: "cervical canal epithelial cell" EXACT [GOC:tfm] synonym: "cervical canal of uterus epithelial cell" EXACT [GOC:tfm] synonym: "cervix epithelial cell" EXACT [GOC:tfm] synonym: "cervix of uterus epithelial cell" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal" EXACT [GOC:tfm] synonym: "epithelial cell of cervical canal of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of cervix of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of neck of uterus" EXACT [GOC:tfm] synonym: "epithelial cell of uterine cervix" EXACT [GOC:tfm] synonym: "neck of uterus epithelial cell" EXACT [GOC:tfm] synonym: "uterine cervix epithelial cell" EXACT [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0002371 ! somatic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0000002 ! uterine cervix relationship: part_of UBERON:0004801 ! cervix epithelium created_by: tmeehan creation_date: 2011-02-24T08:20:08Z [Term] id: CL:0002536 name: amniotic epithelial cell namespace: cell def: "An epithelial cell that is part of the amnion." [GOC:tfm] is_a: CL:0000066 {is_inferred="true"} ! epithelial cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000066 ! epithelial cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:38:01Z [Term] id: CL:0002537 name: amnion mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the amnion membrane." [GOC:tfm, PMID:20446274, PMID:21339039] synonym: "amniotic membrane stem cell" EXACT [] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0000305 ! amnion relationship: part_of UBERON:0000305 ! amnion created_by: tmeehan creation_date: 2011-02-28T12:44:24Z [Term] id: CL:0002538 name: intrahepatic bile duct epithelial cell namespace: cell def: "An epithelial cell of the intrahepatic portion of the bile duct." [GOC:tfm] is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell is_a: CL:0000182 ! hepatocyte intersection_of: CL:0000069 ! branched duct epithelial cell intersection_of: part_of UBERON:0004823 ! intrahepatic bile duct epithelium relationship: part_of UBERON:0004823 ! intrahepatic bile duct epithelium created_by: tmeehan creation_date: 2011-02-28T01:20:20Z [Term] id: CL:0002539 name: aortic smooth muscle cell namespace: cell def: "A smooth muscle cell of the aorta." [GOC:tfm] xref: BTO:0004577 is_a: CL:0000359 {is_inferred="true"} ! vascular associated smooth muscle cell intersection_of: CL:0000359 ! vascular associated smooth muscle cell intersection_of: part_of UBERON:0004178 ! aorta smooth muscle tissue relationship: part_of UBERON:0004178 ! aorta smooth muscle tissue created_by: tmeehan creation_date: 2011-02-28T01:42:12Z [Term] id: CL:0002540 name: mesenchymal stem cell of the bone marrow namespace: cell def: "A mesenchymal stem cell that is part of the bone marrow." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0002092 ! bone marrow cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0002371 ! bone marrow relationship: part_of UBERON:0002371 ! bone marrow created_by: tmeehan creation_date: 2011-02-28T01:47:47Z [Term] id: CL:0002541 name: chorionic membrane mesenchymal stem cell namespace: cell def: "A mesenchymal stem cell of the chorionic membrane." [GOC:tfm] is_a: CL:0000134 {is_inferred="true"} ! mesenchymal cell is_a: CL:0000349 ! extraembryonic cell intersection_of: CL:0000134 ! mesenchymal cell intersection_of: part_of UBERON:0003124 ! chorion relationship: part_of UBERON:0003124 ! chorion created_by: tmeehan creation_date: 2011-02-28T03:04:35Z [Term] id: CL:0002543 name: vein endothelial cell namespace: cell alt_id: CL:1000393 def: "An endothelial cell that is part of the vein." [GOC:tfm] synonym: "endothelial cell of vein" EXACT [] xref: FMA:62104 xref: KUPO:0001099 is_a: CL:0000071 {is_inferred="true"} ! blood vessel endothelial cell intersection_of: CL:0000071 ! blood vessel endothelial cell intersection_of: part_of UBERON:0001638 ! vein relationship: part_of UBERON:0001638 ! vein created_by: tmeehan creation_date: 2011-02-28T03:48:11Z [Term] id: CL:0002544 name: aortic endothelial cell namespace: cell def: "An arterial endothelial cell that